“FORMULATION, OPTIMIZATION AND EVAULATION OF …

The systemic bioavailabilty of losartan potassium is approximately 33%, protein binding is 99.7% primarily to albumin, the plasma half-life is about 2 hours and that of metabolite E-3174 is 6-9 hours2. The purpose of the study is to develop a pulsatile tablet in capsule dosage form of losartan potassium for controlled delivery. ................
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