Glioblastoma in the Elderly: Treatment planning, toxicity ...



Original article

Glioblastoma treatment in the elderly in the temozolomide therapy era

Linda Coate1,2, Mairéad G. McNamara1, Zarnie Lwin1,3, Derek MacFadden1, Ahmed Al-Zahrani1,4, Christine Massey5, Cynthia Menard6, Barbara Ann Millar6, Arjun Sahgal6, Normand Laperriere6, Warren P.Mason1.

1Pencer Brain Tumour Centre, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.

2Mid-Western Regional Hospital Limerick, Limerick, Ireland.

3Department of Medical Oncology, Royal Brisbane and Women’s Hospital, University of Queensland, Brisbane, Australia.

4Department of Medical Oncology, King Faisal Cancer Center, Riyadh, Saudi Arabia.

5Department of Biostatistics, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.

6Department of Radiation Oncology, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.

Corresponding author

Dr. Warren P. Mason,

Pencer Brain Tumour centre,

Princess Margaret Cancer Centre,

610 University Avenue, Suite 18-717,

Toronto, Ontario M5G 2M9,

Canada.

Tel: +1 416 946 2277

Fax: +1 416 946 2284

Email: warren.mason@uhn.ca

Running title

Glioblastoma in the elderly

This work was presented in part at the 2011 American Society of Clinical Oncology annual meeting, Chicago, USA.

Abstract

Background: Optimal treatment of glioblastoma (GBM) in the elderly remains unclear. The impact of age on treatment planning, toxicity, and efficacy at a Canadian Cancer Centre was retrospectively reviewed.

Methods: Glioblastoma patients treated consecutively between 2004 and 2008 were reviewed. Utilizing 70 years as the threshold for definition of an elderly patient, treatments and outcome were compared in younger and elderly populations.

Results: Four hundred and twenty one patients were included in this analysis and median overall survival (OS) for the entire cohort was 9.8 months. 290 patients were aged 70 who were treated with radiotherapy received ................
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