Metabolic Bone - Columbia University

Normal and Abnormal Skeletal Metabolism;

Pathophysiology of Osteoporosis

.JTIBFMB33VCJO .%

5IF5ISFF "HFTPG 8PNFO

(VTUBW,MJNU

1

-FDUVSF0VUMJOF

0TUFPQPSPTJT &QJEFNJPMPHZ

1BUIPQIZTJPMPHZ %JBHOPTJT 4FDPOEBSZDBVTFT

0TUFPNBMBDJB

Osteoporosis: Definition

2

-FDUVSF0VUMJOF

0TUFPQPSPTJT &QJEFNJPMPHZ

1BUIPQIZTJPMPHZ %JBHOPTJT 4FDPOEBSZDBVTFT

0TUFPNBMBDJB

0TUFPQPSPTJT 1SFWBMFODFBOE&QJEFNJPMPHZ

w0TUFPQPSPTJT

wNJMMJPOXPNFOBOENJMMJPONFO

w-PXCPOFNBTT

w"EEJUJPOBMNJMMJPO

w'SBDUVSFT

w"QQSPYJNBUFMZ?PGXPNFOBOE?PGNFO ZSTXJMMTVGGFSBOPTUFPQPSPTJTSFMBUFEGSBDUVSFJO UIFJSMJGFUJNF

3

0TUFPQPSPUJD'SBDUVSFTBOE*ODJEFODF

0WFSNJMMJPOGSBDUVSFTZFBSJONFOBOE XPNFOPWFSBHF

#VSHFFUBM+#.3

Cost of Osteoporosis

wCJMMJPOJOEJSFDUNFEJDBMDPTUT w IPTQJUBMBENJTTJPO wNJMMJPOQIZTJDJBOWJTJUT w OVSTJOHIPNFBENJTTJPOT

4

0TUFPQPSPUJDGSBDUVSFT $PNQBSJTPOXJUIPUIFSEJTFBTFT

Annual incidence x 1000

2000 annual incidence all ages

1 500 000 1500

1000

250 000 forearm

250 000 other sites

500

750 000 vertebral

annual estimate women 29+

513 000

annual estimate

women 30+

228 000

184

300

1996 new all ages

cases,

Osteoporotic Heart Fractures Attack

Stroke

Breast Cancer

American Heart Association,1996 American Cancer Society,1996

Riggs BL & Melton LJ 3rd, Bone, 1995;17(5 suppl):505S-511S

3250

Projected number of osteoporotic

Projected to reach 3.250

hip fractures worldwide

million in Asia by 2050

378 742

100 629 400 668 600

Total number of hip fractures:

1950 = 1.66 million 2050 = 6.26 million

1950 2050

1950 2050

1950 2050

1950 2050

Estimated no of hip fractures: (1000s)

Adapted from Cooper C et al, Osteoporosis Int, 1992;2:285-289

5

 ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download