Appendix 1 - ICD9 Mapping -cdn.com



Supplementary materialTable of Contents TOC \o "1-3" \h \z \u Appendix 1 - ICD9 Mapping PAGEREF _Toc33625680 \h 2Appendix 2 – Italian stop words used in the ICD9-CM TM analysis PAGEREF _Toc33625681 \h 15Appendix 3 – English stop words used in the Remapped Procedures TM analysis PAGEREF _Toc33625682 \h 16Appendix 4 – TM on CCS remapped procedures PAGEREF _Toc33625683 \h 17Appendix 5 – Complete list of the extracted careflows and remapping into clusters PAGEREF _Toc33625684 \h 19Appendix 6– Grid search evaluation of CFM parameters PAGEREF _Toc33625685 \h 23Appendix 7–CFM only based histories (Admission and SPU events) PAGEREF _Toc33625686 \h 25Appendix 1 - ICD9 MappingMapped ProceduresCount of ICD9 CODESCount of ObservationsLumpectomy104102Plastic Reconstruction On The Breast 263413Injection Infusion Of Chemotherapeutic Substances 22436Operations on the hemic and lymphatic system81995Cardiovascular System Procedures 71257Mastectomy121134Microscopic examination111104Operations on axillary lymph nodes31043Injection Of Therapeutic Substance And Transfusion 22839Other 20672Biopsy 5585Diagnostic Radiology 16476Diagnostic Ultrasound - Metastases1364Rehabilitation 18345General Surgery 54289CAT MRI - Metastases9282Radioisotope Scan And Function Study - Metastases5224Plastic Surgery 13165Diagnostic Ultrasound 5156Operations On Respiratory System 11123Therapeutic Radiology - Metastases4109Operations on the nervous system14103Operations On The Cardiovascular system 1195Operation On Musculoskeletal System 1059Endoscopic Procedure On Digestive System 1155Diagnostic Radiology - Metastases1250Biopsy - Metastases1447Procedures Related To The Psyche 541Nervous System Procedures 634Hyperthermia for Cancer Treatment 219Operation On The Female Genital Organs 817Ophthalmologic And Otologic Procedures 415Operation On The Urinary System 69Endoscopic Procedure On Digestive System - Metastases25Respiratory intubation and mechanical ventilation12PROCEDURE REMAPPINGICD9 - CODESBiopsy 06.1140.1185.1185.1286.11Biopsy - Metastases33.2433.2633.2741.3145.2550.1150.1250.9152.1154.2354.2455.2377.4077.49Cardiovascular System Procedures 88.7288.7789.4389.4489.5089.5289.54CAT MRI - Metastases87.0387.0487.4187.4288.0188.0288.3888.9188.93Diagnostic Radiology85.9188.9887.1187.1787.3787.4487.4987.6187.6287.6587.6987.7488.0388.1988.3489.53Diagnostic Radiology - Metastases87.2187.2287.2387.2487.2987.4388.2188.2688.2788.2888.2988.33Diagnostic Ultrasound 88.7188.7388.7488.7588.79Diagnostic Ultrasound - Metastases88.76Endoscopic Procedure On Digestive System 44.1345.1645.2345.4245.4351.8551.8854.2157.3257.3357.49Endoscopic Procedure On Digestive System - Metastases33.2233.23General Surgery 00.6200.6404.3705.4406.8908.6440.4142.9243.4143.4943.9944.3944.9945.7345.7545.7645.9346.2146.5147.0147.1948.6348.7449.0149.1149.2949.3949.4950.2250.2951.1051.2251.2351.9853.0353.0453.1453.1753.2153.4153.4953.5153.5953.6154.5954.9154.9355.0370.5283.6586.8396.0797.8298.20Hypertermia For Cancer Treatement 93.3499.85Injection Infusion Of Chemotherapeutic Substances 99.2599.28Injection Of Therapeutic Substance And Transfusion 09.6639.9541.0141.0450.9483.9899.0099.0199.0399.0499.0599.1499.1599.1799.1899.1999.2199.2399.2499.2699.2999.52Lumpectomy85.2085.2185.2285.2385.2485.2585.8192.1692.1892.28Mastectomy39.9885.3385.3485.3585.3685.4185.4285.4385.4485.4585.4685.48Microscopic examination90.5390.5990.7991.0691.3191.3291.3391.4291.6691.8991.99Nervous System Procedures 03.3189.1389.1489.1589.1789.19Operation on Musculoskeletal System 77.6080.5981.9181.9283.3283.9188.3193.0893.1697.87Operation On The Female Genital Organs 65.3165.4965.5365.6265.6368.2969.1989.26Operation On The Urinary System 05.5405.9855.5156.3156.8196.49Operations on axillary lymph nodes40.2240.2340.51Operations On Respiratory System 34.0934.9134.9389.3789.3889.6693.1893.9093.9193.9693.99Operations On The Cardiovascularsystem 03.7038.5938.9138.9338.9538.9939.2739.5039.9086.0799.61Operations on the hemic and lymphatic system04.0304.0940.1940.2440.2940.5240.5340.59Operations on the nervous system00.3600.4203.5303.9003.9103.9203.9303.9403.9604.8004.8104.9905.3105.39Ophthalmologic and Otologic Procedures 21.8640.2195.0295.03Other 08.2308.6108.6308.8608.8708.9757.9489.0189.0289.0389.0589.0689.0789.0889.0989.6189.6593.0799.7999.84Plastic Reconstruction On The Breast85.8208.5683.4385.3185.3285.5085.5185.5385.5485.8585.8785.8985.9385.9485.9585.9686.0286.6386.6986.7086.7286.7586.8486.9388.9488.97Plastic Surgery86.6078.4986.0186.0486.0986.1986.2286.2386.2886.5986.8993.5796.59Procedures Related To The Psyche 94.0994.1294.3794.3894.42Radioisotope Scan And Function Study - Metastases92.0192.0992.1492.1592.19Rehabilitation 93.0193.0393.0993.1193.1293.1393.1493.1793.1993.2293.2793.3693.3893.3993.7493.8293.8394.63Respiratory intubation and mechanical ventilation96.70Therapeutic Radiology - Metastases92.2492.2592.2692.29Appendix 2 – Italian stop words used in the ICD9-CM TM analysisList of stop words available in the R package topicmodels [1] "ad" "al" "allo" "ai" "agli" "all" [7] "agl" "alla" "alle" "con" "col" "coi" [13] "da" "dal" "dallo" "dai" "dagli" "dall" [19] "dagl" "dalla" "dalle" "di" "del" "dello" [25] "dei" "degli" "dell" "degl" "della" "delle" [31] "in" "nel" "nello" "nei" "negli" "nell" [37] "negl" "nella" "nelle" "su" "sul" "sullo" [43] "sui" "sugli" "sull" "sugl" "sulla" "sulle" [49] "per" "tra" "contro" "io" "tu" "lui" [55] "lei" "noi" "voi" "loro" "mio" "mia" [61] "miei" "mie" "tuo" "tua" "tuoi" "tue" [67] "suo" "sua" "suoi" "sue" "nostro" "nostra" [73] "nostri" "nostre" "vostro" "vostra" "vostri" "vostre" [79] "mi" "ti" "ci" "vi" "lo" "la" [85] "li" "le" "gli" "ne" "il" "un" [91] "uno" "una" "ma" "ed" "se" "perché" [97] "anche" "come" "dov" "dove" "che" "chi" [103] "cui" "non" "più" "quale" "quanto" "quanti" [109] "quanta" "quante" "quello" "quelli" "quella" "quelle" [115] "questo" "questi" "questa" "queste" "si" "tutto" [121] "tutti" "a" "c" "e" "i" "l" [127] "o" "ho" "hai" "ha" "abbiamo" "avete" [133] "hanno" "abbia" "abbiate" "abbiano" "avrò" "avrai" [139] "avrà" "avremo" "avrete" "avranno" "avrei" "avresti" [145] "avrebbe" "avremmo" "avreste" "avrebbero" "avevo" "avevi" [151] "aveva" "avevamo" "avevate" "avevano" "ebbi" "avesti" [157] "ebbe" "avemmo" "aveste" "ebbero" "avessi" "avesse" [163] "avessimo" "avessero" "avendo" "avuto" "avuta" "avuti" [169] "avute" "sono" "sei" "è" "siamo" "siete" [175] "sia" "siate" "siano" "sarò" "sarai" "sarà" [181] "saremo" "sarete" "saranno" "sarei" "saresti" "sarebbe" [187] "saremmo" "sareste" "sarebbero" "ero" "eri" "era" [193] "eravamo" "eravate" "erano" "fui" "fosti" "fu" [199] "fummo" "foste" "furono" "fossi" "fosse" "fossimo" [205] "fossero" "essendo" "faccio" "fai" "facciamo" "fanno" [211] "faccia" "facciate" "facciano" "farò" "farai" "farà" [217] "faremo" "farete" "faranno" "farei" "faresti" "farebbe" [223] "faremmo" "fareste" "farebbero" "facevo" "facevi" "faceva" [229] "facevamo" "facevate" "facevano" "feci" "facesti" "fece" [235] "facemmo" "faceste" "fecero" "facessi" "facesse" "facessimo" [241] "facessero" "facendo" "sto" "stai" "sta" "stiamo" [247] "stanno" "stia" "stiate" "stiano" "starò" "starai" [253] "starà" "staremo" "starete" "staranno" "starei" "staresti" [259] "starebbe" "staremmo" "stareste" "starebbero" "stavo" "stavi" [265] "stava" "stavamo" "stavate" "stavano" "stetti" "stesti" [271] "stette" "stemmo" "steste" "stettero" "stessi" "stesse" [277] "stessimo" "stessero" "stando" List of stop words added for the analysis presented in this paper[1] "altra" "altre" "altro" "altri" "altrove" [6] "routine" "nas" "semplice" "strutture" "classificate" [11] "classificato" "microscopici" "sistema" "sostanza" "sostanze" [16] "determinazione" "diagnostica" "dinamico" "assiale" "computerizzata"[21] "farmaci" "apparato" "arteriosa" "arterioso" "venosa" [26] "venoso" "misto" "mista" "monitoraggio" "sistemica" [31] "periferico" "ossa" "cellule" "gruppo" "mammella" [36] "definito" "limitato" "invasive" "misure" "procedure" [41] "body" "total" "complessive" "definite" "generale" [46] "attivi" "passivi" "stato" "passo" "coltura" [51] "approfondito" "esame" "accesso" "dispositivo" "limitate" [56] "continua" "positiva" "contemporaneo" "mediante" "occupazionale" [61] "matrice" "plica" "ungueale" "unghia" "dilatazione" [66] "esofago" "iniezione" "infusione" Appendix 3 – English stop words used in the Remapped Procedures TM analysisList of stop words available in the R package topicmodels [1] "i" "me" "my" "myself" "we" "our" [7] "ours" "ourselves" "you" "your" "yours" "yourself" [13] "yourselves" "he" "him" "his" "himself" "she" [19] "her" "hers" "herself" "it" "its" "itself" [25] "they" "them" "their" "theirs" "themselves" "what" [31] "which" "who" "whom" "this" "that" "these" [37] "those" "am" "is" "are" "was" "were" [43] "be" "been" "being" "have" "has" "had" [49] "having" "do" "does" "did" "doing" "would" [55] "should" "could" "ought" "i'm" "you're" "he's" [61] "she's" "it's" "we're" "they're" "i've" "you've" [67] "we've" "they've" "i'd" "you'd" "he'd" "she'd" [73] "we'd" "they'd" "i'll" "you'll" "he'll" "she'll" [79] "we'll" "they'll" "isn't" "aren't" "wasn't" "weren't" [85] "hasn't" "haven't" "hadn't" "doesn't" "don't" "didn't" [91] "won't" "wouldn't" "shan't" "shouldn't" "can't" "cannot" [97] "couldn't" "mustn't" "let's" "that's" "who's" "what's" [103] "here's" "there's" "when's" "where's" "why's" "how's" [109] "a" "an" "the" "and" "but" "if" [115] "or" "because" "as" "until" "while" "of" [121] "at" "by" "for" "with" "about" "against" [127] "between" "into" "through" "during" "before" "after" [133] "above" "below" "to" "from" "up" "down" [139] "in" "out" "on" "off" "over" "under" [145] "again" "further" "then" "once" "here" "there" [151] "when" "where" "why" "how" "all" "any" [157] "both" "each" "few" "more" "most" "other" [163] "some" "such" "no" "nor" "not" "only" [169] "own" "same" "so" "than" "too" "very" List of stop words added for the analysis presented in this paper [1] "system" "substance" "substances" "procedure" "procedures" [6] "operation" "operations" "general" "related" "microscopic"[11] "study" "function" "scan"Appendix 4 – TM on CCS remapped proceduresUsing the same procedure described in the Methods section and applied to the ICD9-CM case, to choose the number of topics of the model we performed a grid search on K ranging from 2 to 13, and evaluated consistency, redundancy, importance, and perplexity. Consistency does not change with k, and it is always greater than 0.75. Redundancy is 0 up until K=6, never reaching values higher than 0.25. Importance slowly decreases between K=3 and K=7, with a steeper decrease from K=7. Perplexity shows a fast increase for K>7. In general, given the low number of words in the dictionary, models with higher number of topics over-describe the documents’ space. a) b) c) d) Remapped proceduresTOPICWORDS# WordsTOPIC LABEL1axillarylymphnodes3Lymph nodes operations2plasticbreastreconstruction3Plastic3therapeuticmetastasestransfusiondiagnosticcardiovascularradiologyultrasoundotherrehabilitationexamination10Other exams and therapies4injectionchemotherapeuticinfusion3Chemotherapy5lumpectomyhemiclymphatic3Lumpectomy6mastectomybiopsy2Mastectomy / BiopsyAppendix 5 – Complete list of the extracted careflows and remapping into clustersClusterEvent 1Event 2Event 3Event 41Lumpectomy; prosthesisOUTOUTOUT1Mastectomy; prosthesisOUTOUTOUT1Mastectomy; prosthesisPlastic; prosthesisOUTOUT1Mastectomy; prosthesisSkin graft / Lymph nodes operations; skinOUTOUT1Plastic; prosthesisOUTOUTOUT1Plastic; prosthesisPlastic; prosthesisOUTOUT1Plastic; prosthesisSkin graft / Lymph nodes operations; skinOUTOUT1Plastic; prosthesisSkin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skinOUT1Skin graft / Lymph nodes operations; skinOUTOUTOUT1Skin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skinOUTOUT1Skin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skinPlastic; prosthesisOUT1Skin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skinOUT1Skin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skinPlastic; prosthesis1Skin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skin1Skin graft / Lymph nodes operations; prosthesisOUTOUTOUT2Lumpectomy; removalChemotherapy; tumorChemotherapy; tumorChemotherapy; tumor2Lumpectomy; removalChemotherapy; tumorChemotherapy; tumorOUT2Lumpectomy; removalChemotherapy; tumorDay Hospital; SPU visitOUT2Lumpectomy; removalChemotherapy; tumorOther exams and therapies; tumorOUT2Lumpectomy; removalChemotherapy; tumorOUTOUT2Lumpectomy; removalDay Hospital; SPU visitDay Hospital; SPU visitDay Hospital; SPU visit2Lumpectomy; removalDay Hospital; SPU visitDay Hospital; SPU visitOUT2Lumpectomy; removalDay Hospital; SPU visitOUTOUT2Lumpectomy; removalLumpectomy; removalDay Hospital; SPU visitOUT2Lumpectomy; removalLumpectomy; removalOUTOUT2Lumpectomy; removalOther exams and therapies; tumorChemotherapy; tumorOUT2Lumpectomy; removalOther exams and therapies; tumorOUTOUT2Lumpectomy; quadrantectomyDay Hospital; SPU visitDay Hospital; SPU visitOUT2Lumpectomy; quadrantectomyDay Hospital; SPU visitOUTOUT2Mastectomy; removalChemotherapy; tumorChemotherapy; tumorOUT2Mastectomy; removalChemotherapy; tumorOUTOUT2Mastectomy; removalDay Hospital; SPU visitDay Hospital; SPU visitOUT2Mastectomy; removalDay Hospital; SPU visitOUTOUT2Mastectomy; unilateralChemotherapy; tumorChemotherapy; tumorOUT2Mastectomy; unilateralChemiotherapy; tumorOUTOUT2Mastectomy; unilateralDay Hospital; SPU visitOUTOUT2Mastectomy; prosthesisChemiotherapy; tumorOUTOUT2Mastectomy; prosthesisDay Hospital; SPU visitOUTOUT2Skin graft / Lymph nodes operations; removalChemiotherapy; tumorChemiotherapy; tumorOUT2Skin graft / Lymph nodes operations; removalChemiotherapy; tumorOUTOUT2Skin graft / Lymph nodes operations; removalDay Hospital; SPU visitDay Hospital; SPU visitOUT2Skin graft / Lymph nodes operations; removalDay Hospital; SPU visitOUTOUT3Mastectomy; removalChemotherapy; tumorChemotherapy; tumorPlastic; prosthesis3Mastectomy; removalChemiotherapy; tumorPlastic; prosthesisOUT3Mastectomy; removalDay Hospital; SPU visitDay Hospital; SPU visitPlastic; prosthesis3Mastectomy; removalDay Hospital; SPU visitPlastic; prosthesisDay Hospital; SPU visit3Mastectomy; removalDay Hospital; SPU visitPlastic; prosthesisOUT3Mastectomy; removalPlastic; prosthesisDay Hospital; SPU visitOUT3Mastectomy; unilateralChemotherapy; tumorPlastic; prosthesisOUT4Lumpectomy; removalLumpectomy; quadrantectomyOUTOUT4Lumpectomy; removalMastectomy; removalOUTOUT4Lumpectomy; removalMastectomy; unilateralOUTOUT4Lumpectomy; quadrantectomyLumpectomy; removalOUTOUT4Lumpectomy; quadrantectomyLumpectomy; quadrantectomyOUTOUT5Lumpectomy; removalPlastic; prosthesisOUTOUT5Lumpectomy; removalSkin graft / Lymph nodes operations; removalOUTOUT5Lumpectomy; removalSkin graft / Lymph nodes operations; skinOUTOUT5Lumpectomy; removalSkin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skinOUT5Mastectomy; removalPlastic; prosthesisOUTOUT5Mastectomy; removalPlastic; prosthesisPlastic; reconstructionOUT5Mastectomy; removalPlastic; prosthesisSkin graft / Lymph nodes operations; skinOUT5Mastectomy; removalPlastic; prosthesisSkin graft / Lymph nodes operations; skinSkin graft / Lymph nodes operations; skin5Mastectomy; unilateralPlastic; prosthesisOUTOUT5Mastectomy; unilateralPlastic; prosthesisPlastic; reconstructionOUT5Mastectomy; unilateralPlastic; prosthesisSkin graft / Lymph nodes operations; skinOUT6Day Hospital; SPU visitLumpectomy; removalOUTOUT6Day Hospital; SPU visitMastectomy; removalDay Hospital; SPU visitOUT6Day Hospital; SPU visitMastectomy; removalOUTOUT6Day Hospital; SPU visitOUTOUTOUT6Day Hospital; SPU visitSkin graft / Lymph nodes operations; removalOUTOUT7Lumpectomy; removalOther exams and therapies; exercisesOUTOUT7Mastectomy; removalOther exams and therapies; exercisesOUTOUT8Chemiotherapy; biopsyOUTOUTOUT8Lumpectomy; removalOUTOUTOUT8Lumpectomy; quadrantectomyOUTOUTOUT8Mastectomy; removalOUTOUTOUT8Mastectomy; unilateralOUTOUTOUT8Skin graft / Lymph nodes operations; removalOUTOUTOUT9Lumpectomy; removalOther exams and therapies; ultrasoundOUTOUT9Lumpectomy; removalOther exams and therapies; examsOUTOUTAppendix 6 – Grid search evaluation of CFM parameters CFM algorithm parameters were selected following the grid-search approach presented in Section 2.3. In particular, we performed a grid search by varying min_support in the range 2-50 and max_length in the range 3-10. The Figure below shows a heatmap with the corresponding values for the number of careflows, the average number of patients per careflow, the average number of missed events, and the true match rate for each value of the pair of parameters min_support and max_length.Red values should be avoided, choosing minimum support and maximum history length accordingly. As can be seen from red boxes on heatmap, some indicators need to be maximized (true match rate and mean number of patients per careflow), and other to be minimized (number of mined careflows, mean number of missed events). The last heatmap reports a normalized score that combines all four parameters. All the single indicators have been normalized on a scale from 0 to 1, where 0 corresponds to the old red box values and 1 to the lighter values. The normalized values are combined together using the mean. As seen in the last heatmap, the best score is reached in the interval between 5 and 10 events for minimum_support and a maximum_history_length larger than 5 events. Choosing 10 as minimum support allows deriving less than one hundred histories.-64135165100088265368300011474451016000Appendix 7–CFM only based histories (Admission and SPU events) History Regrouping HistoryHistEventsRecodeHist_1_SubHist_9_SPUBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUT_OUT_OUTH0Hist_1_SubHist_3_SPUBreastSurgery_OUT_OUT_OUT_OUT_OUT_OUTH0Hist_1_SubHist_4_SPUOncology_OUT_OUT_OUT_OUT_OUT_OUTH0Hist_1_SubHist_2_AdmissionBreastSurgery_OUT_OUT_OUT_OUT_OUT_OUTH1Hist_1_SubHist_17_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUTH2Hist_1_SubHist_14_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUTH2Hist_1_SubHist_10_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUT_OUTH2Hist_1_SubHist_5_AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUT_OUT_OUTH2Hist_1_SubHist_11_AdmissionBreastSurgery_AdmissionBreastSurgery_SPUOncology_OUT_OUT_OUT_OUTH2Hist_1_SubHist_6_AdmissionBreastSurgery_AdmissionOncology_OUT_OUT_OUT_OUT_OUTH3Hist_1_SubHist_7_AdmissionBreastSurgery_SPUBreastSurgery_OUT_OUT_OUT_OUT_OUTH4Hist_1_SubHist_8_AdmissionBreastSurgery_SPUOncology_OUT_OUT_OUT_OUT_OUTH5Hist_1_SubHist_13_AdmissionBreastSurgery_SPUOncology_SPUOncology_OUT_OUT_OUT_OUTH5Hist_1_SubHist_16_AdmissionBreastSurgery_SPUOncology_SPUOncology_SPUOncology_OUT_OUT_OUTH5Hist_1_SubHist_18_AdmissionBreastSurgery_SPUOncology_SPUOncology_SPUOncology_SPUOncology_OUT_OUTH5Hist_1_SubHist_12_AdmissionBreastSurgery_SPUOncology_AdmissionBreastSurgery_OUT_OUT_OUT_OUTH6Hist_1_SubHist_15_AdmissionBreastSurgery_SPUOncology_SPUOncology_AdmissionBreastSurgery_OUT_OUT_OUTH6Phenotypes – Table 1HisotryH0H1H2H3H4H5H6Number of patients16015137065165604247Age55.7(14.0)63.1(13.0)52.7(11.6)66.1(13.0)59.2(13.9)58.6(12.2)50(10.7)Type of SurgeryLumpectomy99(61.88)1329(87.84)287(40.65)34(66.67)38(58.46)479(79.3)62(25.1)Mastectomy61(38.12)184(12.16)419(59.35)17(33.33)27(41.54)125(20.7)185(74.9)Histological TypeDCIS In situ cancer 25(15.62)170(11.24)116(16.43)5(9.8)9(13.85)6(0.99)6(2.43)CDI Invasive ductal cancer120(75)1090(72.04)464(65.72)38(74.51)39(60)511(84.6)195(78.95)CLI Invasive lobular cancer15(9.38)253(16.72)126(17.85)8(15.69)17(26.15)87(14.4)46(18.62)GradingG125(15.62)272(17.98)91(12.89)6(11.76)6(9.23)16(2.65)11(4.45)G287(54.37)965(63.78)432(61.19)30(58.82)38(58.46)268(44.37)114(46.15)G348(30)276(18.24)183(25.92)15(29.41)21(32.31)320(52.98)122(49.39)Neoadjuvant chemotherapy No85(53.12)1407(92.99)642(90.93)39(76.47)61(93.85)525(86.92)213(86.23)Yes74(46.25)88(5.82)60(8.5)12(23.53)2(3.08)70(11.59)31(12.55)Unknown1(0.62)18(1.19)4(0.57)0(0)2(3.08)9(1.49)3(1.21)Cancer multifocality NO121(75.62)1230(81.3)471(66.71)38(74.51)47(72.31)468(77.48)153(61.94)Yes39(24.38)283(18.7)235(33.29)13(25.49)18(27.69)136(22.52)94(38.06)StagingStage 054(33.75)201(13.28)128(18.13)6(11.76)10(15.38)28(4.64)12(4.86)Stage 163(39.38)925(61.14)343(48.58)21(41.18)30(46.15)221(36.59)67(27.13)Stage 222(13.75)333(22.01)181(25.64)12(23.53)20(30.77)236(39.07)104(42.11)Stage 321(13.12)54(3.57)54(7.65)12(23.53)5(7.69)119(19.7)64(25.91)Biomolecular subtypeLuminal A69(43.12)1048(69.27)400(56.66)28(54.9)38(58.46)152(25.17)88(35.63)Luminal B52(32.5)366(24.19)213(30.17)17(33.33)19(29.23)279(46.19)98(39.68)Her2+27(16.88)17(1.12)31(4.39)2(3.92)0(0)71(11.75)27(10.93)TNBC12(7.5)82(5.42)62(8.78)4(7.84)8(12.31)102(16.89)34(13.77)Hormone therapy NO60(37.5)250(16.52)143(20.25)16(31.37)14(21.54)213(35.26)71(28.74)Yes100(62.5)1263(83.48)563(79.75)35(68.63)51(78.46)391(64.74)176(71.26)Chemotherapy NO64(40)1341(88.63)480(67.99)27(52.94)52(80)90(14.9)30(12.15)Yes96(60)172(11.37)226(32.01)24(47.06)13(20)514(85.1)217(87.85)Radiotherapy NO74(46.25)328(21.68)412(58.36)17(33.33)28(43.08)103(17.05)126(51.01)Yes86(53.75)1185(78.32)294(41.64)34(66.67)37(56.92)501(82.95)121(48.99)Lipofilling intervention No142(88.75)1496(98.88)425(60.2)46(90.2)55(84.62)579(95.86)164(66.4)Yes18(11.25)17(1.12)281(39.8)5(9.8)10(15.38)25(4.14)83(33.6)Local/loco-regional recurrence (Yes)18(11.25)14(0.93)76(10.76)2(3.92)8(12.31)40(6.62)37(14.98)Metastasis - Distant recurrence (Yes)32(20)18(1.19)38(5.38)8(15.69)6(9.23)115(19.04)43(17.41)Exitus (Yes)18(11.25)15(0.99)27(3.82)16(31.37)5(7.69)68(11.26)27(10.93)Loco-Regional Recurrence – Survival (disease-free) curves – time in monthsDistant Metastasis - survival (disease-free) curvesDeath – survival curves ................
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