THE BEST ANTIBIOTIC SENSITIVITY CHART EVER (at least …

THE "BEST" ANTIBIOTIC SENSITIVITY CHART EVER (at least the best we could make)

Bacteria

Streptococci

Gram Positive Cocci Staphylococci

Streptococci (pneumoniae/

pyogenes/ viridans group)

Enterococci (Group D strep)

Staph epidermidis (coagulase

negative)

Staph aureus (Methicillin sensitive)

Community acquired (Methicillin resistant)

Hospital acquired (Methicillin resistant)

Created by James McCormack, BSc(Pharm), PharmD and Fawziah Lalji, BSc(Pharm), PharmD, FCSHP with assistance from Tim Lau Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC

Gram Negative Bacilli

Non-beta-lactamase producing Escherichia coli,

Klebsiella pneumoniae, Haemophilus influenzae

SPACE

ESBL

Beta-lactamase producing Escherichia coli,

Serratia marcescens,

(Extended spectrum beta-lactamase

Klebsiella pneumoniae, Haemophilus influenzae

Proteus mirabilis, Acinetobacter sp.,

Citrobacter sp.,

producing) Escherichia coli, Klebsiella pneumoniae

Enterobacter sp.

CRE (Carapenem-resistant Enterobacteriaceae)

Pseudomonas aeruginosa

Gram Negative Coccobacilli

Neisseria meningitidis

Neisseria gonorrhea

Anaerobes

Atypicals

Above the diaphragm (Peptostreptococcus)

Below the diaphragm (Bacteroides sp)

Clostridium difficile

Mycoplasma pneumoniae, Chlamydophila

spp

Legionella pneumophila

Chlamydia trachomatis

Location

Penicillins

Cephalosporins

Brain, oral, respiratory tract,

Intraabdominal,

heart, skin

urinary tract

Pencillin V/G Amoxicillin/ampicillin

Amoxicillin-clavulanate Piperacillin-tazobactam Cefazolin/cephalexin Cefuroxime Cefoxitin Ceftriaxone/cefotaxime Cefixime

Skin, prosthetics

Oral, respiratory tract, heart, skin, bones/joint

Cloxacillin Amoxicillin-clavulanate Piperacillin-tazobactam Cefazolin/cephalexin Cefuroxime Cefoxitin Ceftriaxone/cefotaxime

Carbapenems Macrolides Tetracyclines

Cefipime Ceftibiprole

Meropenem/imipenem/doripenem Ertapenem Erythromycin Clarithromycin/azithromycin Tetracycline/doxycycline

Cefipime

Meropenem/imipenem/doripenem Ertapenem Erythromycin

Clarithromycin/azithromycin Tetracycline/doxycycline

Ceftibiprole Tigecycline

Fluoroquinolones

Levofloxacin/moxifloxacin

Aminoglycosides

Polymyxin

Lincosamides

Clindamycin

Clindamycin

Glycopeptides/lipoglycopeptides

Vancomycin/daptomycin

Oxazolidinones

Linezolid/tedizolid

Trimethoprim-Sulfamethoxazole

Trimethoprim-sulfamethoxazole

Chloramphenicol

Chloramphenicol

Metronidazole

Nitrofurantoin/fosfomycin

Nitrofurantoin/fosfomycin

(JUST BLADDER INFECTIONS)

JUST E.faecalis

Rifampin

Rifampin

Fidaxomicin

Cloxacillin and clindamycin typically have less than 40% activity for S.epidermidis, thus usage depends on local susceptibility data Enterococci has two main species - Enterococcus faecalis and Enterococcus faecium; the antibiotics listed are active against E.faecalis, but have limited activity for E.faecium

Cephalosporins have in-vitro activity for SPACE organisms but induce production of beta-lactamases

Tigecycline has no activity against Pseudomonas aeruginosa, but for Acinetobacter it depends on local susceptibility data; Tigecycline is active against SPACE organisms, but for Proteus spp it depends on local susceptibility data

Brain, respiratory tract, intraabdominal, urinary tract

Amoxicillin/ampicillin

Amoxicillin-clavulanate Piperacillin-tazobactam

Cefazolin/cephalexin Cefuroxime Cefoxitin

Ceftriaxone/cefotaxime Cefixime

Ceftazidime Ceftolozane - tazobactam

Cefipime

Meropenem/imipenem/doripenem Ertapenem

Clarithromycin/azithromycin JUST H.flu Tetracycline/doxycycline JUST H.flu

Ciprofloxacin/norfloxacin BUT JUST bladder infections for norfloxacin Levofloxacin/moxifloxacin Gentamicin/tobramycin/amikacin

Colistin/polymyxin B

Trimethoprim-sulfamethoxazole Chloramphenicol

Nitrofurantoin/fosfomycin

Nitrofurantoin/fosfomycin

Brain

Pencillin G-IV Ampicillin-IV

Pelvic inflammatory disease/STI

Oral, respiratory tract

Pencillin V/G Amoxicillin/ampicillin

Intraabdominal, pelvic inflammatory disease

Intraabdominal

Piperacillin-tazobactam

Ceftazidime Ceftolozane-tazobactam

Cefipime

Ceftriaxone/cefotaxime Cefixime

Amoxicillin-clavulanate Piperacillin-tazobactam

Cefazolin/cephalexin Cefuroxime Cefoxitin

Ceftolozane-tazobactam Cefipime

Meropenem/imipenem/doripenem

Meropenem/imipenem/doripenem Ertapenem

JUST Azithromycin

Tetracycline/doxycycline Tigecycline

Gentamicin/tobramycin/amikacin Colistin/polymyxin B

Levofloxacin/moxifloxacin

JUST Moxifloxacin

Clindamycin Vancomycin/daptomycin

Linezolid/tedizolid

Vancomycin oral

Chloramphenicol

Metronidazole

Respiratory tract

Pelvic inflammatory disease/STI

Erythromycin

Clarithromycin/azithromycin

JUST Azithromycin

Tetracycline/doxycycline

Tigecycline

JUST Ciprofloxacin

Levofloxacin/moxifloxacin

Rifampin

Fidaxomicin

NOVEMBER 2019

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