Compartmental Analysis Revisited:
Compartmental Analysis Revisited:
A study on the dissolution kinetics of a potassium chloride pill
Group R1
Magdalena Jonikas
Kevin Kedra
Eric Sussman
Jay Sy
I. Abstract
Compartmental analysis is a useful means of tracking the transfer of mass between multiple-compartment systems and is analogous to many processes in the body, including drug transfer from blood to tissue. In this study, the dissolution behavior of solid potassium chloride (KCl) pills was studied under various conditions in a 1- and 2-compartment experimental setup. For dissolution trials, we found that the grain size of the pill or an initial concentration of KCl in the compartment did not have an effect on its dissolution rate. However, adding gelatin to the pill by 25% mass increased the dissolution constant from 0.0093 ± 0.0005 s-1 to 0.0398 s-1. For two-compartment analysis, we found that the transfer of KCl between compartments could be accurately modeled.
Additionally, three models for describing the transfer of mass between the two compartments were explored and their concentration predictions were compared to experimental data. The first model is based on a mass balance of KCl and uses the exponential change in the mass of the pill to solve the differential equations. The second method uses two-compartment trial data to model the transfer of KCl from the pill, which is also expected to dissolve exponentially. The third and final model is based on the exponential decay of the surface area of the pill and a mass transfer coefficient. When we compared the dissolution constants for each method of analysis, we found that the same constants were produced (P=0.006, n=6). However, by comparing the square error between each model and the data, we found that the first model is not a sufficient predictor of the compartment concentration (P>0.05, n=7) for dissolution studies, however this model is sufficient for two-compartment studies (P ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related searches
- what is a standard financial analysis plan
- business analysis application
- why financial analysis is important
- breath analysis for medical applications
- data analysis questions examples
- best free stock analysis websites
- example of financial analysis paper
- is hair analysis testing accurate
- cooper applied behavior analysis citation
- financial analysis of a company
- best stock analysis websites
- stock analysis on net