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Department of Medicinal ChemistryWelcome to the Department of Medicinal ChemistryDrug discovery and development maintains its role in traditional drug therapy, but its application to pharmacogenomics may become the treatment modality of the future. The scope of knowledge in organic chemistry, biochemistry, pharmacology and therapeutics allows scientists to make generalizations connecting the physico-chemical properties of small organic molecules and peptides to the receptor and biochemical properties of living systems. Therefore, these generalizations, validated by repetitive examples, emerge in time as principles of drug discovery and drug mechanisms, principles that describe the structural relationships between diverse organic molecules and the bimolecular functions that predict their mechanisms toward controlling diseases.The graduate programs of medicinal chemistry department are regulated to train outstanding medicinal chemists who will be able to work in research and teaching areas as well as in pharmaceutical technologies and industries.Message of the Head of Department From the historical aspect, medicinal chemistry is focused on organic synthetic chemistry with the broad goals of drug discovery and optimization. Since the past few decades, medicinal chemistry has been conducted to consider the physical, computational, analytical, and chemical properties of drugs and drug targets. These innovations include enzyme chemistry, protein design, protein structure prediction, proteomics and chemical biology that bring about the accelerated discovery of new drugs. This approach in modern medicinal chemistry allows for the elucidation of disease pathways and drug actions mechanisms. From several years ago, the department has tried to orient its educational and research programs to modern medicinal chemistry. Therefore, the aim of research programs has been extended in two known drug discovery areas, including traditional and modern drug discovery. The scopes of both fields are sufficiently broad to give students with different science backgrounds an interesting and challenging program of study. Organic synthesis of medicinal agents, computational chemistry, structural biology, cell and molecular biology, drug metabolism, natural products chemistry, bio-analytical and molecular toxicology, biological evaluation and animal models are areas of active interest. Our current research focus is cancer, inflammation disorders, neurodegenerative disorders and antifungal and antimicrobial compounds, hypertension and diabetes diseases. The department has excellent collaborations with other research groups in the faculty and university, in order to research in the major areas of medicinal Chemistry and receive related research support.About the Department of Medicinal ChemistryThe department of Medicinal Chemistry is one the oldest departments in the Faculty of Pharmacy, established in 1963. All the undergraduate students are required to pass 31 units in the Department of Medicinal Chemistry as theoretical and practical courses. Students have access to a wide range of modern instrumentation and equipment used in the design and synthesis of new therapeutic agents, both within the department’s facilities and nearby laboratories of our research centers. Various research groups actively collaborate with groups from departments such as biochemistry, biological sciences, chemistry, and pharmacology. The scope of this field is sufficiently broad to give students with many different science backgrounds a rewarding and challenging program of study.Our research focus is on the following areas:Design, and synthesis of new medicinal agents Investigation of biological activity of new medicinal agentsStructural elucidation of active natural compoundsImprovement of structures of existing drugs by molecular modificationDevelopment of new analytical methods for the determination of drug in formulation and different complex matrix Broad research projects introduce new analytical methods for the determination of drugs in pharmaceutical dosage forms and biological fluids.Current major department research areas includes:-Discovery and validation of new anti-cancer, anti-inflammatory, antibiotic, anti-Alzheimer and anti-hypertension drugs.-Molecular modeling and simulation of bimolecular structure, dynamics and interactions.-Separation and identification of natural products-Application of Mass, NMR and other spectrophotometric techniques to the elucidation of natural products and small molecular structures.-Synthesis and evaluation of novel biopolymers for site-targeted drug delivery.-Synthesis of new chromogenic and fluorogenic markers for the analysis of elements and drugs.-The development of new analytical methods for the determination and identification of chemical compounds and drugs in different matrices.Department ProfileThe Department of Medicinal Chemistry is located in the Faculty of Pharmacy, and is an integral part of Tehran University of Medical Sciences at Tehran. This Department is located in the Faculty of Pharmacy on the 1st floor of the new building at Tehran University of Medicinal Sciences. Currently, the Department has 13 members, including seven full professors, four associate professors, and two assistant professors. In addition, several people, including organic and analytical chemists with M.S. or B.S. degrees work in laboratories of Medicinal Chemistry Department. The Department has several teaching laboratories including general and analytical chemistry, organic and medicinal chemistry, and instrumentation. Pharm.D. and Ph.D. students work on their thesis in eight research laboratories. Research interests of the Department are design and QSAR study, synthesis and biological evaluation, and pharmaceutical analysis. Department ChartMission and VisionMission As defined by IUPAK, medicinal chemistry is a chemistry-based discipline, involving the aspects of biological, medical, and pharmaceutical sciences. Our mission is to educate and train scientists to achieve excellence in medicinal chemistry for the improvement of human health. In this regard our research focused on the invention, discovery, design, identification, and preparation of biologically active compounds, the study of their metabolisms, interpretation of their modes of action in the molecular level and construction of structure-activity relationships (SAR), the relationship between chemical structure and pharmacological activity for a series of compounds.The major mission of the Medicinal Chemistry Department is to create new knowledge to discover and develop new pharmaceutical drugs, paralleled with general aims of the faculty. Since twenty years ago, the mission has developed to conduct basic research in chemistry and biological chemistry related to drug discovery, to teach these principles in the professional and graduate programs and to provide service to the scientific community. Areas of active interest include drug discovery, organic synthesis of medicinal agents, natural product chemistry, pro-drugs, molecular modeling, and pharmaceutical analysis. VisionThe objective of the Department of Medicinal Chemistry is to raise and maintain the standing of Tehran University of Medical Sciences in academic circles, both domestically and internationally in applied fields, in terms of basic medicinal chemistry and analytical skills and synthesis. Outline of Courses:The Medicinal Chemistry Department presents the following courses for pharm. D. student in faculty of pharmacy. These courses are presented for 100 pharm. D. students every year.Core courses of Pharm. D. No.Coursecreditshour1General Chemistry4682Practical General Chemistry1173Analytical Chemistry2344Practical Analytical Chemistry2345Organic Chemistry (I)3516Practical Organic Chemistry (I)1177Organic Chemistry (II)3518Practical Organic Chemistry (II)1179Instrumentation analysis (I)35110Instrumentation analysis (II)23411Practical Instrumentation analysis11712Medicinal Chemistry (I)35113Medicinal Chemistry (II)35114Medicinal Chemistry (III)351Four Ph.D. students are accepted in Ph.D. program in medicinal chemistry every year. Core courses of Ph. D. in medicinal chemistry are as followed:No.Coursecreditshour1Advanced organic chemistry and synthesis 3513Practical medicinal chemistry1174Advanced Instrumentational analysis2345Advanced biochemistry4516Advanced pharmacology2347Heterocyclic chemistry2348Advanced medicinal chemistry I3519Advanced medicinal chemistry II35110Seminar I and II2-9Non-core courses6-10Thesis22-Research Centers & LaboratoriesThe department has been jointed to two research centers (Pharmaceutical Sciences Research Center and Drug Design & development Research Center) to develop its research activities. Several instrumentations such as Mass, NMR, IR and laboratory devices are available for both Pharm. D and Ph. D students. Research properties in the above research centers include:Docking study for finding new lead compoundsSynthesis of new compounds in order to develop biological activitiesDevelopment of analytical methods for identification and determination of drugs in different matrixes The following laboratories are completely under management of the department;: Medicinal Chemistry LaboratoriesAnalytical Chemistry LaboratoryGeneral Chemistry LaboratoryInstrumentational Analysis LaboratoryBasic Organic Chemistry Research Laboratory Department MembersName of the faculty member: Ali KhalajEducation: PharmD, PhD of Medicinal ChemistryAcademic position: ProfessorEmail:khalaj@ams.ac.irResearch Interest: 1- Synthesis and biological evaluation of new small molecules in several areas of medicinal chemistry2- Synthesis of new compounds labeled with radionuclides 3- Application of radio pharmacy in medicinal chemistryName of the faculty member: Fazel ShamsaEducation: PharmD, PhD of Medicinal ChemistryAcademic position: ProfessorEmail:shamsa@tums.ac.irResearch Interest: 1- Development of analytical techniques for chemical and drug compound assays in natural products2- Traditional medicine in aspect of analytical chemistry Name of the faculty member: Mohsen VosooghiEducation: PharmD, PhD of BiochemistryAcademic position: Associate-ProfessorEmail: vosoghim@tums.ac.irResearch Interest: 1- Synthesis and biological evaluation of new small molecules in several areas of medicinal chemistry2- Chemistry of SteroidsName of the faculty member: Effat Sori Education: PharmD, PhD of Medicinal ChemistryAcademic position: Professor, Head of the DepartmentEmail:souri@tums.ac.irResearch Interest: 1- Development of analytical techniques for determination of drugs compound in dosage forms using spectrophotometric, spectrofluorimetric and HPLC methods2- Analysis of chiral drugs3- Evaluation of biological activity of plants Name of the faculty member: Seyed Esmaeil Sadat EbrahimiEducation: PharmD, PhD of Medicinal ChemistryAcademic position: Associate ProfessorEmail: sesebrahimi@sina.tums.ac.irResearch Interest: 1- Synthesis and biological evaluation of new small molecules, peptides, and radio labeled compounds in several areas of medicinal chemistry2- QSAR studies 3- Structure elucidation of natural products by spectroscopic methods (NMR, IR, UV,…)Name of the faculty member: Morteza Pirali HamedaniEducation: PharmD, PhD of Medicinal ChemistryAcademic position: ProfessorEmail: piraliha@tums.ac.irResearch Interest: 1- Synthesis and biological evaluation of new small molecules and peptide compounds in several areas of medicinal chemistry2- Development of analytical techniques for chemical and drug compound bio-assays in biological matrices3- Structure elucidation of natural products Name of the faculty member: Maliheh Barazandeh TehraniEducation: PharmD, PhD of Medicinal ChemistryAcademic position: Assistant ProfessorEmail: barazand@tums.ac.irResearch Interest: 1- Development of analytical techniques for chemical and drug compound assays in dosage form and biological matrices2- Development of analytical techniques for chemical compound assays based on the formation of metal-analyte complexName of the faculty member: Masoud AmanlouEducation: PharmD, PhD of Medicinal ChemistryAcademic position: ProfessorEmail:amanlou@tums.ac.irResearch Interest: 1- Synthesis and biological evaluation of new small molecules and peptide compounds in several areas of medicinal chemistry2- Development of analytical techniques for chemical and drug compound bio-assays in biological matrices3- Docking technique and QSAR study Name of the faculty member: Mohsen AminiEducation: PharmD, PhD of Medicinal ChemistryAcademic position: ProfessorEmail:moamini@tums.ac.irResearch Interest: 1- Synthesis and biological evaluation of new small molecules in several areas of medicinal chemistry2- Development of analytical techniques for assay of chemical and drug compounds in dosage form and biological matrices3- Structure elucidation of natural products Name of the faculty member: Reza Dolatabadi BazazEducation: PharmD, PhD of Radio PharmacyAcademic position: Associate ProfessorEmail: dolataba@tums.ac.irResearch Interest: 1- Synthesis and biological evaluation of new small molecules in several areas of medicinal chemistry2- Development of analytical techniques for assay of chemical and drug compounds in dosage form and biological matrices3- Genomics and proteomicsName of the faculty member: Latifeh NavidpourEducation: PharmD, PhD of Medicinal ChemistryAcademic position: Associate ProfessorEmail: navidpur@tums.ac.irResearch Interest: 1- Synthesis and biological evaluation of new small molecules as well as peptides in several areas of medicinal chemistry2- Synthesis of new heterocyclic compounds3- Synthesis of new compounds in aspect of stereochemistry4- Usage of virtual screening to find new active compoundsName of the faculty member: Tahmineh AkbarzadehEducation: PharmD, PhD of Medicinal ChemistryAcademic position: Assistant ProfessorEmail: akbarzad@tums.ac.irResearch Interest: 1- Synthesis and biological evaluation of new small molecules in several areas of medicinal chemistry2- Synthesis of new heterocyclic compounds3- Study on chemistry of formation ligand-metal complexAdmission:For further study in the medicinal chemistry field, it is necessary to participate in the faculty professional entrance exam. This exam is held every year in June.Academic CalendarTests DateBeginning and end of the semesterDuration of Training10–31 January20 September – 31 January16 weeksFirst Semester20 June –10 July10 February–10 July16 weeksSecond Semester--Not availableSummer SemesterAdministrative StaffF. KayghobadiPosition: Lab ExpertContact Details: Telephone: 021-64122234L. JaliliPosition: Lab ExpertContact Details: Telephone: 021-64122140M. TehraniPosition: Lab ExpertContact Details: Telephone: 021-6412158A. JavidniaPosition: Lab ExpertContact Details: Telephone: 021-64122149M. AgharaziPosition: Lab ExpertContact Details: Telephone: 021-64121122M. MajouriPosition: Lab ExpertContact Details: Telephone: 021-64121108R. FaridiPosition: SecreteryContact Details: Telephone: 021-64121123Department's Regulations and PrivilegesThe educational legislation of Medicinal Chemistry Department agrees to the general educational legislation of the faculty and has carried out as same.Lab regulationsStudents should use general safety guidelines that have been educated by Health, Safety and Environment office Students learn how to work with all lab facilities according to the Lab supervisor's guidanceStudents must fill in the form to work in the lab.Students must keep their workbench clean and tidy.Students must use common sense and do not rush in the laboratoryEating and drinking is prohibited in labOur Alumni and Job Placement of GraduatesSince 1992, the department has educated more than 80 medicinal chemists and in the present time they are working as faculty members of other pharmacy faculties in IRAN or other countries. Some of them are work in pharmaceutical companies in Iran or other countries. Job Placement of Graduates:Graduates of this course are going to act in several fields as below:Educational fieldsPharm. D courses: Including theoretical and practical of all chemistry courses in the Faculty of PharmacyPhD courses of medicinal chemistryIndustrial fieldsRaw material Industry Finished product industry QC and R&D centers in pharmaceutical companiesOther general activities: Analysis of the final product, product safety, quality control, and safety, qualification of process chemical and drugs.Research fieldsDevelopment of new bioassay techniqueDesign and development of new molecules with biological activity approaches New drugs, proteins and lead compounds discoveryCharacterization of natural molecules Management fieldsEngagement in regulatory authorities (i.e. environmental or health authority)Project management of medicinal chemistry or synthesis of raw materialRecommended Reference Books for Each Program1- Finding Information in Science, Technology and Medicine Jill Lambert, Taylor & Francis, latest edition2- Information Technology Solutions for Healthcare Krzysztof Zieli?nski et al. , latest edition 3- Basic and Clinical Pharmacology, B. G. Katzung, S. B. Masters, J. Trevor Last Edition4- Analytical Chemistry: an introduction Douglas A. Shoog, Donald M. West, F. James Holler, Stanley R. Crouch, Last Edition5- Biochemistry, Berg, Tymoczko and Stryer, Last Edition 6- Protein Structure and Function, Whitford, Last Edition 7- Principle of Biochemistry, Lehninger, Last Edition 8- Principles of Drug Action, B. Profvtt and P. Taylor, Churchill Livingstone (ISBN: 044308671)9- Advanced Organic Chemistry, Francis A. Carey and Richard J. Sundberg. Last Edition10- Introduction to the Principles of Drug Design, H. J. Smith and Williams, (ISBN: 0723612110) Last Edition, 11- Medical Chemistry and drug discovery, Manufred E. Wolff, Burgers, Wiley (ISBN: 0471575569, Last Edition12- Molecular orbital calculations of biological systems, Anne- Mar Sapseie, Oxford Uiversity Press (ISBN: 0195098730), Last Edition13- Molecular Similarity in Drug Design, P.M. Dean, Blackie Academic & Professional (ISBN: 0751402214), Last Edition14- Drugs of Future (ISSN: 0377- 8282)15- Drugs (ISSN: 0012- 6667)16-Foye's Principles of Medicinal Chemistry, Last Edition17- Guide to Spectroscopic Identification of Organic Compounds. K. Feinsten, Last Edition18- The Systematic Identification of Organic Compounds, C.K.F. Hermman, R.H.Shriner, Last Edition 19- Principles of Instrumental Analysis, D. A. Skoog, F. J. Holler, T.A. Nieman, Last Edition20-Chemical Analysis: Modern Instrumentation methods and Techniques, F.Rouessac, A. Rouessac, Last Edition21- The Heterocyclic Chemistry, Mas L. Gilchrist, Last Edition22- Heterocyclic Chemistry, Gupta R. R., Kumar M., and Gupta V., Last Edition23- The organic chemistry of drug synthesis volumes 1 ,2, 3, D. Lednicer, L.A. Mitcher, John Wiley & Sons (ISBN: 0- 471- 09250- 9), Last Edition24- Guide to Spectroscopic Identification of Organic Compounds. K. Feinsten, C.R.C. (ISBN: 084934481), Last Edition 25- The Systematic Identification of Organic Compounds, 7E. Solutions Manual. C.K.F. Hermman, R.H.Shriner, John Wiley & Sons (ISBN 0471161357), Last EditionExaminations and AwardsSome of the department members has received different awards in research or educational fields - First degree of Razi Award (2005). - The Distinguished Honor of Global Science Contribution, Iran Society of Biophysical Chemistry (2006) - First degree of Tehran University Research award (2007). - Outstanding Professor of Tehran University of Medical Sciences (2008)- Dr. Afzalipour Highest Award for Research (2011)- Outstanding Scientist of Islamic Countries (2011)- Highest National Medal of Medical Sciences (2011)- First degree of Razi award (2011). - Allameh Tabatabaee Award from Elites National Foundation (2012).FAQs:Am I eligible to apply?Applicants must have Pharm. D. or MS. of chemistry (Organic, analytical, and medicinal chemistry) degree to apply for medicinal chemistry postgraduate program. ................
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