Angiotensin Receptor Blocker (ARB) Recommend ...
Angiotensin Receptor Blocker (ARB) Antihypertensive Dose Comparison
Recommend Generics
Generic (Brand) Candesartan (Atacand) Irbesartan (Avapro) Losartan (Cozaar)
Valsartan (Diovan)
Telmisartan (Micardis) Benicar (Olmesartan) Edarbi (Azilsartan) Not on medicare formulary Teveten (Eprosartan)
Average 30-Day Supply Cost to Health Alliance/Carle
$72
FDA-Labeled Indications and Usual or Target Adult Daily Dosage Range
Heart failure: 32mg/day Hypertension: 8-32mg/day
Comments Correct volume-depletion before starting
$10
Diabetic nephropathy: 300mg/day
Initial dose of 75mg once daily
Hypertension: 150-300mg/day
recommended for volume/sodiumdepleted patients
$2
HTN: 50-100mg daily
Starting dose for volume/sodium-depleted
Diabetic nephropathy: 50-100mg daily HTN w/left ventricular hypertrophy: 50-
patients or patients with (or with a history of) hepatic impairment is 25mg once daily
100mg daily in combo with a thiazide diuretic
$40
HTN: 80-320 daily
Dose cautiously in hepatic or severe renal
CHF: 80-320 in two divided doses
impairment
Post-MI: 40-320mg in two divided doses
$20
HTN: 40-80mg daily
Use lower starting dose for hepatic
CV risk Reduction: 80mg daily
impairment or volume/sodium-depleted
patients
$35
Hypertension: 20-40mg/day
Consider lower starting dose for volume-
depleted patients
$100
Hypertension: 80mg/day
Starting dose for volume/sodium-depleted
patients is 40mg once daily
$75
Hypertension: 400-800mg/day
Do not exceed 600mg daily in moderate or
severe renal impairment
Comparison of Angiotensin Receptor Blockers (ARBs). Pharmacist's Letter/Prescriber's Letter. September 2018.
Generic (Brand) Irbesartan (Avapro) Losartan (Cozaar) Olmesartan (Benicar) Valsartan (Diovan)
Candesartan (Atacand)
Azilsartan (Edarbi) Telmisartan (Micardis) Eprosartan (Teveten)
75mg daily 25mg daily 10mg daily
Approximate Dose Equivalencies for Hypertension (1)
150mg daily
300mg daily
300mg daily
50mg daily or 25mg 100mg daily or 50mg -
twice/day
twice daily
20mg daily
20-40mg daily
40mg daily
40mg daily or 20mg twice daily 4mg daily
40mg daily
80mg daily or 40mg 160mg daily or 80mg 320mg daily or 160mg twice daily
twice daily
twice daily
8mg daily or 4mg twice daily
40mg daily
16mg daily or 8mg twice daily
40mg daily
16-32mg daily or divided twice daily 40mg daily
20mg daily
40mg daily
40-80mg daily
80mg daily
400mg daily 600mg daily
800mg daily or
800mg daily or 400mg twice daily
400mg twice daily
80mg daily
(1) based on therapeutic interchange studies, comparative clinical trials and manufacturers' recommended dosing for hypertension Angiotensin Receptor Blocker (ARB) Antihypertensive Dose Comparison. Pharmacist's Letter/Prescriber's Letter. September 2018.
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