CLIFFORD E. BERKMAN - Johns Hopkins University



Jessie R. Nedrow Curriculum vitae

(Formerly Jessie R Nedrow-Byers)

Department of Radiology, Johns Hopkins University

1550 Orleans St, CRBII 4M.62, Baltimore, MD, 21205

(509) 339-3695 jnedrow1@jhmi.edu

Education

Idaho State University, Pocatello, ID B.A. in Chemistry May 2007

Washington State University, Pullman, WA Ph.D. in Chemistry August 2012

HONORS & AWARDS

Patricia Bell Scholarship August 2002

Idaho Promise Scholarship August 2002 - May 2004

ASUISU Scholarship August 2003 - May 2004

Gardner Stacey Research Endowment August 2010

International Symposium on Radiopharmaceutical Sciences Travel Bursary May 2013

DOE Postdoctoral Fellowship: Integrated Nuclear Medicine September 2012 – March 2015

Research and Training Projects of Excellence

Ciceric Rad BriteStar Award February 2017 – February 2018

10th International Symposium on Targeted Alpha Therapy Travel Award May 2017

Grants

Susan G. Komen Career Catalyst Research Grant July 2016 – July 2019

Basic/Translational and Clinical Funding

Radiology Bridge/Development Funding Initiative February 2017 – February 2018

to Stimulate and Advance Research (Ciceric Rad BriteStar Award)

research experience

Instructor of Radiology and Radiological Science: Johns Hopkins University March 2015 – present

• Development of radiopharmaceuticals for targeted alpha therapy and

imaging applications.

Post-Doctoral Research: University of Pittsburgh July 2012 – March 2015

Research Advisor: Carolyn J. Anderson

• The synthesis and evaluation of peptides modified for labeling with copper-64, gallium-68, and lutetium-177 for use as molecular imaging and therapeutic agents.

• The development and application of PSMA-targeted radiotheranostics.

Doctoral Research: Washington State University August 2007 – June 2012

Research Advisor: Clifford E. Berkman

• The development and evaluation of prostate specific membrane antigen (PSMA) targeted phosphoramidate and phosphate inhibitors, modified to deliver an imaging payload to PSMA positive cells in vitro and in vivo.

Undergraduate Research: Idaho State University January 2005 – May 2007

Research Advisor: Robert Holman

• The exploration of green chemistry for the formation and reaction of Grignard’s chemistry.

• Computational modeling of Thalidomide interaction with DNA and RNA subunits.

Teaching Experience

Teaching Assistant: Washington State University August 2007 – May 2012

• Organic Chemistry I

• Organic Chemistry II

• General Chemistry 101

Publications & Presentations

Publications (Chronological Order)

Bold – First Author * - Co-first Author

1. Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer. Suzanne E. Lapi, Hilla Wahnishe, David Pharm, Lisa Y. Wu, Jessie R. Nedrow-Byers, Tiancheng Liu, Kaveh Vejdani, Henry F. VanBrocklin, Clifford E. Berkman, and Ella F. Jones. Journal of Nuclear Medicine, 2009, 50(12): 2042-8.

2. The Question-Driven Laboratory Exercise: A New Pedagogy Applied to a Green Modification of Grignard Reagent Formation and Reaction. Jennifer M. Teixeira, Jessie Nedrow-Byers, Marilu G. Perez and R. W. Holman. Journal of Chemical Education, 2010. 87(7): 714-716.

3. Detection of prostate-specific membrane antigen on HUVECs in response to breast tumor-conditioned medium. Tiancheng Liu, Mohamed Jabbes, Jessie R. Nedrow-Byers, Lisa Y. Wu, Jeffery N Bryan, and Clifford E. Berkman. International journal of oncology, May 2011, 38(5): 1349-55.

4. A phosphoramidate-based prostate-specific membrane antigen-targeted SPECT agent. Jessie Nedrow-Byers, Mohamed Jabbes, Cayla Jewett, Tanushuree Ganguly, Haiyang He, Tiancheng Liu, Paul Benny, Jeffery N. Bryan, and Clifford E. Berkman. The Prostate, 2011, 72: 904-912.

5. Spacer Length Effects on In Vitro Imaging and Surface Accessibility of Fluorescent Inhibitors of Prostate Specific Membrane Antigen. Tiancheng Liu, Jessie R Nedrow-Byers, Mark R Hopkins and Clifford E. Berkman. Bioorganic & Medicinal Chemistry Letters, 2011, 21 (23): 7013-6. 

6. Targeting Prostate Cancer Cells with a Multivalent PSMA Inhibitor-Guided Streptavidin Conjugate. Tiancheng Liu, PhD; Jessie R Nedrow-Byers; Mark R Hopkins; Lisa Y Wu, PhD; Jeonghoon Lee, PhD; Peter T Reilly, PhD; Clifford E. Berkman, PhD.  Bioorganic & Medicinal Chemistry Letters 2012, 22 (12): 3931-4.

7. PSMA-targeted SPECT agents: Mode of Binding effect on in vitro Performance. Jessie R Nedrow-Byers, Adam L Moore, Tanushuree Ganguly, Mark R Hopkins, Melody R Fulton, Paul Benny, and Clifford E Berkman. The Prostate, 2013, 73:355-362.

8. Targeting prostate cancer cells with PSMA inhibitor-guided gold nanoparticles. Benjamin B. Kasten, Tiancheng Liu, Jessie R. Nedrow-Byers, Paul D. Benny, and Clifford E. Berkman. Bioorganic & Medicinal Chemistry Letters 2012, 23 (2): 565-568.

9. PET imaging of Copper-64 and Gallium-68 Labeled Chelator Conjugates of the Somatostatin Agonist, Tyr3-octreotate. Jessie R. Nedrow, Alexander G. White, Jalpa Modi, Kim Nguyen, Albert J. Chang, and Carolyn J. Anderson. Molecular Imaging 2014, 13:1-13.

10. Evaluation of 68Ga- and 177Lu-DOTA-PEG4-LLP2A for VLA-4 targeted PET imaging and treatment of metastatic melanoma. Wissam Beaino*, Jessie R. Nedrow*, and Carolyn J. Anderson. Molecular Pharmaceutics, 2015, 12(6).

11. Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities. Zora Novakova, Jiri Cerny. Cindy J Choy, Jessie Nedrow, Joseph K Choi, Jacek Lubkowski, Clifford E Berkman, Cyril Barinka. FEBS Journal, 2016, 283(1): 130-43.

12. Targeting PSMA with a 64Cu-labeled phosphoramidate inhibitor for PET/CT imaging of variant PSMA-expressing xenografts in a mouse model of prostate cancer. Jessie R. Nedrow, Kathryn E. Day, Joseph Latoche, Tanushree Ganguly, Dexing Zeng, Clifford E. Berkman and Carolyn J. Anderson. Molecular Imaging and Biology, 2016, 18(3): 402-10.

13. Imaging, biodistribution, and dosimetry of radionuclide-labeled PD-L1 antibody in an immunocompetent mouse model of breast cancer. Anders Josefsson*, Jessie R. Nedrow*, Sunju Park, Sangeeta Ray Banerjee, Andrew Rittenbach, Fabien Jammes, Benjamin Tsui, George Sgouros. Cancer Research, 2016, 76(2): 472-9.

14. Emerging Radiometals for PET Imaging. Jessie R. Nedrow and Carolyn J. Anderson. Encyclopedia of Inorganic and Bioinorganic Chemistry, Online @ 2011-2016 John Wiley & Sons, Ltd.

15. Imaging of programmed death ligand-1 (PD-L1): impact of protein concentration on distribution of anti-PD-L1 SPECT agent in an immunocompetent melanoma murine model. Jessie R. Nedrow, Anders Josefsson, Sunju Park, Sagar Ranka, Sanchita Roy, and George Sgouros. Journal of Nuclear Medicine, accepted.

16. Human HER2 overexpressing mouse breast cancer cell lines derived from MMTV.f.HuHer2 mice: Characterization and use in a model of metastatic breast cancer. Sunju Park, Jessie R. Nedrow, Anders Josefsson, and George Sgouros. Oncotarget, accepted.

17. Pharmacokinetics, micro-scale distribution and dosimetry of alpha-emitter labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model. Jessie R Nedrow*, Anders Josefsson*, Sunju Park, Tom Bäck, Robert F. Hobbs, Cory Brayton, Frank Bruchertseifer, Alfred Morgenstern, and George Sgouros. European Journal of Nuclear Medicine and Molecular Imaging, accepted.

Presentations (Chronological Order)

Bold – Oral Presentation

1. On the nature of Grignard reagent formation and reaction in hydrocarbon media with catalytic butyldiglyme, and various ether additives. Holman, Robert; Aduke, Ratimo; Byers, Jessie; Lefler, Brian; Miller, Brian; Perez, Marilu; Sadek, Chris. 61st Northwest Regional Meeting of the American Chemical Society, Reno, NV, United States, June 2006.

2. On the mechanism of Thalidomide interaction with DNA sub-units. Byers, Jessie; Holman, R. W.; Teixeira, Jennifer; Stephens, T. 62nd Northwest Regional Meeting of the American Chemical Society, Boise, ID, United States, June 2007.

3. The development of a PSMA targeted imaging agent for prostate cancer. Byers, Jessie; Berkman, Clifford; Benny, Paul; Porter, Tom. 237th ACS National Meeting, Salt Lake City, UT, United States, March 2009.

4. Optimization of PSMA-targeted PET imaging agents. Jessie R Nedrow-Byers, Clifford E. Berkman. 239th ACS National Meeting, San Francisco, CA, United States, March 2010.

5. Development of PSMA-targeted PET and SPECT imaging agents for prostate cancer. J. Nedrow-Byers; C. E. Berkman; P. Benny; J. E. Blecha; D. Pharm; E. F. Jones; H. F. VanBrocklin; M. Jabbes; J. N. Bryan. Pacifichem, Honolulu, HI, United States, December 2010.

6. The effects of mode of binding on clickable PSMA-targeted imaging agents. Jessie R Nedrow-Byers, Tanushree Gangly, Adam Moore, Paul Benny, Henry VanBrocklin, Ella Jones and Clifford Berkman. SNM Annual Meeting, Miami, FL, United States June 2012.

7. Copper-64 and Gallium-68 labeled SCN-benzyl-NOTA-Y3-TATE analogs for PET imaging of somatostatin receptor expression. Jessie R. Nedrow, Alexander G. White, Jalpa Modi and Carolyn J. Anderson. ISRS, Jeju, South Korea, May 2013.

8. Imaging PSMA in mouse models of prostate cancer. Jessie R. Nedrow. Prostate and Urologic Cancer Program Seminar Series, Pittsburgh, PA, United States, September 2013.

9. Imaging PSMA in mouse models of prostate cancer. Jessie R. Nedrow. Molecular and Cellular Cancer Biology weekly work in progress, Pittsburgh, PA, United States, November 2013.

10. Improving specific activity of 64Cu-labeled Y3-TATE analogs. Jessie R. Nedrow, Dexing Zeng, and Carolyn J Anderson. National Institute of Biomedical Imaging and Bioengineering 2014 Training Grantees Meeting, Washington D.C., United States, June 2014.

11. Targeting PSMA with a 64Cu-labeled phosphoramidate inhibitor for PET/CT imaging of variant PSMA-expressing xenografts in a mouse model of prostate cancer. Jessie R. Nedrow, Joseph Latoche, Kathryn Day, Tanushree Ganguly, Dexing Zeng, Clifford E. Berkman, and Caroyln J. Anderson. Society of Nuclear Medicine and Molecular Imaging Annual Meeting, St. Loius, MO, United States, June 2014.

12. 64Cu-, 68Ga-, and 177Lu-LLP2A conjugates for imaging and treatment of very late antigen-4 (VLA-4). Jessie Nedrow, Wissam Beaino, and Carolyn J. Anderson. AACR-SNMMI Joint Conference, San Diego, CA, United States, February 2015.

13. The impact of protein concentration on the distribution of 111In-antibody conjugate for imaging of Programmed death-ligand 1 (PD-L1). Jessie R. Nedrow, Anders Josefsson, Sunju Park, Sagar Ranka, and George Sgouros. AACR Annual Meeting, New Orleans, LA, United States, March 2016.

14. Combining α-particle radiopharmaceutical therapy using Actinium-225 and immunotherapy with anti-PD-L1 antibodies in a murine immunocompetent metastatic breast cancer model. Jessie R. Nedrow, Anders Josefsson, Sunju Park, Sagar Ranka, and George Sgouros. Johns Hopkins 7th Annual Breast Cancer Retreat, Baltimore, MD, United States, May 2016.

15. Radionuclide Therapy and Dosimetry (RTD) Lab: Pre-Clinical Applications. Jessie R. Nedrow, Division of Nuclear Medicine and Molecular Imaging, Baltimore, MD, February 2017.

16. Pharmacokinetic profiling and therapeutic efficacy of alpha-emitter labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model. Jessie R. Nedrow, Anders Josefsson, Sunju Park, Tom Back, Robert F. Hobbs, Cory Brayton, Frank Bruchertseifer, Alfred Morgenstern, and George Sgouros. Johns Hopkins 10th Annual Breast Cancer Retreat, Baltimore, MD, United States, April 2017.

17. Pharmacokinetic profiling and therapeutic efficacy of alpha-emitter labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model. Jessie R. Nedrow, Anders Josefsson, Sunju Park, Tom Back, Robert F. Hobbs, Cory Brayton, Frank Bruchertseifer, Alfred Morgenstern, and George Sgouros. 10th International Symposium on Targeted Alpha Therapy, Kanazawa, Japan, May 2017.

18. Reducing renal uptake of free 213Bi associated with the decay of 225Ac-labeled radiopharmaceuticals. Jessie R. Nedrow, Anders Josefsson, Sunju Park, Tom Back, Robert F. Hobbs, Frank Bruchertseifer, Alfred Morgenstern, and George Sgouros. 10th International Symposium on Targeted Alpha Therapy, Kanazawa, Japan, May 2017.

Professional & Civic Activities

Professional Affiliations

American Chemical Society January 2005-present

Society of Nuclear Medicine and Molecular Imaging May 2014 – present

American Association of Cancer Research February 2016 - present

Professional Service Activities

Idaho State University: Chemistry Club August 2005 - May 2007

Member

4 Participated in club sponsored activities including working with local grade schools, tutoring, and organizing annual retreats

Washington State University: Graduate Chemistry Students (WSUGCS) August 2007 - May 2012

• Member

7 Participated in club sponsored activities, lobbied on behalf of the graduate student body, volunteered at fundraising activities, and helped organize monthly events

• Treasurer (2008-2009)

o Responsible for monitoring WSUGCS budget

4th Annual Maryland STEM Career Fair November 12, 2016

• Volunteer

o Represented Johns Hopkins University’s Radiology Department to highlight potential careers with a scientific focus for local middle and high school students

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