Current and Future Therapeutics and Clinical Trials

[Pages:9]Cambridge University Press 978-1-107-05386-1 -- Parkinson's Disease Edited by N?stor G?lvez-Jim?nez , Hubert H. Fernandez , Alberto J. Espay , Susan H. Fox Frontmatter More Information

Parkinson's Disease

Current and Future Therapeutics and Clinical Trials

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Cambridge University Press 978-1-107-05386-1 -- Parkinson's Disease Edited by N?stor G?lvez-Jim?nez , Hubert H. Fernandez , Alberto J. Espay , Susan H. Fox Frontmatter More Information

Parkinson's Disease

Current and Future Therapeutics and Clinical Trials

Edited by

N?stor G?lvez-Jim?nez

Professor of Medicine (Neurology-Florida), Cleveland Clinic Lerner College of Medicine, CaseWestern Reserve University; Pauline M. Braathen Endowed Chair; Director, Neurological Center, Chairman, Department of Neurology, and Chief, Movement Disorders Unit, Cleveland Clinic Florida,Weston, FL, USA

Hubert H. Fernandez

Professor of Medicine (Neurology), Cleveland Clinic Lerner College of Medicine, Head of Movement Disorders, Centre for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA

Alberto J. Espay

Associate Professor of Neurology, Director and Endowed Chair James J and Joan A Gardner Center for Parkinson's Disease and Movement Disorders, University of Cincinnati Academic Health Center, Cincinnati, OH, USA

Susan H. Fox

Associate Professor of Neurology, University ofToronto; Associate Director of the Movement Disorders Clinic atTorontoWestern Hospital, Staff Neurologist Division of Neurology, Department of Medicine, University Health Network,Toronto, Canada

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Cambridge University Press 978-1-107-05386-1 -- Parkinson's Disease Edited by N?stor G?lvez-Jim?nez , Hubert H. Fernandez , Alberto J. Espay , Susan H. Fox Frontmatter More Information

University Printing House, Cambridge CB2 8BS, United Kingdom One Liberty Plaza, 20th Floor, New York, NY 10006, USA 477 Williamstown Road, Port Melbourne, VIC 3207, Australia 314-321, 3rd Floor, Plot 3, Splendor Forum, Jasola District Centre, New Delhi - 110025, India 103 Penang Road, #05-06/07, Visioncrest Commercial, Singapore 238467

Cambridge University Press is part of the University of Cambridge. It furthers the University's mission by disseminating knowledge in the pursuit of education, learning and research at the highest international levels of excellence. Information on this title: 9781107053861 ? Cambridge University Press 2016 This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published 2016 A catalogue record for this publication is available from the British Library ISBN 978-1-107-05386-1 Hardback Cambridge University Press has no responsibility for the persistence or accuracy of URLs for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate.

Every effort has been made in preparing this book to provide accurate and up-to-date information which is in accord with accepted standards and practice at the time of publication. Although case histories are drawn from actual cases, every effort has been made to disguise the identities of the individuals involved. Nevertheless, the authors, editors and publishers can make no warranties that the information contained herein is totally free from error, not least because clinical standards are constantly changing through research and regulation. The authors, editors and publishers therefore disclaim all liability for direct or consequential damages resulting from the use of material contained in this book. Readers are strongly advised to pay careful attention to information provided by the manufacturer of any drugs or equipment that they plan to use.

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Cambridge University Press 978-1-107-05386-1 -- Parkinson's Disease Edited by N?stor G?lvez-Jim?nez , Hubert H. Fernandez , Alberto J. Espay , Susan H. Fox Frontmatter More Information

Contents

List of contributors vii Acknowledgments xi

Section I: The Pharmacological Basis for Parkinson's Disease Treatment

1 The pharmacological basis of Parkinson's disease therapy: an overview 1 N?stor G?lvez-Jim?nez, Hubert H. Fernandez, Alberto J. Espay and Susan H. Fox

2 Anticholinergic agents in the management of Parkinson's disease 5 Juan Carlos Giugni and Ramon L. Rodriguez-Cruz

3 Amantadine and antiglutamatergic drugs in the management of Parkinson's disease 13 Marco Onofrj, Valerio Frazzini, Laura Bonanni and Astrid Thomas

4 Monoamine oxidase inhibitors in the management of Parkinson's disease 23 Sven-Eric P?lhagen

5 Oral dopamine agonists in the management of Parkinson's disease 34 Javier Pagonabarraga, Juan Mar?n-Lahoz and Jaime Kulisevsky

6 Subcutaneous, intranasal and transdermal dopamine agonists in the management of Parkinson's disease 48 Antoniya Todorova and K. Ray Chaudhuri

7 Oral and infusion levodopa therapy in the management of Parkinson's disease 63 M. Angela Cenci-Nilsson and Per Odin

8 Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease 76 Ilana Schlesinger and Amos D. Korczyn

9 Experimental pharmacological agents in the management of Parkinson's disease 83 Krishe Menezes, Lawrence W. Elmer and Robert A. Hauser

Section II: Management of Nonmotor Symptoms of Parkinson's Disease

10 Management of autonomic dysfunction in Parkinson's disease 93 Shen-Yang Lim and Ai Huey Tan

11 Management of cognitive impairment in Parkinson's disease 111 Dawn M. Schiehser, Eva Pirogovsky-Turk and Irene Litvan

12 A neurobehavioralist approach to the management of cognitive impairment in Parkinson's disease 122 Po-Heng Tsai

13 Management of disease-related behavioral disturbances in Parkinson's disease 127 Joseph H. Friedman

14 Management of treatment-related behavioral disturbances in Parkinson's disease 139 Mayur Pandya, Dimitrios A. Nacopoulos and Naveed Khokhar

15 Management of sleep disorders in Parkinson's disease 151 Daniela Calandrella and Alberto Albanese

16 Management of pain and neuromuscular complications in Parkinson's disease 162 John A. Morren

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Cambridge University Press 978-1-107-05386-1 -- Parkinson's Disease Edited by N?stor G?lvez-Jim?nez , Hubert H. Fernandez , Alberto J. Espay , Susan H. Fox Frontmatter More Information

Contents

Section III: Surgical Management of Parkinson's Disease

17 Thalamotomy, pallidotomy and subthalamotomy in the management of Parkinson's disease 175 Malco Rossi, Daniel Cerquetti, Jorge Mandolesi and Marcelo Merello

18 Deep-brain stimulation of the globus pallidus internus in the management of Parkinson's disease 187 Lilia C. Lovera, Alberto J. Espay and Andrew P. Duker

19 Deep-brain stimulation of the subthalamic nucleus in the management of Parkinson's disease 195 David A. Schmerler, Alberto J. Espay and Andrew P. Duker

20 Deep-brain stimulation of the thalamic ventral intermediate nucleus in the management of Parkinson's disease 206 Diana Apetauerova, Jay L. Shils and Peter K. Dempsey

21 Emerging targets and other stimulationrelated procedures in the management of Parkinson's disease 216 Tiago A. Mestre and Elena Moro

Section IV: Clinical Trials in Parkinson's Disease: Lessons, Controversies and Challenges

22 Rating scales and clinical outcome measures in the evaluation of patients with Parkinson's disease 231 Pablo Martinez-Martin and Carmen Rodr?guez-Bl?zquez

23 Functional imaging markers as outcome measures in clinical trials for Parkinson's disease 242 Ryan R. Walsh

24 Cerebrospinal fluid and blood biomarkers as outcome measures in clinical trials for Parkinson's disease 249 Thomas F. Tropea and Claire Henchcliffe

25 Lessons learned: neuroprotective trials in Parkinson's disease 265 Isabelle Beaulieu-Boire and Anthony E. Lang

26 Lessons learned: symptomatic trials in early Parkinson's disease 280 Ramon Lugo-Sanchez and N?stor G?lvez-Jim?nez

27 Controversy: globus pallidus internus versus subthalamic nucleus deep-brain stimulation in the management of Parkinson's disease 287 Sarah K. Bourne, Sean J. Nagel and Darlene A. Lobel

28 Controversy: ablative surgery vs deep-brain stimulation in the management of Parkinson's disease 297 Gian D. Pal and Leo Verhagen Metman

29 Controversy: midstage vs advanced-stage deep-brain stimulation in the management of Parkinson's disease 313 Mallory L. Hacker and David Charles

30 Lessons and challenges of trials for cognitive and behavioral complications of Parkinson's disease 325 Daniel Weintraub and Lama M. Chahine

31 Lessons and challenges of trials for other nonmotor complications of Parkinson's disease 337 Federico E. Micheli and Carlos Z??iga-Ram?rez

32 Lessons and challenges of trials involving ancillary therapies for the management of Parkinson's disease 349 Chris J. Hass, Elizabeth L. Stegem?ller, Madeleine E. Hackney and Joe R. Nocera

Index 361 Color plate section between pp. 324 and 325

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Cambridge University Press 978-1-107-05386-1 -- Parkinson's Disease Edited by N?stor G?lvez-Jim?nez , Hubert H. Fernandez , Alberto J. Espay , Susan H. Fox Frontmatter More Information

Contributors

Alberto Albanese MD Department of Neurology, Istituto Neurologico Carlo Besta, Milan, Italy

Diana Apetauerova MD Department of Neurology, Lahey Hospital and Medical Center, Burlington, MA, USA

Isabelle Beaulieu-Boire MD FRCPC Department of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada

Laura Bonanni MD PhD Department of Neuroscience and Imaging, Universit? "G. D'Annunzio" Chieti-Pescara, Chieti, Italy

K. Ray Chaudhuri FRCP DSc National Parkinson Foundation Centre of Excellence, Department of Neurology, King's College Hospital, London, UK

Peter K. Dempsey MD Department of Neurosurgery, Lahey Clinic and Medical Center, Burlington, MA, USA

Andrew P. Duker MD Department of Neurology, University of Cincinnati Health Center, Cincinnati, OH, USA

Lawrence W. Elmer MD Department of Neurology, University of Toledo, Toledo, OH, USA

Sarah K. Bourne MD Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA

Alberto J. Espay MD MSc Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, OH, USA

Daniela Calandrella MD Department of Neurology, Istituto Neurologico Carlo Besta, Milan, Italy

Hubert H. Fernandez MD Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA

M. Angela Cenci-Nilsson MD PhD Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden

Daniel Cerquetti Eng Neuroscience Department, Raul Carrea Institute for Neurological Research, Buenos Aires, Argentina

Lama M. Chahine MD Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

David Charles MD Department of Neurology, Vanderbilt University, Nashville, TN, USA

Susan H. Fox MD PhD Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada

Valerio Frazzini MD PhD Department of Neuroscience and Imaging, Universit? "G. D'Annunzio" Chieti-Pescara, Chieti, Italy

Joseph H. Friedman MD Department of Neurology, Butler Hospital, Providence, RI, USA

N?stor G?lvez-Jim?nez MD Department of Neurology/Pauline M. Braathen Neurological Center, Cleveland Clinic Florida, Weston, FL, USA

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Cambridge University Press 978-1-107-05386-1 -- Parkinson's Disease Edited by N?stor G?lvez-Jim?nez , Hubert H. Fernandez , Alberto J. Espay , Susan H. Fox Frontmatter More Information

List of contributors

Juan Carlos Giugni MD Department of Neurology, University of Florida, Gainesville, FL, USA

Darlene A. Lobel MD Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA

Mallory L. Hacker PhD Department of Neurology, Vanderbilt University, Nashville, TN, USA

Lilia C. Lovera MD Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA

Madeleine E. Hackney PhD

Ramon Lugo-Sanchez MD

Atlanta VA Center for Visual & Neurocognitive Rehabilitation, Emory University School of Medicine, Atlanta, GA, USA

Chris J. Hass PhD Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, USA

Robert A. Hauser MD MBA Parkinson's Disease and Movement Disorders Center, NPF Center of Excellence, Department of Neurology, University of South Florida College of Medicine, Tampa, FL, USA

Claire Henchcliffe MD DPhil FANA Department of Neurology & Neuroscience, Weill Medical College of Cornell University, New York, NY, USA

Pauline M. Braathen Neurological Center, Cleveland Clinic Florida, Weston, FL, USA

Jorge Mandolesi MD Department of Neurosurgery, Raul Carrea Institute for Neurological Research, Buenos Aires, Argentina

Pablo Martinez-Martin MD PhD National Center of Epidemiology, Instituto de Salad Carlos III, Madrid, Spain

Juan Mar?n-Lahoz MD Department of Neurology, Sant Pau Hospital, Barcelona, Spain

Krishe Menezes MD Department of Neurology, University of Toledo, Toledo, OH, USA

Naveed Khokhar MD Department of Psychiatry, Cleveland Clinic, Cleveland, OH, USA

Marcelo Merello MD PhD Neuroscience Department, Raul Carrea Institute for Neurological Research, Buenos Aires, Argentina

Amos D. Korczyn MD Neurology Department, Tel Aviv Medical Center, Tel Aviv, Israel

Tiago A. Mestre MD Division of Neurology, University of Ottawa Hospital, Ottawa, Ontario, Canada

Jaime Kulisevsky MD PhD Department of Neurology, Sant Pau Hospital, Barcelona, Spain

Federico E. Micheli MD PhD Neurology Service, Jos? de San Mart?n Clinicas Hospital, Buenos Aires, Argentina

Anthony E. Lang OC MD FRCPC

Division of Neurology, University of Toronto; Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, Ontario, Canada

Elena Moro MD PhD Department of Neurology, University Hospital Center of Grenoble, Grenoble, France

John A. Morren MD Neuromuscular Center, Cleveland Clinic, Cleveland, OH, USA

Shen-Yang Lim MD FRACP Division of Neurology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia

Dimitrios A. Nacopoulos MD Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA

Irene Litvan MD

viii Department of Neurosciences, University of

California San Diego, La Jolla, CA, USA

Sean J. Nagel MD Department of Neurosurgery, Cleveland Clinic, Cleveland, OH, USA

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Cambridge University Press 978-1-107-05386-1 -- Parkinson's Disease Edited by N?stor G?lvez-Jim?nez , Hubert H. Fernandez , Alberto J. Espay , Susan H. Fox Frontmatter More Information

List of contributors

Joe R. Nocera PhD

Ilana Schlesinger MD

Center for Visual & Neurocognitive Rehabilitation, Atlanta VA Medical Center, Emory University, Atlanta, GA, USA

Per Odin MD PhD Department of Neurology, Sk?ne University Hospital, Lund, Sweden; Central Hospital, Bremerhaven, Germany

Marco Onofrj MD Department of Neuroscience and Imaging, Universit? "G. D'Annunzio" Chieti-Pescara, Chieti, Italy

Javier Pagonabarraga MD PhD Department of Neurology, Sant Pau Hospital, Barcelona, Spain

Gian D. Pal MD Department of Neurology, Rush University Medical Center, Chicago, IL, USA

Department of Neurology, Rambam Health Care Campus, Haifa, Israel

David A. Schmerler DO Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA

Jay L. Shils PhD Department of Anesthesiology, Rush University Medical Center, Chicago, IL, USA

Elizabeth L. Stegem?ller MT-BC PhD Kinesiology Department, Iowa State University, Ames, IA, USA

Ai Huey Tan MD MRCP Division of Neurology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia

Astrid Thomas MD Department of Neuroscience and Imaging, Universit? "G. D'Annunzio" Chieti-Pescara, Chieti, Italy

Sven-Eric P?lhagen MD PhD Department of Clinical Neuroscience, Huddinge, Karolinska Institute, Stockholm, Sweden

Mayur Pandya DO

Antoniya Todorova PhD

National Parkinson Foundation Centre of Excellence, Department of Neurology, King's College Hospital, London, UK

Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA

Eva Pirogovsky-Turk PhD

Thomas F. Tropea DO MPH Department of Neurology, NY Presbyterian Hospital, New York, NY, USA

Department of Psychiatry, University of California San Diego, La Jolla, CA; Veteran's Affairs San Diego Health Care System, San Diego, CA, USA

Carmen Rodr?guez-Bl?zquez PhD National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain

Ramon L. Rodriguez-Cruz MD Department of Neurology, University of Florida, Gainesville, FL, USA

Po-Heng Tsai MD Lou Ruvo Center for Brain Health, Pauline M. Braathen Neurological Center, Cleveland Clinic Florida, Weston, FL, USA

Leo Verhagen Metman MD PhD Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA

Ryan R. Walsh MD PhD Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA

Malco Rossi MD

Neuroscience Department, Raul Carrea Institute for Neurological Research, Buenos Aires, Argentina

Daniel Weintraub MD Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Carlos Z??iga-Ram?rez MD

Dawn M. Schiehser PhD

Department of Neurology, Hospital Civil de

Department of Neurosciences, University of

Guadalajara "Fray Antonio Alcalde,"

California San Diego, La Jolla, CA, USA

Guadalajara, Mexico

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