Compartmental Analysis Revisited:



Compartmental Analysis Revisited:

A study on the dissolution kinetics of a potassium chloride pill

Group R1

Magdalena Jonikas

Kevin Kedra

Eric Sussman

Jay Sy

I. Abstract

Compartmental analysis is a useful means of tracking the transfer of mass between multiple-compartment systems and is analogous to many processes in the body, including drug transfer from blood to tissue. In this study, the dissolution behavior of solid potassium chloride (KCl) pills was studied under various conditions in a 1- and 2-compartment experimental setup. For dissolution trials, we found that the grain size of the pill or an initial concentration of KCl in the compartment did not have an effect on its dissolution rate. However, adding gelatin to the pill by 25% mass increased the dissolution constant from 0.0093 ± 0.0005 s-1 to 0.0398 s-1. For two-compartment analysis, we found that the transfer of KCl between compartments could be accurately modeled.

Additionally, three models for describing the transfer of mass between the two compartments were explored and their concentration predictions were compared to experimental data. The first model is based on a mass balance of KCl and uses the exponential change in the mass of the pill to solve the differential equations. The second method uses two-compartment trial data to model the transfer of KCl from the pill, which is also expected to dissolve exponentially. The third and final model is based on the exponential decay of the surface area of the pill and a mass transfer coefficient. When we compared the dissolution constants for each method of analysis, we found that the same constants were produced (P=0.006, n=6). However, by comparing the square error between each model and the data, we found that the first model is not a sufficient predictor of the compartment concentration (P>0.05, n=7) for dissolution studies, however this model is sufficient for two-compartment studies (P ................
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