PHARMACOLOGY BASIC PRINCIPLES
Max inotropic response to catecholamine can be achieved even if 90% β-receptors blocked by irreversible antagonist ... Explains why sensitivity of tissue to certain conc of agonist doesn’t only depend on affinity of receptor/drug but on concentration of receptors. Eg. There are 100 receptors: ... Phenylephrine, methoxamine (α2 also but to ... ................
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