Sample Size Estimation in Clinical Research: from ...
formulas for RCTs below, we denote k be the ratio of the sample size of treatment group n T to the sample size of control group n C , so that n T =k n C .. 1.1Continuous outcomes. Non-inferiority design . The testing hypotheses are: H 0 : μ T - μ C ≤ -δ . vs. . H 1 : μ T - μ C > -δ . where . δ>0 . denotes the non-inferiority margin, which is a (clinically meaningful) minimal detectable ................
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