A Message From the Past President



• MECHANISMS •

A Specialty Section of the Society of Toxicology

Volume 21, Number 1 Fall, 2003

A Message From the President

Over the past 15-20 years, Toxicology has evolved and grown from a largely descriptive science to a more mechanistic driven discipline. Indeed, mechanistic based research has become a dominant theme at almost every annual SOT meeting over the past decade or so. In large measure, this can be attributed to the exciting and fast-paced advances in science and technology and a greater application of mechanistic based research into risk assessment. The Mechanisms Specialty Section continues to play a strong and vital role in promoting mechanism based research at the annual SOT meeting. Needless to say, expertise in ‘mechanisms’ does not reside exclusively in our Specialty Section but permeates throughout many other specialty sections as well. As such, we need to engage/collaborate and/or recruit experts from other specialties if we are to continue to grow as a Specialty Section, advance mechanistic concepts and be a strong driving force for SOT. As a Specialty Section, we are a tremendous resource and knowledge base for the Society and can serve the Society by not only providing high quality and provocative mechanistic-based sessions at the annual meeting but also by providing our expertise vis-à-vis position statements and committee work. Collaboration with and/or recruitment of ‘mechanistic’ experts will strengthen the platform of our SS and our contributions to SOT.

I am pleased to report to you that once again, the Mechanisms Specialty Section was a major and significant contributor to the annual SOT meeting. In Salt Lake City this year we had a number of outstanding Symposia, Workshops, and Continuing Education courses (9 of 18 proposals were accepted for presentation- see below). We were also well represented by the number of platform and poster presentations throughout the meeting. I’d like to thank you, as members of the Mechanisms Specialty Section, for your active participation and for your contributions to the success of this year’s meeting. Serrine Lau, our Vice President, has worked hard this past year in soliciting and putting together many excellent symposia, workshops and CE courses for the upcoming annual meeting in Baltimore. I would like to express my gratitude to Serrine for her efforts and I am confident that our sponsored sessions will be of high quality. Dan Liebler , our VP-Elect, will be responsible for proposing Mechanism sponsored sessions for the 2005 meeting – so be sure to contact Dan in Baltimore! I would also like to take this opportunity to thank my predecessor, Terry Monks, for his leadership and commitment to the Mechanisms SS and for his strong advocacy of graduate education and graduate students, the real lifeblood of our SS and our Society at large. I owe special thanks to Gary Rankin, who as Secretary/Treasurer not only manages to keep good track of our finances and meeting minutes, but also keeps us all in line with gentle, friendly reminders of impending deadlines.

On a final note, it has been a privilege for me to be a member of this Specialty Section, let alone to serve you as President. Please feel free to email me with any comments you have regarding the Specialty Section and how we can better serve you (robin.goldstein@pharma.)

Thank you for your support and I look forward to seeing you in Baltimore.

Robin Goldstein

From the Editor’s Desk

Gary Rankin

As I start my second year as Secretary/Treasurer of the Mechanisms Specialty Section, let me thank let me thank everyone for the assistance that you all has given me. Throughout last year our Past Secretary/Treasurer Marc Fariss was really helpful getting me started and seeing me through the year. This issue of the Mechanisms Newsletter is my second issue to organize for the membership. Once you have had a chance to read it, please feel free to contact me (rankin@marshall.edu) with any suggestions you may have on how to improve our newsletter or the Mechanisms Specialty Section.

Some special reminders for each of you:

1. Please make sure that your graduate students sign up for student membership in the Mechanisms Specialty Section. SOT will reimburse our Specialty Section for 1 student per Full member. In other words, each full member can have one student join SOT for free.

2. When you give a donation to the Carl C. Smith Fund, please e-mail me (rankin@marshall.edu) with your contribution amount. This helps the Specialty Section keep an accurate account of the annual donations to this fund. Thanks!

3. SOT Council has reduced Specialty Section dues to $15 per Specialty Section with students getting one free Specialty Section membership after becoming a student member of SOT. This change went into effect with the dues renewal at the end of last year.

In this issue, you will find a report on our 2003 Mechanisms Specialty Section Business meeting that includes a list of the winners and judges for the 2003 Carl C. Smith Graduate Student Awards. Information on requirements, deadlines, etc. is also provided for the 2004 Carl C. Smith Graduate Student Awards. These awards are one way of recognizing the excellence of our student’s research efforts, so please consider having your students apply. We are fortunate indeed to have Tee Smith lending her interest, energy and continued support to these awards. A list of 2002/2003 Contributors to the Carl C. Smith Endowment Fund is also included. Thanks so much to all of you who contributed last year, as your contributions make these awards possible. If you did not contribute to this fund last year, please consider contributing this year, and for our past contributors, pleases consider continuing you support of these very worthwhile awards.

It is also time to begin thinking about preparing proposals for Symposia, Workshops and Continuing Education Courses for the SOT 2005 Annual Meeting. Vice-President Elect Dan Liebler will be coordinating the review of the proposals this year. The quality of proposals from the Mechanisms Specialty Section has been exceptional over the years, so please help us maintain our record of excellence by submitting your proposals.

Summary of the Mechanisms Specialty Section Business Meeting

The Annual Business Meeting of the Mechanisms Specialty Section was held in Ballroom I of the Salt Palace Convention Center in Salt Lake City, Utah on Monday, March 10, 2003. The reception began at 6:00 PM and President Terry Monks called the Business Meeting to order at 6:30 PM. He welcomed approximately 150 attendees to the meeting, and then called on the Secretary/Treasurer to make his report.

Secretary/Treasurer Gary Rankin reported that as of the January 31, 2003 financial report received from SOT headquarters it was estimated that the net assets for the Mechanisms SS at the end of the fiscal year (June 30, 2003) would be $16,901 based on a beginning balance (July 1, 2002) of $11,973 plus dues ($4,167) and interest ($805) and minus expenses to date ($43). He pointed out that this accounting did not include meeting income or expenses for the annual meeting, plaques, SOT staff labor time or non-labor expenses. Based on SOT estimates for this income and expenses, Gary calculated net assets at the end of this fiscal year to be $17,108.52. There was a lengthy discussion as to what to do with the growing balance in the Mechanisms account. Ideas for use of this money included giving travel awards to students and transferring part of the balance to the Carl C. Smith Award Fund. President Terry Monks indicated that members of the Executive Committee would consider all ideas later this year and determine the best way to utilize these funds. Gary also discussed the balance for the Carl C. Smith Fund. He estimated that the balance should be ~$37,500, but that he couldn’t be sure as detailed accounting had yet to be presented by SOT Headquarters. He thanked all donors to the Carl C. Smith Fund and encouraged continued member support of this Mechanisms Specialty Section program.

Vice President Robin Goldstein provided an update on the Continuing Education Courses, Workshops and Symposia sponsored or co-sponsored by the Mechanisms Specialty Section for the March 9-13, 2003 SOT Meeting in Salt Lake City, UT. A total of eighteen proposals were submitted and nine were approved for presentation. These programs included:

Continuing Education Courses

Unfolding the Secrets in Culturing Brain Cells: Theory, Techniques, and Beyond

Timothy J. Shafer and Wei Zheng Sunday, 8:15 AM

Genomic and Proteomic Array Formats on the Cutting-Edge

Mary Jane Cunningham Sunday, 1:15 PM

Workshop Sessions

Dose-Dependent Transitions in Toxic Mechanisms

William Slikker, Jr. and Kendall B. Wallace Wednesday, 1:30 PM

Vanilloid Receptors: Mediators of Respiratory Injury

Garold S. Yost and John B. Morris Wednesday, 1:30 PM

Symposia

Understanding Mechanisms of Toxicity of Immunosuppressive Drugs to Improve and Broaden the Scope of Their Use

Uwe Christians and Raymond Novak Monday, 9:30 AM

Free Radicals in the Toxicity of Alcohols

Ronald P. Mason and John L. Lemasters Monday, 1:30 PM

Stress Activated Signal Transduction Pathways

Qin M. Chen and Jeffery A. Johnson Tuesday, 8:30 AM

Innovations in Toxicological Sciences: Beyond Genomics: Image Analysis and Computational Biology

Kenneth S. Ramos and Cheryl L. Walker Wednesday, 8:30 AM

Innovation in Applied Toxicology: Genomic and proteomic Analysis of Surrogate Tissues for Assessing Toxic Exposures and Disease States

David J. Dix and John C. Rockett Wednesday, 1:30 PM

Vice-President Elect Serrine Lau encouraged everyone to consider submitting a Continuing Education Course, Workshop or Symposium proposal for the 2004 Annual Meeting in Baltimore, MD. She indicated that the deadline for submission was April 15th, 2003 and that an on-line submission process to SOT had been instituted. She reviewed the guidelines for submission and indicated that Continuing Education speakers would receive $500 for their presentations

Terry Monks announced the results of the recent election for Vice-President Elect and Councilor of the Mechanisms Specialty Section. He recognized Dan Liebler as the new Vice-President and John Richburg as the new Councilor. He also thanked Judy Bolton and Tim Miller for their willingness to be candidates for these positions. He indicated that a Student Councilor would be elected to the Executive Committee during the next election and that to be considered for this position, names should be submitted to Councilor Mike Aleo who will Chair the Nominating Committee.

Terry Monks presented a plaque of appreciation to previous and outgoing Officers of the Mechanisms Specialty Section David Ross (Past President) and Jose Manautou (Senior Councilor).

Terry Monks announced that the Carl C. Smith Awards would be presented. He thanked all of the members for their support of this important Mechanisms Specialty Section activity and acknowledged the generous support of Taylor & Francis. He indicated that Taylor and Francis made a $500 contribution to the Carl C. Smith Fund and has provided subscription gifts for the top three awardees. Corey Gray, a representative of Taylor & Francis was recognized. Terry then briefly reviewed the history of the Carl C. Smith Awards and acknowledged the continuing contributions of Mrs. Tee Smith.

Mike Aleo, who Chaired the selection process, then reviewed the criteria for the Carl C. Smith Award competition. He indicated that of the seventeen submitted applications, ten were selected for recognition. Mike thanked the both sets of judges for all of their hard work and acknowledged how difficult it was to pick the winners because of the excellence of the applications. He indicated that plaques of appreciation would be sent to Final Judges in the near future.

Screening Judges

Dr. Michael F. Hughes Dr. Raymond Novak

US EPA/NHEERL/PKB Wayne State University

Research Triangle Park, NC 27711 Detroit, MI 48201-2654

Dr. Donald G. Robertson

Pfizer Global Research

Ann Arbor, MI 48105-1047

Final Judges

Dr. Gary P. Carlson Dr. Dean P. Jones

Purdue University Emory University

School of Health Sciences Department of Biochemistry

Civil Engineering Building Rollins Research Center

550 Stadium Mall Drive 1510 Clifton Road

West Lafayette, IN 47907-2051 Atlanta, GA 30322

Dr. Joan B. Tarloff

University of the Sciences in Philadelphia

Department of Pharmaceutical Sciences

600 South 43rd Street

Philadelphia, PA 19104

The following awards were presented by Mike Aleo and Terry Monks with assistance from Corey Gray of Taylor & Francis for the First, Second and Third Place winners:

FIRST PLACE

PALLAVI B. LIMAYE, U.M. Apte, T.J. Bucci. A. Warbritton and H.M. Mehendale. Department of Toxicology, The University of Louisiana at Monroe, Monroe, LA. “WHY DOES INJURY PROGRESS EVEN AFTER TOXICANT IS GONE? A NOVEL MECHANISM.”

SECOND PLACE

JOHN E. REICHARD, M. S Taylor and D.R. Petersen. University of Colorado Health sciences Center, Denver, CO. “INVOLVEMENT OF PHOSPHATIDYLINOSITOL 3-KINASE IN HEPATIC STELLATE CELL ACTIVATION AND ARE-REGULATED GENE INDUCTION.”

THIRD PLACE

KINARM KO and R.E. Peterson. School of Pharmacy, University of Wisconsin, Madison, WI. “2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN (TCDD) INHIBITS PROSTATIC EPITHELIAL BUD FORMATION IN THE UROGENITAL SINUS (UGS) OF C57BL/6J MICE WITHOUT INHIBITING ANDROGEN SIGNALING.”

HONORABLE MENTION

(Listed Alphabetically)

NICOLE C. BROWN, M. Nagarkatti and P. Nagarkatti. Departments of Microbiology/Immunology and Pharmacology/Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA. “CROSS-TALK BETWEEN DEATH RECEPTOR-MEDIATED AND MITOCHONDRIAL PATHWAYS OF APOPTOSIS BY DES IN JURKAY CELLS.”

JING DONG, S. Ramachandiran, K. Tikoo, S.S. Lau and T.J. Monks. Center for Molecular and Cellular Toxicology, University of Texas at Austin, Austin, TX. “THE COORDINATE ACTIVATION OF ERK AND p38 MAPK IS REQUIRED FOR HISTONE H3 PHOSPHORYLATION IN RESPONSE TO ROS-INDUCED DNA DAMAGE.”

MARC T. HOLDERMAN, C. Partridge, R. Mouneimne and K.S. Ramos. Center for Environmental and Rural Health, Texas A & M University, College Station, TX. “EXPRESSION AND LOCALIZATION OF P70 ALBUMIN PRECURSOR PROTEIN AND PHI AP3 IN OXIDATIVELY STRESSED VASCULAR SMOOTH MUSCLE CELLS.”

ZHE SOPHIE JIA, M.D. Person, J. Shen, S.C. Hensley, J.L. Stevens, T.J. Monks and S.S. Lau. Center for Molecular and Cellular Toxicology, University of Texas at Austin, Austin, TX. “ROLE OF BIP/GRP78 IN 11-DEOXY-16,16-DIMETHYL PROSTAGLANDIN E MEDIATED CYTOPROTECTION IN RENAL EPITHELIAL CELLS.”

DONALD KIRKPATRICK, R.R. Vaillancourt, Z.E. Derbyshire and A.J. Gandolfi. Superfund Basic Research Program, Center for Toxicology, University of Arizona, Tucson, AZ. “INCREASED UBIQUINATION OF THE KINASE TAK1 FOLLOWING As (III) EXPOSURE IN HEK293 CELLS.”

VISHAL S. VAIDYA, K. Shankar, D. Dixon, E.A. Lock and H.M. Mehendale. Department of Toxicology, The University of Louisiana at Monroe, Monroe, LA. “MECHANISMS OF STIMULATED TISSUE REPAIR IN SURVIVAL FROM ACUTE RENAL TUBULAR NECROSIS: ROLE OF MAPK PATHWAY.”

YI YANG, Y. Chen, M.Z. Dieter, H.G. Shertzer, D.W. Nebert and T.P. Dalton. Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati, Cincinnati, OH. “INITIAL CHARACTERIZATION OF THE GLUTAMATE-CYSTEINE LIGASE MODIFIED SUBUNIT Gclm(-/-) KNOCKOUT MOUSE: NOVEL MODEL SYSTEM FOR A SEVERELY COMPROMISED OXIDATIVE STRESS RESPONSE.”

Terry Monks presented Gary Rankin with a gift of appreciation for his service as Secretary/Treasurer during the past year. Terry asked if there was any other business, but no business was brought forth from the membership.

The meeting was adjourned at 7:30 PM.

CARL C. SMITH MECHANISMS GRADUATE STUDENT AWARDS

DEADLINE: OCTOBER 7, 2003

The Mechanisms Specialty Section of the Society of Toxicology is pleased to announce the Twenty-third Annual Graduate Student Awards for Meritorious Research in Mechanisms of Toxicology. The awards will be presented during the 43st Annual Meeting of the Society of Toxicology in Baltimore, MD, March 21-25, 2004.

For consideration as a candidate for an award:

1. An abstract must been submitted to the 2004 Annual SOT Meeting with the graduate student as the presenting author.

2. A copy of the abstract and a statement that it is to be considered for this award must be mailed to Tee Smith, 2707 Eden Avenue, Cincinnati, OH 45219-2201, post-marked no later than October 7, 2003. Two letters recommending the graduate student and the research project must accompany the abstract. One of the recommendations must be from the Department or Section Head. The letter must verify that the work reported in the abstract was done while the student was enrolled in the graduate program and that this is the only specialty section to which this abstract is being submitted for an award. The letter must also specially cite the role and contribution of the student in the completion of the work, especially when there are multiple authors.

3. Up to three candidates may be nominated by a department or program. The department or program must decide which graduate students best represent them.

4. The graduate student may be sponsored for this award by any person who is a member (active or pending) of the Mechanisms Specialty Section of the Society of Toxicology. Member sponsorship from the Mechanisms Specialty Section should be noted in one of the letters of recommendation.

As many as twelve finalists will be selected to submit a full-length manuscript on the research described in their abstract. Instructions for preparing and submitting the manuscript will be provided in the letter announcing their selection as a finalist. The deadline for submission of the full-length manuscript will be January 8, 2004. First, second and third place winners will receive a plaque and a cash award of $500, $300 and $100, respectively. Remaining finalists will receive honorable mention awards (framed certificates).

Any questions concerning these awards should be directed to Tee Smith at 513-751-3315. For additional information contact Dr. John Richburg at (512) 471-4736; FAX (512) 471-5002; e-mail John_richburg@mail.utexas.edu.

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A Call for Contributions

One of the main efforts of the Mechanisms Specialty Section is the annual recognition of outstanding research done by graduate students in Toxicology. Graduate student awards were begun at the time the Mechanisms Section was established, and over the years, have been spearheaded by Carl Smith and his wife Thelma (Tee). Presently, with Tee’s help, the Mechanisms Specialty Section solicits the student papers, organizes the judging, prepares the plaques and certificates and distributes the awards at the annual Mechanisms Section Meeting. In 1990, the Mechanisms Section recognized the hard work and dedication that Carl put into these awards and named these awards in his honor. These awards have also been financially supported by Carl and Tee Smith and an anonymous donor that Carl recruited. The awards are also sponsored by publishers and by individual members of the Specialty Section. The graduate student awards in toxicology bring visibility to our section and serves to educate and encourage the next generation of toxicologists. It is important that we continue to support this program. To that end, we again solicit donations from our members, particularly those who have received one of these awards in the past. And remember, your contributions are tax deductible.

Donations to the Carl Smith Endowment Fund:

I wish to contribute $ to help support graduate students engaged in mechanistic research in toxicology.

Name:

Address:

Phone:

Please make checks payable to: The Carl Smith Fund/SOT

And mail them to : Dr. Gary O. Rankin

Department of Pharmacology

Joan C. Edwards School of Medicine

Marshall University

1542 Spring Valley Drive

Huntington, WV 25704-9388

In grateful recognition of all of the contributors to the Carl Smith Endowment Fund for 2002/2003: $1,670

R. Hays Bell Charles C. Barton James V. Bruckner Steven D. Cohen Steven T. Cragg David L Eaton

Marion F. Ehrich Thomas A. Gasiewicz James W Holder Andrea Hubbard Mary F. Kanz Gerald Kennedy, Jr.

Thomas W. Kensler R. Tim Miller Julie A Moran

Daniel F. Muldoon Sidney Nelson Alan R. Parrish

Dennis R. Petersen Gary O. Rankin Joseph K. Ritter Robert Snyder David C. Spink James L. Stevens

Steven P. Stratton Taylor & Francis Publishers Robert L. Thies

Craig E. Thomas Monica A. Valentovic Kendall Wallace

Garold S. Yost

If you contributed to the Carl Smith Fund, but don’t see you name listed here, please contact Gary O. Rankin, Mechanisms Specialty Section Secretary/Treasurer at rankin@marshall.edu.

Current Officers and Councilors of the Mechanisms Specialty Section (2003-2004)

President Robin Goldstein

Vice-President Serrine Lau

Vice-President Elect Daniel Liebler

Secretary/Treasurer Gary Rankin

Councilors Mike Aleo

John Richburg

Past President Terrence Monks

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