Mouse Formulary



Rabbit Anesthesia and Analgesia Formulary

Effective Date: November 2015

Note that all of these doses are approximations and must be titrated to the animal’s age, sex and individual responses. Significant departures from these doses should be discussed with a veterinarian. Doses will also vary depending on what other drugs are being administered concurrently.

All doses are listed as milligrams per kilogram (mg/kg) unless otherwise noted.

This is a formulary of the most commonly used anesthetics and analgesics at UCSF; LARC veterinarians can assist with dosage recommendations when less commonly used drugs are required.

|Drug name |Dose (mg/kg) & Route |Frequency |Notes |

|Inhalation anesthetics |

|Recommended: |1-3% inhalant to effect |Whenever general anesthesia |Survival surgery requires |

|Isoflurane |(up to 5% for induction). |is required |concurrent preemptive |

| | | |analgesia. |

| | | |Must use precision |

| | | |vaporizer |

|Sevoflurane |2-5% inhalant to effect |Whenever general anesthesia |Survival surgery requires |

| |(up to 8% for induction). |is required |concurrent preemptive |

| | | |analgesia. |

| | | |Must use precision |

| | | |vaporizer |

| | | | |

|Anesthetic Combinations |

|Recommended anesthesia protocol for | |Once to induce general |When combined with |

|most surgeries: |Buprenorphine 0.01-0.03 IM|anesthesia. For maintenance,|buprenorphine premed, the |

| | |follow with Isoflurane to |K/X induction will produce |

|Buprenorphine IM as premed |Ketamine 35-50 + Xylazine |effect |surgical-plane anesthesia |

|Followed at least 30 minutes later by |5-10 IM (in same syringe) | |for 30-45 min. |

|Ketamine-Xylazine IM for induction | | |If more anesthetic duration|

|Isoflurane for anesthesia maintenance | | |is required, add isoflurane|

| | | |to effect for maintenance. |

| | | | |

|Ketamine-Xylazine-Acepromazine |35 Ket + 5 Xylazine +0.75 |Once to induce general |May not produce |

| |Acepromazine; |anesthesia. For maintenance |surgical-plane anesthesia |

|Best used in conjunction with |(in same syringe) |follow with Isoflurane to |for major procedures. |

|isoflurane | |effect |Follow with isoflurane to |

| | | |maintain anesthesia |

| | | | |

|Ketamine-Diazepam |10K + 0.5 D IV (in same |Once to induce general |Follow with isoflurane to |

| |syringe) |anesthesia. For maintenance |maintain anesthesia |

|Best used in conjunction with | |follow with Isoflurane to | |

|isoflurane | |effect | |

| | | | |

|Opioid analgesia |

|Recommended: |0.01-0.05 IM |For premedicant sedation and|Re-dose in 4 – 8 hours as |

|Buprenorphine | |analgesia and for pain |needed. |

| |Most typically |management after surgeries. | |

| |0.03 IM is used for premed| | |

| |with Ket/xyl induction | | |

| | | | |

|Sustained-Release Buprenorphine |0.1-0.5 mg/kg SC only |Used once at time of surgery|Availability is limited by |

| | |for very invasive surgeries |requirement for special |

| | |(thoracotomy; orthopedics) |veterinary prescription. |

| | |that will otherwise require | |

| | |multiple follow up doses of | |

| | |opiate. | |

|Non-steroidal anti-inflammatory analgesia (NSAID) |

|Recommended: Meloxicam |Loading dose of 1.0 mg/kg |Used pre-operatively for |Depending on the procedure,|

| |PO/SC, then follow up with|preemptive analgesia, and |may be used as sole |

| |0.5 PO |then every 24 hour as needed|analgesic, or as |

| | | |multi-modal analgesia with |

| | | |buprenorphine. |

|Recommended: |1-2 SC or IM |Used pre-operatively for |Depending on the procedure,|

|Flunixin Meglumine | |preemptive analgesia, then |may be used as sole |

| | |every 12 hour as needed |analgesic, or as |

| | | |multi-modal analgesia with |

| | | |buprenorphine +/- local. |

|Other NSAIDs: |2 – 4 SC |Used pre-operatively for |Depending on the procedure,|

|Carprofen |Recc: dilute with 1x |preemptive analgesia and |may be used as sole |

| |volume of sterile saline |post-operatively every 24 |analgesic, or as |

| |for SC injection |hour |multi-modal analgesia with |

| | | |buprenorphine +/- local. |

| | | | |

|Local anesthetic/analgesics |

|Recommended: |Dilute to 0.25%, do not |Use intradermally before |Slower onset than lidocaine|

|Bupivacaine |exceed 8 mg/kg total dose,|making surgical incision |but longer (~ 4-8 hour) |

| |ID or intra-incisional |(recommended), or can be |duration of action |

| | |used as as “splash block” | |

| | |just prior to skin closure | |

|Lidocaine hydrochloride |Dilute to 0.5%, do not |Use locally before making |Faster onset than |

| |exceed 7 mg/kg total dose,|surgical incision |bupivicaine but short ( ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download