LEARNING OBJECTIVES

3/7/2019

CAR T-CELL THERAPY FOR HEMATOLOGIC MALIGNANCIES:

FOCUS ON DIFFUSE LARGE B-CELL LYMPHOMA

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LEARNING OBJECTIVES

Describe the latest developments in CAR T-cell therapy options for adults and pediatric patients

Explain short and long-term side-effect management, including CRS and neurotoxicities

Discuss practical information in considering and treating a patient in a CAR T trial

Be more prepared to identify resources for professionals as well as for their patients

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FACULTY

Julio C. Chavez, MD, MS

Assistant Member Department of Malignant Hematology

Moffitt Cancer Center Tampa, FL

Rachel Lundberg, PA-C

Physician Assistant, Cellular Immunotherapy Department of Blood Marrow and Cellular Immunotherapy Moffitt Cancer Center Tampa, Fl

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CAR T-cell Therapy for Hematologic Malignancies: Focus on Diffuse Large B-cell Lymphoma

Julio C. Chavez, MD, MS Assistant Member Department of Malignant Hematology Moffitt Cancer Center Tampa, FL Rachel Lundberg, PA-C Physician Assistant, Cellular Immunotherapy Department of Blood Marrow and Cellular Immunotherapy Moffitt Cancer Center Tampa, FL

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Outline

1. Overview of refractory/relapsed Diffuse Large Bcell Lymphoma

2. Overview of Cancer Immunotherapy 3. CAR-T cell structure and manufacturing 4. Efficacy of multicenter CAR-T cell studies in

DLBCL 5. CAR-T cell therapy in pediatric acute lymphoblastic

leukemia (ALL) 6. CAR-T cell toxicity and principles of management 7. Patient selection, toxicity management and post

CAR-T cell therapy monitoring 8. Future directions

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Overview of Refractory/Relapsed DLBCL

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Cell of origin of B-cell lymphomas

3/7/2019

Kuppers. Nature Reviews Cancer 2005; (5): 4.

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Most Common Subtypes of NHL

Burkitt (2.5%)

Other subtypes

(9%) T- and NK-

cell (12%)

Diffuse large B-cell (30%)

Mantle cell (6%)

Follicular (25%)

SLL/CLL (7%)

MALT-type marginal-zone B-cell (7.5%)

Nodal-type marginal-zone

B-cell ( ................
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