PROPOSAL FOR M



DEENBANDHU CHHOTU RAM UNIVERSITY OF SCIENCE & TECHNOLOGY MURTHAL (SONEPAT) HARYANA

FACULTY OF ENGINEERING & TECHNOLOGY

DEPARTMENT OF BIOMEDICAL ENGINEERING

Scheme & Syllabus (Choice based Credit System)

Master of Technology (BioMedical Engineering)

w.e.f. 2018-19

May 2018

Deenbandhu Chhotu Ram University of Science & Technology, Murthal (Sonepat)

Faculty of Engineering & Technology

Department of Biomedical Engineering

Scheme of Examination- Master of Technology (Biomedical Engineering)

(Choice based Credit System)

I Semester ( wef 2018-19)

|Sr. No. |Course |Course Title|Teaching |Marks of | Exam. |Total |Credits |

| |Code | |Load |Class |marks |Marks | |

| | | | |work | | | |

TOTAL = 68 credits

MTBM501C Advanced Biomechanics

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I: Introduction

Biomechanics, Kinematics and Dynamics of Motion, Types of Motion, Kinematics Concepts, Vectors & Trigonometry, Position of Anatomical Axis & Corresponding Movements of the Body Part. Different operations on vector. Forces and moments, system of forces, resultant of system of forces in 3D and 2D. Equilibrium equations. Applications with example on human body. Work-energy equations: Applications to Biomedical system. Stress-strain diagram.

Unit II: Tissue Biomechanics

Mechanics of Hard Tissue, Musculoskeletal Soft Tissue Mechanics, Joint-articulating Surface Motion, Cochlear Mechanics, Vestibular Mechanics, Stress concentration. Mechanical properties of human bone. Mechanical properties of cortical bone, properties of cancellous bone, viscoelasticity, elastic model of bone. Mechanical testing of soft tissues.

Unit III: Gait & Biofluid Mechanics

Biofluid Mechanics: Basic Concepts; Mechanics of Heart, Lungs, Blood Vessels, Heart Valves.

Gait and Sports Biomechanics: Gait Terminology, Analysis of Gait, Exercise Physiology, Factors Affecting Mechanical Work in Humans.

Unit IV: Prosthesis & Orthosis

Prosthetics and Orthotics: Classification, Upper Limb prosthesis, Lower Limb prosthesis, Spinal Orthosis, Recent Advances in Prosthesis and Orthosis; Neural Prosthesis

Rehabilitation Engineering: Introduction to Rehabilitation, Rehabilitation Team, Principles of Assistive Technology Assessment, Sensory Rehabilitation- Tactual, Auditory, Visual, Speech.

Course Outcomes: After the completion of the course, students will be able to find and utilize sources of information concerning biomechanical research, describe the systems of instrumentation used in biomechanical research, apply anatomical and mechanical principles to the description and analysis of human movemen, demonstrate an objective and scientific approach to the study of human motion, critically analyse human movement to be able to identify normal normal and pathological gait function and the parameters integral to successful movement execution, Design and conduct a research project incorporating biomechanical data collection.

References:

1. Biomechanics-Principles & Applications by Schnek & Bronzino, CRC Press

2. Biomedical Engineering Handbook by J D Bronzino, CRC Press

3. Introduction to Biomedical Engineering by John D Enderle, Academic Press Series

4. Applied Biofluid Mechanics by Lee Waite & Jerry fine, McGraw Hill

5. Biomechanics-Principles & Applications by Peterson & Bronzino, CRC Press

6. Cytoskeletal Mechanics: Models & Measurements by Mofrad & Kamm, Cambridge Press

7. Dynamics of the Vascular System by John Li, World Scientific Publishing Co.

8. Fung Y.C., Biomechanics,Springer Verlag,1984.

9. Text book of Rehabilitation by S Sunder, Jaypee Publishers

10. The Physics of Coronary blood Flow by M Zamir, Springer Publishers

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and

sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph

papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM503C Biomaterials & Artificial Organs

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I

Polymeric materials for drug delivery systems, active and passive targeting, intelligent materials Tissue response to biomaterials - inflammation and wound healing, foreign body response, blood compatibility, implant associated infection. Pathological classification and toxicity of biomaterials. Testing of blood-materials interaction, animal models, Degradation of material in biological environments, Chemical and biochemical degradation of polymers, Degradative effects of biological environment on metals and ceramics - corrosion, environmental stress cracking.

Unit II

Good Manufacturing practice regulations, biomedical materials, quality assurance and quality control Labeling, Device failure, synthetic and biopoloymers Bioerodible materials, Host reactions to biomaterials. Sterilization of Medical devices, Advances in Sterilization Technology of clean room.

Unit III

Materials characterization - definition ; importance and application, Principles and general methods of compositional and structural characterization, techniques of X-ray, electron and neutron diffraction, EDAX, Thermal methods - DTA, TGA, DSC, DMA, temperature dependent rheology.

Microscopy - optical, electron (TEM, SEM), Atomic force microscopy, confocal laser scanning microscopy, Spectroscopy – UV-visible, fluorescence & phosphorescence IR, Raman and NMR spectroscopy, ESCA and Auger spectroscopy.

Unit IV

Artificial Blood: Modern history of transfusion and blood substitutes, oxygen carrying artificial blood, Hb-based artificial blood. Development aspects of artificial organs: Kidney, liver, heart, pancreas, liver etc.

Recent developments in Biomaterials, Legal issues related to development of biomaterials, Natural materials for various biomedical applications.

Course Outcomes: After completion of the course, learner will be able to

1. Understand the definition, classification and general applications of biomaterials. Study the surface characterization technique

2. Understand properties and applications of polymeric, degradable and composite biomaterials.

3. Understand properties and applications of metals and ceramic biomaterials.

4. Selection of materials on the basis of testing of the biomaterials done biologically, mechanically, physio-chemically and thermally before implantation in the human body.

References:

1. Biomaterial Science and Engineering: J.V. Park (Plenum Press- New York)

2. Fundaments of Biomedical Engineering: G S. Sawhney (New Age International Publication)

3. Biomaterial Science: An Introduction to Materials in Medicine, Ratner & Hoffmann

4. American Atlas of Orthopedics: Prosthetics, C. V. Mosby.

5. American Atlas of Orthopedics: Orthotics, C. V. Mosby

6. Basics of Biomechanics by Ajay Bahl, Jaypee publications

7. Encyclopedia of Medical Devices and Instrumentation: John G. Webster. Vol. I, II, III, IV

(Marcel Dekkar Pub).

8. Encyclopedia – Handbook of Biomaterials and Bioengineering: Part-A: Materials Vol I, II

(Marcel Dekkar Pub) Part – B: Applications Vol. I, II.

9. Design Engineering on Biomaterials for medical devices: David Hill, John Willey Publication

10. Biological Performance of Materials, 2nd Edition – Jonathan Black, Marcel Dekker Inc. New

York.Basel. Hong Kong

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

1. The use of programmable devices such as programmable calculators, phones etc. and

sharing of any material during examination are not allowed.

2. A specific note shall be inserted in relevant question paper wherever the use of graph

papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM505C Design Principles of Medical Devices (Elective I)

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I: Introduction to Biomedical Engineering Design

Essentials of Design, Idea generation, Design management, Product definition, Product documentation, Product development, structured and unstructured design techniques.

Unit II: Product design and material selection

Computer aided design process, rapid prototyping, industrial design, Biocompatibility, international regulatory efforts, biological control tests, Safety analysis in design.

Unit III: Product testing and Quality Control

Prototyping and testing, premarket testing and validation, drug development and clinical trials, system testing, regulation and standards, manufacturing and quality control.

Unit IV: Design Case Studies

Multi-detector brain scanning system, testing of anesthetists, apnea detection system, cancer clinic charting, EKG analysis techniques, choosing the correct plastic material.

Course Outcomes: At the end of this course, students will be able to

1. Have an understanding of the multi- and inter-disciplinary nature of the medical device field.

2. Understand advanced concepts and theories of biocompatibility and quality control.

3. Apply knowledge in a rational way to analyze a particular problem.

4. Conduct coherent and thorough analyses of complex problems using established techniques/principles and judgment.

5. Communicates (oral and/or written) ideas, issues, results and conclusions clearly and effectively in relation to medical device design.

References:

1. P. H. King, R. C. Fries, “Design of biomedical devices and systems”, CRC Press, 2003.

2. Richard C. Fries, “Reliable Design of Medical Devices”, CRC Press, 2013.

3. Carl T. DeMarco, “Medical Device Design and Regulation”, ASQ Quality Press, 2011.

4. Richard C. Fries, “Handbook of Medical Device Design”, CRC Press, 2000

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and

sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph

papers, semilog papers, steam tables, etc. shall be allowed during examination

.

MTBM507C Human Physiology (Elective I)

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03Hours Credits : 03

Unit I

General Physiology: Body fluids, Membrane Potential & Action Potentials, Functional Morphology of cell, Homeostasis & Ageing.

Physiology of Muscular Tissue: Nerve, Skeletal Muscle, Cardiac Muscle, Smooth Muscle, functional classification of joints, physiology of muscle contraction and sliding filament model, Muscle twitches and tetanus.

Unit II

Circulation: Erythropoiesis, Circulating Body fluids, Origin of the Heart beat & the electrical activity of the Heart, the Heart as a pump, Dynamics of Blood and Lymph flow, Cardiovascular Regulatory Mechanisms, Circulation through special regions, and Nervous control of Heart.

Respiration: Pulmonary function, Gas transport between the lungs and tissues, Regulation of Breathing and action of brain, Disturbance of respiration function, Cardio-pulmonary Resuscitation

Unit III

Gastrointestinal Function: Innervations of GIT, Secretion, GI motility, Digestion and Absorption, Functions of Liver & LFT (Liver Function Testing).

Excretory System: Formation and excretion of urine, Regulation of extracellular fluid composition & volume.

Unit IV

Neurophysiology and special senses: Synaptic transmission and Neuronal integration, Nervous system organisation and Reflexes, Neurophysiology of Vision, Mechanism of Hearing – Auditory pathway.

General Pathology: cell injury-causes and mechanism, Acute and chronic inflammation and repair, Mechanism of adaptive immunity.

Course Outcomes: After the completion of the course, the students will be aware of the structure and functioning of human body, the concepts of which are essential for any studies or work related to biomedical engineering. Since all the devices and engineering is related to human body is the field.

References:

1. Arthur.C.Guyton – Textbook of Medical Physiology – Prism Book (p) Ltd. 1996.

2. CL.Ghai – A textbook of Practical physiology – 5th Ed Jaypee Medical Publishers, 2003

3. Sarada Subramanyam, K.Madhavan Kutty and H.D.Singh – Text book of ‘Human

Physiology – S.Chand & Company, 1996

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and

sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph

papers, semilog papers, steam tables, etc. shall be allowed during examination

.

MTBM509C Biomedical Ethics & Patient Safety (Elective I)

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03Hours Credits : 03

Unit I: Introduction to Medical Ethics

Definition of Medical ethics, Scope of ethics in medicine, American medical Association code of ethics, CMA code of ethics- Fundamental Responsibilities ,The Doctor And The Patient, The Doctor And The Profession, Professional Independence, The Doctor And Society. Ethical Theories & Moral Principles - Theories-Deontology & Utilitarianism ,Casuist theory, Virtue theory, The Right Theory. Principles, Non- Maleficence, Beneficence, Autonomy, Veracity, Justice. Autonomy & Confidentiality issues in medical practice, Ethical Issues in biomedical research ,Bioethical issues in Human Genetics & Reproductive Medicine

Unit II: Hospital Accreditation & Safety Standards

Accrediation- JCI Accreditation & its Policies. Patient centered standards, Healthcare Organization management standards -Indian Perspective. Hospital Safety Standards - Life Safety Standards- Protecting Occupants, Protecting the Hospital From Fire, Smoke, and Heat, Protecting Individuals From Fire and Smoke, Providing and Maintaining Fire Alarm Systems, Systems for Extinguishing Fires Environment of Care Standards-Minimizing EC Risks, Smoking Prohibitions, Managing Hazardous Material and Waste, Maintaining Fire Safety Equipment, Features, Testing, Maintaining, and Inspecting Medical Equipment.

Unit III: Medical Equipment Safety Standards

General requirements for basic safety & essential performance of medical equipments.IEC 60601 standards- Base Standard-general requirement of electrical medical devices, Collateral StandardsEMC radiation protection &programmable medical device system, Particular Standards-type of medical device

Unit IV: Device Regulation

Classification and requirements of medical devices, Harmonized Standards, CE approval, Quality Assurance and Quality - Definition of quality, quality management, principles of TQM, measures for quality control. Safety & Testing of Medical devices. Patenting

Course Outcomes: Upon completion of this course the student should be able to demonstrate a measurable increase in their knowledge, skills and abilities related to:

1. Legal and professional guidelines for the health professions

2. Public duties and consent

3. Guidelines to obtain medical standards in hospitals

References:

1. Biomedical Ethics: A Canadian Focus. Johnna Fisher (ed.), Oxford University Press Canada 2009.

2. Bioethics-―An Introduction for the biosciences‖, 2 nd edition 2008, Ben Mepham, Oxford.

3. Domiel A Vallero ―Biomedical Ethics for Engineers‖, Elsevier Pub.1st edition, 2007

4. Joint Commission Accreditation Standards for Hospitals ,2 nd edition 2003

5. NilsHoppe and JoseMiola - Medical law and Medical Ethics - Cambridge University Press-2014

6. Physical Environment Online: A Guide to The Joint Commission‗s Safety Standards is published by HCPro, Inc. 2010

7. Robert M Veatch‖ Basics of Bio Ethics‖, Second Edition. Prentice- Hall,Inc 2003

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and

sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph

papers, semilog papers, steam tables, etc. shall be allowed during examination

.

MTBM511C Medical Robotics (Elective I)

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03Hours Credits : 03

Unit I: Introduction

Minimally invasive surgery and robotic integration, Definitions and development of surgical robotic systems, Perceptual docking for synergistic control, Conclusions and future trends, Localization and tracking technologies for medical robotics, Requirements for position, Dynamic referencing, Types of position sensors, Future trends

Unit II: Robotics for neurosurgery, Cardiovascular Interventions, Orthopaedics and ENT

Introduction to neurosurgical progression, The evolution of neurosurgical robots, Maintaining operator control, Human–machine interface (HMI), Heart conditions and the evolving role of cardiac surgeons and cardiologists, Surgical robot requirements and availability for cardiovascular interventions, Proposed novel robots for cardiovascular interventions, Existing orthopaedic robotic systems, Evaluation of impact of orthopaedic surgical robots, Robotic-assisted knee replacement surgery, Apex robotic technology (ART), Robotics in ear, nose and throat (ENT) surgery, Telemanipulators in ENT, Image-guided interventions, Computer numerical control (CNC)

Unit III: Robot-assisted vitreoretinal surgery, MIS and Ensoscopy

Requirements for vitreoretinal surgery, Master console, Slave robot, Robotics for minimally invasive surgery (MIS) and natural orifice transluminal endoscopic surgery (NOTES), Minimally invasive surgery (MIS), Natural orifice transluminal endoscopic surgery (NOTES), Mesoscale mobile robots for gastrointestinal minimally invasive surgery (MIS), Commercial gastrointestinal wireless capsule endoscopes, Robotic capsule modules

Unit IV: Magnetic Robots and Ethical Issues

Real-time software platform using MRI for in vivo navigation of magnetic microrobots, Magnetic resonance imaging (MRI) navigation, Microrobot navigation, Types of robotic surgery, patient experience of robotic surgery, marketing of robotic surgery, Comparing robotic surgery with other types of surgery, need for training, Costs versus benefits, Ethical issues relating to remotely operated surgery, the automated hospital

Course Outcomes: By the end of this class, the students will:

1. Identify and describe different types of medical robots and their potential applications

2. Know basic concepts in kinematics, dynamics, and control relevant to medical robotics

3. Develop the analytical and experimental skills necessary to design and implement robotic assistance for both minimally invasive surgery and image-guided interventions

4. Be familiar with the state of the art in applied medical robotics and medical robotics research

5. Understand the various roles that robotics can play in healthcare

6. Create a compelling proposal for a new medical robot technology

References:

1. Paula Gomes, “Medical Robotics”, Elsevier Woodhead publishing Series, 1st Edition2012.

2. Vanja Bozovic, “Medical Robotics”, I-Tech Education & Publishing, 2008

3. Schweikard, Achim, Ernst, Floris, “Medical Robotics”, Springer

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and

sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph

papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM513C Biomathematics (Elective II)

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I: Descriptive statistics & Introduction to Probability

Scope & Purpose of statistics, population and sample, data, data sources, data presentation, numerical summaries of data. Random experiments, concept of probability, axioms and theorem of probability, conditional probability, Bayes’ theorem, special probability distributions.

Unit II: Hypothesis testing & Analysis of variance

Statistical hypothesis, type I and type II errors, one tailed and two tailed tests, P value, Chi-square test for goodness of fit, student’s t-test, quality control charts. Purpose of analysis of variance, one-way classifications & two way classifications, experimental design.

Unit III: Regression, Correlation & Linear Programming Problems

Linear regression, method of least squares, multiple regression, generalized correlation coefficient, probability interpretation of regression and correlation. Introduction & formations of the problems, graphical method, simplex method, duality concept in LPP & solution of the dual.

Unit IV: Mathematical Modeling

Mathematical modeling and solution of biomedical problems namely respiratory rate, blood flow, cardiac output and impedance diffusion, ultra filtration etc.

Course Outcomes: At the end of this course, students will be able to

1. understand advanced concepts of hypothesis testing and mathematical modelling.

2. apply biostatistical knowledge to real-life problems in medical research.

3. conduct coherent and thorough analyses of complex problems using established techniques/principles of biostatistics.

4. interpret and communicate the results of statistical analysis, orally and in writing

References:

1. Fundamentals of Biostatistics by Bernard Rosner 7th ed., 2010, (BROOKS/ COLE Cengage learning)

2. Modern Medical Statistics: A Practical Guide by Brian S. Everitt, (Edward Arnold, 2003)

3. Biostatistics by S. Prasad , (S.Chand Publishers)

4. Statistical Methods for the Analysis of Biomedical Data, 2nd Edition by Robert F. Woolson, and William R. Clarke , (Wiley - Interscience, 2nd edition, 2002)

5. An Introduction to Medical Statistics, Third Edition, Martin Bland, (Oxford Medical Publications)

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and

sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph

papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM515C Electronics for Biomedical Engineering (Elective II)

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I: Circuit Elements

Resistance, capacitor, inductor and power sources (dependent and independent), parallel and serial combination of circuit elements. DC circuits: Ohm’s law, KCL & KVL, current and voltage division rules, power distribution in circuit elements, network theorems.

Unit II: AC fundamentals

Sinusoidal AC Voltage Characteristics and Definitions, Phase Relations, Elementary concepts of Energy Meter, Watt Meter, Volt Meter and Ammeter. The Basic Elements and Phasors: Response of Basic R, L and C Elements to sinusoidal signals, concept of Average Power and Power Factor. Series and parallel AC circuits.

Unit III: Diodes

Biasing the Diode, Voltage - Current Characteristic, Half Wave and Full Wave Rectifiers, Special Purpose Diodes: Zener diode, Photo diode, Light Emitting Diode & varactor diodes. Transistors: BJTs, FETs & MoSFETs.

Unit IV: Operational amplifiers

Op-amp parameters, feedback configurations, integrator and differentiator configurations, comparators. Non-linear Applications: Active filters (LPF, HPF, BPF, BRF), Multivibrators, waveform generators, 555 timer.

Course Outcomes: At the end of this course, students will be able-

1. to get basic idea about types, specification and common values of active/passive components.

2. to familiarize the working and characteristics of diodes, transistors, MOSFETS.

3. to understand working of diodes in circuits and in rectifiers.

4. to understand working of op-amp in amplifiers and special circuits.

References:

1. Millman & Grabel: Microelectronics, McGraw Hill International, 2nd edition.1988.

2. Ramakant A. Gayakwad, Op-Amp and Linear Integrated Circuits”, Pearson Education Asia. 4th ed

3. Sedra & Smith: Microelectronic circuits, Oxford University Press. 5th ed.

4. Abhijit Chakrabarti: Circuit Theory : Analysis and Synthesis, Dhanpat Rai & Co

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and

sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph

papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM517C Radiodiagnosis & Therapy Techniques (Elective II)

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I: Radiotherapy Physics & Pre-treatment Imaging

Atoms, nuclei and radioactivity- Radiation interactions with matter- Radiation measurement and detection- Imaging with X-ray, MRI and ultrasound-Imaging with radio nuclides- Therapy with unsealed radio nuclides-Radiotherapy beam production.

Unit II: Radiation Treatment planning

Immobilization, localization and verification techniques- Principles and practice of radiation treatment planning- Brachytherapy-Networking, data and image handling and computing in radiotherapy- Quality management in radiotherapy.

Unit III: Radiotherapy Effects

Epidemiology of cancer-screening- Biological and pathological introduction-Molecular, cellular and tissue effects of radiotherapy- Principles and management of patients with cancer- Chemotherapy and hormones- Skin and lip cancer-head and neck cancer

Unit IV: Radiotherapy Assisting Devices

Features of conventional simulator and modern simulator – Immobilization equipment for head, neck, pelvic and extremities. Cobalt units, Gamma knife, Linear accelerators, Helical tomotheraphy, Ancillary equipment – Superficial and ortho voltage equipment

Course Outcomes: After completion of the course, learner will be able to

1. Understand the basics of radiotherapy physics.

2. Have in depth knowledge about the different pretreatment imaging and treatment verification

and radiotherapy effects.

3. Understand the function of various types of Radiotherapy equipments

References:

1. Symonds, Deehan, Meredith & Mills Walter and Miller, “Textbook of Radiotherapy: Radiation Physics, Therapy and Oncology”, Churchill Livingstone, Seventh Edition, 2012.

2. Pam Cherry, Angela Duxbury, “Practical Radiotherapy-Physics and Equipment”, John Wiley & Sons, Second Edition, 2009.

3. Todd Powliki, Peter Dunscombe B, Arno J, Mundt, Pierre Scalliet, “Quality and safety in radiotherapy”, CRC Press, First Edition, 2010.

4. Subramania Jayaraman, Lawrence Lanzl H, “Clinical Radiotherapy Physics”, CRC Press, Second Edition, 1996.

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM519C BioMEMS and Microsystems (Elective II)

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I: Introduction to MEMS: micro- and nano-scale size domains; scaling of physical laws, MEMS materials and processes, MEMS devices and applications

Unit II: Introduction to Submicron Technology: semiconductor materials, photolithography, doping, thin film growth and deposition, CVD and Ion Implantation, metallization, wet and dry etching, silicon micromachining, metal MEMS processes, submicron optical lithography, electron beam lithography, soft lithography and printing.

Unit III: MEMS Sensors and Actuators: mechanics including elasticity, beam bending theory, membranes/plates, microactuators based on various principles, electrostatic, electromagnetic, piezoelectric and SMA, actuator applications e.g. inkjet, electrical and optical switching; physical sensors e.g. acceleration, strain, flow; chemical sensors.

Unit IV: Microfluidics: transport in micro-channels; microfluidic components (filters, mixers, valves, and pumps), BioNano (Materials and processes for BioMEMS, Applications: µTAS, Biochips)

Course Outcomes: At the end of this course, students will be able-

1. to understand the basic science behind the design and fabrication of nano scale systems.

2. to understand and formulate new engineering solutions for current fabrication problems .

3. to design a system, component, or process to meet desired needs within realistic constraints .

4. to gather detailed knowledge of the operation of fabrication and characterisation

References:

1. Foundations of MEMS, Chang Liu, Prentice Hall (2006)

2. Fundamentals of Micro fabrication, Marc Madou, CRC (2002)

3. Introduction to BioMEMS – Albert Folch, CRC (2012)

4. Fundamentals of BioMEMS and Medical Microdevices, Steven S. Saliterman, SPIE Publications (2006)

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM521C Advanced Biomechanics Lab

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

- - 4 Practical : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 02

List of Experiments

1. To perform stress strain analysis of lower limb using BIOPAC.

2. To perform stress strain analysis of upper limb using BIOPAC.

3. To determine the hardness of given bone using hardness tester/UTM.

4. To determine the moment of Inertia of a stepped pulley or a flywheel.

5. To study recording and analysis of EMG signals using Biopac MP-100 system available in the laboratory.

6. To verify Bernoulli’s Theorem, for fluid flow through pipes.

7. To perform cardio- EMG analysis using ergometry and TMT system available in the laboratory.

8. To determine muscle force using dynamometer.

9. To analyse EMG signal using Advance Biofeedback system available in the laboratory.

10. To determine the center of gravity of human body.

11. To analyse the motion of joint using human skeleton

12. To study human Gait & its analysis techniques

13. To study the exercise physiology of human body

Note: 1. Each laboratory class/ section shall not be more than 20 students.

2. To allow fair opportunity of practical hands-on experience to each student, each experiment may either be done by each student individually or in a group of not more than 3-4 students. Larger groups be strictly discouraged/ disallowed.

3. Pre-experimental and post-experimental quiz/ questions may be offered for each lab experiment to reinforce and aid comprehension of the experiment.

MTBM523C Cell & Biomaterials Lab

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

- - 4 Practical : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 02

List of Experiments

1. To study the Basic Lab Skills.

2. To perform colorimetric protein Assay using Spectrophotometer.

3. To perform fabrication of biomaterials taking example of polymeric beads.

4. To perform FTIR characterization of biomaterials,

5. To study Scanning Electron Microscopy.

6. To perform tensile testing of biomaterials Using Instron Mechanical Tester

7. To study basic techniques in Mammalian Cell Culture.

8. To perform MTT Assay to study toxicity.

9. To study Microencapsulation Techniques.

10. To perform DNA Quantization Assay Using Spectrofluorometer.

11. To perform Flow Cytometry Analysis

Note: 1. Each laboratory class/ section shall not be more than 20 students.

2. To allow fair opportunity of practical hands-on experience to each student, each experiment may either be done by each student individually or in a group of not more than 3-4 students. Larger groups be strictly discouraged/ disallowed.

3. Pre-experimental and post-experimental quiz/ questions may be offered for each lab experiment to reinforce and aid comprehension of the experiment.

MTBMRM521C Research Methodology and IPR

M.Tech. Semester – I (Biomedical Engineering)

L T P Class Work : 25 Marks

2 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I

Meaning of research problem, Sources of research problem, Criteria Characteristics of a good research problem, Errors in selecting a research problem, Scope and objectives of research problem.

Approaches of investigation of solutions for research problem, data collection, analysis, interpretation, Necessary instrumentations.

Unit II

Effective literature studies approaches, analysis Plagiarism, Research ethics, Effective technical writing, how to write report, Paper Developing a Research Proposal, Format of research proposal, a presentation and assessment by a review committee .

Unit III

Nature of Intellectual Property: Patents, Designs, Trade and Copyright. Process of Patenting and Development: technological research, innovation, patenting, development. International Scenario: International cooperation on Intellectual Property. Procedure for grants of patents, Patenting under PCT.

Unit IV

Patent Rights: Scope of Patent Rights. Licensing and transfer of technology. Patent information and databases. Geographical Indications New Developments in IPR: Administration of Patent System. New developments in IPR; IPR of Biological Systems, Computer Software etc. Traditional knowledge Case Studies, IPR and IITs.

Course Outcomes: At the end of this course, students will be able to

1. Understand research problem formulation.

2. Analyze research related information.

3. Follow research ethics.

4. Understand the notion that tomorrow world will be ruled by ideas, concept, and creativity.

5. Understand that IPR protection provides an incentive to inventors for further research work

References:

1. Stuart Melville, “Research methodology: an introduction for science & engineering students’”

2. Wayne Goddard and Stuart Melville, “Research Methodology: An Introduction”

3. Ranjit Kumar, 2nd Edition, “Research Methodology: A Step by Step Guidefor beginners”

4. Halbert, “Resisting Intellectual Property”, Taylor & Francis Ltd ,2007.

5. Niebel, “Product Design”, McGraw Hill, 1974.

6. Asimov, “Introduction to Design”, Prentice Hall, 1962.

7. Robert P. Merges, “ Intellectual Property in New Technological Age”, 2016.

8. T. Ramappa, “Intellectual Property Rights Under WTO”, S. Chand, 2008

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and

sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph

papers, semilog papers, steam tables, etc. shall be allowed during examination

|AUD531C: ENGLISH FOR RESEARCH PAPER WRITING (AUDIT COURSE 1 & 2) |

|M. Tech. Semester – I/II (Biomedical Engineering) |

|L |P |Credits | |Class Work |: |25Marks |

|2 |-- |-- | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

Students will be able to:

1. Understand that how to improve your writing skills and level of readability,

2. Learn about what to write in each section,

3. Understand the skills needed when writing a Title, and

4. Ensure the good quality of paper at very first-time submission

Course Outcomes:

The Students will become conscious citizens of India aware of their duties, rights and functions of various bodies of governance and welfare; thereby well equipped to contribute to India.

Syllabus contents:

UNIT I: Basics of Writing Skills:

Subject Verb Agreements; Parallelism; Structuring Paragraphs and Sentences; Being Concise and Removing Redundancy; Avoiding Ambiguity and Vagueness; Dangling Modifiers

UNIT II: Reviewing and Citation:

Clarifying Who Did What; Highlighting Your Findings from Literature; Hedging and Critiquing; Paraphrasing; Avoiding Plagiarism; Formatting and Citation (Publication Manual of the American Psychological Association)

UNIT III: Sections of a Research Paper:

Writing Effective and Impressive Abstract; Writing Introduction; Review of Literature; Defining Objectives of the Study; Methodology Adopted; Results Obtained; Discussion and Conclusion; Editing and Proof Reading to Ensure Quality of paper

UNIT IV: Oral Presentation for Academic Purposes:

Oral Presentation for Seminars, Conferences and Symposiums; Poster Presentation; Choosing AppropriateMedium; Interaction and Persuasion

TEXT / REFERENCE BOOKS:

1. Goldbort R (2006) Writing for Science, Yale University Press (available on Google Books).

2. Day R (2006) How to Write and Publish a Scientific Paper, Cambridge University Press.

3. Highman N (1998), Handbook of Writing for the Mathematical Sciences, SIAM. Highman’sbook.

4. Adrian Wallwork, English for Writing Research Papers, Springer, New York Dordrecht Heidelberg London, 2011

5. Mc Murrey,David A. and Joanne Buckley. Handbook for Technical Writing. New Delhi: Cengage Learning, 2008.

NOTE:

1. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

|AUD533C: DISASTER MANAGEMENT (AUDIT COURSE 1 & 2) |

|M. Tech. Semester – I/II (Biomedical Engineering) |

|L |P |Credits | |Class Work |: |25Marks |

|2 |-- |-- | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

1. Learn to demonstrate a critical understanding of key concepts in disaster risk reduction and humanitarian response

2. Critically evaluate disaster risk reduction and humanitarian response policy and practice from multiple perspectives

3. Develop an understanding of standards of humanitarian response and practical relevance in specific types of disasters and conflict situations

4. Critically understand different aspects of disaster management

Course Outcomes:

A student will be able to:

1. Know the significance of disaster management,

2. Study the occurrences, reasons and mechanism of various types of disaster

3. Learn the preventive measures as Civil Engineer with latest codal provisions

4. Apply the latest technology in mitigation of disasters

Syllabus contents:

UNIT I: Introduction to Disaster Management: Definitions: Disaster, Emergency, Hazard, Mitigation, Disaster Prevention, Preparedness and Rehabilitation, Risk and Vulnerability, Classification of Disaster, Natural and Man made Disasters, Disaster Management Act 2005, Role of NDMA, NDRF, NIDM

Risk and Vulnerability to disaster mitigation and management options: Concept and Elements, Risk Assessment, Vulnerability, Warning and Forecasting.

UNIT II: Hydro-meteorological based disasters I: Tropical Cyclones, Floods, droughts, mechanism, Causes, role of Indian Metrological Department, Central Water Commission, structure and their impacts, classifications, vulnerability, Early Warning System, Forecasting, Flood Warning System, Drought Indicators, recurrence and declaration, Structural and Non-structural Measures.

Hydro-meteorological based disasters II: Desertification Zones, causes and impacts of desertification, Characteristics, Vulnerability to India and Steps taken to combat desertification, Prevention.

UNIT III: Geological based disasters: Earthquake, Reasons, Direct and Indirect Impact of Earthquake; Seismic Zones in India, Factors, Prevention and Preparedness for Earthquake, Tsunamis, Landslides and avalanches: Definition, causes and structure; past lesson learnt and measures taken; their Characteristic features, Impact and prevention, structural and non-structural measures.

UNIT IV: Manmade Disasters I: Chemical Industrial hazards; causes and factors, pre- and post disaster measures; control ; Indian Standard Guidelines and Compliance; Oil Slicks and Spills, Outbreak of Disease and Epidemics, Traffic accidents; classification and impact, War and Conflicts; Fire risk assessment; Escape routes; fire fighting equipment;

Use of remote sensing and GIS in disaster mitigation and management.

TEXT / REFERENCE BOOKS:

1. Thomas D. Schneid., Disaster Management and Preparedness, CRC Publication, USA, 2001

2. Patrick Leon Abbott, Natural Disasters, Amazon Publications, 2002

3. Ben Wisner., At Risk: Natural Hazards, People vulnerability and Disaster, Amazon Publications, 2001

4. Oosterom, Petervan, Zlatanova, Siyka, Fendel, Elfriede M., “Geo-information for Disaster Management”, Springer Publications, 2005

5. Savindra Singh and Jeetendra Singh, Disaster Management, Pravalika Publications, Allahabad

6. Nidhi GaubaDhawan and AmbrinaSardar Khan, Disaster Management and Preparedness, CBS Publishers & Distribution

7. Selected Resources Published by the National Disaster Management Institute of Home Affairs, Govt. of India, New Delhi.

NOTE:

1. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

|AUD535C: SANSKRIT FOR TECHNICAL KNOWLEDGE (AUDIT COURSE 1 & 2) |

|M. Tech. Semester – I/II (Biomedical Engineering) |

|L |P |Credits | |Class Work |: |25Marks |

|2 |-- |-- | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

1. To get a working knowledge in illustrious Sanskrit, the scientific language in the world

2. Learning of Sanskrit to improve brain functioning

3. Learning of Sanskrit to develop the logic in Mathematics, Science & other subjects

4. Enhancing the memory power

Course Outcomes:

Students will be able to

1. Understand basic Sanskrit language

2. Understand Ancient Sanskrit literature about science and technology

3. Get equipped with Sanskrit and explore the huge knowledge from ancient literature

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TEXT / REFERENCE BOOKS:

1. “Abhyaspustakam” – Dr.Vishwas, Samskrita-Bharti Publication, New Delhi

2. “Teach Yourself Sanskrit” Prathama Deeksha-VempatiKutumbshastri, Rashtriya Sanskrit Sansthanam, New Delhi Publication

3. “India’s Glorious Scientific Tradition” Suresh Soni, Ocean books (P) Ltd., New Delhi.

NOTE:

1. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

|AUD537C: VALUE EDUCATION (AUDIT COURSE 1 & 2) |

|M. Tech. Semester – I/II (Biomedical Engineering) |

|L |P |Credits | |Class Work |: |25Marks |

|2 |-- |-- | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

The students will be able to

1. Understand value of education and self- development

2. Imbibe good values in students

3. Let the should know about the importance of character

Course Outcomes:

The students will be able to

1. Knowledge of self-development

2. Learn the importance of Human values

3. Developing the overall personality

4. Strengthen the “EQ”

Syllabus contents:

Unit I: Hierarchy and Classification of values,

Values and Belief Systems, Competence in professional ethics,

Value judgment based on cultural, tradition and interdependence.

Unit II: Need for value education

Sense of duty.Devotion, Self-reliance.

Honesty, Humanity, trust.Patriotism and national Unity.

Harmony in the nature and realization of coexistence

Vision of better India

Unit III: Understanding the meaning and realizing the effect of the following:

Aware of self- destructive habits, Knowledge, Acceptance, Love, Situations, happiness, Bliss, Peace,Power, Purity , Realization, Assertiveness, Regard, Respect, Sensitive, Divinity, emotions, Repentance, hurt, Ego, Attachment, worry, Resentment, Fear, Anxiety, Greed, Criticism, Tension, Frustration, Expectation, Irritation, Anger, Guilt, Jealous, Pear Pressure, True Friendship, Cooperation -Coordination- competition.

Enhancing self esteem and personality.

Unit IV: Hinduism, Jainism, Buddhism, Christianity, Islam, Sikhism.

Self-management and Good health ( Role, Responsibility, Relation, Routine, Requirements, Resources)

My True self and Original qualities.Supreme-soul- source of values.

What Scientists say about super power?

TEXT / REFERENCE BOOKS:

1. Chakroborty, S.K. Values and Ethics for organizations Theory and practice. Oxford University Press, New Delhi.

2. R R Gaur, R Sangal, G P Singh.Human Values and Professional Ethics. Excell Books, New Delhi.

3. Value Education in Spirituality- Course-I, course -II by Brahma Kumaris Education Wing, RajyogaEducation & Research Foundation, Mount Abu, Rajasthan.

4. True Management: I K International Publication 2018.

NOTE:

1. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

|AUD539C: CONSTITUTION OF INDIA (AUDIT COURSE 1 & 2) |

|M. Tech. Semester – I/II (Biomedical Engineering) |

|L |P |Credits | |Class Work |: |25Marks |

|2 |-- |-- | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

Students will be able to:

1. Understand the premises informing the twin themes of liberty and freedom from a civil rights perspective.

2. To address the growth of Indian opinion regarding modern Indian intellectuals’ constitutional role and entitlement to civil and economic rights as well as the emergence of nationhood in the early years of Indian nationalism.

3. To address the role of socialism in India after the commencement of the Bolshevik Revolution in 1917 and its impact on the initial drafting of the Indian Constitution.

Course Outcomes:

The Students will become conscious citizens of India aware of their duties, rights and functions of various bodies of governance and welfare; thereby well equipped to contribute to India.

Syllabus contents:

Unit I: Making of the Indian Constitution and its Philosophy

Sources of Indian Constitution, its Preamble and Salient Features.

Unit II: Constitutional Rights & Duties

Fundamental Rights: Right to Equality, Right to Freedom, Right against Exploitation, Right to Freedom of Religion, Cultural and Educational Rights, Right to Constitutional Remedies

Fundamental Duties

Unit III: Organs of Governance

Legislature: Parliament and its Composition; Qualifications and Disqualifications of Its members

Executive: President, Governor and Council of Ministers

Judiciary: Appointments, Qualifications, Powers and Functions of judges

Unit IV: Local Administration and institutes for welfare

District Administration Head: Role and Importance; Municipalities: Introduction, Mayor and role of Elected Representative

Panchayati Raj Institutions: Introduction, Gram Panchayat, Panchayat Samiti and Zila Panchayat

Institutes and Bodies for the welfare of SC/ST/OBC and women

TEXT / REFERENCE BOOKS:

1. The Constitution of India, 1950 (Bare Act), Government Publication.

2. Dr. S. N. Busi, Dr. B. R. Ambedkar. Framing of Indian Constitution, 1st Edition, 2015.

3. M. P. Jain, Indian Constitution Law, 7th Ed., Lexis Nexis, 2014

NOTE:

1. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

|AUD541C: PEDAGOGICAL STUDIES (AUDIT COURSE 1 & 2) |

|M. Tech. Semester – I/II (Biomedical Engineering) |

|L |P |Credits | |Class Work |: |25Marks |

|2 |-- |-- | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

The course will enable the student teachers:

1. To understand the concept of pedagogy and conceptual framework.

2. To gain insight on the meaning and nature of different pedagogies.

3. To determine aims and strategies of teaching- learning.

4. To understand the principals, maxims of successful teaching and the different methods of teaching.

5. Comprehend the need and importance of various devices of teaching and learning and their relationship between the two.

6. Point out and illustrate the difference between teaching and learning and their relationship between the two.

7. To appreciate that science/ engineering is a dynamic and expanding body of knowledge.

Course Outcomes:

Students will be able to understand:

1. It will improve teaching effectiveness of prospective teachers.

2. A prospective teacher will be able to design curriculum and assess the curriculum of their discipline in an effective way by understating the needs of the learners.

3. How can teacher education, school curriculum and guidance support effective pedagogy?

4. It will be functional for professional development among teachers.

Syllabus contents:

Unit I: Introduction and Methodology

• Aims and Rationale, Conceptual Framework, Terminology related to Pedagogy

• Contexts, Research Questions

• Theories of Learning, Curriculum, Scope of Pedagogy

Unit II: Teaching

• Meaning and importance of Behavioral Objectives

• Writing of Objectives in Behavioral Terms

• Phases and Variables of Teaching

• Principles, levels and maxims off teaching

• Relationship between Teaching and Learning

Unit III: Methods of Teaching

• Methods: Inductive, Deductive, Project, Analytic, Synthetic, Brain Storming, Case Discussion

• Concept and Significance of Individualized and Cooperative Teaching-Language Laboratory, Tutorials, Keller’s Plan (PSI), Computer Supporting Collaborative Learning

• Mastery Learning: Concept, Basic Elements, Components and Types of Mastery Learning Strategies

Unit IV: Evaluation Strategies

• Evaluation in Teaching: Concept of Evaluation, Relationship between Teaching and Evaluation, Types of Evaluation (Formative and Summative)

• Methods of Evaluation through Essay Type. Objective Type and Oral Method, Comparative merits and demerits of evaluation methods

• Latest Trends in Evaluation

TEXT / REFERENCE BOOKS:

1. Ackers J, Hardman F (2001) Classroom interaction in Kenyan primary schools, Compare, 31 (2): 245-261.

2. Agrawal M (2004) Curricular reform in schools: The importance of evaluation, Journal of

Curriculum Studies, 36 (3): 361-379.

3. Akyeampong K (2003) Teacher training in Ghana - does it count? Multi-site teacher education research project (MUSTER) country report 1. London: DFID.

4. Akyeampong K, Lussier K, Pryor J, Westbrook J (2013) Improving teaching and learning of basic maths and reading in Africa: Does teacher preparation count? International Journal Educational Development, 33 (3): 272–282.

5. Alexander RJ (2001) Culture and pedagogy: International comparisons in primary education. Oxford and Boston: Blackwell.

6. Chavan M (2003) Read India: A mass scale, rapid, ‘learning to read’ campaign.

7. images/resource%20working%20paper%202.pdf.

8. Dyer C (2008) Early years literacy in Indian urban schools: Structural, social and pedagogical issues, Language and Education, 22 (5): 237-253.

9. Sharma N (2013) An exploration of teachers’ beliefs and understanding of their pedagogy, MPhil thesis, Mumbai: TATA Institute of Social Sciences.

10. Zeichner K, Liston D (1987) Teaching student teachers to reflect, Harvard Educational Review, 56 (1): 23-48.

11. Watkins C, Mortimore P (1999) Pedagogy: What do we know? In Mortimore P (ed.) Understanding pedagogy and its impact on learning. London: Paul Chapman Publishing.

12. Tyler R (1949) Basic principles of curriculum and instruction. Chicago: Chicago University Press.

13. Arends, R.1. ( 1 994) Learning to Teach, New York: McGraw-Hill.

14. Lunenberg M, Korthagen F, Swennen A (2007) The teacher educator as a role model, Teaching and Teacher Education, 23: 586-601.

15. Meena . Wilberforce E. Curriculum Innovation in Teacher Education: Exploring Conceptions among Tanzanian Teacher Educators. ÅBO AKADEMI UNIVERSITY PRESS, 2009.

16. Cooley, W. W., and Lohnes, P. R. (1976). Evaluation research in education. New York: Irvington.

17. Hassard, Jack, 2004, The Art of Teaching Science, Oxford Univesity Press.

18. Joyce, B., Weil, M., Calhoun, E. : (2000). Models of teaching, 6th edition, Allyn & Bacon.

19. Kyriacou, C. (2007) Effective teaching in schools – theory and practice. Cheltenham: Nelson Thornes.

20. Nye, B., Konstantopoulos, S. & Hedges, L.V. (2004) ‘How large are teacher effects?’ Educational evaluation and policy analysis, 26(3), 237-257.

21. National Staff Development Council. (2001). NSDC’s standards for staff development. Oxford, OH: Author. 

22. Serpell, Z. & Bozeman, L. (1999). Beginning teacher induction: A report on beginning teacher effectiveness and retention. Washington, DC: National Partnership for Excellence and Accountability in Teaching.

NOTE:

1. Inthe semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

|AUD543C: STRESS MANAGEMENT BY YOGA (AUDIT COURSE 1 & 2) |

|M. Tech. Semester – I/II (Biomedical Engineering) |

|L |P |Credits | |Class Work |: |25Marks |

|2 |-- |-- | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

1. To achieve overall health of body and mind

2. To overcome stress

Course Outcomes:

Students will be able to:

1. Develop healthy mind and healthy body thus improving social health also

2. Improve efficiency

3. Improving “SQ”

Syllabus contents:

Unit I: 1. Causes of stress, consequences of stress, diagnosis of stress, solution of reducing stress.

2. Difference and relation b/w Yog and Yoga,

3. benefits of meditation and Yoga,

4. Rules and Regulation of Yog and Yoga.

5. Empowerment of Soul and fitness of body.

Unit II: 1. Do`s and Don’t’s in life.

2. How to be and not to be?

3. Understanding spirituality and materials.

4. Impact of: Truth at mouth/ Truth in thoughts

Non Violence outside / Compassion in thoughts, Celibacy (kamnayn- desire), purity of mind, non-covetousness, Cleanliness, satisfaction, self study and surrender to almighty, Austerity, Penance

Unit III: Role of Meditation in reducing Stress.

Role of Yoga in reducing Stress.

Pranyama: AnulomVilom ,Ujjai, Costal Breathing, Abdominal Breathing, Sunyak, Kumbhak

Unit IV: Asan: Sukhasana, Vajrasana, Padmasana, Swastik Asana, Ling Mudra, Gorakshasana, Talasana, Konasana, Trikonasana, Chakrasana, Utkatasana, Dhurva Asana, Garuda Asana, Bhadrasana, Parvatasana, Yoga Mudra, Paschimottasana, Vakrasana, Gomukhasana, Bakasana, Tulasana, Matsyasana, Mayuri Asana, Bhujagasana, DhanurVakrasana, PavanMuktasana, Viprtkarani, Makarasana, Shavasana, Dridasana, Yonimudra, Nauli, Dhenu Mudra.

TEXT / REFERENCE BOOKS:

1. ‘Yogic Asanas for Group Tarining-Part-I”: Janardan Swami Yogabhyasi Mandal, Nagpur

2. “Rajayoga or conquering the Internal Nature” by Swami Vivekananda, AdvaitaAshrama, (Publication Department), Kolkata

3. “Value Education in Spirituality- Course-IV” by Brahma Kumaries Education Wing, Rajyoga Education Research Foundation, Mount Abu, Rajasthan.

4. “Stress Management for Dummies” by Allen Elkin, IDG Books India (P) Ltd.

5. “Yoga Courses for All” by Dr Hansraj Yadav, BhartyaVidyaBhawan, Mumbai

NOTE:

1. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

|AUD545C: PERSONALITY DEVELOPMENT THROUGH LIFE ENLIGHTENMENT SKILLS (AUDIT COURSE 1 & 2) |

|M. Tech. Semester – I/II (Biomedical Engineering) |

|L |P |Credits | |Class Work |: |25Marks |

|2 |-- |-- | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

Students will be able to:

1. To learn and achieve the highest goal happily

2. To become a person with stable mind, pleasing personality and determination

3. To awaken wisdom in students

Course Outcomes:

1. The study of Shrimad-Bhagwad-Geeta will help the student in developing his personality and achieve the highest goal in life.

2. The person who has studied Geeta will lead the nation and mankind to peace and prosperity.

3. Study of Neetishatakam will help in developing versatile personality of students.

Syllabus contents:

Unit I: Holistic Development of Personality

Neetisatakam-Verses-19,20,21,22 (Wisdom), Verses-29, 31 32 (Pride and Heroism) ,Verses-26,28,63,65 (Virtue)

Unit II: Approach to Day to Day Work and Duties

Shrimad BhagwadGeeta: Chapter 2 (Verses- 41, 47, 48), Chapter 3 (Verses- 13, 21, 27, 35), Chapter 6 (Verses- 05, 13, 17, 23, 35), Chapter 18 (Verses- 45, 46, 48)

Unit III: Statements of Basic Knowledge

Shrimad BhagwadGeeta: Chapter 2 (Verses- 56, 62,68), Chapter 12 (Verses- 13, 14, 15, 16, 17, 18)

Unit IV: Personality of a Role Model

Shrimad BhagwadGeeta: Chapter 2 (Verses- 17), Chapter 3 (Verses 36, 37, 42), Chapter 4 (Verses 18, 38, 39), Chapter 18 ( Verses 37, 38 63)

TEXT / REFERENCE BOOKS:

1. Srimad Bhagavad Gita by Swami SwarupanandaAdvaita Ashram (Publication Department), Kolkata

2. Bhartrihari’s Three Satakam (Niti-sringar-vairagya) by P.Gopinath, Rashtriya Sanskrit Sansthanam, New Delhi.

3. BhagvadGeeta- Prof. Satyavrata Siddhantalankar, Orient Publishing.

NOTE:

1. Inthe semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

MTBM502C Advanced Biomedical Signal Processing

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03.

Unit I: Introduction to Biomedical Signals & Filtering Techniques

Nature and types of Biomedical Signals- action potential, electrocardiogram (ECG), electroencephalogram (EEG), electromyogram (EMG), electrogastrogram (EGG), electrooculogram (EOG), electroretinogram (ERG); Types of digital filters, The z-plane and pole-zero plots, The rubber membrane concept; FIR filters- Smoothing filters, derivative filters, Notch filters, Window design; IIR filters, Integer filters, Adaptive filters, Signal averaging

Unit II: Cardiovascular system and ECG Signal Processing

Electrical activity of heart, ECG leads and recording system, Heart rhythms, Heartbeat morphologies, Noise and artifacts in ECG; ECG Signal Processing- baseline wander removal, powerline interference removal, QRS detection- differentiation and template matching techniques, Pan-Tompkins algorithm; P and T wave detection, first and second heart sound detection

Unit III: Nervous System and EEG Signal Processing

The nervous system, EEG rhythm and waveforms, EEG recording techniques, EEG applications-epilepsy, sleep disorders, brain computer interfacing; EEG signal processing – artifacts in EEG, artifact cancellation using reference signals, non-parametric spectral analysis; The auto-regressive and auto-regressive moving average models (ARMA)

Unit IV: EMG Signal Processing & Advanced Biomedical Signal Processing Techniques

The electrical Activity of Muscles, Amplitude Estimation in the surface EMG, Spectral Analysis of the surface EMG, Conduction velocity Estimation, Modeling the EMG, EMG Signal Decomposition, Multi-resolution analysis (MRA) and Wavelets, Principal component analysis (PCA), Independent component analysis (ICA), Pattern classification- Supervised and Unsupervised classification, Neural networks, Support vector machines, Hidden-Markov model

Course Outcomes: The course enables the students for

1. Acquisition and interpretation of various physiological signals

2. Applying the advanced signal processing techniques on ECG signals to analyse cardiovascular disorders.

3. Applying the advanced signal processing techniques on EEG signals to analyse neurological disorders

4. Applying the advanced signal processing techniques on EMG signals to analyse muscular disorders

References:

1. Leif Sornmo and Pablo Laguna, Bioelectrical Signal Processing in Cardiac and Neurological

Applications, Academic Press, 2005

2. Willis J. Tompkins, Biomedical Digital Signal Processing, Prentice-Hall, 1993.

3. Rangraj M. Rangayyan, Biomedical Signal Analysis, John Wiley & Sons

4. Rangaraj M. Rangayyan, Akay Metin(Editor),Biomedical Signal Analysis: A Case Study

Approach, Wiley Interscience, 2001

5. Roberto Cristi, Modern Digital Signal Processing

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. 3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM504C Advanced Biomedical Instrumentation

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I

Concept of Instrument: Chronological history of medical instruments, problems encountered while measuring medical parameters, static and dynamic characteristics of medical instrument. Sensors & Transducers: Resistive, Inductive and Capacitive Transduction. Strain Gauge based Blood pressure transducer, and Electromagnetic Blood flow transducer.

Unit II

Bio-potentials and Amplifiers: Resting and action potential, Electrode-Electrolyte interface, half cell potential, polarizable and nonpolarizable electrodes, Ag/AgCl electrodes. Characteristics of ideal and real op-amp, instrumentation amplifier, ECG "leads", differential bio-amplifier – right leg driven ECG amplifier, Design and analysis of EMG & EEG pre amplifiers.

Unit III

Clinical Laboratory Instruments: Blood Cell Counters, Blood gas analyzers, Auto analyzers. Stimulators: Basic principle, working and technical specifications of Shortwave Diathermy, Surgical Diathermy machine, Ultrasonic therapy unit, Nerve and Muscle Stimulator.

Unit IV

Patient monitoring & ICU equipments: components of patient monitoring system, holter monitor (cardiac stress test), Anaesthesia Machine, Heart-lung machine, Haemodialysis machine

Pacemaker & Defibrillators: Cardiac Pacemakers: Modes of operation, leads and electrodes. DC defibrillator, Modes of operation and electrodes.

Course Outcomes: At the end of this course, students will be able-

1. to understand the canonical structure of biomedical instrumentation systems.

2. to apply latest knowledge of medical assistance / techniques and therapeutic equipments.

3. to understand the basic principle, working and design of various ICU equipments.

4. to develop skills enabling biomedical engineers to solve real life problems related to medical field.

References:

1. Sensors And Tranducers, D. Patranabi, Phi Learning Pvt. Ltd., 01-Jan-2003

2. Medical Instrumentation, Application and Design, Fourth Edition, John G. Webster, John Wiley & Sons

3. Biomedical Transducers And Instruments, By Tatsuo Togawa, Toshiyo Tamura, P. Ake Oberg

4. Introduction to Biomedical Equipment Technology: Carr –Brown. (PH Pub)

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM506C Advanced Tissue Engineering (Elective III)

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I

Introduction, structural organization of tissues: Epithelial, connective; vascularity and angiogenesis, cell migration, current scope of development and use in therapeutic and in-vitro testing. Cell culture- Different cell types, progenitor cells and cell differentiations, different kind of matrix, cell-cell interaction. Aspect of cell culture: cell expansion, cell transfer, cell storage and cell characterization, Bioreactors.

Unit II

Molecular biology aspect- Cell signaling molecules, growth factors, hormone and growth factor signaling, growth factor delivery in tissue engineering, cell attachment: differential cell adhesion, receptor-ligand binding, and Cell surface markers.

Unit III

Introduction to biomaterials and scaffolds, Criteria of modifying biomaterials as tissue engineering scaffolds, Properties and types of scaffolds, Different methods employed in the synthesis of scaffolds, stem cells, organization of cells into tissues, tissue microenvironment, tissue injury and wound healing 3-D architecture and cell incorporation. Engineering tissues for replacing bone, cartilage, tendons, ligaments, skin and liver.

Unit IV

Basic immunology, response of body to foreign materials. Animal cell culture on scaffolds, consequences, optimization strategies and important considerations for Skin, Liver, Bone, Cartilage, Nerve and Vascular tissue engineering; Case study and regulatory issues-cell transplantation for liver, musculoskeletal, cardiovascular, neural, visceral tissue engineering. Ethical, FDA and regulatory issues.

References:

1. Bernhard Palsson, Sangeeta Bhatia ,Tissue Engineering, Pearson Prentice Hall, 2003

2. Robert. P.Lanza, Robert Langer & William L. Chick, Principles of tissue engineering, Academic press,1997

3. Gordana Vunjak-Novakovic, R. Ian Freshney, Culture of Cells for Tissue Engineering, WIS, 2006

4. B. Palsson, J.A. Hubbell, R.Plonsey & J.D. Bronzino, Tissue Engineering, CRC- Taylor & Francis

5. Joseph D., Bronzino The Biomedical Engineering –Handbook, CRC; 3rd edition , 2006

Course Outcomes: After completion of the course, learner will be able to

1. Understand the basic concepts of Tissue Engineering.

2. Get familiar with different tissue engineering techniques and their application in Biomedical Engineering

3. Demonstrate ability of correlating theoretical concepts with their practical implementation while performing laboratory exercises and project work

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

.

MTBM508C Drug Delivery Systems (Elective III)

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I

Fundamentals of drug delivery, including physiology, pharmacokinetics, drug diffusion and permeation through biological barriers

Unit II

Various types of drug and gene delivery routes including oral, transdermal, implantable, targeted and pulmonary, controlled drug delivery, biomaterials used in drug deliver.

Unit III

Particle targeting via receptor-ligand interactions, intracellular transport of colloidal particles, protein and peptide delivery, synthetic gene delivery vectors; Case studies of current pharmaceutical products.

Unit IV

Smart Delivery Systems : Vascular Zip Codes and Nanoparticle Targeting – Theragnostic Metal Nanoshells - Photothermally-modulated Drug Delivery Using Nanoshell-Hydrogel Composites - Nanoporous Microsystems for Islet Cell Replacement - Molecularly-derived Therapeutics - Transdermal Drug Delivery using Low-Frequency Sonophoresis - Nanoporous Implants for Controlled Drug Delivery- Functionalized Cyclodextrin nanoparticles .

Course Outcomes: After completion of the course, learner will be able to

1. Devise and develop novel drug carriers with advantages over conventional therapeutics.

2. Understand the effect of varied nanoparticles as drug delivery systems.

3. Get familiarize with the new concepts of advanced techniques in therapeutics.

References:

Saltzman WM, Engineering Principles for Drug Therapy, Oxford University Press (2001).

Wang B, Siahaan T, Soltero R, Drug delivery principles and applications, WileyInterscience (2005).

3. Irene Brigger, Catherine Dubernet, Patrick Couvreur “Nanoparticles in cancer therapy and diagnosis Advanced Drug Delivery”, CRC Press, 2002.

4. Tejal Desai, “BioMEMS and Biomedical Nanotechnology: Therapeuti micro/ nanotechnology, Volume 3”, Springer, 2006.

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM510C Biological Transport Phenomena (Elective III)

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I

Introduction to fluid flow, heat transfer and mass transfer. Unified approach of momentum; Heat and Mass transfer; flow behaviours of Newtonian and non-Newtonian fluids;

Unit II

Application of momentum; heat and mass transfer principles of biological system with particular emphasis on human beings; fluid mechanics of time dependent flows in pulmonary and urinary systems

Unit III

Engineering models and their utilization in describing in-vivo observations. Modeling of the body as compartment; Source and stream; heat exchange between human body and its environment; mass transfer in membrane; heamodialysis as related to artificial kidney; extra corporal oxygenerators.

Unit IV

Artificial Heart, Lungs and Kidney along with the case studies at clinical trial level.

Course Outcomes: After completion of the course, the learner will be able to understand the biological transport phenomena involved in the physiology of the various organs and would also be ablke to design them in the in vitro environment.

References:

1. B. Palsson, J.A. Hubbell, R.Plonsey & J.D. Bronzino, Tissue Engineering, CRC- Taylor & Francis

2. Joseph D., Bronzino The Biomedical Engineering –Handbook, CRC; 3rd edition , 2006

3. Tejal Desai, “BioMEMS and Biomedical Nanotechnology: Therapeuti micro/ nanotechnology, Volume 3”, Springer, 2006.

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination .

MTBM512C BioNanotechnology (Elective III)

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I

Introduction to Bio-Nanotechnology, Cellular nanostructures, self-assembly of colloidal nanostructures of biological relevance, biofunctional nanoparticles, Nanoparticles for drug delivery (including solid lipid nanoparticles, synthetic and biopolymeric nanoparticles)

Unit II

Carbon nanotubes, polymeric nanofibers, quantum dots, magnetic nanoparticles and gold nanostructures for theranostics, Application of Quantum Dots, Gold nanostructures & magnetic nanoparticles in biomedical engineering

Unit III

Multilayer Thin Film: Polyelectrolyte multilayers, coated colloids, smart capsules, Nanoengineered biosensors, Nanotechnology for Biodefense

Unit IV

Implants and Prosthesis, Implications in neuroscience, tissue engineering and cancer therapy, Environmental and safety aspects of bio-nanotechnology.

Course Outcomes: After completion of the course, the learner will be able

1. Get the theoretical and practical knowledge related to modern materials chemistry, materials physics, energy physics and nanotechnology.

2. Learner will demonstrate an ability to identify and Model the problems of the field of Biomedical Engineering and solve it.

3. To understand the essential features of biology and nanotechnology that are converging to create the new area of bionanotechnology

4. To recognize the structural and functional principles of bionanotechnology

5. To employ bionanomaterials for analysis and sensing techniques

6. To apprehend and explain the biomedical applications of nanotechnology

References:

1. Multilayer Thin Films; GeroDecher, J B. Schlenoff, Wiley-VCH Verlag GmbH & Co. KGaA, 2003

2. Bionanotechnology: Lessons from Nature; David S. Goodsell, Wiley-Liss, 2004

3. Biomedical Nanotechnology; Neelina H. Malsch; CRC Press, 2005

4. Nanotechnologies for the Life Sciences, Vol 2, Biological and pharmaceutical nanomaterials; Challa Kumar, Wiley-VCH, 2006

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM514C Medical Imaging & Image Processing (Elective IV)

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I

Image Acquisition: Introduction to physics of X-ray, CT, PET, MRI, and ultrasound, properties of the resulting images, advantages and disadvantages of each imaging modality.

Image Storage & Communication: Medical Image Storage, Archiving and Communication Systems and Formats: PACS, DICOM, TIFF, RIS and HIS.

Unit II

Image Reconstruction: Reconstruction techniques for CT (filtered back projection) and MRI (using the FFT) i.e. Theory of the Radon transform, the Fourier transform, and how they relate to each other.

Image Enhancement: Contrast adjustment, denoising (convolution, FFT), deblurring (solving an ill-conditioned sparse linear system), edge detection (numerical approximation to a partial derivative).

Unit III

Image Segmentation: Simple methods such as thresholding, region growing and watershed. More depth on the method of snakes (adaptive mesh), level set method (numerical solution of partial differential equations), and clustering (classifiers).

Image Registration: Intensity based methods, cost functions (correlation, least squares, mutual information, robust estimators), and optimization techniques (fixed-point iteration, gradient descent, Nelder-Mead simplex method, etc.). Implement registration for rigid and non-rigid transformations.

Unit IV

Application of Image Processing:, Medical image fusion in neurosurgery and orthopedics, digital subtracted angiography, MRI motion compensation, calcification detection in digital mammography

References:

1. Rafel C Gonzalez, Richard E Woods, “Digital Image Processing”, 2nd ed, Addison-Wesley Publishing Company, New Delhi, 2002.

2. William R Hendee, E. Russell Ritenour, “Medical Imaging Physics”, 4th ed.John Wiley, & Sons, Inc., New York, 2002.

3. J. Michael Fitzpatrick and Milan Sonka, “Handbook of Medical Imaging, Vol. 2, SPIE Press, 2000.

4. Paul Suetens, “Fundamentals of Medical Imaging”, 2nd ed., Cambridge University press, 2009.

5. Anil K Jain “Fundamentals of Digital Image Processing”, Prentice Hall of India Pvt.Ltd., NewDelhi,1988.

6. Digital image processing for medical applications. Geoff dougherty .

7. Applied Medical Image Processing. W. Birkfellner. CRC Press, Taylor and Francis, 2010.

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM516C Embedded Systems in Biomedical Engineering (Elective IV)

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I: Introduction to Embedded System

Introduction, design challenge, processor technology, IC technology, Design technology, Trade-offs, General Purpose Processors: Basic architecture, operation, Pipelining, Programmer’s view, development environment, application Specific Instruction-Set Processors (ASIPs) – Micro Controllers and Digital Signal Processors

Unit II: State Machine and Concurrent Process Models

Introduction, models Vs. languages, finite state machines with data path model (FSMD), using state machines, program state machine model (PSM), concurrent process model, concurrent processes, communication among processes, synchronization among processes, implementation, data flow model, real-time systems

Unit III Communication Interfaces

Need for communication interfaces, RS232 / UART, RS422 / RS485, USB, infrared, IEEE 1394 Firmwire, Ethernet, IEEE 802.11, Blue tooth.

Unit IV: Basic Concepts of Real Time Operating System

Architecture of the Kernel, Tasks and Task scheduler, Interrupt service routines, Semaphores, Mailboxes , Message Queues, Event Registers, Pipes, Signals, Timers, Memory Management, Priority inversion problem, Embedded operating systems Embedded Linux, Real-time operating systems, RT Linux, Handheld operating systems.

Course Outcomes: At the end of this course, students will be able to

1. provide in‐depth knowledge about embedded processor and its hardware.

2. explain real time operating systems and inter‐task communication.

3. explain different types of communication interfaces

References:

1. Embedded System Design – A Unified Hardware/Software Introduction - Frank Vahid, Tony D. Givargis, John Wiley, 2002.

2. Embedded / Real Time Systems – KVKK Prasad, Dreamtech Press, 2005

3. Introduction to Embedded Systems – Raj Kamal, TMS, 2002.

4. Embedded Real Time Systems Programming – Sri Ram V Iyer, Pankaj Gupta, TMH, 2004

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM518C Medical Informatics and Telemedicine (Elective IV)

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I: Introduction to Medical Informatics

Structure of medical informatics, Application and importance of Medical informatics, Knowledge and Models, Information and Communication Systems, Medical Computer Systems - Systematization of Computer Applications, Database management system for a hospital environment, Information Safety and Security in Health Care Information Systems.

Unit II: Health Care Information Systems

Introduction, Electronic Patient Record, Electronic referral - consulting system, Primary Care Systems, Clinical Departmental Information Systems, Clinical Support Systems, Nursing Information Systems. Decision models - quantitative models, qualitative models, Knowledge Based systems - characteristic features of KBS, knowledge representation in KBS.

Unit III: Introduction to Telemedicine

Block diagram of telemedicine system, Definition of telemedicine, Tele health, Tele care, Origin & development of telemedicine, Scope, benefits and limitation of telemedicine, ethical and legal aspects of telemedicine.

Unit IV: Communication & Networks

Types of Information: Audio, Video, Still image, Text and Data, Fax. Types of Communication & network: PSTN, POTS, ATN, ISDN, Internet and Wireless Communications: GSM, Satellite and Micro wave.

Tele communication based biomedical systems: Tele-radiology system, Tele-pathology, Tele-cardiology, Tele-oncology, Tele-surgery, Tele-education and Tele-Monitoring.

Course outcomes: After the completion of course, students will be able to work on the applications of IT in Biomedical Engineering, Hospital Informatics Systems, the Network Issues in Medicine, Protocols and scope of communication engineering in health sciences.

References:

1. Computers in Medicine: Progress in medical informatics – R.D.Lele, Tata McGraw Hill 2005.

2. A .C. Norris, Essentials of Telemedicine and Telecare, John Wiley & Sons, 2002

3. R. Wootton& Victor Patterson, Introduction to Telemedicine, RSM Press, 2006

4. Olga Ferrer-Roca & M. Sosa ludicissa, Handbook of Telemedicine, IOS Press 2002

5. A. Darkins& M. Cary, Telemedicine and Telehealth: Principles, Policies, Performance and Pitfalls,Springer Publishing Company; 1 edition, 2000

6. R. Latifi, Current Principles and Practices of Telemedicine and e-Health: Volume 131Studies in Health Technology and Informatics,IOS Press; 1 edition, 2008

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM520C Modeling & Simulation (Elective IV)

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I

System, Modeling & Simulation: Physical Models, Mathematical Models, Computer Models, Cobweb Models, Monte Carlo Simulation

Probability as used in Simulation: Basic probability Concept, Discrete Random Variables, Expected value and variance, Continuous Random Variable, Exponential Distribution, Normal Distribution, CEP and PE

Unit II

Discrete Simulation: Generation of Uniform Random Numbers, Testing of random Numbers, random Variate for Non-Uniform Distribution, Normal random number generation, Applications

Continuous System Simulation: Continuous Simulation, Modeling of Fluid Flow, Modeling of shock waves, Simulation of pursuit Evasion problem, Simulation of an Autopilot, Modeling of projectile Trajectory

Unit III

Simulation of Queuing System: Kendall’s Notation, Principle of Queuing theory, Arrival Service Model, Simulation of a single server queue.

System Dynamics: Exponential growth models, exponential decay models, Modified exponential growth models, Logistic models, Multisegment models, Modeling of a chemical reaction, Time delay, A biological model

Unit IV

Modeling Formalisms and Simulation Algorithms: Basic Formalisms: DEVS, DTSS, DESS, Basic Formalisms: Coupled Multicomponent Systems. Simulators for Basic Formalisms. Multiformalism Modeling and Simulation. DEVS-Based Extended Formalisms. Parallel and Distributed Discrete Event Simulation. Cost Effectiveness Models

Course Outcomes: After the completion of the course, the students shall be able to model and simulate practical problems using statndard modeling and simulation methods/ techniques and thus will be able to model and simulate biological systems.

References:

1. V.P.Singh, “System Modeling & Simulation”, New Age Publishers 2009

2. Bernard P. Zeigler Bernard Zeigler Tag Kim Herbert Praehofe, “Theory of Modeling & Simulation” Eldevier 2000

3. Averill Law, “Simulation Modeling & Analysis”, Mc Graw Hill, 2015

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM522C Biomedical Signal & Image Processing Lab

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

- - 4 Practical : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 02

List of Experiments

1. To study the cross correlation, auto correlation and convolution functions in MATLAB.

2. To develop a MATLAB program to perform synchronized averaging for a noisy signal.

3. To write a MATLAB program to compute RMS value at each instant for the EMG signal.

4. To write a MATLAB program to compute the wavelet coefficients for EEG signal using continuous wavelet transform.

5. To write a MATLAB program for performing discrete wavelet transform of the various bio-signals.

6. To remove occular artifacts from EEG using Wavelet Transform

7. To study the spectrogram of normal and abnormal EEG

8. To extract features from physiological signals using PCA & ICA.

9. To study spectral analysis of surface EMG

10. To perform AR modelling of EEG time series

11. To perform Digital Image representation in MATLAB.

12. To Perform Histogram Processing & Function Plotting using MATLAB.

13. To perform spatial filtering in Ultrasound Images & Speckle noise removal.

14. To perform Weiner filtering in Medical Images.

15. To study Constrained Least square filtering.

16. To study Colour Image Representation in MATLAB.

Note: 1. Each laboratory class/ section shall not be more than 20 students.

2. To allow fair opportunity of practical hands-on experience to each student, each experiment may either be done by each student individually or in a group of not more than 3-4 students. Larger groups be strictly discouraged/ disallowed.

3. Pre-experimental and post-experimental quiz/ questions may be offered for each lab experiment to reinforce and aid comprehension of the experiment

MTBM524C Advanced Biomedical Instrumentation Lab

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

- - 4 Practical : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 02

List of Experiments

1. Wheatstone Bridge Circuit and Measurement of Resistance

2. Strain gauge application and Measurement of Unknown Load

3. Linear Variable Differential Transformer and Measurement of Distance

4. Measurement of pressure using piezoelectric pick-up

5. Study of temperature transducers- thermistors, RTD, thermocouple

6. Study of pH electrode and measurement of blood pH

7. Measurement of blood flow using electromagnetic flow transducer

8. Study of ultrasonic transducers and their application

9. Study of external pacemaker as an artificial heart

10. Study and design of electronic stethoscope

11. Real time monitoring and simulation studies of Echocardiography

12. Study of different types of Diathermy equipments

13. Respiratory System analysis using spirometer

14. Design of Bio-amplifier for picking up ECG signal

15. Study of linear and non-linear applications of op-amps

Note: 1. Each laboratory class/ section shall not be more than 20 students.

2. To allow fair opportunity of practical hands-on experience to each student, each experiment may either be done by each student individually or in a group of not more than 3-4 students. Larger groups be strictly discouraged/ disallowed.

3. Pre-experimental and post-experimental quiz/ questions may be offered for each lab experiment to reinforce and aid comprehension of the experiment

MTBMMP522C Mini Project

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

- - 4 Practical : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 02

The objective of mini project is to develop in students the professional quality of synthesis employing technical knowledge obtained in the field of Engineering & Technology through a project work involving design/ analysis augmented with creativity, innovation and ingenuity.

The student shall take up investigative study on a topic in the broad relevant field of engineering, involving hardware or software or both hardware and software, to be assigned by the department on an individual basis, under the guidance of a supervisor from the department. This is expected to provide a good initiation for the student(s) in R&D work.

The activities under mini project may normally include:

1. Literature survey on the assigned topic.

2. Working out a preliminary approach to the problem relating to the assigned topic.

3. Conducting preliminary analysis/modeling/simulation/experiment/design.

4. Compilation of the work and presenting it in two seminar talks in the semester, before a committee having M. Tech. coordinator and supervisor(s).

5. Submit a written spiral-bound report on the work undertaken to the M.Tech. Coordinator.

The internal evaluation of the Mini project will be done at the end of the semester through a seminar by the committee consisting of the following:

1.    Chairperson/Head of Department/Nominee : Chairperson

2.    M. Tech. Coordinator : Member Secretary

3.    Respective Project Supervisor(s) : Member(s)

Final exam. will be conducted by the internal examiner (M.Tech. Coordinator/ faculty nominated by Chairperson) and external examiner to be appointed by the Controller of Examinations from the panel of examiners submitted by the Dept.

M. Tech. coordinator will be assigned a load of 1 hour per week excluding his/her own guiding load. Project supervisor (guiding teacher) will be assigned the load of 1 hour per week per student subject to a maximum load of 2 hours.

MTBM601C Diagnostic Imaging & Radiation Biology (Elective V)

M.Tech. Semester – III (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I: Radioactive Emissions

Physics of Radioactivity: Radionuclide Decay Terms and Relationships – Activity – Physical half Life – Fundamental Decay Equation, Nuclear Transformation – Alpha Decay, Beta-Minus Decay-Beta Plus – Electron Capture – Isomeric Transition – Decay Schemes

Unit II: Radiation Detectors

Radionuclide detection and measurement - Type of detectors – pulsed and current mode - spectroscopy, Gas Filled detectors, Scintillation detectors, Semiconductor detectors, Pulse height spectroscopy, Non– imaging detector applications, Counting statistics

Unit III: Pharmaceuticals & Imaging

Radiopharmaceuticals Characteristics, applications, quality control and regulatory issues in medical imaging, Radiopharmaceutical mechanisms of localization, Gamma Camera, Construction and working, Performance characteristics, PET

Unit IV: Radiation Safety

Radiation Protection, Safety, Ionizing and non-ionizing radiations, stochastic and non-stochastic effects, safety limits, risk factors. Principles of radiation dosimetry

Course Outcomes: After completion of the course, the learner will be able to

1. Understand the applications of radiations in biomedical imaging

2. They would also be able to work with Gamma Camera and PET

3. The risk & safety aspects of radiations would also be known.

References:

1. Saha G ,”Physics and Radiobiology in Nuclear Medicine”, Springer

2. H E Johns and Gunningham, “Physics of Radiology “, Pub. Thomas

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

.

MTBM603C Computational Neuroscience (Elective V)

M.Tech. Semester – III (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I: Excitable Membranes and Neural Conduction

Membrane Potentials, The Hodgkin-Huxley Theory (Modeling Conductance Change with Differential

Equations, The Potassium Channel, The Sodium Channel, Combining the Conductances in Space Clamp) An Analytical Approximation: The FitzHugh-Nagumo Equations, Passive Conduction, Propagating Action Potentials

Unit II: Receptive Fields and the Specificity of Neuronal Firing

Spatial Summation (Correlation and Linear Spatial Summation, Lateral Inhibition: Convolution, Correlation and Convolution, Spatio-Temporal Summation, Peri-Stimulus Time Histogram (PSTH) and Tuning Curves), Functional Descriptions of Receptive Fields (Isotropic Profiles: Gaussians, Orientation: Gabor Functions, Spatio-Temporal Gabor Functions), Non-linearities in Receptive Fields (Linearity Defined: The Superposition Principle, Static Non-linearity), Non-linearity as Interaction: Volterra Kernels (Energy-Type Non-linearity, Summary: Receptive Fields in the Primary Visual Pathway), Motion Detection (Motion and Flicker, Coincidence Detector, Correlation Detector, Motion as Orientation in Space-Time)

Unit III: Learning Mechanisms

Plasticity and learning, Classical conditioning and reinforcement learing, Representational learning, Classical conditioning and instrumental condition, Sensitization, habituation and priming, Cellular correlates of learning, Hebbian learning, Long-term Potentiation (LTP) and Long-term Depression (LTD)

Unit IV: Neural Networks

Elements of Neural Networks (Activity and the States of a Neural Network, Activation Function and Synaptic Weights, The Dot Product, Matrix Operations, Weight Dynamics ("Learning Rules")), Classification (The Perceptron, Linear Classification, Limitations, Supervised Leaming and Error Minimization, Support Vector Machines)

Course Outcomes: The course contents are sufficient to lay a strong foundation for the students-

1. To develop single neuron model

2. To understand the cognitive abilities of human beings.

3. To develop BCI systems.

4. To develop neural disorder diagnostic models

References:

1. Computational Neuroscience-A First Course by Hanspeter A. Mallot, Springer

2. Peter Dayan & LF Abbot, Theoretical Neuroscience: Computational and Mathematical Modeling of Neural Systems, MIT Press. ISBN 0-262-04199-5.

3. Feng, Jianfeng, ed. Computational neuroscience: a comprehensive approach. CRC press, 2003

4. Trappenberg, Thomas. Fundamentals of computational neuroscience. OUP Oxford, 2009.

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM605C Anesthesia Technology (Elective V)

M.Tech. Semester – III (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I

Gas Supply and Distribution Systems: Medical Gas Cylinders and Containers, Medical Gas Pipeline Systems, Suction Equipment, Oxygen Concentrators. Standards and Regulatory Considerations

Unit II

Anesthesia Machines and Breathing Systems: The Anesthesia Machine, Vaporizers, The Breathing System, Manual Resuscitators, Humidification Equipment, Anesthesia Ventilators, Hazards of Anesthesia Machines and Breathing Systems

Unit III

Airway Equipment: Face Masks and Airways, Supraglottic Airway Devices, Laryngoscopes, Tracheal Tubes and Associated Equipment, Lung Isolation Devices, Devices for Managing the Difficult Airway

Unit IV

Monitoring Devices: Gas Monitoring, Airway Volumes, Flows and Pressures, Pulse Oximetry, Neuromuscular Transmission Monitoring, Alarm Devices,Noninvasive Blood Pressure Monitors,Data Management Systems,Temperature Monitoring. Equipment Care: Machine Checkout and Quality Assurance, Cleaning and Sterilization.

Course Outcomes: At the end of this course, students will be able to

1. understand the basic science behind the design of anesthesia systems.

2. understand and formulate new engineering solutions for current anestheisa problems .

3. design a system, component, or process to meet desired needs within realistic constraints .

4. gather detailed knowledge of the operation of aneshesia machine

References:

1. Anesthesia Equipment: Principles and Applications, 2nd Edition, by Dr. Jan Ehrenwerth and Dr. James B. Eisenkraft, Saunders(2013)

2. Understanding Anesthesia Equipment, 5th edition by Jerry A. Dorsch, Wolters Kluver(2008)

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

MTBM607C Soft Computing Methods (Elective V)

M.Tech. Semester – II (Biomedical Engineering)

L T P Class Work : 25 Marks

3 - - Theory : 75 Marks

Total : 100 Marks

Duration of Exam : 03 Hours Credits : 03

Unit I: Genetic Algorithms

Goals of optimization, comparison with traditional methods, schemata, Terminology in GA – strings, structure, parameter string, data structures, operators, coding fitness function, algorithm, applications.

Unit II: Fuzzy Logic

Concepts of uncertainty and imprecision, sets, concepts, properties and operations on classical sets & fuzzy sets, classical & fuzzy relations, fuzzy propositions, membership functions, fuzzy logic, fuzzification, fuzzy rule based systems, and applications.

Unit III: Artificial Neural Networks

Basics of ANN: Models of a Neuron, Topology, Multi Layer Feed Forward Network (MLFFN), Radial Basis Function Network (RBFN), Recurring Neural Network (RNN), learning processes: supervised and unsupervised learning. error-correction learning, Hebbian learning; single layer perceptrons, multilayer perceptrons, least mean square algorithm, back propagation algorithm applications.

Unit IV: Hybrid Systems

Fuzzy Neural systems, Genetic Fuzzy systems, Genetic Neural systems

Course Outcome: After learning the course the students should be able:

1. To get basic idea of modern computing techniques which are useful for solving the non-linear and complex functions that may come across during dissertation/research work.

2. To be conversant with artificial intelligent techniques like GA, Fuzzy logic, Artificial Neural Network and

their hybrid systems which are used for solving different transportation problems

References:

1. Timothy J.Ross, Fuzzy Logic with Engineering Applicatios, McGraw-Hill

2. Simon Haykin, Neural Netwroks, Prentice Hall

3. J.M. Zurada, .Introduction to artificial neural systems., Jaico Publishers

4. H.J. Zimmermann, Fuzzy set theory and its applications., III Edition, Kluwer Academic Publishers, London.

5. Suran Goonatilake, Sukhdev Khebbal (Eds), .Intelligent hybrid systems., John Wiley & Sons, New York, 1995

6. Goldberg, D. E, Genetic algorithm in search, optimization and machine learning,Addison-Wesley, Reading Mass.

7. Kalyanmoy Deb, Optimization for Engineering Design – Algorithms and examples, PHI, New Delhi, ISBN-81-203-0943-x.

Note:

1. The paper setter will set two questions (with/without parts) from each of the four units. The

examinee will attempt five questions in all selecting at least one question from each unit. All questions carry equal marks.

2. The use of programmable devices such as programmable calculators, phones etc. and sharing of any material during examination are not allowed.

3. A specific note shall be inserted in relevant question paper wherever the use of graph papers, semilog papers, steam tables, etc. shall be allowed during examination

.

MTBMDP609C Dissertation Phase-I

M.Tech. Semester – III (Biomedical Engineering)

L T P Class Work : 50 Marks

- - 20 Practical : 100 Marks

Total : 150 Marks

Duration of Exam : 03 Hours Credits : 10

The objective of this course is to develop in students the capacity for analysis and judgment and the ability to carry out independent investigation in design/development through a dissertation work involving creativity, innovation and ingenuity. The work should start with comprehensive literature search and critical appreciation thereof so as to select research problem and finalize the topic of dissertation.

Each student will carry out an independent dissertation under the supervision of supervisor(s). In no case, more than two supervisors may be associated with one dissertation work. The first supervisor must be from the department and the second supervisor may be from the other departmentof the university/ outside university/industry depending upon the interdisciplinary nature of the research work, however, consent of the second supervisor with justification thereof needs to be submitted to the dissertation coordinator.

The Dissertation (Phase-I) involving literature survey and problem formulation along with data collection (if required) which commences in the 3rd semester will be completed as dissertation in 4th semester. Every student will be required to present three seminar talks, first at the beginning of the dissertation (phase-I) to present the scope of the work and to finalize the topic, second in the middle of the semester involving literature survey and fine-tuning of work, and third towards the end of the semester, presenting the progress report containing the partial results if any of the work carried out by him/her in the semester. The student will be required to submit one copy of spiral-bound progress report to the M.Tech. coordinator.

Internal evaluation of the Dissertation (Phase-I) will be done by following committee:

1. Chairperson of the Department/Nominee : Chairperson

2. M.Tech. Coordinator/Senior Faculty: Member Secretary

3. Respective Dissertation Supervisor(s): Member(s)

Final exam will be conducted by the internal examiner (M.Tech. Coordinator/ faculty nominated by Chairperson) and the external examiner to be appointed by the controller of examinations from the panel of examiner submitted by the department.

For this course, M. Tech. coordinator will be assigned a load of 1 hour per week excluding his/her own guiding load and dissertation supervisor (guiding teacher) will be assigned a load of 1 hours per week for the first student and additional 1 hour per week (for their own department only) for the subsequent student/students subject to a maximum load of 2 hours.Work load allocated for the joint supervision within the department will be treated as half for each supervisor.

|MTOE651C: BUISNESS ANALYTICS (OPEN ELECTIVE) |

|M. Tech. Semester – III (Common for all Branches) |

|L |P |Credits | |Class Work |: |25Marks |

|3 |-- |3 | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

The main objective of this course is to give the student a comprehensive understanding of business analytics methods

1. Understand the role of business analytics within an organization.

2. Business Analytics industry sequence is to familiarize the students with the concept of Data Analytics (Big Data) and its applicability in a business environment

3. Analyze data using statistical and data mining techniques and understand relationships between the underlying business processes of an organization.

4. To gain an understanding of how managers use business analytics to formulate and solve business problems and to support managerial decision making.

5. To become familiar with processes needed to develop, report, and analyze business data.

6. Use decision-making tools/Operations research techniques.

7. Mange business process using analytical and management tools.

Analyze and solve problems from different industries such as manufacturing, service, retail, software, banking and finance, sports, pharmaceutical, aerospace etc

Course Outcomes:

1. At the end of the Fall semester, students should have acquired an understanding of Analytics – the terminology, concepts and familiarity of potential tools and solutions that exist today Students will demonstrate knowledge of data analytics.

2. Students will demonstrate the ability of think critically in making decisions based on dataand deep analytics

3. Students will demonstrate the ability to use technical skills in predicative and prescriptivemodeling to support business decision-making

4. Students will demonstrate the ability to translate data into clear, actionable insights. student should be better familiar with overall analytics tools/techniques and their use in corporate

Syllabus contents:

UNIT I: Business analytics: Overview of Business analytics, Scope of Business, analytics, Business Analytics Process, Relationship of Business Analytics, Process and organisation, competitive advantages of Business Analytics. Statistical Tools: Statistical Notation, Descriptive Statistical methods, Review of probability distribution and data modelling, sampling and estimation methods overview.

UNIT II: Trendiness and Regression Analysis: Modelling Relationships and Trends in Data, simple Linear Regression, Important Resources, Business Analytics Personnel, Data and models for Business analytics, problem solving, Visualizing and Exploring Data, Business Analytics Technology.

UNIT III: Organization Structures of Business analytics, Team management, Management Issues, Designing Information Policy, Outsourcing, Ensuring Data Quality, Measuring contribution of Business analytics, Managing Changes. Descriptive Analytics, predictive analytics, predicative Modelling, Predictive analytics analysis, Data Mining, Data Mining Methodologies, Prescriptive analytics and its step in the business analytics Process, Prescriptive Modelling, nonlinear Optimization.

UNIT IV: Decision Analysis: Formulating Decision Problems, Decision Strategies, with the without Outcome Probabilities, Decision Trees, the Value of Information, Utility and Decision Making.

Forecasting Techniques: Qualitative and Judgmental Forecasting, Statistical Forecasting Models, Forecasting Models for Stationary Time.

TEXT / REFERENCE BOOKS:

1. Project Management: The Managerial Process by Erik Larson and, Clifford Gray

2. Business Analysis by James Cadle et al.

3. Bajpai Naval, Business Statistics, Pearson, New Delhi.

4. Whigham David, Business Data Analysis, Oxford University, Press, Delhi.

5. Predictive Analytics: The Power to Predict Who Will Click, Buy, Lie or Die. Eric Siegel.

6. Big Data, Analytics and the Future of Marketing and Sales. McKinsey.

NOTE:

1. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

|MTOE653C: INDUSTRIAL SAFETY (OPEN ELECTIVE) |

|M. Tech. Semester – III (Common for all Branches) |

|L |P |Credits | |Class Work |: |25Marks |

|3 |-- |3 | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

Course Outcomes:

Syllabus contents:

UNIT I: Industrial safety: Accident, causes, types, results and control, mechanical and electrical hazards, types, causes and preventive steps/procedure, describe the salient points of factories act 1948 for health and safety, washrooms, drinking water layouts, light, cleanliness, fire, guarding, pressure vessels, etc., Safety color codes. Fire prevention and firefighting, equipment and methods.

Fundamentals of maintenance engineering: Definition and aim of maintenance engineering, Primary and secondary functions and responsibility of the maintenance department, Types of maintenance, Types and applications of tools used for maintenance, Maintenance cost & its relation to replacement economy, Service life of the equipment.

UNIT II: Wear and Corrosion and their prevention: Wear- types, causes, effects, wear reduction methods, lubricants-types and applications, Lubrication methods, general sketch, working and applications, (i). Screw down grease cup, (ii). Pressure grease gun, (iii). Splash lubrication, (iv). Gravity lubrication, (v). Wick feed lubrication (vi). Side feed lubrication, (vii). Ring lubrication, Definition, principle and factors affecting the corrosion. Types of corrosion, corrosion prevention methods.

UNIT III: Fault Tracing: Fault tracing-concept and importance, decision tree concept, need and applications, sequence of fault finding activities, show as decision tree, draw decision trees for problems in machine tools, hydraulic, pneumatic, automotive, thermal and electrical equipment’s like, (i). Any one machine tool, (ii). Pump (iii). Air compressor, (iv). Internal combustion engine, (v). Boiler, (vi). Electrical motors, Types of faults in machine tools and their general causes.

UNIT IV: Periodic and Preventive Maintenance: Periodic inspection-concept and need, degreasing, cleaning and repairing schemes, overhauling of mechanical components, overhauling of electrical motor, common troubles and remedies of electric motor, repair complexities and its use, definition, need, steps and advantages of preventive maintenance. Steps/procedure for periodic and preventive maintenance of: (i). Machine tools, (ii). Pumps, (iii). Air compressors, (iv). Diesel generating (DG) sets, Program and schedule of preventive maintenance of mechanical and electrical equipment, advantages of preventive maintenance. Repair cycle concept and importance.

TEXT / REFERENCE BOOKS:

|1 |Maintenance Engineering Handbook |Higgins & Morrow |Da Information Services |

|2 |Maintenance Engineering |H. P. Garg |S. Chand and Company |

|3 |Pump-hydraulic Compressors, |Audels |Mcgraw Hill Publication |

|4 |Foundation Engineering Handbook |Winterkorn, Hans |Chapman & Hall London. |

NOTE:

4. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

5. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

6. Electronics gadgets including Cellular phones are not allowed in the examination.

|MTOE655C: OPERATIONS RESEARCH (OPEN ELECTIVE) |

|M. Tech. Semester – III (Common for all Branches) |

|L |P |Credits | |Class Work |: |25Marks |

|3 |-- |3 | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

1. To develop modeling skills in students.

2. To develop skill in students for efficient designing analysis and control of complete system.

3. To make students capable of formulating the practical problems into mathematical problems.

4. To acquaint student with linear as well as non-linear programming problem and their application.

Course Outcomes:

1. Students will be able to apply the dynamic programming to solve problems of discrete and continuous variables.

2. Students will be able to carry out sensitivity analysis.

3. Student will be able to model the real world problem and simulate it.

4. The students will be able to carry forward the operation research techniques in practical problems.

Syllabus contents:

UNIT I: Linear optimization methods: General mathematical model formation of L.P.P, its solution by Graphical method, Simplex method, big –M method, two phase method sensitivity analysis (change in cj, bj&aij’s)

Revised Simplex method.Concept of duality, formation of Dual L.P.P, advantage of Duality, dual simplex method, parametric programming.

UNIT II: Non liner programming: NLPP Mathematical formulation and solution with equally constraints, Lagrange’s method, Graphical method, Kuhn—Tucker necessary &sufficient conditions for the optimality of objective function in GNLP problem.

Dynamic programming: Kuhn –Tucker condition’s, Wolfe’s and Bcale’s method.

UNIT III: Deterministic inventory control models: Meaning & function role of inventory control, reason for carrying inventory, single item inventory control model with & without shortages.

Probabilistic inventory control models: Inventory control models without set up cost and with set up cost.

UNIT IV: Project management; PERT and CPM, Basic difference between PERT & CPM, Phases up project management PERT /CPM network component & precedence relationships, critical path analyses, projects scheduling with uncertain activity times, project time –cost trade-off.

Sequencing problem: Processing an jobs through two machines, three machines and through m-machines. Theory of games: Two- person zero –sum games,pure strategies (with saddle points) mixed strategies (without saddle point), algebraic method only.

TEXT / REFERENCE BOOKS:

1. H.A Taha, Operations Research, An introduction, PHI, 2008

2. H.M.Wanger, Principles of Operation Research PHI, Delhi, 1982

3. J.K.Sharma, Operations Research, Mcmillan India. Ltd,1990

4. S.D.Sharma, Operations Research, KedarnathRamnath publication,1985

5. P.K.Gupta and D.S Hira, Operations Research, S.Chand& Co.,1987

6. Pannerselvam, Operations Research; PHI, 2010

7. Harvey M Wanger , Principles of Operations Research; PHI, 2010

NOTE:

1. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

|MTOE657C: COST MANAGEMENT OF ENGINEERING PROJECTS (OPEN ELECTIVE) |

|M. Tech. Semester – III (Common for all Branches) |

|L |P |Credits | |Class Work |: |25Marks |

|3 |-- |3 | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

Course Outcomes:

Syllabus contents:

UNIT I: INTRODUCTION AND OVERVIEW

Chapter 1 Introduction, basic economic concepts, interest formulae, present worth, rate of return. Elements of financial accounting: depreciation, taxes and their impact in economic studies

Chapter 2 Cost concepts in decision making; elements of cost, relevant cost, overheads, differential cost, incremental cost and opportunity cost, objectives of a costing system, inventory valuation, creation of a data base for operational control, provision of data for decision making.

UNIT II: PROJECT

Chapter 3 Meaning, different types, why to manage, cost overrun centres, various stages of project execution, concept to commissioning. Project execution as conglomeration of technical and non technical activities. Detailed engineering activities, Pre project execution main clearances and documents project team: Role of each member.

Chapter 4 Importance Project site: Data required with significance. Project contracts.Types and contents. Project cost control. Bar charts and network diagram. Project commissioning: Mechanical and process. Project appraisal and selection, recent trends in project management

UNIT III: ECONOMIC ANALYSIS FOR ENGINEERING PROJECTS

Chapter 5 Cost behavior and profit planning, Marginal costing, distinction between marginal costing and absorption costing, Break even analysis, cost volume profit relationship, various decision making problems.

Standard costing and variance analysis, pricing strategies Pareto analysis, Target analysis, life cycle costing, Costing of service sector.

Chapter 6 just in time approach, material requirement planning, enterprise resource planning, Total Quality management and theory of constraints, Activity based cost management, Bench marking, Balanced score card, value chain analysis,

Budgetory control, Flexible budget, Performane budget, Zero based budget, Measurement of divisional profitability pricing decisions including transfer pricing.

UNIT IV: QUANTITATIVE TECHNIQUES FOR COST MANAGEMENT

Chapter 7 PERT CPM; Activity networks, basic PERT/CPM calculations, Planning and scheduling of activity networks, Assumptions in PERT modeling, time cost tradeoffs, PERT/ cost accounting, Scheduling with limited resources, Generalized activity networks GERT, Prospects of PERT/CPM

Chapter 8 Linear programming, Transportation problems, Assignment problems, Simulation, Learning curve theory.

TEXT / REFERENCE BOOKS:

|1 |Cost Accounting: A Managerial Emphasis |Charles T. Horngren, Srikant M. Datar, |Pearson Edu. |

| | |Madhav V. Rajan | |

|2 |Fundamentals of Financial Management |Prasanna Chandra |Tata McGraw Hill |

|3 |Quantitative Techniques in Management |N D Vohra |Tata McGraw Hill |

|4 |Foundation Engineering Handbook |Winterkorn, Hans |Chapman & Hall London. |

|5 |Principles and Practice of cost accounting |Ashish K Bhattacharya |A H Wheeler |

|6 |Principles of engineering economy |E L Grant et al. |John Wiley and Sons, New York. |

NOTE:

1. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

|MTOE659C: COMPOSITE MATERIALS (OPEN ELECTIVE) |

|M. Tech. Semester – III (Common for all Branches) |

|L |P |Credits | |Class Work |: |25Marks |

|3 |-- |3 | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

Course Outcomes:

Syllabus contents:

UNIT I: INTRODUCTION: Definition – Classification and characteristics of Composite materials. Advantages and application of composites.Functional requirements of reinforcement and matrix.Effect of reinforcement (size, shape, distribution, volume fraction) on overall composite performance.REINFORCEMENTS: Preparation-layup, curing, properties and applications of glass fibers, carbon fibers, Kevlar fibers and Boron fibers. Properties and applications of whiskers, particle reinforcements. Mechanical Behavior of composites: Rule of mixtures, Inverse rule of mixtures. Isostrain and Isostress conditions.

UNIT II: Manufacturing of Metal Matrix Composites: Casting – Solid Stat e diffusion technique, Cladding – Hot isostatic pressing.Properties and applications. Manufacturing of Ceramic Matrix Composites: Liquid Metal Infiltration – Liquid phase sintering. Manufacturing of Carbon – Carbon composites: Knitting, Braiding, Weaving. Properties and applications.

UNIT III: Manufacturing of Polymer Matrix Composites: Preparation of Moulding compounds and prepregs – hand layup method – Autoclave method – Filament winding method – Compression moulding – Reaction injection moulding. Properties and applications.

UNIT IV: Strength: Laminar Failure Criteria-strength ratio, maximum stress criteria, maximum strain criteria, interacting failure criteria, hygrothermal failure. Laminate first play failure-insight strength; Laminate strength-ply discount truncated maximum strain criterion; strength design using caplet plots;stress concentrations.

TEXT / REFERENCE BOOKS:

1. Material Science and Technology – Vol 13 – Composites by R.W.Ca hn – VCH, West Germany.

2. Materials Science and Engineering, An introduction. WD Callister, Jr., Adapted by R. Balasubramaniam, John Wiley & Sons, NY, Indian edition, 2007.

3. Hand Book of Composite Materials-ed-Lubin.

4. Composite Materials – K.K.Chawla.

5. Composite Materials Science and Applications – Deborah D.L. Chung.

6. Composite Materials Design and Applications – Danial Gay, Suong V. Hoa, and Stephen W. Tasi.

NOTE:

1. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

|MTOE661C: WASTE TO ENERGY (OPEN ELECTIVE) |

|M. Tech. Semester – III (Common for all Branches) |

|L |P |Credits | |Class Work |: |25Marks |

|3 |-- |3 | |Examination |: |75 Marks |

| | | | |Total |: |100 Marks |

| | | | |Duration of Examination |: |3 Hours |

Course Objectives:

To give an idea about different biomass and other solid waste materials as energy source and their processing and utilization for recovery of energy and other valuable products. A comprehensive knowledge of how wastes are utilized for recovery of value would be immensely useful for the students from all fields.

Course Outcomes:

In these days of energy crisis and environmental deterioration, students will understand the concept of energy by waste products. It is being used globally to generate electricity and provide industrial and domestic applications. Students will also enable to understand the environmental issues related to harnessing and utilization of various sources of energy and related environmental degradation.

Syllabus contents:

UNIT I: Sun as Source of Energy, Availability of Solar Energy, Nature of Solar Energy, Solar Energy & Environment. Various Methods of using solar energy –Photothermal, Photovoltaic, Photosynthesis, Present & Future Scope of Solar energy.

UNIT II: Introduction to Energy from Waste: Classification of waste as fuel – Agro based, Forest residue, Industrial waste, MSW

UNIT III: Biogas: Properties of biogas (Calorific value and composition) - Biogas plant technology and status - Bio energy system - Design and constructional features - Biomass resources and their classification, Biomass conversion processes, Thermo chemical conversion, Direct combustion, Types of biogas Plants, Applications.

UNIT IV: Thermo-chemical Conversion: Pyrolysis, Combustion, Gasification, Liquification. Bio-Chemical Conversion: Aerobic and Anaerobic conversion, Fermentation etc. Bio-fuels: Importance, Production and applications. Bio-fuels: Types of Bio-fuels, Production processes and technologies, Bio fuel applications, Ethanol as a fuel for I.C. engines, Relevance with Indian Economy.

TEXT / REFERENCE BOOKS:

1. Non Conventional Energy, Desai, Ashok V., Wiley Eastern Ltd., 1990.

2. Biogas Technology - A Practical Hand Book - Khandelwal, K. C. and Mahdi, S. S., Vol. I & II, Tata McGraw Hill Publishing Co. Ltd., 1983.

3. Food, Feed and Fuel from Biomass, Challal, D. S., IBH Publishing Co. Pvt. Ltd., 1991.

4. Biomass Conversion and Technology, C. Y. WereKo-Brobby and E. B. Hagan, John Wiley & Sons, 1996.

NOTE:

1. In the semester examination, the examiner will set 08 questions in all selecting two from each unit. The candidates will be required to attempt five questions in all selecting at least one from each unit. All questions will carry equal marks.

2. The students will be allowed to use non-programmable scientific calculator. However, sharing/exchange of calculator is prohibited in the examination.

3. Electronics gadgets including Cellular phones are not allowed in the examination.

MTBMDP602C Dissertation Phase-II

M.Tech. Semester – IV (Biomedical Engineering)

L T P Class Work : 100 Marks

- - 32 Practical : 200 Marks

Total : 300 Marks

Credits : 16

The Dissertation (Phase-II) shall be the extension of Dissertation (Phase-I) carried out in 3rd semester. Every student will be required to present three seminar talks, first at the beginning of the semester to present the progress made during the winter break, second in the middle of the semester involving partial results obtained and comparative analysis; and third towards the end of the semester, presenting the dissertation report of the work carried out. Each student will be required to submit two copies of dissertation report to M.Tech. coordinator. The committee constituted by the Chairperson of the department will screen all the presentations so as to award the sessional marks.

INTERNAL ASSESSMENT:

The internal assessment (Class-work evaluation) will be effected through presentation and discussion thereon by the following committee:

1. Chairperson/Head of the Department: Chairperson

2. M.Tech. Coordinator/Senior Faculty : Member Secretary

3. Respective Dissertation Supervisor(s): Member(s)

EXTERNAL ASSESSMENT:

Dissertation will be evaluated by the following committee:

1. Chairperson/Head of the Department: Chairperson

2. Respective Dissertation Supervisor(s): Member(s)

3. External Expert : To be appointed by the University

For this course, supervisor(s) will be assigned a load of 2 hours per week for the first student and additional 1 hour per week for the subsequent student(s) subject to a maximum load of 3 hours. Work load allocated for the joint supervision within the department will be treated as half for each supervisor.

Note: There is a desirable requirement of one publication in a UGC-listed journal/unpaid journal. The external expert must be from the respective area of the specialization. Chairperson and M.Tech. Coordinator with mutual consultation will divide the submitted dissertation into groups depending upon area of specialization and recommend the list of experts for each group separately to the Vice-Chancellor for selecting the examiners (one examiner for not more than four students of a group).

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