Disposition, layout og vejledning i udformning af kliniske ...
Non-alkoholisk fedtleversygdom (NAFLD): Diagnostik og behandlingForfattere og korrespondanceHenning Gr?nb?k (tovholder), Peter Thielsen, Konstantin Kazankov, Sara Heeb?ll, Sanne Dam Larsen, Synne Semb, Lars Peter Skovgaard Larsen, Peter Holland-Fischer, Th?ger Th?gersen, Jens Meldgaard Bruun (Dansk Endokrinologisk Selskab og Dansk Selskab for Adipositasforskning). Korrespondance: Professor Henning Gr?nb?k, Medicinsk Hepatogastroenterologisk Afdeling, Aarhus Universitetshospital, N?rrebrogade 44, 8000 Aarhus C. E-mail: henngroe@rm.dkStatusF?rste udkast: 01.07.2016Diskuteret p? Hindsgavl: 27.08 2016Korrigeret udkast:20.01 2017Endelig guideline:20.01 2017Guideline skal revideres senest:21.01 2021Afgr?nsning af emnet Non-alkoholisk fedtleversygdom (Non-Alcoholic Fatty Liver Disease, NAFLD) er den hyppigste leversygdom i den vestlige verden. NAFLD omfatter spektret fra simpel steatose (Non-Alcoholic fatty liver, NAFL) til steatohepatitis (Non-alcoholic steatohepatitis, NASH). Patienter med NASH kan udvikle fibrose (der kan progrediere til cirrose) og prim?r leverkr?ft (HCC). Det er vigtigt at diagnostisere NASH og vurdere behov for behandling. Denne guideline omhandler diagnosticering og behandling af NAFLD. Guidelinen omhandler ikke andre former for fedtleversygdom, f.eks. sekund?rt til alkohol, toxisk/medikamentel p?virkning eller sult/malnutrition. Quick-guideNAFLD skal mist?nkes ved udredning for transaminas?mi og steatose p?vist ved UL. Risikofaktorer for metabolisk syndrom (MetS) b?r identificeres og alkoholoverforbrug samt andre differential diagnoser udelukkes. Patienter med MetS b?r udredes for NAFLD.Simpel steatose (NAFL) p?virker ikke d?delighed mens NASH (s?rligt ved fibrose ≥ F2) er associeret med ?get leverrelateret morbiditet og mortalitet. Jo h?jere alder og jo flere risikofaktorer for MetS des st?rre er risikoen for fibrose. Serum fibrose scores (FIB-4 og NAFLD fibrosis score) og elastografi kan benyttes til at vurdere risiko for NASH og fibrose. Leverbiopsi anbefales til diagnostisk vurdering af patienter med h?j risiko for NASH og differentialdiagnoser. Leverbiopsi er den eneste metode, der sikkert kan skelne NAFL fra NASH og kvantitere fibrosegraden. Det anbefales at den histologiske vurdering st?tter sig til ”Steatosis, Activity and Fibrosis” (SAF) score i diagnosticering og NAFLD Activity Score (NAS) til vurdering af behandlingseffekt og opf?lgning. Den prim?re behandling af NAFLD best?r af livsstils?ndring (kost og motion) med henblik p? v?gttab og bedring af MetS. V?gttab > 3-10 % reducerer graden af steatose (> 3 %), inflammation (> 5-10 %) og fibrose (> 10 %).Der foreligger ikke sikker evidens for, at medicinsk behandling har gavnlig effekt p? kliniske endepunkter. Medicinsk behandling kan overvejes til behandling af NASH ved insufficient effekt af livsstilsintervention ved: 1) fibrose ≥ F2, 2) ?get risiko for progression af fibrose (alder > 50 ?r, MetS, ?get ALAT), eller 3) udtalt necroinflammatorisk aktivitet. Vitamin E kan overvejes til patienter uden diabetes. Til NASH patienter med diabetes kan overvejes pioglitazon under hensyntagen til risiko for bivirkninger inklusive v?gt?gning, kongestiv hjertesygdom, bl?recancer og frakturer.Bariatrisk kirurgi overvejes hvis ovenst?ende behandlinger er uden tilstr?kkelig effekt og patienten i ?vrigt opfylder kravene til bariatrisk kirurgi.Behandling af MetS er vigtig for patienter med NAFLD of f?lger g?ldende retningslinjer.NAFLD er associateret med en ?get risiko for udvikling af HCC, men der er ikke sikker evidens for screening for HCC.Figur 1: Flowchart for udredning af patienter med mistanke om NAFLD/NASH1) Levertal: ALAT, ASAT, γ-Glutamyltransferase (γ-GT). 2) Serum fibrose mark?rer (se Tabel 1 Appendiks): FIB-4, NAFLD Fibrosis Score (ELF, FibroTest).3) Vejledning for udredning af NAFLD-patienter.Prim?r udredning:Dispositioner til MetS (diabetes, hypertension, hyperlipid?mi, hjertekarsygdom, polycystisk ovarie syndrom)Taljem?l, h?jde, v?gt, BMI, v?gt?gningAlkohol indtag: < 20 g/dag for kvinder, < 30 g/dag for m?ndMedicin inkl. naturmedicin anamneseH?moglobin, leukocytter, trombocytterSerum total og HDL-kolesterol, triglyceridFaste blodsukker, HbA1c, faste insulin/c-peptidUdelukkelse af hepatitis B og C infektionJern, ferritin og transferrin (jernm?tning)Autoimmune mark?rer (IgG, IgM, IgA, glatmuskelcelle antistof, anti-mitokondrie antistof, antinukl?re antistoffer)Ultralydsskanning af leveren.Udvidet udredningsprogram:Tests for c?liaki og stofskiftesygdom, polycystisk ovarie syndrom;Tests for sj?ldne lever sygdomme hvis relevant (Wilson, α1-antitrypsin mangel, LAL-D).IndledningNAFLD er oftest en langsomt progredierende sygdom og den hyppigste leversygdom i vestlige lande og afficerer 17-46 %. Forekomst og sv?rhedsgrad er ?get hos ?ldre. NAFL uden inflammation og fibrose har en god prognose mens NASH har ?get morbiditet og mortalitet PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW5naDwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW5naDwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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ADDIN EN.CITE.DATA (1). Det er prim?rt tilstedev?relsen af fibrose i index leverbiopsien, som er korreleret med ?get mortalitet, levertransplantation og leverrelateret sygdom og d?d PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bbmd1bG88L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bbmd1bG88L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (2, 3). Forekomsten af NAFLD f?lger pr?valensen af det metaboliske syndrom (MetS) og syndromets komponenter (taljem?l, type 2 diabetes mellitus (type-2 DM), hypertension, dyslipid?mi). NAFLD ses s?ledes hyppigere blandt diabetikere og sv?rt overv?gtige. Pr?valens og incidens af hjertekarsygdom er h?jere hos NAFLD patienter, og er drevet af sammenh?ngen mellem NAFLD og komponenter af MetS. Indtag af kaloriet?t di?t og manglende motion er associeret med udvikling af NAFLD. Der er en st?rk association mellem NAFLD og risiko for udvikling af DM og forbedring af NAFLD har vist at mindske risikoen for udvikling af type-2 DM PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZYW1hemFraTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZYW1hemFraTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+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ADDIN EN.CITE.DATA (4). NAFLD forekommer ogs? hos normalv?gtige, og her kan leversygdommen ogs? v?re progredierende. NAFLD hos normalv?gtige eller let overv?gtige ses is?r i udviklingslandene og er ikke n?dvendigvis ledsaget af MetS ADDIN EN.CITE <EndNote><Cite><Author>Vernon</Author><Year>2011</Year><RecNum>11628</RecNum><DisplayText>(5)</DisplayText><record><rec-number>11628</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463053442">11628</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Vernon, G.</author><author>Baranova, A.</author><author>Younossi, Z. M.</author></authors></contributors><auth-address>Department of Medicine, Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA 22042, USA.</auth-address><titles><title>Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults</title><secondary-title>Aliment Pharmacol Ther</secondary-title></titles><periodical><full-title>Aliment Pharmacol Ther</full-title></periodical><pages>274-85</pages><volume>34</volume><number>3</number><keywords><keyword>Adult</keyword><keyword>Biopsy</keyword><keyword>Fatty Liver/diagnosis/*epidemiology</keyword><keyword>Humans</keyword><keyword>Non-alcoholic Fatty Liver Disease</keyword><keyword>Prevalence</keyword><keyword>Prognosis</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2011</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1365-2036 (Electronic)
0269-2813 (Linking)</isbn><accession-num>21623852</accession-num><urls><related-urls><url>;(5).Risikoen for udvikling af HCC ved NASH varierer fra 0,25 % til 7,6 % over 5 ?r. Patienter med NASH-associeret HCC er ?ldre og har hyppigere ko-morbiditet p? diagnose tidspunktet. Amerikanske studier rapporterer en HCC incidens p? 2,6 % hos patienter med NASH-cirrose og med stigende incidens. Et amerikansk populations studie af HCC patienter viser at ca. 60 % af HCC tilf?lde optr?der ved NAFLD og at NAFLD er den n?sthyppigste indikation for HCC-relateret levertransplantation ADDIN EN.CITE <EndNote><Cite><Author>Wong</Author><Year>2014</Year><RecNum>11629</RecNum><DisplayText>(6)</DisplayText><record><rec-number>11629</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463053503">11629</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wong, R. J.</author><author>Cheung, R.</author><author>Ahmed, A.</author></authors></contributors><auth-address>Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA; Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA.</auth-address><titles><title>Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>2188-95</pages><volume>59</volume><number>6</number><keywords><keyword>Aged</keyword><keyword>Carcinoma, Hepatocellular/epidemiology/*etiology/surgery</keyword><keyword>Fatty Liver/*complications/epidemiology/surgery</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Liver Neoplasms/epidemiology/*etiology/surgery</keyword><keyword>Liver Transplantation/*statistics & numerical data</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Non-alcoholic Fatty Liver Disease</keyword><keyword>Retrospective Studies</keyword><keyword>United States/epidemiology</keyword></keywords><dates><year>2014</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1527-3350 (Electronic)
0270-9139 (Linking)</isbn><accession-num>24375711</accession-num><urls><related-urls><url>;(6). Der er ikke evidens for systematisk HCC screening i denne store risikopopulation eller NASH cirrose patienter ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7). DefinitionerNAFLD er karakteriseret ved en ?get m?ngde af fedt i leveren (> 5 %) og er associeret med insulin resistens (IR) som led i MetS (Tabel 1). NAFLD omfatter to kliniske enheder: 1) Simpel steatose (NAFL), hvor der alene er fedtophobning i leveren uden eller med kun let lobul?r inflammation og 2) NASH, hvor der udover steatose ses hepatocyt ballooning samt lobul?r inflammation med risiko for udvikling af fibrose, cirrose samt HCC. (Tabel 1) ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7).Tabel 1KarakteristikaNAFLDKan v?re NAFL eller NASH. Associeret med MetS inclusive Taljem?l > 94/> 80 cm for m?nd/kvinderBlodtryk > 130/85 mm Hg eller i behandling for hypertensionFaste glukose > 5.6 mmol/L eller i behandling for diabetesSerum triglycerid > 1.7 mmol/LHDL-kolesterol < 1.0 (m?nd)/< 1.3 mmol/L (kvinder). NAFLGodartet prognose. Histologisk enten ren (simpel) steatose eller steatose og mild lobul?r inflammation.NASH?get lever-associereet mortalitet og morbiditet. ?get risiko for alvorlig hjertesygdom. Hisologisk ses steatose, hepatocyt ballooning, lobul?r inflammation. Fibrosegrad kan v?re ingen (F0), let (F1), signifikant (≥ F2), bro-fibrose (≥ F3) eller svarende til cirrose (F4).DifferentialdiagnoserHyppigeAlkoholToksisk/medikamentel (bl.a. prednisolon, ?strogen, tamoxifen)Kronisk hepatitis B eller CMindre hyppigeH?mokromatoseAutoimmun hepatitisAlfa-1 antitrypsin mangelC?liakiWilson’s sygdomA-/hypo-betalipoprotein?miLysosomal acid lipase deficiency (LAL-d)HypotyroidismeParenteral ern?ring.Tabel 2. EvidensniveauELRGHvilken billedteknik anbefales til at stille diagnosen leversteatose? Ultralydskanning kan anvendes 1bAMR spectroskopi eller kvantitativ MR proton-densitet fedt fraktion har h?jere sensitivitet og specificitet end UL, men anbefales ikke rutinem?ssigt.1bAHvorn?r skal man mist?nke NAFLD og NASH?Det anbefales at screene patienter med IR/MetS for NAFLD. Risiko for NAFLD ?ges successivt jo flere risikofaktorer for MetS som er til stede. 1bADiagnosen kr?ver udelukkelse af andre ?rsager til lever steatose eller leverp?virkning (Tabel 1).1bADiagnosticeringen af NASH giver vigtig prognostisk viden om risikoen for progression af sygdom, behov for monitorering og behandlings indikation.1bAAnvendelse af leverbiopsi i diagnosen NAFL/NASH? Leverbiopsi er eneste sikre metode til at skelne NAFL fra NASH og vurdere fibrosegrad. Ved ?get risiko for NASH anbefales leverbiopsi.1bADet anbefales, at st?tte sig til SAF score mhp. at stille diagnosen og Kleiner fibrose score til at vurdere graden af fibrose. NASH diagnosen stilles ved en leverbiopsi, der viser steatose, hepatocyt ballooning og lobul?r inflammation.1bANAS score anbefales til vurdering af behandlingseffekt og opf?lgning n?r NASH diagnosen er stillet.1bAHvilke non-invasive metoder kan anvendes til vurdering af graden af fibrose ved NASH? Sammensatte fibrose scores (FIB-4 og NAFLD fibrosis score) og elastografi kan anvendes til at identificere patienter med lav eller h?j risiko for betydende fibrose og til at monitorere fibrosegraden.1bAHos patienter med h?j risiko for progression af fibrose anbefales leverbiopsi (se ovenfor).2bBFibrose scores og samtidig elastografi styrker muligvis den diagnostiske n?jagtighed. 2aBKan livsstilsintervention anvendes ved NAFLDV?gttab opn?et via livsstilsintervention (kost og motion) anbefales som den prim?re behandling af NAFL og NASH.1bAHos nogle patienter med NASH kan v?gttab p? mindst 7% medf?re reduktion af fibrose.1bADer er ikke evidens for fysisk tr?ning uden kost?ndring til behandling af NASH.1bAHvilken farmakologisk intervention kan anvendes til behandling af NAFLD?Der er ikke evidens for farmakologisk behandling af patienter med NAFL.2cBMedicinsk behandling af NASH kan overvejes ved fibrose ≥F2 eller risikofaktorer (DM, MetS, ALAT forh?jelse eller betydende necroinflammation). 2bBVitamin E behandling (800 IU/dag) kan overvejes under hensyntagen til risiko for prostata cancer.2bBPioglitazon (30-45 mg/dag) kan overvejes til behandling samtidig diabetes under hensyntagen til risiko for bivirkninger inklusive v?gt?gning, kongestiv hjertesygdom, bl?recancer og frakturer.2aBDet er uafklaret hvor l?nge behandling b?r p?g? og hvilke metoder, der egner sig til behandlingsmonitorering. Man kan overveje at stoppe behandlingen, hvis der ikke ses fald i ALAT hos patienter med transaminas?mi ved behandlingsstart.3BBNon-farmakologisk og farmakologisk behandling af komorbiditet anbefales vedr?rende diabetes, hypertension, hyperlipid?m, overv?gt og isk?misk hjertesygdom.2aADer er ikke tilstr?kkelig evidens for at anbefale rutinem?ssig behandling med obeticholsyre (FXR agonist) eller liraglutid (GLP-1 analog).3BCKan bariatrisk kirurgi anvendes i behandling af NASH?Der er ikke sikker evidens for at tilbyde bariatrisk kirurgi til patienter med NASH med mindre patienterne opfylder de accepterede kriterier.2aBI henhold til Centre for Evidence Based Medicine, University of OxfordEmneopdelt gennemgangHvorn?r skal man mist?nke NAFLD og hvorledes skelner man mellem NAFL og NASH? NAFLD b?r mist?nkes ved tilf?ldigt fund af transaminas?mi i screeningsblodpr?ver, leversteatose ved abdominal UL unders?gelse, eller ved forekomsten af tilstande som er ledsaget af ?get risiko for NAFLD; prim?rt faktorer, der indg?r i MetS (Tabel 1). NAFLD er oftest asymptomatisk eller viser sig ved uspecifikke symptomer som tr?thed og abdominalt ubehag ADDIN EN.CITE <EndNote><Cite><Author>Angulo</Author><Year>2002</Year><RecNum>235</RecNum><DisplayText>(8)</DisplayText><record><rec-number>235</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1309711806">235</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Angulo, P.</author></authors></contributors><titles><title>Nonalcoholic fatty liver disease</title><secondary-title>N.Engl.J.Med.</secondary-title></titles><periodical><full-title>N.Engl.J.Med.</full-title></periodical><pages>1221-1231</pages><volume>346</volume><number>16</number><reprint-edition>NOT IN FILE</reprint-edition><keywords><keyword>Biopsy</keyword><keyword>diagnosis</keyword><keyword>Disease</keyword><keyword>etiology</keyword><keyword>Fatty Liver</keyword><keyword>Gastroenterology</keyword><keyword>Humans</keyword><keyword>Liver</keyword><keyword>Liver Function Tests</keyword><keyword>pathology</keyword><keyword>Prevalence</keyword><keyword>radiography</keyword><keyword>Risk Factors</keyword><keyword>therapy</keyword><keyword>Ultrasonography</keyword><keyword>Weight Loss</keyword></keywords><dates><year>2002</year></dates><urls></urls></record></Cite></EndNote>(8). Med mindre patienten har udviklet tegn p? levercirrose er den objektive unders?gelse ofte normal fraset mulig hepatomegali. MetS er t?t forbundet med NAFLD med IR som f?llesn?vner. Forekomsten af MetS er afg?rende for at identificere patienter i fare for at udvikle NAFLD og NASH. NASH forekommer s?ledes v?sentligt hyppigere hos patienter med MetS PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJjaGVzaW5pPC9BdXRob3I+PFllYXI+MjAwMzwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJjaGVzaW5pPC9BdXRob3I+PFllYXI+MjAwMzwvWWVh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ADDIN EN.CITE.DATA (9, 10), og hos patienter med NAFLD har ca. 30 % MetS og > 90 % har mindst en af risikofaktorerne. S?ledes b?r fund af NAFLD f?re til udredning for MetS og omvendt. Den objektive unders?gelse b?r indeholde vurdering af ern?ringstilstand med m?ling af taljem?l, h?jde og v?gt for udregning af BMI, tegn p? IR i form af acanthosis nigricans hos unge og tegn p? polycystisk ovariesyndrom med hirsutisme og/eller akne hos kvinder. Ved anamnese optagelse, objektiv unders?gelse og blodpr?ver s?ges at udelukke andre ?rsager til leverp?virkning (Tabel 1). For at skelne mellem NAFLD og alkoholbetinget fedtlever anvendes gr?nsen for alkoholindtag < 30 g/dag for m?nd og < 20 g/dag for kvinder sv.t. 3 genstande for m?nd og 2 for kvinder. Anvendelse af leverbiopsi til diagnosticering af NASH: Leverbiopsi med histologisk unders?gelse er guldstandard for diagnosen, og kan samtidig gradere og stadieinddele NAFLD. Leverbiopsi er s?ledes den eneste metode til sikkert at identificere NASH og fibrosegraden. Patologen vil kunne diagnosticere steatose, der er tilstede n?r leverbiopsiens fedtindhold overstiger 5 %. Steatose graderes fra 1-3 i intervallerne 5-33 %, 33-66 % og > 66 % PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CcnVudDwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+PFJl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CcnVudDwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+PFJl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 EN.CITE.DATA (11, 12). Den histologiske unders?gelse vil endvidere kunne kvantificere graden af levercelleskade (ballooning og apoptose), inflammation (celletype og lokalisation) og fibrose (lokalisation og udbredning). NASH forekommer, n?r der er samtidig forekomst af steatose, ballooning og lobul?r inflammation ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7). Disse variabler indg?r i sammensatte scores NAFLD Activity Score (NAS) ADDIN EN.CITE <EndNote><Cite><Author>Kleiner</Author><Year>2005</Year><RecNum>11642</RecNum><DisplayText>(12)</DisplayText><record><rec-number>11642</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463054433">11642</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kleiner, D. E.</author><author>Brunt, E. M.</author><author>Van Natta, M.</author><author>Behling, C.</author><author>Contos, M. J.</author><author>Cummings, O. W.</author><author>Ferrell, L. D.</author><author>Liu, Y. C.</author><author>Torbenson, M. S.</author><author>Unalp-Arida, A.</author><author>Yeh, M.</author><author>McCullough, A. J.</author><author>Sanyal, A. J.</author><author>Nonalcoholic Steatohepatitis Clinical Research, Network</author></authors></contributors><auth-address>Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA. KleinerD@mail.</auth-address><titles><title>Design and validation of a histological scoring system for nonalcoholic fatty liver disease</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>1313-21</pages><volume>41</volume><number>6</number><keywords><keyword>Adult</keyword><keyword>Child</keyword><keyword>Fatty Liver/*pathology</keyword><keyword>Fibrosis</keyword><keyword>Humans</keyword><keyword>Inflammation/pathology</keyword><keyword>Liver/*pathology</keyword><keyword>Logistic Models</keyword><keyword>Observer Variation</keyword><keyword>*Severity of Illness Index</keyword></keywords><dates><year>2005</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0270-9139 (Print)
0270-9139 (Linking)</isbn><accession-num>15915461</accession-num><urls><related-urls><url>;(12) (Appendiks Tabel 3) og ”Steatosis, Activity and Fibrosis” (SAF) score (Appendiks Figur 2), som er udarbejdet for at bedre reproducerbarheden. Fibrose graden angives ved Kleiner klassifikationen, der indg?r i en modificeret form i SAF score PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZWRvc3NhPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZWRvc3NhPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48
UmVjTnVtPjExNjQ0PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxMywgMTQpPC9EaXNwbGF5VGV4dD48
cmVjb3JkPjxyZWMtbnVtYmVyPjExNjQ0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh
cHA9IkVOIiBkYi1pZD0iZjkycHMyZnBhZjBkcDllYXZhYnY1OXN0ejl0NXN4dzl0dHd3IiB0aW1l
c3RhbXA9IjE0NjMwNTQ3MTEiPjExNjQ0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5h
bWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+
PGF1dGhvcj5CZWRvc3NhLCBQLjwvYXV0aG9yPjxhdXRob3I+UG9pdG91LCBDLjwvYXV0aG9yPjxh
dXRob3I+VmV5cmllLCBOLjwvYXV0aG9yPjxhdXRob3I+Qm91aWxsb3QsIEouIEwuPC9hdXRob3I+
PGF1dGhvcj5CYXNkZXZhbnQsIEEuPC9hdXRob3I+PGF1dGhvcj5QYXJhZGlzLCBWLjwvYXV0aG9y
PjxhdXRob3I+VG9yZGptYW4sIEouPC9hdXRob3I+PGF1dGhvcj5DbGVtZW50LCBLLjwvYXV0aG9y
PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkFzc2lzdGFuY2UgUHVibGlx
dWUtSG9waXRhdXggZGUgUGFyaXMsIEJlYXVqb24gSG9zcGl0YWwsIFBhdGhvbG9neSBEZXBhcnRt
ZW50LCBDbGljaHksIEZyYW5jZS4gcGllcnJlLmJlZG9zc2FAYmpuLmFwaHAuZnI8L2F1dGgtYWRk
cmVzcz48dGl0bGVzPjx0aXRsZT5IaXN0b3BhdGhvbG9naWNhbCBhbGdvcml0aG0gYW5kIHNjb3Jp
bmcgc3lzdGVtIGZvciBldmFsdWF0aW9uIG9mIGxpdmVyIGxlc2lvbnMgaW4gbW9yYmlkbHkgb2Jl
c2UgcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SGVwYXRvbG9neTwvc2Vjb25kYXJ5
LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkhlcGF0b2xvZ3k8L2Z1bGwt
dGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xNzUxLTk8L3BhZ2VzPjx2b2x1bWU+NTY8L3ZvbHVt
ZT48bnVtYmVyPjU8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29y
ZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3Jk
PkFsYW5pbmUgVHJhbnNhbWluYXNlL2Jsb29kPC9rZXl3b3JkPjxrZXl3b3JkPipBbGdvcml0aG1z
PC9rZXl3b3JkPjxrZXl3b3JkPkFuYWx5c2lzIG9mIFZhcmlhbmNlPC9rZXl3b3JkPjxrZXl3b3Jk
PkFzcGFydGF0ZSBBbWlub3RyYW5zZmVyYXNlcy9ibG9vZDwva2V5d29yZD48a2V5d29yZD5CaW9w
c3k8L2tleXdvcmQ+PGtleXdvcmQ+RmF0dHkgTGl2ZXIvYmxvb2QvZXRpb2xvZ3kvKnBhdGhvbG9n
eTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3
b3JkPjxrZXl3b3JkPkxpdmVyLypwYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TGl2ZXIgQ2ly
cmhvc2lzL2V0aW9sb2d5LypwYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29y
ZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Ob24tYWxjb2hvbGljIEZh
dHR5IExpdmVyIERpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+T2Jlc2l0eSwgTW9yYmlkLypjb21w
bGljYXRpb25zL3N1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+T2JzZXJ2ZXIgVmFyaWF0aW9uPC9r
ZXl3b3JkPjxrZXl3b3JkPlJlcHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3b3JkPjxrZXl3
b3JkPllvdW5nIEFkdWx0PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8L3ll
YXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3Y8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4x
NTI3LTMzNTAgKEVsZWN0cm9uaWMpJiN4RDswMjcwLTkxMzkgKExpbmtpbmcpPC9pc2JuPjxhY2Nl
c3Npb24tbnVtPjIyNzA3Mzk1PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVy
bD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIyNzA3Mzk1PC91cmw+PC9yZWxh
dGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDAyL2hlcC4yNTg4
OTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+
QmVkb3NzYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051bT4xMTY0NTwvUmVjTnVtPjxy
ZWNvcmQ+PHJlYy1udW1iZXI+MTE2NDU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw
cD0iRU4iIGRiLWlkPSJmOTJwczJmcGFmMGRwOWVhdmFidjU5c3R6OXQ1c3h3OXR0d3ciIHRpbWVz
dGFtcD0iMTQ2MzA1NDgxMCI+MTE2NDU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt
ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48
YXV0aG9yPkJlZG9zc2EsIFAuPC9hdXRob3I+PGF1dGhvcj5GbGlwIFBhdGhvbG9neSBDb25zb3J0
aXVtPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RkxJUCBQ
YXRob2xvZ3kgQ29uc29ydGl1bS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5VdGlsaXR5
IGFuZCBhcHByb3ByaWF0ZW5lc3Mgb2YgdGhlIGZhdHR5IGxpdmVyIGluaGliaXRpb24gb2YgcHJv
Z3Jlc3Npb24gKEZMSVApIGFsZ29yaXRobSBhbmQgc3RlYXRvc2lzLCBhY3Rpdml0eSwgYW5kIGZp
YnJvc2lzIChTQUYpIHNjb3JlIGluIHRoZSBldmFsdWF0aW9uIG9mIGJpb3BzaWVzIG9mIG5vbmFs
Y29ob2xpYyBmYXR0eSBsaXZlciBkaXNlYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkhlcGF0
b2xvZ3k8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5I
ZXBhdG9sb2d5PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NTY1LTc1PC9wYWdlcz48
dm9sdW1lPjYwPC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFk
dWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+KkFsZ29yaXRobXM8
L2tleXdvcmQ+PGtleXdvcmQ+QmlvcHN5L3N0YXRpc3RpY3MgJmFtcDsgbnVtZXJpY2FsIGRhdGE8
L2tleXdvcmQ+PGtleXdvcmQ+RGlzZWFzZSBQcm9ncmVzc2lvbjwva2V5d29yZD48a2V5d29yZD5G
YXR0eSBMaXZlci9jbGFzc2lmaWNhdGlvbi8qcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZl
bWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TGl2ZXIvKnBh
dGhvbG9neTwva2V5d29yZD48a2V5d29yZD5MaXZlciBDaXJyaG9zaXMvY2xhc3NpZmljYXRpb24v
KnBhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRs
ZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk5vbi1hbGNvaG9saWMgRmF0dHkgTGl2ZXIgRGlzZWFz
ZTwva2V5d29yZD48a2V5d29yZD5PYnNlcnZlciBWYXJpYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+
KlNldmVyaXR5IG9mIElsbG5lc3MgSW5kZXg8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHll
YXI+MjAxNDwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZzwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh
dGVzPjxpc2JuPjE1MjctMzM1MCAoRWxlY3Ryb25pYykmI3hEOzAyNzAtOTEzOSAoTGlua2luZyk8
L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjQ3NTMxMzI8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0
ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjQ3NTMxMzI8
L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEw
MDIvaGVwLjI3MTczPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9F
bmROb3RlPn==
ADDIN EN.CITE.DATA (13, 14). NAS score har i sig selv ikke nogen prognostisk v?rdi, men er vist effektiv til vurdering af behandlingsrespons. SAF score er enkel at anvende og har ?get reproducerbarheden for at stille diagnosen, men er ikke sikkert prognostisk valideret. Anvendelse af non-invasive metoder til diagnosticering af NASH: Der findes ingen validerede non-invasive metoder til at skelne NAFLD og NASH. Der er udviklet flere sammensatte scores, men disse er typisk d?rlige til at skelne mellem NASH og ikke-NASH eller ikke validerede. For en samlet liste henvises til EASL guideline ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7). B?de alaninaminotransferase (ALAT), aspartataminotransferase (ASAT) og gamma-glutamyltransferase (GGT) kan v?re forh?jet, men niveauet relaterer sig kun d?rligt til sv?rhedsgraden. S?ledes er ALAT normal hos ca. 80 % af patienter med steatose PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ccm93bmluZzwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ccm93bmluZzwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+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ADDIN EN.CITE.DATA (15). Dog vil reduktion af ALAT forudsige histologisk bedring efter intervention med AUROC = 0.68 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WdXBwYWxhbmNoaTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WdXBwYWxhbmNoaTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll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 EN.CITE.DATA (16). Anvendelse af biokemiske tests til bestemmelse af fibrose: Graden af fibrose er en vigtig prognostisk faktor og relaterer sig til forekomsten af lever relaterede komplikationer og mortalitet ADDIN EN.CITE <EndNote><Cite><Author>Ekstedt</Author><Year>2015</Year><RecNum>11614</RecNum><DisplayText>(3)</DisplayText><record><rec-number>11614</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463053253">11614</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ekstedt, M.</author><author>Hagstrom, H.</author><author>Nasr, P.</author><author>Fredrikson, M.</author><author>Stal, P.</author><author>Kechagias, S.</author><author>Hultcrantz, R.</author></authors></contributors><auth-address>Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden.</auth-address><titles><title>Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>1547-54</pages><volume>61</volume><number>5</number><keywords><keyword>Cohort Studies</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Liver Cirrhosis/complications/*mortality</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Non-alcoholic Fatty Liver Disease/complications/*mortality/*pathology</keyword><keyword>Prognosis</keyword><keyword>Severity of Illness Index</keyword><keyword>Time Factors</keyword></keywords><dates><year>2015</year><pub-dates><date>May</date></pub-dates></dates><isbn>1527-3350 (Electronic)
0270-9139 (Linking)</isbn><accession-num>25125077</accession-num><urls><related-urls><url>;(3). Flere blodpr?vebaserede tests har acceptabel diagnostisk v?rdi med AUROC > 0,80. De sammensatte fibrose scores Fibrosis-4 calculator (FIB-4) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdGVybGluZzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdGVybGluZzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+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ADDIN EN.CITE.DATA (17) og NAFLD Fibrosis Score ADDIN EN.CITE <EndNote><Cite><Author>Shah</Author><Year>2009</Year><RecNum>11652</RecNum><DisplayText>(18)</DisplayText><record><rec-number>11652</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055410">11652</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Shah, A. G.</author><author>Lydecker, A.</author><author>Murray, K.</author><author>Tetri, B. N.</author><author>Contos, M. J.</author><author>Sanyal, A. J.</author><author>Nash Clinical Research, Network</author></authors></contributors><auth-address>Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.</auth-address><titles><title>Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease</title><secondary-title>Clin Gastroenterol Hepatol</secondary-title></titles><periodical><full-title>Clin Gastroenterol Hepatol</full-title></periodical><pages>1104-12</pages><volume>7</volume><number>10</number><keywords><keyword>Adult</keyword><keyword>Age Factors</keyword><keyword>Alanine Transaminase/blood</keyword><keyword>Aspartate Aminotransferases/blood</keyword><keyword>Biomarkers</keyword><keyword>*Diagnostic Techniques and Procedures</keyword><keyword>Fatty Liver/*complications</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Liver Cirrhosis/*diagnosis</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Platelet Count</keyword><keyword>Predictive Value of Tests</keyword><keyword>ROC Curve</keyword></keywords><dates><year>2009</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1542-7714 (Electronic)
1542-3565 (Linking)</isbn><accession-num>19523535</accession-num><urls><related-urls><url>;(18) er simple at anvende ud fra standard biokemi og kliniske parametre, og valideret i flere studiepopulationer. F?lles for disse metoder er, at de er bedst til at skelne mellem forekomsten sv?r eller ingen fibrose. Derudover er den negative pr?diktive v?rdi for at ekskludere sv?r (≥ F3) fibrose bedre end den positive pr?diktive v?rdi for forekomsten af fibrose. S?ledes kan disse tests udpege patienter med lav risiko for fibrose, hvorimod identificeringen af patienter med betydende fibrose er beh?ftet med st?rre usikkerhed ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7). Der findes to kommercielle assays Enhanced Liver Fibrosis (ELF) score (TIMP-1, PIIINP og hyaluronsyre) og FibroTest (Alpha-2-macroglobulin, haptoglobin, apolipoprotein A1, γ-glutamyltransferase, bilirubin, ALAT) der ogs? er vist at pr?diktere leverrelateret d?delighed ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7). Disse anvendes ikke rutinem?ssigt i klinisk praksis. Anvendelse af billedteknikker til bestemmelse af steatose og fibrose: Ingen billeddiagnostisk metode kan vurdere tilstedev?relsen eller graden af NASH, men det er muligt at anvende billeddiagnostik til at vurdere graden af steatose og fibrose. Steatose kan p?vises ved b?de UL, CT- og MR-scanning. MR spectroskopi betragtes som guld standard billedmodalitet for p?visning af lever steatose. MR spectroskopi registrerer data fra en begr?nset omr?de at leveren mens en ny MR teknik, kvantitativ MR proton-density fedt fraktion, kan estimere fedtfraktionen st?rre dele af leveren. Men da UL er den hurtigste, billigste og nemmmeste metode til bestemmelse af steatose, er det den mest anvendte. Ved moderat og sv?r steatose (fedtindhold > 20 %) har ultralyd h?j sensitivitet (85 %) og specificitet (93 %) med AUROC p? 0,93. Dette er p? h?jde med CT og MR ADDIN EN.CITE <EndNote><Cite><Author>Hernaez</Author><Year>2011</Year><RecNum>11606</RecNum><DisplayText>(19)</DisplayText><record><rec-number>11606</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1462915637">11606</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hernaez, R.</author><author>Lazo, M.</author><author>Bonekamp, S.</author><author>Kamel, I.</author><author>Brancati, F. L.</author><author>Guallar, E.</author><author>Clark, J. M.</author></authors></contributors><auth-address>Department of Medicine The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. rhernae1@jhmi.edu</auth-address><titles><title>Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>1082-90</pages><volume>54</volume><number>3</number><keywords><keyword>Fatty Liver/pathology/*ultrasonography</keyword><keyword>Humans</keyword><keyword>Reproducibility of Results</keyword><keyword>Sensitivity and Specificity</keyword></keywords><dates><year>2011</year><pub-dates><date>Sep 2</date></pub-dates></dates><isbn>1527-3350 (Electronic)
0270-9139 (Linking)</isbn><accession-num>21618575</accession-num><urls><related-urls><url>;(19). Fibrose er den vigtigste mark?r for sv?rhedsgraden af NASH ADDIN EN.CITE <EndNote><Cite><Author>Ekstedt</Author><Year>2015</Year><RecNum>11614</RecNum><DisplayText>(3)</DisplayText><record><rec-number>11614</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463053253">11614</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ekstedt, M.</author><author>Hagstrom, H.</author><author>Nasr, P.</author><author>Fredrikson, M.</author><author>Stal, P.</author><author>Kechagias, S.</author><author>Hultcrantz, R.</author></authors></contributors><auth-address>Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden.</auth-address><titles><title>Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>1547-54</pages><volume>61</volume><number>5</number><keywords><keyword>Cohort Studies</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Liver Cirrhosis/complications/*mortality</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Non-alcoholic Fatty Liver Disease/complications/*mortality/*pathology</keyword><keyword>Prognosis</keyword><keyword>Severity of Illness Index</keyword><keyword>Time Factors</keyword></keywords><dates><year>2015</year><pub-dates><date>May</date></pub-dates></dates><isbn>1527-3350 (Electronic)
0270-9139 (Linking)</isbn><accession-num>25125077</accession-num><urls><related-urls><url>;(3). Der findes flere forskellig ultralydsbaserede elastografiske metoder til fibrosevurdering ved NASH, og den meste udbredte er transient elastografi (TE) evt. med Fibroscan?. Elastografi er p?virkelig af faktorer som f?deindtag (< 4 timer) forud for elastografi, p?g?ende inflammation, kolestase og h?jresidigt hjertesvigt, der kan ?ge leverens stivhed og give et falsk positivt resultat ADDIN EN.CITE <EndNote><Cite><Author>Castera</Author><Year>2010</Year><RecNum>11607</RecNum><DisplayText>(20)</DisplayText><record><rec-number>11607</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1462915731">11607</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Castera, L.</author><author>Foucher, J.</author><author>Bernard, P. H.</author><author>Carvalho, F.</author><author>Allaix, D.</author><author>Merrouche, W.</author><author>Couzigou, P.</author><author>de Ledinghen, V.</author></authors></contributors><auth-address>Services d'Hepato-gastroenterologie, Centre Hospitalo-Universitaire de Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France. laurent.castera@chu-bordeaux.fr</auth-address><titles><title>Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>828-35</pages><volume>51</volume><number>3</number><keywords><keyword>*Elasticity Imaging Techniques/standards/statistics & numerical data</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Liver/*physiopathology</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Prospective Studies</keyword><keyword>Reproducibility of Results</keyword><keyword>Time Factors</keyword></keywords><dates><year>2010</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1527-3350 (Electronic)
0270-9139 (Linking)</isbn><accession-num>20063276</accession-num><urls><related-urls><url>;(20). Det er endnu ikke entydigt vist om steatose i sig selv giver ?get stivhed ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7). I en metaanalyse med NAFLD patienter viste TE f?lgende: For F ≥ 2 med cut-off 6.7-7.7 kPa var sensitivitet 67–94 %, specificitet 61–84 % (AUROC 0.79–0.87). For F ≥ 3 med cut-off 8.0–10.4 kPa var sensitivitet 65–100 % og specificitet 75–97 % (AUROC 0.76– 0.98). For F4 med cut-off 10.3–17.5 kPa var sensitivitet 78–100 %, specificitet 82–98 % (AUROC 0.91–0.99). Samlet estimat for diagnostisk sikkerhed var: F ≥ 2: sensitivitet 79 % og specificitet 75 %; F ≥ 3: sensitivitet 85 % og specificitet 85 %; og F4: sensitivitet 92 % og specificitet 92 % ADDIN EN.CITE <EndNote><Cite><Author>Kwok</Author><Year>2014</Year><RecNum>11858</RecNum><DisplayText>(21)</DisplayText><record><rec-number>11858</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1474915083">11858</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kwok, R.</author><author>Tse, Y. K.</author><author>Wong, G. L.</author><author>Ha, Y.</author><author>Lee, A. U.</author><author>Ngu, M. C.</author><author>Chan, H. L.</author><author>Wong, V. W.</author></authors></contributors><auth-address>Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China; Department of Gastroenterology and Hepatology, Concord Repatriation Hospital, Sydney, Australia.</auth-address><titles><title>Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease--the role of transient elastography and plasma cytokeratin-18 fragments</title><secondary-title>Aliment Pharmacol Ther</secondary-title></titles><periodical><full-title>Aliment Pharmacol Ther</full-title></periodical><pages>254-69</pages><volume>39</volume><number>3</number><keywords><keyword>Biomarkers/metabolism</keyword><keyword>Biopsy</keyword><keyword>Elasticity Imaging Techniques/*methods</keyword><keyword>Fatty Liver/*diagnosis/pathology</keyword><keyword>Humans</keyword><keyword>Keratin-18/*blood</keyword><keyword>Liver Cirrhosis/diagnosis/pathology</keyword><keyword>Non-alcoholic Fatty Liver Disease</keyword><keyword>Obesity/complications</keyword><keyword>Sensitivity and Specificity</keyword></keywords><dates><year>2014</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1365-2036 (Electronic)
0269-2813 (Linking)</isbn><accession-num>24308774</accession-num><urls><related-urls><url>;(21). Mest optimale cut-off for for at finde patienter med betydelig fibrose ved TE ligger s?ledes omkring 7,0-9.0 kPA. Der kan opn?s h?jere succesrate ved brug af XL-probe hos adip?se patienter, men pr?cisionen bedres ikke signifikant og det er bekymrende at op til 20 % af unders?gelserne har vist usikre fund ADDIN EN.CITE <EndNote><Cite><Author>Castera</Author><Year>2010</Year><RecNum>11607</RecNum><DisplayText>(20)</DisplayText><record><rec-number>11607</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1462915731">11607</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Castera, L.</author><author>Foucher, J.</author><author>Bernard, P. H.</author><author>Carvalho, F.</author><author>Allaix, D.</author><author>Merrouche, W.</author><author>Couzigou, P.</author><author>de Ledinghen, V.</author></authors></contributors><auth-address>Services d'Hepato-gastroenterologie, Centre Hospitalo-Universitaire de Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France. laurent.castera@chu-bordeaux.fr</auth-address><titles><title>Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>828-35</pages><volume>51</volume><number>3</number><keywords><keyword>*Elasticity Imaging Techniques/standards/statistics & numerical data</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Liver/*physiopathology</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Prospective Studies</keyword><keyword>Reproducibility of Results</keyword><keyword>Time Factors</keyword></keywords><dates><year>2010</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1527-3350 (Electronic)
0270-9139 (Linking)</isbn><accession-num>20063276</accession-num><urls><related-urls><url>;(20). TE er dog en sikker metode til eksklusion af sv?r fibrose og cirrose med en negativ pr?diktiv v?rdi omkring 90 % ADDIN EN.CITE <EndNote><Cite><Author>Wong</Author><Year>2010</Year><RecNum>11663</RecNum><DisplayText>(22)</DisplayText><record><rec-number>11663</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463057091">11663</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wong, V. W.</author><author>Vergniol, J.</author><author>Wong, G. L.</author><author>Foucher, J.</author><author>Chan, H. L.</author><author>Le Bail, B.</author><author>Choi, P. C.</author><author>Kowo, M.</author><author>Chan, A. W.</author><author>Merrouche, W.</author><author>Sung, J. J.</author><author>de Ledinghen, V.</author></authors></contributors><auth-address>Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.</auth-address><titles><title>Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>454-62</pages><volume>51</volume><number>2</number><keywords><keyword>*Elasticity Imaging Techniques</keyword><keyword>Fatty Liver/*complications</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Liver Cirrhosis/*complications/*diagnosis</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Prospective Studies</keyword><keyword>Reproducibility of Results</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2010</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1527-3350 (Electronic)
0270-9139 (Linking)</isbn><accession-num>20101745</accession-num><urls><related-urls><url>;(22). ?vrige ultralydsbaserede elastografiske metoder har den fordel, at man samtidig kan visualisere det omr?de, ”region of interest” (ROI), hvor der udf?res fibrosem?linger. Metoderne er integreret i et almindeligt ultralydsapparat og er baseret p? ”shear wave” elastografi. De mest anvendte principper er Acoustic-Radiation-Force-Impulse imaging (ARFI) og 2D-Shear Wave Elastography (SWE). Der er kun f? og sm? studier, der sammenligner ARFI, SWE og TE, men studierne viser, at metoderne tilsyneladende er ligev?rdige i vurderingen af fibrosegrad ved NAFLD PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Zb25lZGE8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS
ZWNOdW0+MTE2NjY8L1JlY051bT48RGlzcGxheVRleHQ+KDIzLCAyNCk8L0Rpc3BsYXlUZXh0Pjxy
ZWNvcmQ+PHJlYy1udW1iZXI+MTE2NjY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw
cD0iRU4iIGRiLWlkPSJmOTJwczJmcGFmMGRwOWVhdmFidjU5c3R6OXQ1c3h3OXR0d3ciIHRpbWVz
dGFtcD0iMTQ2MzA1NzIyMyI+MTE2NjY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt
ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48
YXV0aG9yPllvbmVkYSwgTS48L2F1dGhvcj48YXV0aG9yPlN1enVraSwgSy48L2F1dGhvcj48YXV0
aG9yPkthdG8sIFMuPC9hdXRob3I+PGF1dGhvcj5GdWppdGEsIEsuPC9hdXRob3I+PGF1dGhvcj5O
b3pha2ksIFkuPC9hdXRob3I+PGF1dGhvcj5Ib3Nvbm8sIEsuPC9hdXRob3I+PGF1dGhvcj5TYWl0
bywgUy48L2F1dGhvcj48YXV0aG9yPk5ha2FqaW1hLCBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv
bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9uIG9mIEdhc3Ryb2VudGVyb2xvZ3ksIFlv
a29oYW1hIENpdHkgVW5pdmVyc2l0eSBIb3NwaXRhbCwgMy05IEZ1a3UtdXJhLCBLYW5hemF3YS1r
dSwgWW9rb2hhbWEgMjM2LTAwMDQsIEphcGFuLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl
Pk5vbmFsY29ob2xpYyBmYXR0eSBsaXZlciBkaXNlYXNlOiBVUy1iYXNlZCBhY291c3RpYyByYWRp
YXRpb24gZm9yY2UgaW1wdWxzZSBlbGFzdG9ncmFwaHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+
UmFkaW9sb2d5PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0
bGU+UmFkaW9sb2d5PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NjQwLTc8L3BhZ2Vz
Pjx2b2x1bWU+MjU2PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3Jk
PkVsYXN0aWNpdHkgSW1hZ2luZyBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3Jk
PkZhdHR5IExpdmVyLyp1bHRyYXNvbm9ncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+RmF0dHkgTGl2
ZXIsIEFsY29ob2xpYy91bHRyYXNvbm9ncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9r
ZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbWFnZSBJbnRlcnByZXRh
dGlvbiwgQ29tcHV0ZXItQXNzaXN0ZWQvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv
a2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5SZXByb2R1Y2li
aWxpdHkgb2YgUmVzdWx0czwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lm
aWNpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48cHViLWRh
dGVzPjxkYXRlPkF1ZzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjctMTMxNSAo
RWxlY3Ryb25pYykmI3hEOzAwMzMtODQxOSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+
MjA1Mjk5ODk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93
d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjA1Mjk5ODk8L3VybD48L3JlbGF0ZWQtdXJscz48
L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExNDgvcmFkaW9sLjEwMDkxNjYyPC9l
bGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5HdWli
YWw8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxSZWNOdW0+MTE2Njc8L1JlY051bT48cmVjb3Jk
PjxyZWMtbnVtYmVyPjExNjY3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO
IiBkYi1pZD0iZjkycHMyZnBhZjBkcDllYXZhYnY1OXN0ejl0NXN4dzl0dHd3IiB0aW1lc3RhbXA9
IjE0NjMwNTcyOTAiPjExNjY3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv
dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv
cj5HdWliYWwsIEEuPC9hdXRob3I+PGF1dGhvcj5SZW5vc2ksIEcuPC9hdXRob3I+PGF1dGhvcj5S
b2RlLCBBLjwvYXV0aG9yPjxhdXRob3I+U2NvYXplYywgSi4gWS48L2F1dGhvcj48YXV0aG9yPkd1
aWxsYXVkLCBPLjwvYXV0aG9yPjxhdXRob3I+Q2hhcmRvbiwgTC48L2F1dGhvcj48YXV0aG9yPk11
bnRlYW51LCBNLjwvYXV0aG9yPjxhdXRob3I+RHVtb3J0aWVyLCBKLjwvYXV0aG9yPjxhdXRob3I+
Q29sbGluLCBGLjwvYXV0aG9yPjxhdXRob3I+TGVmb3J0LCBULjwvYXV0aG9yPjwvYXV0aG9ycz48
L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNlcnZpY2UgZGUgcmFkaW9sb2dpZSwgaG9waXRh
bCBFZG91YXJkLUhlcnJpb3QsIGhvc3BpY2VzIGNpdmlscyBkZSBMeW9uLCA2OTQzNyBMeW9uLCBG
cmFuY2U7IFNlcnZpY2UgZGUgcmFkaW9sb2dpZSwgY2VudHJlIGhvc3BpdGFsaWVyIGRlIFBlcnBp
Z25hbiwgMjAsIGF2ZW51ZSBkdSBMYW5ndWVkb2MsIDY2MDQ2IFBlcnBpZ25hbiBjZWRleCA5LCBG
cmFuY2UuIEVsZWN0cm9uaWMgYWRkcmVzczogYXltZXJpYy5ndWliYWxAZ21haWwuY29tLiYjeEQ7
U2VydmljZSBkZSByYWRpb2xvZ2llLCBob3BpdGFsIEVkb3VhcmQtSGVycmlvdCwgaG9zcGljZXMg
Y2l2aWxzIGRlIEx5b24sIDY5NDM3IEx5b24sIEZyYW5jZS4mI3hEO1NlcnZpY2UgZGUgcmFkaW9s
b2dpZSwgaG9waXRhbCBkZSBsYSBDcm9peC1Sb3Vzc2UsIGhvc3BpY2VzIGNpdmlscyBkZSBMeW9u
LCA2OTMxNyBMeW9uLCBGcmFuY2UuJiN4RDtTZXJ2aWNlIGQmYXBvczthbmF0b21vLXBhdGhvbG9n
aWUsIGhvcGl0YWwgRWRvdWFyZC1IZXJyaW90LCBob3NwaWNlcyBjaXZpbHMgZGUgTHlvbiwgNjk0
MzcgTHlvbiwgRnJhbmNlLiYjeEQ7RmVkZXJhdGlvbiBkZXMgc3BlY2lhbGl0ZXMgZGlnZXN0aXZl
cywgaG9waXRhbCBFZG91YXJkLUhlcnJpb3QsIGhvc3BpY2VzIGNpdmlscyBkZSBMeW9uLCA2OTQz
NyBMeW9uIGNlZGV4IDAzLCBGcmFuY2UuJiN4RDtGZWRlcmF0aW9uIGRlIGJpb2NoaW1pZSwgaG9w
aXRhbCBFZG91YXJkLUhlcnJpb3QsIGhvc3BpY2VzIGNpdmlscyBkZSBMeW9uLCA2OTQzNyBMeW9u
LCBGcmFuY2UuJiN4RDtIZXBhdG9sb2d5IHJlc2VhcmNoIHVuaXQsIGJpb3ByZWRpY2l0aXZlLCA3
NTAwNyBQYXJpcywgRnJhbmNlLiYjeEQ7U2VydmljZSBkZSByYWRpb2xvZ2llLCBjZW50cmUgaG9z
cGl0YWxpZXIgZGUgUGVycGlnbmFuLCAyMCwgYXZlbnVlIGR1IExhbmd1ZWRvYywgNjYwNDYgUGVy
cGlnbmFuIGNlZGV4IDksIEZyYW5jZS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5TaGVh
ciB3YXZlIGVsYXN0b2dyYXBoeTogQW4gYWNjdXJhdGUgdGVjaG5pcXVlIHRvIHN0YWdlIGxpdmVy
IGZpYnJvc2lzIGluIGNocm9uaWMgbGl2ZXIgZGlzZWFzZXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0
bGU+RGlhZ24gSW50ZXJ2IEltYWdpbmc8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k
aWNhbD48ZnVsbC10aXRsZT5EaWFnbiBJbnRlcnYgSW1hZ2luZzwvZnVsbC10aXRsZT48L3Blcmlv
ZGljYWw+PHBhZ2VzPjkxLTk8L3BhZ2VzPjx2b2x1bWU+OTc8L3ZvbHVtZT48bnVtYmVyPjE8L251
bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+Q2lycmhvc2lzPC9rZXl3b3JkPjxrZXl3b3JkPkVsYXN0
aWNpdHkgaW1hZ2luZyB0ZWNobmlxdWVzPC9rZXl3b3JkPjxrZXl3b3JkPkVsYXN0b2dyYXBoeTwv
a2V5d29yZD48a2V5d29yZD5MaXZlciBmaWJyb3Npczwva2V5d29yZD48a2V5d29yZD5Tb25vZWxh
c3RvZ3JhcGh5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTY8L3llYXI+PHB1
Yi1kYXRlcz48ZGF0ZT5KYW48L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4yMjExLTU2
ODQgKEVsZWN0cm9uaWMpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI2NjU1ODcwPC9hY2Nlc3Npb24t
bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3Yv
cHVibWVkLzI2NjU1ODcwPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJl
c291cmNlLW51bT4xMC4xMDE2L2ouZGlpaS4yMDE1LjExLjAwMTwvZWxlY3Ryb25pYy1yZXNvdXJj
ZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Zb25lZGE8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (23, 24). Vedr. elastografiske unders?gelser skal man v?re opm?rksom p? at v?rdierne er afh?ngige af den anvendte teknik og at der er forskel p? cut-off mellem fibroskanning med standard eller XL-probe lige som man ikke kan sammenligne v?rdier direkte med ARFI og SWE teknik. Et studie har vist at MR elastografi (MRE) til vurdering af fibrose ved NAFLD er mere pr?cis end TE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JbWFqbzwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl
Y051bT4xMTY2OTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMjUpPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjExNjY5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO
IiBkYi1pZD0iZjkycHMyZnBhZjBkcDllYXZhYnY1OXN0ejl0NXN4dzl0dHd3IiB0aW1lc3RhbXA9
IjE0NjMwNTc0NDUiPjExNjY5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv
dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv
cj5JbWFqbywgSy48L2F1dGhvcj48YXV0aG9yPktlc3Nva3UsIFQuPC9hdXRob3I+PGF1dGhvcj5I
b25kYSwgWS48L2F1dGhvcj48YXV0aG9yPlRvbWVubywgVy48L2F1dGhvcj48YXV0aG9yPk9nYXdh
LCBZLjwvYXV0aG9yPjxhdXRob3I+TWF3YXRhcmksIEguPC9hdXRob3I+PGF1dGhvcj5GdWppdGEs
IEsuPC9hdXRob3I+PGF1dGhvcj5Zb25lZGEsIE0uPC9hdXRob3I+PGF1dGhvcj5UYWd1cmksIE0u
PC9hdXRob3I+PGF1dGhvcj5IeW9nbywgSC48L2F1dGhvcj48YXV0aG9yPlN1bWlkYSwgWS48L2F1
dGhvcj48YXV0aG9yPk9ubywgTS48L2F1dGhvcj48YXV0aG9yPkVndWNoaSwgWS48L2F1dGhvcj48
YXV0aG9yPklub3VlLCBULjwvYXV0aG9yPjxhdXRob3I+WWFtYW5ha2EsIFQuPC9hdXRob3I+PGF1
dGhvcj5XYWRhLCBLLjwvYXV0aG9yPjxhdXRob3I+U2FpdG8sIFMuPC9hdXRob3I+PGF1dGhvcj5O
YWthamltYSwgQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz
cz5EZXBhcnRtZW50IG9mIEdhc3Ryb2VudGVyb2xvZ3ksIFlva29oYW1hIENpdHkgVW5pdmVyc2l0
eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNpbmUsIFlva29oYW1hLCBKYXBhbi4mI3hEO0RlcGFy
dG1lbnQgb2YgQmlvc3RhdGlzdGljcyBhbmQgRXBpZGVtaW9sb2d5LCBZb2tvaGFtYSBDaXR5IFVu
aXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljaW5lLCBZb2tvaGFtYSwgSmFwYW4uJiN4
RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lIGFuZCBNb2xlY3VsYXIgU2NpZW5jZSwgR3JhZHVhdGUg
U2Nob29sIG9mIEJpb21lZGljYWwgU2NpZW5jZXMsIEhpcm9zaGltYSBVbml2ZXJzaXR5LCBIaXJv
c2hpbWEsIEphcGFuLiYjeEQ7RGVwYXJ0bWVudCBvZiBHYXN0cm9lbnRlcm9sb2d5IGFuZCBIZXBh
dG9sb2d5LCBLeW90byBQcmVmZWN0dXJhbCBVbml2ZXJzaXR5IG9mIE1lZGljaW5lLCBLYW1pZ3lv
LWt1LCBLeW90bywgSmFwYW4uJiN4RDtEZXBhcnRtZW50IG9mIEdhc3Ryb2VudGVyb2xvZ3kgYW5k
IEhlcGF0b2xvZ3ksIEtvY2hpIE1lZGljYWwgU2Nob29sLCBLb2NoaSwgSmFwYW4uJiN4RDtEaXZp
c2lvbiBvZiBIZXBhdG9sb2d5LCBTYWdhIE1lZGljYWwgU2Nob29sLCBMaXZlciBDZW50ZXIsIFNh
Z2EsIEphcGFuLiYjeEQ7RGVwYXJ0bWVudCBvZiBSYWRpb2xvZ3ksIFlva29oYW1hIENpdHkgVW5p
dmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNpbmUsIFlva29oYW1hLCBKYXBhbi4mI3hE
O0RlcGFydG1lbnQgb2YgUGhhcm1hY29sb2d5LCBTaGltYW5lIFVuaXZlcnNpdHkgRmFjdWx0eSBv
ZiBNZWRpY2luZSwgSXp1bW8sIFNoaW1hbmUsIEphcGFuLiYjeEQ7RGVwYXJ0bWVudCBvZiBHYXN0
cm9lbnRlcm9sb2d5LCBZb2tvaGFtYSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9m
IE1lZGljaW5lLCBZb2tvaGFtYSwgSmFwYW4uIEVsZWN0cm9uaWMgYWRkcmVzczogbmFrYWppbWEt
dGt5QHVtaW4uYWMuanAuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TWFnbmV0aWMgUmVz
b25hbmNlIEltYWdpbmcgTW9yZSBBY2N1cmF0ZWx5IENsYXNzaWZpZXMgU3RlYXRvc2lzIGFuZCBG
aWJyb3NpcyBpbiBQYXRpZW50cyBXaXRoIE5vbmFsY29ob2xpYyBGYXR0eSBMaXZlciBEaXNlYXNl
IFRoYW4gVHJhbnNpZW50IEVsYXN0b2dyYXBoeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5HYXN0
cm9lbnRlcm9sb2d5PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt
dGl0bGU+R2FzdHJvZW50ZXJvbG9neTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjYy
Ni02MzcgZTc8L3BhZ2VzPjx2b2x1bWU+MTUwPC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGtl
eXdvcmRzPjxrZXl3b3JkPkFsYW5pbmUgVHJhbnNhbWluYXNlPC9rZXl3b3JkPjxrZXl3b3JkPkNs
YXNzaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkRpYWdub3Npczwva2V5d29yZD48a2V5d29y
ZD5PdmVyd2VpZ2h0PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTY8L3llYXI+
PHB1Yi1kYXRlcz48ZGF0ZT5NYXI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTI4
LTAwMTIgKEVsZWN0cm9uaWMpJiN4RDswMDE2LTUwODUgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Np
b24tbnVtPjI2Njc3OTg1PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o
dHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI2Njc3OTg1PC91cmw+PC9yZWxhdGVk
LXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDUzL2ouZ2FzdHJvLjIw
MTUuMTEuMDQ4PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmRO
b3RlPn==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JbWFqbzwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl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ADDIN EN.CITE.DATA (25). Pris og den mere ufleksible unders?gelsesteknik har hidtidigt gjort modaliteten mindre egnet i daglig klinisk praksis. Kliniske rekommandationer 1 (se Tabel 2)Fund af NAFLD b?r f?re til udredning for MetS og omvendt.UL anbefales til at stille NAFLD diagnosen, da det er den enkleste og billigste metode at anvende.Diagnosen NAFLD stilles ved fund af steatose (billedunders?gelser eller leverbiopsi) og samtidig udelukkelse af andre ?rsager.Hos patienter med stor risiko for NASH og betydende fibrose anbefales leverbiopsi, der er den eneste sikre metode til at skelne NAFL fra NASH og til at vurdere fibrosegrad. NASH diagnosen stilles ved en leverbiopsi, der viser steatose, hepatocyt ballooning og lobul?r inflammation. Det anbefales under diagnosticering at st?tte sig SAF score og Kleiner fibrose score. Det anbefales at anvende NAS score til monitorering.Sammensatte fibrose scores (FIB-4 og NAFLD fibrosis score) eller elastografi kan identificere patienter med lav eller h?j risiko for betydende fibrose og til at monitorere fibrosegraden hos patienter med NASH. Samtidig anvendelse af fibrose scores og samtidig elastografi styrker muligvis den diagnostiske n?jagtighed. Kan livsstilsintervention anvendes til behandling af NASH? NAFLD betragtes som den hepatiske manifestation af MetS. NAFLD er t?t associeret med overv?gt og fysisk inaktivitet PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJjaGVzaW5pPC9BdXRob3I+PFllYXI+MTk5OTwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJjaGVzaW5pPC9BdXRob3I+PFllYXI+MTk5OTwvWWVh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ADDIN EN.CITE.DATA (26). Livsstilsinterventioner i form af kost?ndringer og ?get fysisk aktivitet med henblik p? v?gttab og bedret metabolisk profil har derfor v?ret afpr?vet som behandlingsmuligheder for NAFLD og NASH. Prospektive unders?gelser har vist en positiv effekt af v?gttab p? fedtindholdet i leveren, og p? leverenzymer hos patienter med NAFLD ADDIN EN.CITE <EndNote><Cite><Author>Thoma</Author><Year>2012</Year><RecNum>362</RecNum><DisplayText>(27)</DisplayText><record><rec-number>362</rec-number><foreign-keys><key app="EN" db-id="sxdxa9s0vtx2ffett92xdzslxpxf29p5z5rp" timestamp="1461451565">362</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Thoma, C.</author><author>Day, C. P.</author><author>Trenell, M. I.</author></authors></contributors><auth-address>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.</auth-address><titles><title>Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><pages>255-66</pages><volume>56</volume><number>1</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Clinical Trials as Topic</keyword><keyword>Combined Modality Therapy</keyword><keyword>Diet Therapy</keyword><keyword>Exercise Therapy</keyword><keyword>Fatty Liver/pathology/physiopathology/*therapy</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>*Life Style</keyword><keyword>Lipid Metabolism</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Motor Activity</keyword><keyword>Non-alcoholic Fatty Liver Disease</keyword><keyword>Prospective Studies</keyword><keyword>Weight Reduction Programs</keyword></keywords><dates><year>2012</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>21723839</accession-num><urls><related-urls><url>;(27). Gennemg?ende har disse studier vist en signifikant reduktion i fedtindholdet i leveren ved et v?gttab p? 3-5 % af kropsv?gten, og med st?rre grad af reduktion med st?rre v?gttab. Studierne er prim?rt hospitalsbaserede og vurderet ved lever biopsi, men det er ogs? vist at v?re effektivt i prim?r sektoren vurderet ved MR spectroscopi. Livsstilintervention i form af kost?ndring, ?get fysisk aktivitet og ?ndring af adf?rd for opn?else af v?gttab har ogs? vist effekt p? NASH. Dette er vist i et randomiseret fors?g ADDIN EN.CITE <EndNote><Cite><Author>Promrat</Author><Year>2010</Year><RecNum>231</RecNum><DisplayText>(28)</DisplayText><record><rec-number>231</rec-number><foreign-keys><key app="EN" db-id="sxdxa9s0vtx2ffett92xdzslxpxf29p5z5rp" timestamp="1456696818">231</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Promrat, K.</author><author>Kleiner, D. E.</author><author>Niemeier, H. M.</author><author>Jackvony, E.</author><author>Kearns, M.</author><author>Wands, J. R.</author><author>Fava, J. L.</author><author>Wing, R. R.</author></authors></contributors><auth-address>Division of Gastroenterology and Hepatology, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. Kittichai_Promrat@Brown.edu</auth-address><titles><title>Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>121-129</pages><volume>51</volume><number>1</number><reprint-edition>NOT IN FILE</reprint-edition><keywords><keyword>Adult</keyword><keyword>Body Mass Index</keyword><keyword>complications</keyword><keyword>diet therapy</keyword><keyword>Fatty Liver</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Inflammation</keyword><keyword>Life Style</keyword><keyword>Liver</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Obesity</keyword><keyword>pathology</keyword><keyword>therapy</keyword><keyword>Weight Loss</keyword></keywords><dates><year>2010</year></dates><work-type>10.1002/hep.23276 doi</work-type><urls><related-urls><url>PM:19827166</url></related-urls></urls></record></Cite></EndNote>(28) og et kohorte studie PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WaWxhci1Hb21lejwvQXV0aG9yPjxZZWFyPjIwMTU8L1ll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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WaWxhci1Hb21lejwvQXV0aG9yPjxZZWFyPjIwMTU8L1ll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ADDIN EN.CITE.DATA (29). Patienter i kohortestudiet, der tabte 7 % af v?gten, havde ogs? regression af fibrose i 50 % af tilf?ldene, mens v?gttab 10 % f?rte til regression af fibrose hos 81 % PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WaWxhci1Hb21lejwvQXV0aG9yPjxZZWFyPjIwMTU8L1ll
YXI+PFJlY051bT4zNjM8L1JlY051bT48RGlzcGxheVRleHQ+KDI5KTwvRGlzcGxheVRleHQ+PHJl
Y29yZD48cmVjLW51bWJlcj4zNjM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i
RU4iIGRiLWlkPSJzeGR4YTlzMHZ0eDJmZmV0dDkyeGR6c2x4cHhmMjlwNXo1cnAiIHRpbWVzdGFt
cD0iMTQ2MTQ4NTYzNSI+MzYzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv
dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv
cj5WaWxhci1Hb21leiwgRS48L2F1dGhvcj48YXV0aG9yPk1hcnRpbmV6LVBlcmV6LCBZLjwvYXV0
aG9yPjxhdXRob3I+Q2FsemFkaWxsYS1CZXJ0b3QsIEwuPC9hdXRob3I+PGF1dGhvcj5Ub3JyZXMt
R29uemFsZXosIEEuPC9hdXRob3I+PGF1dGhvcj5HcmEtT3JhbWFzLCBCLjwvYXV0aG9yPjxhdXRo
b3I+R29uemFsZXotRmFiaWFuLCBMLjwvYXV0aG9yPjxhdXRob3I+RnJpZWRtYW4sIFMuIEwuPC9h
dXRob3I+PGF1dGhvcj5EaWFnbywgTS48L2F1dGhvcj48YXV0aG9yPlJvbWVyby1Hb21leiwgTS48
L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50
IG9mIEhlcGF0b2xvZ3ksIE5hdGlvbmFsIEluc3RpdHV0ZSBvZiBHYXN0cm9lbnRlcm9sb2d5LCBI
YXZhbmEsIEN1YmE7IFVuaXQgZm9yIHRoZSBDbGluaWNhbCBNYW5hZ2VtZW50IG9mIERpZ2VzdGl2
ZSBEaXNlYXNlcywgVmFsbWUgVW5pdmVyc2l0eSBIb3NwaXRhbCwgVW5pdmVyc2l0eSBvZiBTZXZp
bGxlLCBTZXZpbGxlLCBTcGFpbi4gRWxlY3Ryb25pYyBhZGRyZXNzOiBlZHVhcmRvdmlsYXIyMDAw
QHlhaG9vLmNvbS4mI3hEO0RlcGFydG1lbnQgb2YgSGVwYXRvbG9neSwgTmF0aW9uYWwgSW5zdGl0
dXRlIG9mIEdhc3Ryb2VudGVyb2xvZ3ksIEhhdmFuYSwgQ3ViYS4mI3hEO0RlcGFydG1lbnQgb2Yg
UGF0aG9sb2d5LCBOYXRpb25hbCBJbnN0aXR1dGUgb2YgR2FzdHJvZW50ZXJvbG9neSwgSGF2YW5h
LCBDdWJhLiYjeEQ7RGl2aXNpb24gb2YgTGl2ZXIgRGlzZWFzZXMsIEljYWhuIFNjaG9vbCBvZiBN
ZWRpY2luZSBhdCBNb3VudCBTaW5haSwgTmV3IFlvcmssIE5ldyBZb3JrLiYjeEQ7TGl2ZXIgVW5p
dCwgRGVwYXJ0bWVudCBvZiBHYXN0cm9lbnRlcm9sb2d5LCBVbml2ZXJzaXR5IEdlbmVyYWwgSG9z
cGl0YWwsIFZhbGVuY2lhLCBTcGFpbi4mI3hEO1VuaXQgZm9yIHRoZSBDbGluaWNhbCBNYW5hZ2Vt
ZW50IG9mIERpZ2VzdGl2ZSBEaXNlYXNlcywgVmFsbWUgVW5pdmVyc2l0eSBIb3NwaXRhbCwgVW5p
dmVyc2l0eSBvZiBTZXZpbGxlLCBTZXZpbGxlLCBTcGFpbi48L2F1dGgtYWRkcmVzcz48dGl0bGVz
Pjx0aXRsZT5XZWlnaHQgTG9zcyBUaHJvdWdoIExpZmVzdHlsZSBNb2RpZmljYXRpb24gU2lnbmlm
aWNhbnRseSBSZWR1Y2VzIEZlYXR1cmVzIG9mIE5vbmFsY29ob2xpYyBTdGVhdG9oZXBhdGl0aXM8
L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+R2FzdHJvZW50ZXJvbG9neTwvc2Vjb25kYXJ5LXRpdGxl
PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkdhc3Ryb2VudGVyb2xvZ3k8L2Z1bGwt
dGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4zNjctNzggZTU7IHF1aXogZTE0LTU8L3BhZ2VzPjx2
b2x1bWU+MTQ5PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFk
dWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QmlvcHN5PC9rZXl3
b3JkPjxrZXl3b3JkPkJvZHkgTWFzcyBJbmRleDwva2V5d29yZD48a2V5d29yZD5Cb2R5IFdlaWdo
dDwva2V5d29yZD48a2V5d29yZD5GYXR0eSBMaXZlci9wYXRob2xvZ3kvKnRoZXJhcHk8L2tleXdv
cmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZpYnJvc2lzL3BhdGhvbG9neS90
aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qTGlmZSBT
dHlsZTwva2V5d29yZD48a2V5d29yZD5MaXZlci8qcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3Jk
Pk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Tm9u
LWFsY29ob2xpYyBGYXR0eSBMaXZlciBEaXNlYXNlL3BhdGhvbG9neS8qdGhlcmFweTwva2V5d29y
ZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlNldmVyaXR5
IG9mIElsbG5lc3MgSW5kZXg8L2tleXdvcmQ+PGtleXdvcmQ+U2V4IEZhY3RvcnM8L2tleXdvcmQ+
PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+KldlaWdodCBMb3Nz
PC9rZXl3b3JkPjxrZXl3b3JkPkJtaTwva2V5d29yZD48a2V5d29yZD5MaWZlc3R5bGUgSW50ZXJ2
ZW50aW9uPC9rZXl3b3JkPjxrZXl3b3JkPk5BRkxEIEFjdGl2aXR5IFNjb3JlPC9rZXl3b3JkPjxr
ZXl3b3JkPlJlc29sdXRpb24gb2YgU3RlYXRvaGVwYXRpdGlzPC9rZXl3b3JkPjwva2V5d29yZHM+
PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWc8L2RhdGU+PC9wdWIt
ZGF0ZXM+PC9kYXRlcz48aXNibj4xNTI4LTAwMTIgKEVsZWN0cm9uaWMpJiN4RDswMDE2LTUwODUg
KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI1ODY1MDQ5PC9hY2Nlc3Npb24tbnVtPjx1
cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVk
LzI1ODY1MDQ5PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNl
LW51bT4xMC4xMDUzL2ouZ2FzdHJvLjIwMTUuMDQuMDA1PC9lbGVjdHJvbmljLXJlc291cmNlLW51
bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WaWxhci1Hb21lejwvQXV0aG9yPjxZZWFyPjIwMTU8L1ll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ADDIN EN.CITE.DATA (29). V?gttab er ogs? associeret med en bedre livskvalitet.Kost?ndring er en del af livsstilsintervention, men der findes ikke klar evidens for en specifik di?t til patienter med NAFLD. Den s?kaldte middelhavsdi?t (meditterranean diet) som er rig p? monoum?ttede fedtsyrer, har vist en positiv effekt p? IR og den metaboliske profil, og ogs? p? fedt i leveren i et mindre studie PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SeWFuPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj
TnVtPjM1NDwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMzApPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy
ZWMtbnVtYmVyPjM1NDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt
aWQ9InN4ZHhhOXMwdnR4MmZmZXR0OTJ4ZHpzbHhweGYyOXA1ejVycCIgdGltZXN0YW1wPSIxNDYx
MzI1NTE4Ij4zNTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB
cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJ5YW4s
IE0uIEMuPC9hdXRob3I+PGF1dGhvcj5JdHNpb3BvdWxvcywgQy48L2F1dGhvcj48YXV0aG9yPlRo
b2RpcywgVC48L2F1dGhvcj48YXV0aG9yPldhcmQsIEcuPC9hdXRob3I+PGF1dGhvcj5Ucm9zdCwg
Ti48L2F1dGhvcj48YXV0aG9yPkhvZmZlcmJlcnRoLCBTLjwvYXV0aG9yPjxhdXRob3I+TyZhcG9z
O0RlYSwgSy48L2F1dGhvcj48YXV0aG9yPkRlc21vbmQsIFAuIFYuPC9hdXRob3I+PGF1dGhvcj5K
b2huc29uLCBOLiBBLjwvYXV0aG9yPjxhdXRob3I+V2lsc29uLCBBLiBNLjwvYXV0aG9yPjwvYXV0
aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkdhc3Ryb2VudGVyb2xvZ3kgRGVwYXJ0
bWVudCwgU3QgVmluY2VudCZhcG9zO3MgSG9zcGl0YWwsIE1lbGJvdXJuZSwgQXVzdHJhbGlhLiBN
YXJuby5SeWFuQHN2aG0ub3JnLmF1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIE1l
ZGl0ZXJyYW5lYW4gZGlldCBpbXByb3ZlcyBoZXBhdGljIHN0ZWF0b3NpcyBhbmQgaW5zdWxpbiBz
ZW5zaXRpdml0eSBpbiBpbmRpdmlkdWFscyB3aXRoIG5vbi1hbGNvaG9saWMgZmF0dHkgbGl2ZXIg
ZGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEhlcGF0b2w8L3NlY29uZGFyeS10aXRs
ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIEhlcGF0b2w8L2Z1bGwtdGl0bGU+
PC9wZXJpb2RpY2FsPjxwYWdlcz4xMzgtNDM8L3BhZ2VzPjx2b2x1bWU+NTk8L3ZvbHVtZT48bnVt
YmVyPjE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+
QWdlZDwva2V5d29yZD48a2V5d29yZD5Dcm9zcy1PdmVyIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdv
cmQ+KkRpZXQsIE1lZGl0ZXJyYW5lYW48L2tleXdvcmQ+PGtleXdvcmQ+RmF0dHkgTGl2ZXIvKmRp
ZXQgdGhlcmFweS8qbWV0YWJvbGlzbS9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxl
PC9rZXl3b3JkPjxrZXl3b3JkPkdsdWNvc2UgQ2xhbXAgVGVjaG5pcXVlPC9rZXl3b3JkPjxrZXl3
b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW5zdWxpbiBSZXNpc3RhbmNlPC9rZXl3b3Jk
PjxrZXl3b3JkPkxpcGlkIE1ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+TWFnbmV0aWMgUmVz
b25hbmNlIEltYWdpbmc8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5N
aWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Ob24tYWxjb2hvbGljIEZhdHR5IExpdmVyIERp
c2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+T2Jlc2l0eSwgQWJkb21pbmFsL2RpZXQgdGhlcmFweS9t
ZXRhYm9saXNtL3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5QaWxvdCBQcm9qZWN0czwva2V5
d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+
SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTYwMC0wNjQxIChFbGVjdHJvbmlj
KSYjeEQ7MDE2OC04Mjc4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzQ4NTUyMDwv
YWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5s
bS5uaWguZ292L3B1Ym1lZC8yMzQ4NTUyMDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9qLmpoZXAuMjAxMy4wMi4wMTI8L2VsZWN0cm9u
aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SeWFuPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (30). Baseret p? prospektive studier anbefales NAFLD patienter en hypokalorisk di?t ADDIN EN.CITE <EndNote><Cite><Author>American Diabetes</Author><Year>2014</Year><RecNum>378</RecNum><DisplayText>(31)</DisplayText><record><rec-number>378</rec-number><foreign-keys><key app="EN" db-id="sxdxa9s0vtx2ffett92xdzslxpxf29p5z5rp" timestamp="1462539215">378</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>American Diabetes, Association</author></authors></contributors><titles><title>Standards of medical care in diabetes--2014</title><secondary-title>Diabetes Care</secondary-title></titles><periodical><full-title>Diabetes Care</full-title></periodical><pages>S14-80</pages><volume>37 Suppl 1</volume><keywords><keyword>Delivery of Health Care/*standards</keyword><keyword>Diabetes Mellitus/*diagnosis/*therapy</keyword><keyword>Humans</keyword></keywords><dates><year>2014</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1935-5548 (Electronic)
0149-5992 (Linking)</isbn><accession-num>24357209</accession-num><urls><related-urls><url>;(31) f.eks. med underskud af 500–1000 kcal/dag. Til vedligeholdelse af v?gttab kan almindelig varieret kost anbefales og med nedsat forbrug af cholesterol, m?ttede fedtsyrer, trans-fedtsyrer (findes i ”junkfood”) og fruktose, som bla findes i l?skedrikke. Det anbefales at kombinere di?t og fysisk aktivitet. En metaanalyse fra 2012 af 12 studier, viste en mulig effekt af fysisk tr?ning p? fedtindholdet i leveren ADDIN EN.CITE <EndNote><Cite><Author>Keating</Author><Year>2012</Year><RecNum>136</RecNum><DisplayText>(32)</DisplayText><record><rec-number>136</rec-number><foreign-keys><key app="EN" db-id="sxdxa9s0vtx2ffett92xdzslxpxf29p5z5rp" timestamp="1456696817">136</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Keating, S. E.</author><author>Hackett, D. A.</author><author>George, J.</author><author>Johnson, N. A.</author></authors></contributors><auth-address>Discipline of Exercise and Sport Science, University of Sydney, Australia</auth-address><titles><title>Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis</title><secondary-title>J.Hepatol.</secondary-title></titles><periodical><full-title>J.Hepatol.</full-title></periodical><pages>157-166</pages><volume>57</volume><number>1</number><reprint-edition>NOT IN FILE</reprint-edition><keywords><keyword>Adult</keyword><keyword>Australia</keyword><keyword>Diet</keyword><keyword>Exercise</keyword><keyword>Exercise Therapy</keyword><keyword>Fatty Liver</keyword><keyword>Humans</keyword><keyword>Liver</keyword><keyword>methods</keyword><keyword>Non-alcoholic Fatty Liver Disease</keyword><keyword>Obesity</keyword><keyword>physiology</keyword><keyword>physiopathology</keyword><keyword>Resistance Training</keyword><keyword>therapy</keyword><keyword>Weight Loss</keyword><keyword>Weight Reduction Programs</keyword></keywords><dates><year>2012</year></dates><work-type>S0168-8278(12)00210-3 pii ;10.1016/j.jhep.2012.02.023 doi</work-type><urls><related-urls><url>PM:22414768</url></related-urls></urls></record></Cite></EndNote>(32). Den fysiske aktivitet kan b?de best? af konditionstr?ning og styrketr?ning og to randomiserede studier har vist effekt p? steatose, leverenzymer, IR og den metaboliske profil uafh?ngigt af v?gttab PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdDwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdDwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (33, 34). Den st?rte effekt s?s hos patienter som tr?nede >150 min/uge. S?ledes kan tr?ning og di?t individualiseres. Slutteligt skal n?vnes, at livsstils?ndringer og v?gttab er notorisk sv?rt at opn? og vedholde PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaHJpc3RpYW5zZW48L0F1dGhvcj48WWVhcj4yMDA3PC9Z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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaHJpc3RpYW5zZW48L0F1dGhvcj48WWVhcj4yMDA3PC9Z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ADDIN EN.CITE.DATA (35, 36). Det er vist, at patienter med NAFLD har en meget forskellig og generelt ringe parathed til livsstils?ndringer og v?gttab ADDIN EN.CITE <EndNote><Cite><Author>Centis</Author><Year>2013</Year><RecNum>358</RecNum><DisplayText>(37)</DisplayText><record><rec-number>358</rec-number><foreign-keys><key app="EN" db-id="sxdxa9s0vtx2ffett92xdzslxpxf29p5z5rp" timestamp="1461443046">358</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Centis, E.</author><author>Moscatiello, S.</author><author>Bugianesi, E.</author><author>Bellentani, S.</author><author>Fracanzani, A. L.</author><author>Calugi, S.</author><author>Petta, S.</author><author>Dalle Grave, R.</author><author>Marchesini, G.</author></authors></contributors><auth-address>Unit of Metabolic Diseases and Clinical Dietetics, Alma Mater Studiorum University, Bologna, Italy.</auth-address><titles><title>Stage of change and motivation to healthier lifestyle in non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><pages>771-7</pages><volume>58</volume><number>4</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Diet</keyword><keyword>Fatty Liver/*psychology/*therapy</keyword><keyword>Female</keyword><keyword>Health Behavior</keyword><keyword>Humans</keyword><keyword>*Life Style</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Motivation</keyword><keyword>Motor Activity</keyword><keyword>Non-alcoholic Fatty Liver Disease</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>23201248</accession-num><urls><related-urls><url>;(37), og det kr?ver en koordineret indsats fra sundhedspersonale at informere patienterne grundigt om sygdomsenheden NAFLD/NASH og motivere dem til livstils?ndringer; muligvis skal tv?rfaglig indsats med f.eks. di?tister tages i brug.Kliniske rekommandationer 2Livsstilsintervention, der omfatter kost?ndringer (hypokalorisk di?t med underskud af 500–1000 kcal/dag) og fysisk aktivitet (konditionstr?ning eller styrketr?ning 150-200 min/uge) m?lrettet mod v?gttab kan anbefales til alle patienter med NAFLD; V?gttab p? > 5 % kan v?re tilstr?kkeligt for patienter med NAFLD mens patienter med NASH og fibrose b?r opn? et v?gttab > 10 %;Fysisk tr?ning uden v?gttab kan muligvis reducere fedtindholdet i leveren; der er ikke evidens for forbedring i inflammation eller fibrose ved fysisk tr?ning uden di?t.Hvilken medicinsk behandling kan anvendes til NASH?M?let for medicinsk behandling er at forbedre patienternes livskvalitet og prognose og kan overvejes hvis livsstilsintervention alene ikke har haft tilstr?kkelig effekt. Vigtige endepunkter er udvikling af cirrose, HCC og lever-relateret og cardiovaskul?r d?d. Derfor er der ikke indikation for behandling af NAFL. Risikoen ?get mortalitet og morbiditet er s?rligt ?get hos patienter med NASH og fibrose PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bbmd1bG88L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bbmd1bG88L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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 EN.CITE.DATA (2). Behandling kan overvejes hos patienter med NASH og fibrose (≥ F2) eller NASH og risikofaktorer for progression defineret som alder > 50 ?r, type 2 diabetes, forh?jet ALAT, betydelig inflammation i leverbiopsi.Generelle overvejelser vedr?rende den foreliggende evidensDer foreligger ingen sikker evidens p? kliniske endepunkter. P? nuv?rende tidspunkt er der heller ikke overbevisende evidens for at l?gemidler p?virker fibrosegraden selvom forel?bige forsknings resultater giver grund til optimisme PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OZXVzY2h3YW5kZXItVGV0cmk8L0F1dGhvcj48WWVhcj4y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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OZXVzY2h3YW5kZXItVGV0cmk8L0F1dGhvcj48WWVhcj4y
MDE1PC9ZZWFyPjxSZWNOdW0+MTg8L1JlY051bT48RGlzcGxheVRleHQ+KDM4KTwvRGlzcGxheVRl
eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg
YXBwPSJFTiIgZGItaWQ9InYwZGF3ZnhlNWZ0c3dvZWFyNXl2NXNwZnJycmV0ZHBhdHBkdCIgdGlt
ZXN0YW1wPSIxNDQwNDUxNjEyIj4xODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l
PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh
dXRob3I+TmV1c2Nod2FuZGVyLVRldHJpLCBCLiBBLjwvYXV0aG9yPjxhdXRob3I+TG9vbWJhLCBS
LjwvYXV0aG9yPjxhdXRob3I+U2FueWFsLCBBLiBKLjwvYXV0aG9yPjxhdXRob3I+TGF2aW5lLCBK
LiBFLjwvYXV0aG9yPjxhdXRob3I+VmFuIE5hdHRhLCBNLiBMLjwvYXV0aG9yPjxhdXRob3I+QWJk
ZWxtYWxlaywgTS4gRi48L2F1dGhvcj48YXV0aG9yPkNoYWxhc2FuaSwgTi48L2F1dGhvcj48YXV0
aG9yPkRhc2FyYXRoeSwgUy48L2F1dGhvcj48YXV0aG9yPkRpZWhsLCBBLiBNLjwvYXV0aG9yPjxh
dXRob3I+SGFtZWVkLCBCLjwvYXV0aG9yPjxhdXRob3I+S293ZGxleSwgSy4gVi48L2F1dGhvcj48
YXV0aG9yPk1jQ3VsbG91Z2gsIEEuPC9hdXRob3I+PGF1dGhvcj5UZXJyYXVsdCwgTi48L2F1dGhv
cj48YXV0aG9yPkNsYXJrLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+VG9uYXNjaWEsIEouPC9hdXRo
b3I+PGF1dGhvcj5CcnVudCwgRS4gTS48L2F1dGhvcj48YXV0aG9yPktsZWluZXIsIEQuIEUuPC9h
dXRob3I+PGF1dGhvcj5Eb28sIEUuPC9hdXRob3I+PGF1dGhvcj5OYXNoIENsaW5pY2FsIFJlc2Vh
cmNoIE5ldHdvcms8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz
cz5TYWludCBMb3VpcyBVbml2ZXJzaXR5LCBTdCBMb3VpcywgTU8sIFVTQS4gRWxlY3Ryb25pYyBh
ZGRyZXNzOiB0ZXRyaWJhQHNsdS5lZHUuJiN4RDtVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEgU2Fu
IERpZWdvLCBMYSBKb2xsYSwgQ0EsIFVTQS4mI3hEO1ZpcmdpbmlhIENvbW1vbndlYWx0aCBVbml2
ZXJzaXR5LCBSaWNobW9uZCwgVkEsIFVTQS4mI3hEO0NvbHVtYmlhIFVuaXZlcnNpdHksIE5ldyBZ
b3JrLCBOWSwgVVNBLiYjeEQ7Sm9obnMgSG9wa2lucyBVbml2ZXJzaXR5LCBCYWx0aW1vcmUsIE1E
LCBVU0EuJiN4RDtEdWtlIFVuaXZlcnNpdHksIER1cmhhbSwgTkMsIFVTQS4mI3hEO0luZGlhbmEg
VW5pdmVyc2l0eSwgSW5kaWFuYXBvbGlzLCBJTiwgVVNBLiYjeEQ7Q2FzZSBXZXN0ZXJuIFJlc2Vy
dmUgVW5pdmVyc2l0eSwgQ2xldmVsYW5kLCBPSCwgVVNBLiYjeEQ7VW5pdmVyc2l0eSBvZiBDYWxp
Zm9ybmlhIFNhbiBGcmFuY2lzY28sIFNhbiBGcmFuY2lzY28sIENBIFVTQS4mI3hEO1Zpcmdpbmlh
IE1hc29uIE1lZGljYWwgQ2VudGVyLCBTZWF0dGxlLCBXQSwgVVNBLiYjeEQ7Q2xldmVsYW5kIENs
aW5pYywgQ2xldmVsYW5kLCBPSCwgVVNBLiYjeEQ7V2FzaGluZ3RvbiBVbml2ZXJzaXR5LCBTdCBM
b3VpcywgTU8sIFVTQS4mI3hEO1RoZSBOYXRpb25hbCBDYW5jZXIgSW5zdGl0dXRlLCBCZXRoZXNk
YSwgTUQsIFVTQS4mI3hEO1RoZSBOYXRpb25hbCBJbnN0aXR1dGUgb2YgRGlhYmV0ZXMgYW5kIERp
Z2VzdGl2ZSBhbmQgS2lkbmV5IERpc2Vhc2VzLCBCZXRoZXNkYSwgTUQsIFVTQS48L2F1dGgtYWRk
cmVzcz48dGl0bGVzPjx0aXRsZT5GYXJuZXNvaWQgWCBudWNsZWFyIHJlY2VwdG9yIGxpZ2FuZCBv
YmV0aWNob2xpYyBhY2lkIGZvciBub24tY2lycmhvdGljLCBub24tYWxjb2hvbGljIHN0ZWF0b2hl
cGF0aXRpcyAoRkxJTlQpOiBhIG11bHRpY2VudHJlLCByYW5kb21pc2VkLCBwbGFjZWJvLWNvbnRy
b2xsZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TGFuY2V0PC9zZWNvbmRhcnktdGl0
bGU+PGFsdC10aXRsZT5MYW5jZXQ8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs
bC10aXRsZT5MYW5jZXQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5MYW5jZXQ8L2FiYnItMT48L3Blcmlv
ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkxhbmNldDwvZnVsbC10aXRsZT48YWJi
ci0xPkxhbmNldDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjk1Ni02NTwvcGFnZXM+
PHZvbHVtZT4zODU8L3ZvbHVtZT48bnVtYmVyPjk5NzI8L251bWJlcj48a2V5d29yZHM+PGtleXdv
cmQ+QWRtaW5pc3RyYXRpb24sIE9yYWw8L2tleXdvcmQ+PGtleXdvcmQ+Q2hlbm9kZW94eWNob2xp
YyBBY2lkL2FkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZS9hZHZlcnNlIGVmZmVjdHMvKmFuYWxv
Z3MgJmFtcDs8L2tleXdvcmQ+PGtleXdvcmQ+ZGVyaXZhdGl2ZXM8L2tleXdvcmQ+PGtleXdvcmQ+
Q2hvbGVzdGVyb2wsIEhETC9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkNob2xlc3Rlcm9s
LCBMREwvbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5Eb3VibGUtQmxpbmQgTWV0aG9kPC9r
ZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+
PGtleXdvcmQ+TGl2ZXIvZW56eW1vbG9neTwva2V5d29yZD48a2V5d29yZD5MaXZlciBDaXJyaG9z
aXMvZHJ1ZyB0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+
TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Tm9uLWFsY29ob2xpYyBGYXR0eSBMaXZlciBE
aXNlYXNlLypkcnVnIHRoZXJhcHkvZW56eW1vbG9neTwva2V5d29yZD48a2V5d29yZD5SZWNlcHRv
cnMsIEN5dG9wbGFzbWljIGFuZCBOdWNsZWFyL2RydWcgZWZmZWN0czwva2V5d29yZD48a2V5d29y
ZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5XZWlnaHQgTG9zcy9kcnVnIGVm
ZmVjdHM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48cHViLWRh
dGVzPjxkYXRlPk1hciAxNDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NzQtNTQ3
WCAoRWxlY3Ryb25pYykmI3hEOzAxNDAtNjczNiAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u
dW0+MjU0NjgxNjA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6
Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjU0NjgxNjA8L3VybD48L3JlbGF0ZWQtdXJs
cz48L3VybHM+PGN1c3RvbTI+NDQ0NzE5MjwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u
dW0+MTAuMTAxNi9TMDE0MC02NzM2KDE0KTYxOTMzLTQ8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt
PjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE.DATA (38). Af samme ?rsag er det aktuelt vanskeligt at give specifikke behandlings rekommandationer ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7). De gennemf?rte randomiserede fors?g har v?ret alt for korte til at estimere effekt p? kliniske endepunkter. Der er hverken fundet effekt af behandling p? udvikling af cirrose, HCC eller d?d. P? baggrund af naturhistorien er det vanskeligt at gennemf?re fors?g der har tilstr?kkeligt lang follow up og derfor er den kliniske relevans foreksllige endepunkter og surrogat endepunkter diskuteret ADDIN EN.CITE <EndNote><Cite><Author>Sanyal</Author><Year>2011</Year><RecNum>10099</RecNum><DisplayText>(39)</DisplayText><record><rec-number>10099</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1315519607">10099</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sanyal, A. J.</author><author>Brunt, E. M.</author><author>Kleiner, D. E.</author><author>Kowdley, K. V.</author><author>Chalasani, N.</author><author>Lavine, J. E.</author><author>Ratziu, V.</author><author>McCullough, A.</author></authors></contributors><auth-address>Department of Gastroenterology, Virginia Commonwealth University, Richmond, VA, USA. asanyal@mcvh-vcu.edu</auth-address><titles><title>Endpoints and clinical trial design for nonalcoholic steatohepatitis</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>344-53</pages><volume>54</volume><number>1</number><edition>2011/04/27</edition><dates><year>2011</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1527-3350 (Electronic)
0270-9139 (Linking)</isbn><accession-num>21520200</accession-num><urls><related-urls><url>;(39). Det prim?re accepterede surrogat endepunkt er histologi med hovedv?gt p? fibrosegrad ADDIN EN.CITE <EndNote><Cite><Author>Sanyal</Author><Year>2011</Year><RecNum>10099</RecNum><DisplayText>(39)</DisplayText><record><rec-number>10099</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1315519607">10099</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sanyal, A. J.</author><author>Brunt, E. M.</author><author>Kleiner, D. E.</author><author>Kowdley, K. V.</author><author>Chalasani, N.</author><author>Lavine, J. E.</author><author>Ratziu, V.</author><author>McCullough, A.</author></authors></contributors><auth-address>Department of Gastroenterology, Virginia Commonwealth University, Richmond, VA, USA. asanyal@mcvh-vcu.edu</auth-address><titles><title>Endpoints and clinical trial design for nonalcoholic steatohepatitis</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>344-53</pages><volume>54</volume><number>1</number><edition>2011/04/27</edition><dates><year>2011</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1527-3350 (Electronic)
0270-9139 (Linking)</isbn><accession-num>21520200</accession-num><urls><related-urls><url>;(39). Der foreligger ingen valide data for monitorering af behandling eller varighed ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7).Vitamin EVitamin E (α-tocopherol) modvirker oxidativt stress, der anses som en grundl?ggende faktor i NASH patogenesen. I Danmark forhandles E vitamin i h?ndk?b som kapsler af 300-350 mg, sv. t. 500-525 IU pr kapsel. Effekten af E-vitamin i kombination med andre stoffer eller som monoterapi er unders?gt i en metaanalysesom ikke fandt overbevisende evidens ADDIN EN.CITE <EndNote><Cite><Author>Musso</Author><Year>2010</Year><RecNum>10084</RecNum><DisplayText>(40)</DisplayText><record><rec-number>10084</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1315519062">10084</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Musso, G.</author><author>Gambino, R.</author><author>Cassader, M.</author><author>Pagano, G.</author></authors></contributors><auth-address>Gradenigo Hospital, Turin, Italy. giovanni_musso@yahoo.it</auth-address><titles><title>A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease</title><secondary-title>Hepatology</secondary-title></titles><periodical><full-title>Hepatology</full-title></periodical><pages>79-104</pages><volume>52</volume><number>1</number><edition>2010/06/26</edition><keywords><keyword>Adult</keyword><keyword>Antioxidants/therapeutic use</keyword><keyword>Child</keyword><keyword>Fatty Liver/*drug therapy/pathology/radionuclide imaging</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Randomized Controlled Trials as Topic</keyword><keyword>Thiazolidinediones/therapeutic use</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2010</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1527-3350 (Electronic)
0270-9139 (Linking)</isbn><accession-num>20578268</accession-num><urls><related-urls><url>;(40). Der var endvidere store heterogenitet mellem studierne og mulige klinisk betydende forskelle. Den statistiske styrke var ikke tilstr?kkelig til at gennemf?re subgruppe analyser. To af de st?rste randomiserede E vitamin studier fandt en beskeden effekt af behandlingen PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW55YWw8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW55YWw8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (41, 42). Det ene studie inkluderede 247 non-diabetiske NASH patienter randomiseret til placebo, pioglitazone (30 mg/dag) eller Vitamin E (800 IU/dag) i 96 uger. Studiet fandt, at vitamin E medf?rte bedring af histologisk inflammation (steatosis, ballooning og lobul?r inflammation), men ikke fibrose.. Studiet fandt, at kun patienter med ALAT fald havde forbedring PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib29mbmFnbGU8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy
PjxSZWNOdW0+MjI5PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig0Mik8L0Rpc3BsYXlUZXh0PjxyZWNv
cmQ+PHJlYy1udW1iZXI+MjI5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO
IiBkYi1pZD0idjBkYXdmeGU1ZnRzd29lYXI1eXY1c3BmcnJyZXRkcGF0cGR0IiB0aW1lc3RhbXA9
IjE0NTk4NjU3ODciPjIyOTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy
bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+
SG9vZm5hZ2xlLCBKLiBILjwvYXV0aG9yPjxhdXRob3I+VmFuIE5hdHRhLCBNLiBMLjwvYXV0aG9y
PjxhdXRob3I+S2xlaW5lciwgRC4gRS48L2F1dGhvcj48YXV0aG9yPkNsYXJrLCBKLiBNLjwvYXV0
aG9yPjxhdXRob3I+S293ZGxleSwgSy4gVi48L2F1dGhvcj48YXV0aG9yPkxvb21iYSwgUi48L2F1
dGhvcj48YXV0aG9yPk5ldXNjaHdhbmRlci1UZXRyaSwgQi4gQS48L2F1dGhvcj48YXV0aG9yPlNh
bnlhbCwgQS4gSi48L2F1dGhvcj48YXV0aG9yPlRvbmFzY2lhLCBKLjwvYXV0aG9yPjxhdXRob3I+
Tm9uLWFsY29ob2xpYyBTdGVhdG9oZXBhdGl0aXMgQ2xpbmljYWwgUmVzZWFyY2gsIE5ldHdvcms8
L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5MaXZlciBEaXNl
YXNlIFJlc2VhcmNoIEJyYW5jaCwgRGl2aXNpb24gb2YgRGlnZXN0aXZlIERpc2Vhc2VzIGFuZCBO
dXRyaXRpb24sIE5hdGlvbmFsIEluc3RpdHV0ZSBvZiBEaWFiZXRlcyBhbmQgRGlnZXN0aXZlIGFu
ZCBLaWRuZXkgRGlzZWFzZXMsIE5hdGlvbmFsIEluc3RpdHV0ZXMgb2YgSGVhbHRoLCBCZXRoZXNk
YSwgTUQsIFVTQS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5WaXRhbWluIEUgYW5kIGNo
YW5nZXMgaW4gc2VydW0gYWxhbmluZSBhbWlub3RyYW5zZmVyYXNlIGxldmVscyBpbiBwYXRpZW50
cyB3aXRoIG5vbi1hbGNvaG9saWMgc3RlYXRvaGVwYXRpdGlzPC90aXRsZT48c2Vjb25kYXJ5LXRp
dGxlPkFsaW1lbnQgUGhhcm1hY29sIFRoZXI8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVy
aW9kaWNhbD48ZnVsbC10aXRsZT5BbGltZW50IFBoYXJtYWNvbCBUaGVyPC9mdWxsLXRpdGxlPjxh
YmJyLTE+QWxpbWVudGFyeSBwaGFybWFjb2xvZ3kgJmFtcDsgdGhlcmFwZXV0aWNzPC9hYmJyLTE+
PC9wZXJpb2RpY2FsPjxwYWdlcz4xMzQtNDM8L3BhZ2VzPjx2b2x1bWU+Mzg8L3ZvbHVtZT48bnVt
YmVyPjI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+
QWxhbmluZSBUcmFuc2FtaW5hc2UvKmJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlveGlkYW50
cy8qdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkZhdHR5IExpdmVyLypkcnVnIHRo
ZXJhcHkvZW56eW1vbG9neTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdv
cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkh5cG9nbHljZW1pYyBBZ2VudHMvKnRoZXJhcGV1
dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBB
Z2VkPC9rZXl3b3JkPjxrZXl3b3JkPk5vbi1hbGNvaG9saWMgRmF0dHkgTGl2ZXIgRGlzZWFzZTwv
a2V5d29yZD48a2V5d29yZD5UaGlhem9saWRpbmVkaW9uZXMvKnRoZXJhcGV1dGljIHVzZTwva2V5
d29yZD48a2V5d29yZD5WaXRhbWluIEUvKnRoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29y
ZD5XZWlnaHQgTG9zczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFy
PjxwdWItZGF0ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTM2
NS0yMDM2IChFbGVjdHJvbmljKSYjeEQ7MDI2OS0yODEzIChMaW5raW5nKTwvaXNibj48YWNjZXNz
aW9uLW51bT4yMzcxODU3MzwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+
aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzcxODU3MzwvdXJsPjwvcmVsYXRl
ZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMzNzc1MjYyPC9jdXN0b20yPjxlbGVjdHJvbmljLXJl
c291cmNlLW51bT4xMC4xMTExL2FwdC4xMjM1MjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9y
ZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib29mbmFnbGU8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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ADDIN EN.CITE.DATA (42), hvilket antyder at ALAT kan bruges som biomark?r for histologisk behandlingseffekt. For patienter med transaminas?mi foresl?s s?ledes, at E vitamin seponeres hvis der ikke ses et signifikant fald i ALAT ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7). Bivirkninger: Et Cochrane review fandt at h?jdosis E vitamin behandling generelt kan medf?re overd?delighed ADDIN EN.CITE <EndNote><Cite><Author>Bjelakovic</Author><Year>2012</Year><RecNum>244</RecNum><DisplayText>(43)</DisplayText><record><rec-number>244</rec-number><foreign-keys><key app="EN" db-id="v0dawfxe5ftswoear5yv5spfrrretdpatpdt" timestamp="1461182106">244</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bjelakovic, G.</author><author>Nikolova, D.</author><author>Gluud, L. L.</author><author>Simonetti, R. G.</author><author>Gluud, C.</author></authors></contributors><auth-address>Department of InternalMedicine,Medical Faculty, University ofNis,Nis, Serbia. goranb@junis.ni.ac.rs.</auth-address><titles><title>Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases</title><secondary-title>Cochrane Database Syst Rev</secondary-title></titles><periodical><full-title>Cochrane Database Syst Rev</full-title></periodical><pages>CD007176</pages><volume>3</volume><keywords><keyword>Antioxidants/*administration & dosage/adverse effects</keyword><keyword>Ascorbic Acid/administration & dosage/adverse effects</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>*Mortality</keyword><keyword>Primary Prevention/*methods</keyword><keyword>Randomized Controlled Trials as Topic</keyword><keyword>Secondary Prevention/*methods</keyword><keyword>Selenium/administration & dosage/adverse effects</keyword><keyword>Vitamin A/administration & dosage/adverse effects</keyword><keyword>Vitamin E/administration & dosage/adverse effects</keyword><keyword>beta Carotene/administration & dosage/adverse effects</keyword></keywords><dates><year>2012</year></dates><isbn>1469-493X (Electronic)
1361-6137 (Linking)</isbn><accession-num>22419320</accession-num><urls><related-urls><url>;(43). Et stort randomiseret studie fandt, at E vitamin 400 mg/dag ?ger risiko for prostata cancer PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbGVpbjwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbGVpbjwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl
Y051bT4yMzc8L1JlY051bT48RGlzcGxheVRleHQ+KDQ0KTwvRGlzcGxheVRleHQ+PHJlY29yZD48
cmVjLW51bWJlcj4yMzc8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi
LWlkPSJ2MGRhd2Z4ZTVmdHN3b2VhcjV5djVzcGZycnJldGRwYXRwZHQiIHRpbWVzdGFtcD0iMTQ2
MTE1MTU0NSI+MjM3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg
QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5LbGVp
biwgRS4gQS48L2F1dGhvcj48YXV0aG9yPlRob21wc29uLCBJLiBNLiwgSnIuPC9hdXRob3I+PGF1
dGhvcj5UYW5nZW4sIEMuIE0uPC9hdXRob3I+PGF1dGhvcj5Dcm93bGV5LCBKLiBKLjwvYXV0aG9y
PjxhdXRob3I+THVjaWEsIE0uIFMuPC9hdXRob3I+PGF1dGhvcj5Hb29kbWFuLCBQLiBKLjwvYXV0
aG9yPjxhdXRob3I+TWluYXNpYW4sIEwuIE0uPC9hdXRob3I+PGF1dGhvcj5Gb3JkLCBMLiBHLjwv
YXV0aG9yPjxhdXRob3I+UGFybmVzLCBILiBMLjwvYXV0aG9yPjxhdXRob3I+R2F6aWFubywgSi4g
TS48L2F1dGhvcj48YXV0aG9yPkthcnAsIEQuIEQuPC9hdXRob3I+PGF1dGhvcj5MaWViZXIsIE0u
IE0uPC9hdXRob3I+PGF1dGhvcj5XYWx0aGVyLCBQLiBKLjwvYXV0aG9yPjxhdXRob3I+S2xvdHos
IEwuPC9hdXRob3I+PGF1dGhvcj5QYXJzb25zLCBKLiBLLjwvYXV0aG9yPjxhdXRob3I+Q2hpbiwg
Si4gTC48L2F1dGhvcj48YXV0aG9yPkRhcmtlLCBBLiBLLjwvYXV0aG9yPjxhdXRob3I+TGlwcG1h
biwgUy4gTS48L2F1dGhvcj48YXV0aG9yPkdvb2RtYW4sIEcuIEUuPC9hdXRob3I+PGF1dGhvcj5N
ZXlza2VucywgRi4gTC4sIEpyLjwvYXV0aG9yPjxhdXRob3I+QmFrZXIsIEwuIEguPC9hdXRob3I+
PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBVcm9s
b2d5LCBHbGlja21hbiBVcm9sb2dpY2FsIGFuZCBLaWRuZXkgSW5zdGl0dXRlLCBDbGV2ZWxhbmQg
Q2xpbmljLCBDbGV2ZWxhbmQsIE9oaW8gNDQxOTUsIFVTQS4ga2xlaW5lQGNjZi5vcmc8L2F1dGgt
YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5WaXRhbWluIEUgYW5kIHRoZSByaXNrIG9mIHByb3N0YXRl
IGNhbmNlcjogdGhlIFNlbGVuaXVtIGFuZCBWaXRhbWluIEUgQ2FuY2VyIFByZXZlbnRpb24gVHJp
YWwgKFNFTEVDVCk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFNQTwvc2Vjb25kYXJ5LXRpdGxl
PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpBTUE8L2Z1bGwtdGl0bGU+PGFiYnIt
MT5KYW1hPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz4xNTQ5LTU2PC9wYWdlcz48dm9sdW1l
PjMwNjwvdm9sdW1lPjxudW1iZXI+MTQ8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwv
a2V5d29yZD48a2V5d29yZD5BbnRpb3hpZGFudHMvYWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdl
LyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+RGlldGFyeSBTdXBwbGVtZW50cy8q
YWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3
b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tleXdvcmQ+
PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5
d29yZD5Qcm9zdGF0aWMgTmVvcGxhc21zLyplcGlkZW1pb2xvZ3kvcHJldmVudGlvbiAmYW1wOyBj
b250cm9sPC9rZXl3b3JkPjxrZXl3b3JkPlJpc2s8L2tleXdvcmQ+PGtleXdvcmQ+U2VsZW5pdW0v
KmFkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZTwva2V5d29yZD48a2V5d29yZD5WaXRhbWluIEUv
YWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdlLyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PC9r
ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPk9jdCAxMjwv
ZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzgtMzU5OCAoRWxlY3Ryb25pYykmI3hE
OzAwOTgtNzQ4NCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjE5OTAyOTg8L2FjY2Vz
c2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmlo
Lmdvdi9wdWJtZWQvMjE5OTAyOTg8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+
UE1DNDE2OTAxMDwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAwMS9qYW1h
LjIwMTEuMTQzNzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k
Tm90ZT4A
ADDIN EN.CITE.DATA (44). ThiazolidinedionerThiazolidinedioner er peroxisome proliferator-activated receptor (PPAR)-γ agonister, som is?r bedrer insulinf?lsomheden i fedtv?v og reducerer fris?tning af frie fedtsyrer til leveren. Pioglitazon er det eneste indregistrerede pr?parat, og det er godkendt til behandling af type 2 diabetes, sk?nt sj?ldent ordineret pga. risiko for bivirkninger. Effekten af pioglitazon er unders?gt i randomiserede studier med non-diabetiske og diabetiske NASH patienter ADDIN EN.CITE <EndNote><Cite><Author>Boettcher</Author><Year>2012</Year><RecNum>11677</RecNum><DisplayText>(45)</DisplayText><record><rec-number>11677</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1464338861">11677</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Boettcher, E.</author><author>Csako, G.</author><author>Pucino, F.</author><author>Wesley, R.</author><author>Loomba, R.</author></authors></contributors><auth-address>Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.</auth-address><titles><title>Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis</title><secondary-title>Aliment Pharmacol Ther</secondary-title></titles><periodical><full-title>Aliment Pharmacol Ther</full-title></periodical><pages>66-75</pages><volume>35</volume><number>1</number><keywords><keyword>Fatty Liver/complications/*drug therapy</keyword><keyword>Humans</keyword><keyword>Hypoglycemic Agents/*therapeutic use</keyword><keyword>Liver/*drug effects</keyword><keyword>Liver Cirrhosis/*drug therapy</keyword><keyword>Non-alcoholic Fatty Liver Disease</keyword><keyword>Randomized Controlled Trials as Topic</keyword><keyword>Thiazolidinediones/*therapeutic use</keyword></keywords><dates><year>2012</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1365-2036 (Electronic)
0269-2813 (Linking)</isbn><accession-num>22050199</accession-num><urls><related-urls><url>;(45). Et randomiseret studie unders?gte pioglitazon 30 mg/dag versus placebo versus vitamin E PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib29mbmFnbGU8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib29mbmFnbGU8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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ADDIN EN.CITE.DATA (42). Studiet fandt ikke signifikant effekt p? det histologiske score. En meta-analyse som inkluderede tre randomiserede studier (pioglitazon 30-45 mg/dag) fandt en mulig effekt p? histologisk inflammation, men ikke fibrose ADDIN EN.CITE <EndNote><Cite><Author>Boettcher</Author><Year>2012</Year><RecNum>11677</RecNum><DisplayText>(45)</DisplayText><record><rec-number>11677</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1464338861">11677</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Boettcher, E.</author><author>Csako, G.</author><author>Pucino, F.</author><author>Wesley, R.</author><author>Loomba, R.</author></authors></contributors><auth-address>Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.</auth-address><titles><title>Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis</title><secondary-title>Aliment Pharmacol Ther</secondary-title></titles><periodical><full-title>Aliment Pharmacol Ther</full-title></periodical><pages>66-75</pages><volume>35</volume><number>1</number><keywords><keyword>Fatty Liver/complications/*drug therapy</keyword><keyword>Humans</keyword><keyword>Hypoglycemic Agents/*therapeutic use</keyword><keyword>Liver/*drug effects</keyword><keyword>Liver Cirrhosis/*drug therapy</keyword><keyword>Non-alcoholic Fatty Liver Disease</keyword><keyword>Randomized Controlled Trials as Topic</keyword><keyword>Thiazolidinediones/*therapeutic use</keyword></keywords><dates><year>2012</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1365-2036 (Electronic)
0269-2813 (Linking)</isbn><accession-num>22050199</accession-num><urls><related-urls><url>;(45), hvilket heller ikke kunne genfindes i en netv?rksmetaanalyse PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYXdhbmdqaXQ8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYXdhbmdqaXQ8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy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ADDIN EN.CITE.DATA (46)Bivirkninger: Randomiserede studier og observationelle fors?g har vist vedvarende v?gt?gning p? ca. 4 kg PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NdXNzbzwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NdXNzbzwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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ADDIN EN.CITE.DATA (40, 45) og en ?get risiko for is?r bl?recancer PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdWNjb3JpPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48
UmVjTnVtPjIzNDwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNDcpPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjIzNDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg
ZGItaWQ9InYwZGF3ZnhlNWZ0c3dvZWFyNXl2NXNwZnJycmV0ZHBhdHBkdCIgdGltZXN0YW1wPSIx
NDYwNTUxMzM5Ij4yMzQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h
bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlR1
Y2NvcmksIE0uPC9hdXRob3I+PGF1dGhvcj5GaWxpb24sIEsuIEIuPC9hdXRob3I+PGF1dGhvcj5Z
aW4sIEguPC9hdXRob3I+PGF1dGhvcj5ZdSwgTy4gSC48L2F1dGhvcj48YXV0aG9yPlBsYXR0LCBS
LiBXLjwvYXV0aG9yPjxhdXRob3I+QXpvdWxheSwgTC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250
cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5DZW50cmUgZm9yIENsaW5pY2FsIEVwaWRlbWlvbG9neSwg
TGFkeSBEYXZpcyBJbnN0aXR1dGUsIEpld2lzaCBHZW5lcmFsIEhvc3BpdGFsLCBNb250cmVhbCwg
UXVlYmVjLCBDYW5hZGEgRGVwYXJ0bWVudCBvZiBFcGlkZW1pb2xvZ3ksIEJpb3N0YXRpc3RpY3Ms
IGFuZCBPY2N1cGF0aW9uYWwgSGVhbHRoLCBNY0dpbGwgVW5pdmVyc2l0eSwgTW9udHJlYWwuJiN4
RDtDZW50cmUgZm9yIENsaW5pY2FsIEVwaWRlbWlvbG9neSwgTGFkeSBEYXZpcyBJbnN0aXR1dGUs
IEpld2lzaCBHZW5lcmFsIEhvc3BpdGFsLCBNb250cmVhbCwgUXVlYmVjLCBDYW5hZGEgRGVwYXJ0
bWVudCBvZiBFcGlkZW1pb2xvZ3ksIEJpb3N0YXRpc3RpY3MsIGFuZCBPY2N1cGF0aW9uYWwgSGVh
bHRoLCBNY0dpbGwgVW5pdmVyc2l0eSwgTW9udHJlYWwgRGl2aXNpb24gb2YgQ2xpbmljYWwgRXBp
ZGVtaW9sb2d5LCBNY0dpbGwgVW5pdmVyc2l0eS4mI3hEO0NlbnRyZSBmb3IgQ2xpbmljYWwgRXBp
ZGVtaW9sb2d5LCBMYWR5IERhdmlzIEluc3RpdHV0ZSwgSmV3aXNoIEdlbmVyYWwgSG9zcGl0YWws
IE1vbnRyZWFsLCBRdWViZWMsIENhbmFkYS4mI3hEO0NlbnRyZSBmb3IgQ2xpbmljYWwgRXBpZGVt
aW9sb2d5LCBMYWR5IERhdmlzIEluc3RpdHV0ZSwgSmV3aXNoIEdlbmVyYWwgSG9zcGl0YWwsIE1v
bnRyZWFsLCBRdWViZWMsIENhbmFkYSBEaXZpc2lvbiBvZiBFbmRvY3Jpbm9sb2d5LCBKZXdpc2gg
R2VuZXJhbCBIb3NwaXRhbCwgTW9udHJlYWwuJiN4RDtDZW50cmUgZm9yIENsaW5pY2FsIEVwaWRl
bWlvbG9neSwgTGFkeSBEYXZpcyBJbnN0aXR1dGUsIEpld2lzaCBHZW5lcmFsIEhvc3BpdGFsLCBN
b250cmVhbCwgUXVlYmVjLCBDYW5hZGEgRGVwYXJ0bWVudCBvZiBFcGlkZW1pb2xvZ3ksIEJpb3N0
YXRpc3RpY3MsIGFuZCBPY2N1cGF0aW9uYWwgSGVhbHRoLCBNY0dpbGwgVW5pdmVyc2l0eSwgTW9u
dHJlYWwgRGVwYXJ0bWVudCBvZiBQZWRpYXRyaWNzLCBNY0dpbGwgVW5pdmVyc2l0eSwgTW9udHJl
YWwgUmVzZWFyY2ggSW5zdGl0dXRlIG9mIHRoZSBNY0dpbGwgVW5pdmVyc2l0eSBIZWFsdGggQ2Vu
dHJlLCBNb250cmVhbC4mI3hEO0NlbnRyZSBmb3IgQ2xpbmljYWwgRXBpZGVtaW9sb2d5LCBMYWR5
IERhdmlzIEluc3RpdHV0ZSwgSmV3aXNoIEdlbmVyYWwgSG9zcGl0YWwsIE1vbnRyZWFsLCBRdWVi
ZWMsIENhbmFkYSBEZXBhcnRtZW50IG9mIE9uY29sb2d5LCBNY0dpbGwgVW5pdmVyc2l0eSBsYXVy
ZW50LmF6b3VsYXlAbWNnaWxsLmNhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlBpb2ds
aXRhem9uZSB1c2UgYW5kIHJpc2sgb2YgYmxhZGRlciBjYW5jZXI6IHBvcHVsYXRpb24gYmFzZWQg
Y29ob3J0IHN0dWR5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJNSjwvc2Vjb25kYXJ5LXRpdGxl
PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJNSjwvZnVsbC10aXRsZT48L3Blcmlv
ZGljYWw+PHBhZ2VzPmkxNTQxPC9wYWdlcz48dm9sdW1lPjM1Mjwvdm9sdW1lPjxkYXRlcz48eWVh
cj4yMDE2PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTc1Ni0xODMzIChFbGVjdHJvbmljKSYjeEQ7MDk1
OS01MzVYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNzAyOTM4NTwvYWNjZXNzaW9u
LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292
L3B1Ym1lZC8yNzAyOTM4NTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM0
ODE2NjAyPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTM2L2Jtai5pMTU0
MTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdWNjb3JpPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48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=
ADDIN EN.CITE.DATA (47) og frakturer ADDIN EN.CITE <EndNote><Cite><Author>Billington</Author><Year>2015</Year><RecNum>243</RecNum><DisplayText>(48)</DisplayText><record><rec-number>243</rec-number><foreign-keys><key app="EN" db-id="v0dawfxe5ftswoear5yv5spfrrretdpatpdt" timestamp="1461158757">243</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Billington, E. O.</author><author>Grey, A.</author><author>Bolland, M. J.</author></authors></contributors><auth-address>Division of Endocrinology, University of Calgary, Calgary, Canada. e.billington@auckland.ac.nz.
Bone & Joint Research Group, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1010, New Zealand. e.billington@auckland.ac.nz.
Bone & Joint Research Group, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1010, New Zealand.</auth-address><titles><title>The effect of thiazolidinediones on bone mineral density and bone turnover: systematic review and meta-analysis</title><secondary-title>Diabetologia</secondary-title></titles><periodical><full-title>Diabetologia</full-title></periodical><pages>2238-46</pages><volume>58</volume><number>10</number><keywords><keyword>Bone density</keyword><keyword>Diabetes mellitus</keyword><keyword>Meta-analysis</keyword><keyword>Pioglitazone</keyword><keyword>Rosiglitazone</keyword><keyword>Systematic review</keyword><keyword>Thiazolidinediones</keyword></keywords><dates><year>2015</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1432-0428 (Electronic)
0012-186X (Linking)</isbn><accession-num>26109213</accession-num><urls><related-urls><url>;(48). LiraglutidLiraglutid er en glucagon-like peptide-1 (GLP-1) analog, der prim?rt anvendes som anti-diabetikum og til behandling af adipositas. Et 12-ugers, randomiseret fase 2 studie har unders?gt liraglutids effekt p? 52 patienter med NASH PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm1zdHJvbmc8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm1zdHJvbmc8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy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ADDIN EN.CITE.DATA (49). Fors?get fandt at NASH forsvandt hos 39 % af liraglutid patienter og 9 % af placebo patienter og at f?rre patienter i liraglutid gruppen havde progression af fibrose under behandlingen. Der afventes st?rre og l?ngere studier. Liraglutid er associeret med v?gttab, bedre metabolisk regulation (blandt personer med diabetes), faldende blodtryk og lipider.Bivirkninger De hyppigste bivirkninger er gastrointestinale og inkluderer b?de kvalme, opkastning og diarre eller obstipation og flere studier har vist en stigning i puls. Der er rejst mistanke om ?get risiko for pankreatitis. Det b?r n?vnes at pr?paratet er dyrt for patienter, som ikke opfylder kriterier for tilskud. Obetichol syreObetichol syre (obeticholic acid) er en syntetisk galdesyre, som aktiverer farnesoid X nuclear receptoren (FXR). FXR aktivering ?ger insulin sensitivitet og s?nker hepatisk gluconeogenese og plasma triglycerid. Et randomiseret fase 2 studie med 283 NASH og borderline NASH patienter unders?gte effekten af 72 ugers placebo eller obetichol syre behandling, 25 mg/dag PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OZXVzY2h3YW5kZXItVGV0cmk8L0F1dGhvcj48WWVhcj4y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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OZXVzY2h3YW5kZXItVGV0cmk8L0F1dGhvcj48WWVhcj4y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ADDIN EN.CITE.DATA (38). Studiet en effekt p? inflammation og fibrose. Der er desuden v?gttab og bedring af den metaboliske regulation for patienter med diabetes. Der afventes fase III studier.Bivirkninger Pr?paratet er kun godkendt for nyligt og erfaringerne ringe. De prim?re bivirkninger angives at v?re hudkl?e og dyslipid?mi. Andre pr?paraterEffekten af UDCA p? NASH er unders?gt i flere studier med skuffende resultater og kan derfor ikke anbefales ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7). Effekten af metformin p? NASH er ogs? skuffende ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7), men behandlingen er indiceret hvis patienten har en samtidig diabetes. Retrospektive studier tyder desuden p?, at metformin modvirker udviklingen af HCC ADDIN EN.CITE <EndNote><Cite><Author>Zhang</Author><Year>2012</Year><RecNum>241</RecNum><DisplayText>(50)</DisplayText><record><rec-number>241</rec-number><foreign-keys><key app="EN" db-id="v0dawfxe5ftswoear5yv5spfrrretdpatpdt" timestamp="1461157738">241</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhang, Z. J.</author><author>Zheng, Z. J.</author><author>Shi, R.</author><author>Su, Q.</author><author>Jiang, Q.</author><author>Kip, K. E.</author></authors></contributors><auth-address>Department of Epidemiology, School of Public Health, Shanghai Jiao Tong University, 227 South Chongqing Road, Shanghai 200025, China. zhang.zj@</auth-address><titles><title>Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and meta-analysis</title><secondary-title>J Clin Endocrinol Metab</secondary-title></titles><periodical><full-title>J Clin Endocrinol Metab</full-title><abbr-1>The Journal of clinical endocrinology and metabolism</abbr-1></periodical><pages>2347-53</pages><volume>97</volume><number>7</number><keywords><keyword>Algorithms</keyword><keyword>Carcinoma, Hepatocellular/complications/epidemiology/*prevention & control</keyword><keyword>Chemoprevention/methods</keyword><keyword>Diabetes Mellitus, Type 2/complications/*drug therapy/epidemiology</keyword><keyword>Humans</keyword><keyword>Hypoglycemic Agents/therapeutic use</keyword><keyword>Liver Neoplasms/complications/epidemiology/*prevention & control</keyword><keyword>Metformin/*therapeutic use</keyword></keywords><dates><year>2012</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1945-7197 (Electronic)
0021-972X (Linking)</isbn><accession-num>22523334</accession-num><urls><related-urls><url>;(50) hvorfor der stadig afventes studier.Behandling af komorbide tilstandeAlle NAFLD patienter b?r tilbydes diagnostik og behandling af de hyppigt forekommende komorbide tilstande, som dyslipid?mi, hypertension, type 2 diabetes mellitus og s?vnapn? ADDIN EN.CITE <EndNote><Cite><Author>European Association for the Study of the Liver . Electronic address</Author><Year>2016</Year><RecNum>11653</RecNum><DisplayText>(7)</DisplayText><record><rec-number>11653</rec-number><foreign-keys><key app="EN" db-id="f92ps2fpaf0dp9eavabv59stz9t5sxw9ttww" timestamp="1463055554">11653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>European Association for the Study of the Liver . Electronic address, easloffice easloffice eu</author><author>European Association for the Study of, Diabetes</author><author>European Association for the Study of, Obesity</author></authors></contributors><titles><title>EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease</title><secondary-title>J Hepatol</secondary-title></titles><periodical><full-title>J Hepatol</full-title></periodical><dates><year>2016</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1600-0641 (Electronic)
0168-8278 (Linking)</isbn><accession-num>27062661</accession-num><urls><related-urls><url>;(7). Is?r statin behandling kan v?re gavnlig for NAFLD patienter og generelt neds?tte risikoen for HCC PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Eb25naW92YW5uaTwvQXV0aG9yPjxZZWFyPjIwMTU8L1ll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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Eb25naW92YW5uaTwvQXV0aG9yPjxZZWFyPjIwMTU8L1ll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ADDIN EN.CITE.DATA (40, 51, 52). Kliniske rekommandationer 3Ingen l?gemidler har vist effekt p? kliniske endepunkter og anbefalinger om behandling af patienter med NAFLD er vejledendePrognosen ved NAFL er god og der er ikke evidens for at tilbyde medicinsk behandling ved denne tilstandMedicinsk behandling af NASH overvejes, hvis der er fibrose ≥ F2 risikofaktorer best?ende af diabetes, MetS, vedvarende ALAT-forh?jelse, eller betydende histologisk inflammationVitamin E behandling (800 IU/dag) kan overvejes til is?r non-diabetiske NASH patienter under hensyntagen til mulige bivirkninger; metoder til behandlingsmonitorering og varighed er uafklaret; blandt personer med transaminas?mi kan overvejes seponering ved manglende ALAT fald efter seks m?nederPioglitazon (30-45 mg/dag) kan overvejes til behandling af NASH patienter s?rligt ved samtidig diabetes under hensyntagen til mulige bivirkninger; metoder til behandlingsmonitorering og varighed er uafklaretDiagnosticering og behandling af komorbiditet inklusive diabetes, hypertension, hyperlipid?mi, isk?misk hjertesygdom understreges.Kan bariatrisk kirurgi anvendes til behandling af NAFLD?I Danmark anvendes bariatrisk kirurgi til behandling af patienter med sv?r fedme og alder mellem 25-60 ?r, hvor de ikke-kirurgiske behandlingstilbud kan anses for at v?re udt?mte. Personer som indstilles til bariatrisk kirurgi skal opfylde et af f?lgende to kriterier: 1) BMI > 50 kg/m2 eller 2) BMI > 35 kg/m2 med type 2 diabetes, sv?r regulerbar hypertension, dokumenteret s?vnapn? eller polycystisk ovariesyndrom. NAFLD/NASH er ikke en godkendt indikation i Danmark. Et systematisk review fandt at flere patienter, der opn?ede en BMI reduktion p? > 15 kg/m2 ved bariatrisk kirurgi havde forbedret histologisk inflammation og fibrose PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb3dlcjwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb3dlcjwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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ADDIN EN.CITE.DATA (53). Der blev dog ikke fundet ?ndringer i graden af steatohepatitis. Kliniske rekommandationer 4Bariatrisk kirurgi b?r ikke rutinem?ssigt tilbydes patienter med NAFLD med mindre, patienten allerede opfylder standardkriterierne for bariatrisk kirurgi. Litteraturs?gningLitteratur s?gning (April 2016): S?geord: Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, vitamin E, insulin sensitizers, pioglitazone, obeticholic acid, liraglutide, bariatric surgery. Referencer ADDIN EN.REFLIST 1.Singh S, Allen AM, Wang Z, Prokop LJ, Murad MH, Loomba R. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol. 2015;13(4):643-54 e1-9; quiz e39-40.2.Angulo P, Kleiner DE, Dam-Larsen S, Adams LA, Bjornsson ES, Charatcharoenwitthaya P, et al. Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2015;149(2):389-97 e10.3.Ekstedt M, Hagstrom H, Nasr P, Fredrikson M, Stal P, Kechagias S, et al. Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology. 2015;61(5):1547-54.4.Yamazaki H, Tsuboya T, Tsuji K, Dohke M, Maguchi H. Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes. Diabetes Care. 2015;38(9):1673-9.5.Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 2011;34(3):274-85.6.Wong RJ, Cheung R, Ahmed A. Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S. Hepatology. 2014;59(6):2188-95.7.European Association for the Study of the Liver . Electronic address eee, European Association for the Study of D, European Association for the Study of O. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016.8.Angulo P. Nonalcoholic fatty liver disease. NEnglJMed. 2002;346(16):1221-31.9.Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology. 2003;37(4):917-23.10.Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55(6):2005-23.11.Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. AmJ Gastroenterol. 1999;94(9):2467-274.12.Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41(6):1313-21.13.Bedossa P, Poitou C, Veyrie N, Bouillot JL, Basdevant A, Paradis V, et al. Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients. Hepatology. 2012;56(5):1751-9.14.Bedossa P, Consortium FP. Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease. Hepatology. 2014;60(2):565-75.15.Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004;40(6):1387-95.16.Vuppalanchi R, Jain AK, Deppe R, Yates K, Comerford M, Masuoka HC, et al. Relationship between changes in serum levels of keratin 18 and changes in liver histology in children and adults with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014;12(12):2121-30 e1-2.17.Sterling RK, Lissen E, Clumeck N, Sola R, Correa MC, Montaner J, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006;43(6):1317-25.18.Shah AG, Lydecker A, Murray K, Tetri BN, Contos MJ, Sanyal AJ, et al. Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2009;7(10):1104-12.19.Hernaez R, Lazo M, Bonekamp S, Kamel I, Brancati FL, Guallar E, et al. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology. 2011;54(3):1082-90.20.Castera L, Foucher J, Bernard PH, Carvalho F, Allaix D, Merrouche W, et al. Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology. 2010;51(3):828-35.21.Kwok R, Tse YK, Wong GL, Ha Y, Lee AU, Ngu MC, et al. Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease--the role of transient elastography and plasma cytokeratin-18 fragments. Aliment Pharmacol Ther. 2014;39(3):254-69.22.Wong VW, Vergniol J, Wong GL, Foucher J, Chan HL, Le Bail B, et al. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology. 2010;51(2):454-62.23.Yoneda M, Suzuki K, Kato S, Fujita K, Nozaki Y, Hosono K, et al. Nonalcoholic fatty liver disease: US-based acoustic radiation force impulse elastography. Radiology. 2010;256(2):640-7.24.Guibal A, Renosi G, Rode A, Scoazec JY, Guillaud O, Chardon L, et al. Shear wave elastography: An accurate technique to stage liver fibrosis in chronic liver diseases. Diagn Interv Imaging. 2016;97(1):91-9.25.Imajo K, Kessoku T, Honda Y, Tomeno W, Ogawa Y, Mawatari H, et al. Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography. Gastroenterology. 2016;150(3):626-37 e7.26.Marchesini G, Brizi M, Morselli-Labate AM, Bianchi G, Bugianesi E, McCullough AJ, et al. Association of nonalcoholic fatty liver disease with insulin resistance. AmJMed. 1999;107(5):450-5.27.Thoma C, Day CP, Trenell MI. Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review. J Hepatol. 2012;56(1):255-66.28.Promrat K, Kleiner DE, Niemeier HM, Jackvony E, Kearns M, Wands JR, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010;51(1):121-9.29.Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, Torres-Gonzalez A, Gra-Oramas B, Gonzalez-Fabian L, et al. Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis. Gastroenterology. 2015;149(2):367-78 e5; quiz e14-5.30.Ryan MC, Itsiopoulos C, Thodis T, Ward G, Trost N, Hofferberth S, et al. The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease. J Hepatol. 2013;59(1):138-43.31.American Diabetes A. Standards of medical care in diabetes--2014. Diabetes Care. 2014;37 Suppl 1:S14-80.32.Keating SE, Hackett DA, George J, Johnson NA. Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis. JHepatol. 2012;57(1):157-66.33.St GA, Bauman A, Johnston A, Farrell G, Chey T, George J. Independent effects of physical activity in patients with nonalcoholic fatty liver disease. Hepatology. 2009;50(1):68-76.34.Keating SE, Hackett DA, Parker HM, O'Connor HT, Gerofi JA, Sainsbury A, et al. Effect of aerobic exercise training dose on liver fat and visceral adiposity. J Hepatol. 2015;63(1):174-82.35.Christiansen T, Bruun JM, Madsen EL, Richelsen B. Weight loss maintenance in severely obese adults after an intensive lifestyle intervention: 2- to 4-year follow-up. Obesity(SilverSpring). 2007;15(2):413-20.36.Hill JO, Thompson H, Wyatt H. Weight maintenance: what's missing? JAmDietAssoc. 2005;105(5 Suppl 1):S63-S6.37.Centis E, Moscatiello S, Bugianesi E, Bellentani S, Fracanzani AL, Calugi S, et al. Stage of change and motivation to healthier lifestyle in non-alcoholic fatty liver disease. J Hepatol. 2013;58(4):771-7.38.Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet. 2015;385(9972):956-65.39.Sanyal AJ, Brunt EM, Kleiner DE, Kowdley KV, Chalasani N, Lavine JE, et al. Endpoints and clinical trial design for nonalcoholic steatohepatitis. Hepatology. 2011;54(1):344-53.40.Musso G, Gambino R, Cassader M, Pagano G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology. 2010;52(1):79-104.41.Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. The New England journal of medicine. 2010;362(18):1675-85.42.Hoofnagle JH, Van Natta ML, Kleiner DE, Clark JM, Kowdley KV, Loomba R, et al. Vitamin E and changes in serum alanine aminotransferase levels in patients with non-alcoholic steatohepatitis. Alimentary pharmacology & therapeutics. 2013;38(2):134-43.43.Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2012;3:CD007176.44.Klein EA, Thompson IM, Jr., Tangen CM, Crowley JJ, Lucia MS, Goodman PJ, et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Jama. 2011;306(14):1549-56.45.Boettcher E, Csako G, Pucino F, Wesley R, Loomba R. Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2012;35(1):66-75.46.Sawangjit R, Chongmelaxme B, Phisalprapa P, Saokaew S, Thakkinstian A, Kowdley KV, et al. Comparative efficacy of interventions on nonalcoholic fatty liver disease (NAFLD): A PRISMA-compliant systematic review and network meta-analysis. Medicine (Baltimore). 2016;95(32):e4529.47.Tuccori M, Filion KB, Yin H, Yu OH, Platt RW, Azoulay L. Pioglitazone use and risk of bladder cancer: population based cohort study. BMJ. 2016;352:i1541.48.Billington EO, Grey A, Bolland MJ. The effect of thiazolidinediones on bone mineral density and bone turnover: systematic review and meta-analysis. Diabetologia. 2015;58(10):2238-46.49.Armstrong MJ, Hull D, Guo K, Barton D, Hazlehurst JM, Gathercole LL, et al. Glucagon-Like Peptide 1 Decreases Lipotoxicity in Non-Alcoholic Steatophepatitis. Journal of hepatology. 2015.50.Zhang ZJ, Zheng ZJ, Shi R, Su Q, Jiang Q, Kip KE. Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and meta-analysis. The Journal of clinical endocrinology and metabolism. 2012;97(7):2347-53.51.Dongiovanni P, Petta S, Mannisto V, Mancina RM, Pipitone R, Karja V, et al. Statin use and non-alcoholic steatohepatitis in at risk individuals. Journal of hepatology. 2015;63(3):705-12.52.Zhou YY, Zhu GQ, Wang Y, Zheng JN, Ruan LY, Cheng Z, et al. Systematic review with network meta-analysis: statins and risk of hepatocellular carcinoma. Oncotarget. 2016.53.Bower G, Toma T, Harling L, Jiao LR, Efthimiou E, Darzi A, et al. Bariatric Surgery and Non-Alcoholic Fatty Liver Disease: a Systematic Review of Liver Biochemistry and Histology. Obes Surg. 2015;25(12):2280-9.Appendiks:Fibrose scoresUdregning og tolkningFibrosis 4 calculator (FIB-4) FIB-4 =alder x ASATtrombocyttal x √ALATresultat< 1,45: forudsiger ingen signifikant fibrose (F0-F2)1,45 og 3,25: gr?zone> 3,25: forudsiger signifikant fibrose (F3-F4)NAFLD fibrosis score (NFS)-1,675 + 0,037 x alder (?r) + 0,094 x BMI (kg/m2) +1,13 x forekomst af DM/IGT (ja = 1, nej = 0) + 0,99 x AST/ALT ratio -0,013 x trombocyttal (x109/l) - 0,066 x albumin (g/l)resultat< -1,455: forudsiger ingen signifikant fibrose (F0-F2 fibrosis)-1,455 og 0,675: gr?zone (indeterminate score)> 0,675: forudsiger signifikant fibrose (F3-F4 fibrose)Begge kan udregnes online p? henholdsvis og DM = diabetes mellitus; IGT = nedsat glukose toleranceTabel 3 og 4: NAFLD Activity ScoreKarakteristikaScoreVurderingSteatose0<5%15-33%2>33-66%3>66%Lobul?r Inflammation0Ingen foci1<2 foci/200x22-4 foci/200x3>4 foci/200xHepatocyt Ballooning0Ingen1F? balloon celler2Mange celler/prominent ballooningSteatose BalloneringLobul?r inflammation Diagnose19939020955000019886594422Steatose019939099695019886594422119886594422Steatose219886594422Steatose1949451905019939020891500019886594422Steatose1, 2, 31981201003300019886594422119939099695019886594422119886594422NASH219886594422NASH19939020955000019886594422Steatose219939099695019886594422119886594422NASH219886594422NASH ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.