NEUROENDOCRINE TUMORS

E. Histologic Grade. Cytologic atypia in low-grade neuroendocrine tumors has no impact on clinical behavior of these tumors. However, grading systems based on mitotic activity have been shown to have utility for foregut tumors. The following grading system is recommended12: Grade Mitotic Count (per 10 HPF) # Ki-67 Index (%)## G1 ................
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