The MIRD Schema for Radiopharmaceutical Internal Dose …

The MIRD Schema for Radiopharmaceutical Internal Dose Calculation

Learning Objectives

? Describe the MIRD methodology for internal dosimetry

? Identify the similarities and differences between the MIRD and ICRP formalisms

MIRD Schema

Developed by the Medical Internal Radiation Dose (MIRD) Committee of the Society of Nuclear Medicine

Dose calculations needed to evaluate risks of radiopharmaceutical use for imaging, therapy, or noninvasive studies

Standard methodology used in nuclear medicine, but not for occupational internal dosimetry

Reference Material

The MIRD Primer (Lovinger, Budinger, and Watson, 1991)

MIRD Pamphlets 1-14

published periodically in J. Nucl. Med.

Radiation Dose Estimates for Radiopharmaceuticals (Stabin, Stubbs, and Toohey, 1996--NUREG/CR-6345)

Fetal Dose Workbook (Stabin 1998)

Simplified MIRD Dose-rate Equation

Consider a single radionuclide with a single type of radiation uniformly distributed in an almost infinitely large volume of tissue ("source organ")

Define a "particle" as either a photon, an electron, an alpha or a beta (+ or -)

Let E = the mean particle energy,

n = the number of particles per decay, and k = a unit conversion constant

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