Myositis and Your Lungs
Myositis and Your Lungs
2013 TMA Annual Patient Meeting Louisville, Kentucky
Chester V. Oddis, MD University of Pittsburgh Director, Myositis Center
Myositis
Heterogeneous group of autoimmune syndromes characterized by chronic muscle weakness (muscle inflammation), other organ system involvement and a cause that is unknown
Autoimmunity
? Immune response against self
loss of tolerance
? Unknown cause
susceptibility factors (genetic) environmental triggers
e.g. infection
? Multiple diseases and "syndromes"
which sometimes run in families
Autoimmune Diseases
Disease
Rheumatoid Arthritis
Systemic Lupus Erythematosus Scleroderma
Multiple Sclerosis
Myositis
Target Joints (synovium) Skin, joints, kidneys
Skin Nervous system Muscle
Nearly every AI disease has multiple targets!
Autoimmunity (cont'd)
? Immune response against self
loss of tolerance
? Unknown cause
susceptibility factors (genetic) environmental triggers
e.g. infection
? Multiple diseases and "syndromes"
which sometimes run in families
? Formation of autoantibodies
markers of autoimmunity
? Inflammatory in nature
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