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Online AppendixOnline Table 1. Baseline Characteristics of All KNHANES Participants and Those Included in Study Population vs. Those Excluded.aVariableAll KNHANES Participants (N=41,321)Included Study Participants (N=13,346)Excluded Participants (N=27,975)Age Median (IQR), y49 (36-63)63 (53-72)41 (32-53) < 60 years28,525 (69.0)5,233 (39.2)23,292 (83.3) ≥ 60 years12,796 (31.0)8,113 (60.8)4,683 (16.7)Male sex17,908 (43.3)6,081 (45.6)11,827 (42.3)Systolic blood pressure, mm Hg117 (106-130)135 (129-144)110 (102-118)Diastolic blood pressure, mm Hg75 (69-82)82 (74-90)72 (68-79)Heart rate, beats/min56 (54-58)56 (53-58)56 (54-58)Diabetes mellitusb3,911/36,594 (10.7)2,615 (19.6)1,296/23,248 (5.6) Fasting glucose level, mg/dl93 (87-101)98 (91-110)91 (86-97)Chronic kidney diseasec1,537/37,912 (4.1)1,136 (8.5)401/24,566 (1.6) Glomerular filtration rate, mL/min/1.73 m287 (76-98)81 (71-91)90 (80-101)Current smoking7,824/37,886 (20.7)2,271 (17.0)5,553/24,540 (22.6)Hyperlipidemiad4,668/36,346 (12.8)2,611 (19.6)2,057/23,000 (8.9) Total cholesterol, mg/dl185 (163-210)191 (168-216)183 (161-207)Obesity BMI ≥ 25, no. (%)e12,175/39,058 (31.2)5,732 (42.9)6,443/25,712 (25.1) BMI ≥ 30, no. (%)1,509/39,058 (3.9)792 (5.9)717/25,712 (2.8)Prevalent cardiovascular diseasef1,653/38,560 (4.3)1,198 (9.0)455/25,214 (1.8)Receiving antihypertensive agents7,389/38,560 (19.2)7,373 (55.2)16/25,214 (0.1)Framingham risk score <10%27,365/36,330 (75.3)7,272 (54.5)20,093/22,984 (87.4) 10-20%6,385/36,330(17.6)3,977 (29.8)2,408/22,984 (10.5) >20%2,580/36,330 (7.1)2,097 (15.7)483/22,984 (2.1)Abbreviations: BMI, body mass index; KNHANES, Korea National Health and Nutrition Examination Surveys.a Data are expressed as median (interquartile range) or number (%).b Diabetes mellitus was defined as a fasting glucose level higher than 126 mg per deciliter or current use of antidiabetic drugs or by physician’s diagnosis. c Chronic kidney disease was defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m2d Hyperlipidemia was defined as a total cholesterol level of 240 mg/dl or more or receiving statin therapy.e The BMI is the weight in kilograms divided by the square of the height in meters.f Cardiovascular disease includes coronary heart disease, angina, and stroke. Online Table 2. Comparison of Characteristics and Risk Factor Profiles of the KNAHNES Sample with Hypertension and Those Who Meet or Not Meet BP Goals According to the SPRINT Criteria and the 2014 BP Guideline.a VariableAll Adults with Hypertension(N=13,346)Status of BP ControlbP ValueBelow SPRINT BP Goal (N=1,677) Above SPRINT BP Goal, but below 2014 Guideline BP Goal (N=7,914)Above 2014 Guideline BP Goal (N=3,755) Age Median (IQR), y63 (53-72)65 (57-73)63 (53-72)62 (52-72)<0.001 < 60 years5,233 (39.2)539 (32.1)2,960 (37.4)1,734 (46.2)<0.001 ≥ 60 years8,113 (60.8)1,138 (67.9)4,954 (62.6)2,021 (53.8)<0.001Male sex6,081 (45.6)728 (43.4)3,667 (46.3)1,686 (44.9)0.06Systolic blood pressure, mm Hg135 (129-144)113 (108-116)133 (130-138)151 (144-160)<0.001Diastolic blood pressure, mm Hg82 (74-90)71 (66-77)81 (75-89)90 (80-97)<0.001Heart rate, beats/min56 (53-58)56 (52-58)56 (53-58)56 (54-64)0.02Diabetes mellitusc2,615 (19.6)449 (26.8)1,230 (15.5)936 (24.9)<0.001 Fasting glucose level, mg/dl98 (91-110)99 (91-114)97 (91-108)100 (92-113)<0.001Chronic kidney diseased1,136 (8.5)221 (13.2)490 (6.2)425 (11.3)<0.001 Glomerular filtration rate, mL/min/1.73 m281 (71-91)77 (68-87)82 (71-92)81 (70-92)<0.001Current smoking2,271 (17.0)289 (17.2)1,322 (16.7)660 (17.6)0.49Hyperlipidemiae2,611 (19.6)402 (24.0)1,486 (18.8)723 (19.3)<0.001 Total cholesterol, mg/dl191 (168-216)183 (159-206)191 (16-216)195 (171-220)<0.001Obesity BMI ≥ 25, no. (%)f5,732 (42.9)764 (45.6)3,312 (41.8)1,656 (44.1)0.005 BMI ≥ 30, no. (%)792 (5.9)101 (6.0)455 (5.7)236 (6.3)0.51Prevalent cardiovascular diseaseg1,198 (9.0)239 (14.3)647 (8.2)312 (8.3)<0.001Receiving antihypertensive agents7,373 (55.2)1,669 (99.5)4,071 (51.4)1,633 (43.5)<0.001Framingham risk score<0.001 <10%7,272 (54.5)1,163 (69.4)4,334 (54.8)1,775 (47.3) 10-20%3,977 (29.8)412 (24.6)2,397 (30.3)1,168 (31.1) >20%2,097 (15.7)102 (6.1)1,183 (14.9)812 (21.6)Abbreviations: BMI, body mass index; BP, blood pressure; CKD, chronic kidney disease; KNHANES, Korea National Health and Nutrition Examination Surveys.a Data are expressed as median (interquartile range) or number (%).b BP target used in the SPRINT criteria was defined as systolic BP <120 mm Hg ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1"><Year>2015</Year><RecNum>7</RecNum><DisplayText>(1)</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="rfvd5r2dasv5wdet0vivvzexr2v5v9ee2sfr" timestamp="1449276943">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>The SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control</title><secondary-title>N Engl J Med</secondary-title></titles><periodical><full-title>N Engl J Med</full-title></periodical><pages>2103-16</pages><volume>373</volume><number>22</number><dates><year>2015</year><pub-dates><date>Nov 9</date></pub-dates></dates><isbn>1533-4406 (Electronic)&#xD;0028-4793 (Linking)</isbn><accession-num>26551272</accession-num><urls><related-urls><url>;(1) and those used in the 2014 hypertension guidelines were defined as BP <140/90 mm Hg in ages 18-59 years without CKD or diabetes, BP <150/90 mm Hg in ages ≥60 years without CKD or diabetes, BP <140/90 mm Hg in CKD, and BP <140/90 mm Hg in diabetes PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW1lczwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

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ADDIN EN.CITE.DATA (2).c Diabetes mellitus was defined as a fasting glucose level higher than 126 mg per deciliter or current use of antidiabetic drugs or by physician’s diagnosis. d Chronic kidney disease was defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m2e Hyperlipidemia was defined as a total cholesterol level of 240 mg/dl or more or receiving statin therapy.f The BMI is the weight in kilograms divided by the square of the height in meters.g Cardiovascular disease includes coronary heart disease, angina, and stroke.Online Table 3. Standardized Event Rates and Hazard Ratios for Adverse Cardiovascular Events According to Status of BP Control Based On the SPRINT and JNC 7 Guideline Among Adults with Hypertension in the NHIS Health Examinee Cohort.All Adults with Hypertension(N=67,965)Status of BP Control LevelsaP for TrendVariableBelow SPRINT BP Goal (N=5,639) Above SPRINT BP Goal, but below JNC 7 BP Goal(N=37,494)Above JNC 7 BP Goal(N=24,832) Major cardiovascular eventsb No. of events1,15899484575 Rate (95% CI)c2.60 (2.45-2.75)2.53 (2.08-3.08)2.29 (2.10-2.51)3.08 (2.84-3.34) Hazard ratio Age- and sex-adjustedReferent1.00 (0.80-1.24)1.34 (1.08-1.66)<0.001 Multivariable adjusteddReferent1.14 (0.92-1.43)1.36 (1.09-1.69)<0.001Death from cardiovascular causes No. of events29825120153 Rate (95% CI)0.67 (0.60-0.75)0.58 (0.39-0.86)0.57 (0.47-0.68)0.82 (0.70-0.96) Hazard ratio Age- and sex-adjustedReferent1.02 (0.66-1.57)1.34 (0.88-2.05)0.03 Multivariable adjustedReferent1.28 (0.82-1.99)1.47 (0.96-2.26)<0.001Myocardial infarction No. of events51342202269 Rate (95% CI)1.15 (1.06-1.26)1.19 (0.88-1.62)0.95 (0.82-1.09)1.43 (1.27-1.61) Hazard ratio Age- and sex-adjustedReferent0.93 (0.67-1.30)1.43 (1.04-1.99)<0.001 Multivariable adjustedReferent1.13 (0.81-1.59)1.46 (1.05-2.03)0.003Stroke No. of events66458287319 Rate (95% CI)1.49 (1.38-1.61)1.36 (1.05-1.76)1.37 (1.22-1.54)1.71 (1.53-1.91) Hazard ratio Age- and sex-adjustedReferent1.05 (0.79-1.39)1.29 (0.98-1.71)0.008 Multivariable adjustedReferent1.16 (0.86-1.54)1.31 (0.99-1.75)0.03All-cause mortality No. of events1,982245791946 Rate (95% CI)4.45 (4.25-4.65)5.79 (5.11-6.57)3.94 (3.67-4.22)4.77 (4.48-5.09) Hazard ratio Age- and sex-adjustedReferent0.68 (0.59-0.78)0.83 (0.72-0.95)0.95 Multivariable adjustedReferent0.78 (0.67-0.90)0.84 (0.73-0.97)0.30Abbreviations: BMI, body mass index; BP, blood pressure; CI confidence interval; CKD, chronic kidney disease; JNC, Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; KNHANES, Korea National Health and Nutrition Examination Surveys; NHIS, National Health Insurance Service; SPRINT, Systolic Blood Pressure Intervention Trial. a BP target used in the SPRINT criteria was defined as systolic BP <120 mm Hg ADDIN EN.CITE <EndNote><Cite><Year>2015</Year><RecNum>7</RecNum><DisplayText>(1)</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="rfvd5r2dasv5wdet0vivvzexr2v5v9ee2sfr" timestamp="1449276943">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>The SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control</title><secondary-title>N Engl J Med</secondary-title></titles><periodical><full-title>N Engl J Med</full-title></periodical><pages>2103-16</pages><volume>373</volume><number>22</number><dates><year>2015</year><pub-dates><date>Nov 9</date></pub-dates></dates><isbn>1533-4406 (Electronic)&#xD;0028-4793 (Linking)</isbn><accession-num>26551272</accession-num><urls><related-urls><url>;(1) and those used in the JNC 7 hypertension guidelines were defined as BP <140/90 mm Hg in any ages (18-59 years and ≥60 years) without CKD or diabetes, BP <130/80 mm Hg in CKD, and BP <130/80 mm Hg in diabetes PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaG9iYW5pYW48L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFy

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ADDIN EN.CITE.DATA (3).b Major cardiovascular events included nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes. Each component of myocardial infarction and strokes included fatal and nonfatal events.c The event rates were standardized for age and sex. The rates are per 1000 person-years. d For the multivariable-adjusted hazard ratios, data were adjusted for age at baseline, sex, presence or absence of diabetes, presence or absence of chronic kidney disease, smoking status, presence or absence of hyperlipidemia, body-mass index, use or nonuse of antihypertensive treatment, use or nonuse of aspirin, use or nonuse of statin therapy, and Charlson comorbidity index.Online Table 4. Standardized Event Rates and Hazard Ratios for Adverse Cardiovascular Events According to Status of BP Control Based On the SPRINT and 2014 Hypertension Guideline Among Adults with Hypertension in the NHIS Health Examinee Cohort By the Time-Updated Cox Models, Adjusting Systolic Blood Pressure as a Time-Varying Covariate.All Adults with Hypertension(N=61,222)Status of BP Control LevelsaP for TrendVariableBelow SPRINT BP Goal (N=5,046) Above SPRINT BP Goal, but below 2014 Guideline BP Goal (N=40,118)Above 2014 Guideline BP Goal(N=16,058) Major cardiovascular eventsb No. of events89074507309 Rate (95% CI)c2.07 (1.71-2.43)2.01 (0.77-3.24)1.85 (1.43-2.27)2.68 (1.88-3.48) Hazard ratio Age- and sex-adjustedReferent1.05 (0.82-1.34)1.53 (1.19-1.97)<0.001 Multivariable adjusteddReferent1.14 (0.89-1.46)1.56 (1.20-2.03)<0.001Death from cardiovascular causes No. of events155128954 Rate (95% CI)0.36 (0.21-0.51)0.29 (-0.18-0.77)0.33 (0.15-0.51)0.46 (0.13-0.79) Hazard ratio Age- and sex-adjustedReferent1.12 (0.62-2.06)1.64 (0.88-3.07)0.03 Multivariable adjustedReferent1.32 (0.71-2.44)1.83 (0.96-3.49)0.03Myocardial infarction No. of events41731242144 Rate (95% CI)0.97 (0.72-1.22)0.95 (0.10-1.80)0.88 (0.59-1.17)1.22 (0.68-1.76) Hazard ratio Age- and sex-adjustedReferent1.47 (0.79-1.67)1.62 (1.10-2.39)<0.001 Multivariable adjustedReferent1.14 (0.89-1.46)1.59 (1.20-2.03)0.001Stroke No. of events48644271171 Rate (95% CI)1.13 (0.86-1.40)1.09 (0.18-1.99)0.99 (0.68-1.30)1.52 (0.91-2.12) Hazard ratio Age- and sex-adjustedReferent0.98 (0.71-1.34)1.48 (1.06-2.06)<0.001 Multivariable adjustedReferent1.34 (0.92-1.97)1.76 (1.17-2.63)0.001All-cause mortality No. of events1054126611317 Rate (95% CI)2.45 (2.06-2.84)3.07 (1.55-4.60)2.23 (1.77-2.69)2.77 (1.95-3.58) Hazard ratio Age- and sex-adjustedReferent0.72 (0.59-0.87)0.90 (0.73-1.10)0.55 Multivariable adjustedReferent0.85 (0.70-1.04)1.06 (0.85-1.31)0.11Abbreviations: BMI, body mass index; BP, blood pressure; CI confidence interval; CKD, chronic kidney disease; JNC, Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; KNHANES, Korea National Health and Nutrition Examination Surveys; NHIS, National Health Insurance Service; SPRINT, Systolic Blood Pressure Intervention Trial. a BP target used in the SPRINT criteria was defined as systolic BP <120 mm Hg ADDIN EN.CITE <EndNote><Cite><Year>2015</Year><RecNum>7</RecNum><DisplayText>(1)</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="rfvd5r2dasv5wdet0vivvzexr2v5v9ee2sfr" timestamp="1449276943">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>The SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control</title><secondary-title>N Engl J Med</secondary-title></titles><periodical><full-title>N Engl J Med</full-title></periodical><pages>2103-16</pages><volume>373</volume><number>22</number><dates><year>2015</year><pub-dates><date>Nov 9</date></pub-dates></dates><isbn>1533-4406 (Electronic)&#xD;0028-4793 (Linking)</isbn><accession-num>26551272</accession-num><urls><related-urls><url>;(1) and those used in the 2014 hypertension guideline were defined as BP <140/90 mm Hg in ages 18-59 years without CKD or diabetes, BP <150/90 mm Hg in ages ≥60 years without CKD or diabetes, BP <140/90 mm Hg in CKD, and BP <140/90 mm Hg in diabetes PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW1lczwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

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ADDIN EN.CITE.DATA (2).b Major cardiovascular events included nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes. Each component of myocardial infarction and strokes included fatal and nonfatal events.c The event rates were standardized for age and sex. The rates are per 1000 person-years. d For the multivariable-adjusted hazard ratios, data were adjusted for age at baseline, sex, presence or absence of diabetes, presence or absence of chronic kidney disease, smoking status, presence or absence of hyperlipidemia, body-mass index, use or nonuse of antihypertensive treatment, use or nonuse of aspirin, use or nonuse of statin therapy, Charlson comorbidity index, and systolic BP as time-varying covariate. Online Table 5. Standardized Event Rates and Hazard Ratios for Adverse Cardiovascular Events According to Status of BP Control Based On the SPRINT and 2014 Hypertension Guideline Among Adults with Hypertension in the NHIS Health Examinee Cohort Adopting Alternative Hypertension Definition.aAll Adults with Hypertension(N=42,781)Status of BP Control LevelsbP for TrendVariableBelow SPRINT BP Goal (N=4,287) Above SPRINT BP Goal, but below 2014 Guideline BP Goal (N=20,384)Above 2014 Guideline BP Goal(N=18,110) Major cardiovascular eventsc No. of events92089426405 Rate (95% CI)d3.15 (2.95-3.35)3.05 (2.48-3.76)2.77 (2.52-3.05)3.66 (3.32-4.03) Hazard ratio Age- and sex-adjustedReferent0.95 (0.76-1.20)1.34 (1.07-1.69)<0.001 Multivariable adjustedeReferent0.98 (0.78-1.23)1.28 (1.02-1.61)<0.001Death from cardiovascular causes No. of events25825126107 Rate (95% CI)0.88 (0.78-1.00)0.86 (0.58-1.27)0.82 (0.69-0.98)0.97 (0.80-1.17) Hazard ratio Age- and sex-adjustedReferent1.13 (0.74-1.74)1.24 (0.80-1.92)0.30 Multivariable adjustedReferent1.21 (0.77-1.88)1.37 (0.87-2.16)0.16Myocardial infarction No. of events40236184182 Rate (95% CI)1.37 (1.25-1.52)1.31 (0.94-1.81)1.21 (1.05-1.40)1.61 (1.40-1.87) Hazard ratio Age- and sex-adjustedReferent1.01 (0.71-1.45)1.46 (1.02-2.08)0.001 Multivariable adjustedReferent1.05 (0.74-1.51)1.35 (0.94-1.94)0.02Stroke No. of events53554249232 Rate (95% CI)1.83 (1.68-1.99)1.78 (1.36-2.33)1.60 (1.42-1.81)2.14 (1.88-2.43) Hazard ratio Age- and sex-adjustedReferent0.92 (0.69-1.24)1.29 (0.96-1.74)0.002 Multivariable adjustedReferent0.94 (0.70-1.26)1.26 (0.94-1.70)0.009All-cause mortality No. of events1,579201780598 Rate (95% CI)5.40 (5.14-5.67)6.79 (5.92-7.80)4.93 (4.60-5.29)5.73 (5.29-6.21) Hazard ratio Age- and sex-adjustedReferent0.72 (0.62-0.84)0.85 (0.73-1.00)0.99 Multivariable adjustedReferent0.78 (0.66-0.91)0.86 (0.73-1.01)0.52Abbreviations: BMI, body mass index; BP, blood pressure; CI confidence interval; CKD, chronic kidney disease; KNHANES, Korea National Health and Nutrition Examination Surveys; NHIS, National Health Insurance Service; SPRINT, Systolic Blood Pressure Intervention Trial.a In this analysis, hypertension was alternatively defined as physician-diagnosed, patient-reported BP treatment, or a systolic BP ≥140 mm Hg or a diastolic BP ≥90 mm Hg.b BP target used in the SPRINT criteria was defined as systolic BP <120 mm Hg ADDIN EN.CITE <EndNote><Cite><Year>2015</Year><RecNum>7</RecNum><DisplayText>(1)</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="rfvd5r2dasv5wdet0vivvzexr2v5v9ee2sfr" timestamp="1449276943">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>The SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control</title><secondary-title>N Engl J Med</secondary-title></titles><periodical><full-title>N Engl J Med</full-title></periodical><pages>2103-16</pages><volume>373</volume><number>22</number><dates><year>2015</year><pub-dates><date>Nov 9</date></pub-dates></dates><isbn>1533-4406 (Electronic)&#xD;0028-4793 (Linking)</isbn><accession-num>26551272</accession-num><urls><related-urls><url>;(1) and those used in the 2014 hypertension guideline were defined as BP <140/90 mm Hg in ages 18-59 years without CKD or diabetes, BP <150/90 mm Hg in ages ≥60 years without CKD or diabetes, BP <140/90 mm Hg in CKD, and BP <140/90 mm Hg in diabetes PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW1lczwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

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ADDIN EN.CITE.DATA (2).c Major cardiovascular events included nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes. Each component of myocardial infarction and strokes included fatal and nonfatal events.d The event rates were standardized for age and sex. The rates are per 1000 person-years. e For the multivariable-adjusted hazard ratios, data were adjusted for age at baseline, sex, presence or absence of diabetes, presence or absence of chronic kidney disease, smoking status, presence or absence of hyperlipidemia, body-mass index, use or nonuse of antihypertensive treatment, use or nonuse of aspirin, use or nonuse of statin therapy, and Charlson comorbidity index.Online Figure 1. Participant Inclusion and Exclusion Criteria for the KNHANES Study and the NHIS Health Examinee Cohort Study.41471857810500-217805781050039624066061200 Online Figure 2. Estimated Percentages of Adults with Hypertension Who Would Meet or Not Meet Blood-Pressure Targets Under the 2014 Guideline and the SPRINT Criteria, According to Major Subgroups.Online Figure 3. Ten-Year Predicted Risk of Cardiovascular Events According to Status of Blood-Pressure Control Under the 2014 Hypertension Guideline and the SPRINT Criteria, as Measured by the Korean CHD risk score PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KZWU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO

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ADDIN EN.CITE.DATA (4).The mean estimate of the 10-year risk of cardiovascular events on the basis of the Korean CHD risk score was lowest in adults who met the SPRINT goals (1.46; 95% confidence interval [CI], 1.38 to 1.54), intermediate in those who met the 2014 guideline goals, but not the SPRINT goals (1.67; 95% CI, 1.63 to 1.71), and highest in those who did not meet the 2014 guideline goals (2.36; 95% CI, 2.26 to 2.46) (P<0.001).Online Figure 4. Estimated Percentages of Adults with Hypertension Who Would Meet or Not Meet Blood-Pressure Targets Under the JNC 7 Guideline and the SPRINT Criteria.Percentages were weighted on the basis of the KNHANES results. Hypertension was defined as physician-diagnosed, patient-reported BP treatment, or systolic BP of 130 mm Hg or higher. The BP target used in the SPRINT criteria was defined as systolic BP <120 mm Hg and those used in the JNC 7 hypertension guideline were defined as BP <140/90 mm Hg in any ages (18-59 years and ≥60 years) without CKD or diabetes, BP <130/80 mm Hg in CKD, and BP <130/80 mm Hg in diabetes. Online Figure 5. Ten-Year Predicted Risk of Cardiovascular Events According to Status of Blood-Pressure Control Under the JNC 7 Guideline and the SPRINT Criteria, as Measured by the Framingham Risk Score.The mean estimate of the 10-year risk of cardiovascular events on the basis of the Framingham risk score was lowest in adults who met the SPRINT goals (6.43; 95% confidence interval [CI], 6.10 to 6.76), intermediate in those who met the JNC 7 guideline goals, but not the SPRINT goals (7.54; 95% CI, 7.30 to 7.78), and highest in those who did not meet the JNC 7 guideline goals (10.80; 95% CI, 10.55 to 11.05) (P<0.001).100584065722500Online Figure 6. Hazard Ratios for Major Cardiovascular Events and Each Component According to Status of Blood-Pressure Control the JNC 7 Guideline and the SPRINT Criteria.Major cardiovascular events included nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes. Each component of myocardial infarction or stroke included fatal and nonfatal events. Increasing levels of BP control status were classified according to the SPRINT and the JNC 7 criteria; below SPRINT BP goals vs. above SPRINT goals, but below JNC 7 BP goals vs. above JNC 7 BP goals. All estimates were adjusted for age, sex, presence or absence of diabetes, presence or absence of CKD, smoking status, presence or absence of hyperlipidemia, body-mass index, use or nonuse of antihypertensive treatment, use or nonuse of aspirin, use or nonuse of statin therapy, and Charlson comorbidity index. The bars represent 95% confidence intervals.Abbreviations: BP, blood pressure; CKD, chronic kidney disease; JNC, Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; KNHANES, Korea National Health and Nutrition Examination Surveys; SPRINT, Systolic Blood Pressure Intervention Trial. REFERENCES ADDIN EN.REFLIST 1.The SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med 2015;373:2103-16.2.James PA, Oparil S, Carter BL et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311:507-20.3.Chobanian AV, Bakris GL, Black HR et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003;289:2560-72.4.Jee SH, Jang Y, Oh DJ et al. A coronary heart disease prediction model: the Korean Heart Study. BMJ Open 2014;4:e005025. ................
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