Antimicrobial resistance prevalence at the UKs first ...



Homogeneity of antimicrobial policy, yet heterogeneity of antimicrobial resistance: antimicrobial non-susceptibility among 108,717 clinical isolates from primary, secondary and tertiary care patients in London

Authors:

Moore, Luke SP 1,2

Freeman, Rachel 2

Gilchrist, Mark J 2

Gharbi, Myriam 1

Brannigan, Eimear T 2

Donaldson, Hugo 2

Livermore, David M 3,4

Holmes, Alison H 1,2*

1 National Centre for Infection Prevention and Management, Imperial College London, Hammersmith Campus, Du Cane Road, London. W12 0HS. United Kingdom.

2 Imperial College Healthcare NHS Trust, Fulham Palace Road, London.W6 8RF. United Kingdom.

3 Norwich Medical School, University of East Anglia, Norwich. NR4 7TJ. United Kingdom.

4 Antimicrobial Resistance & Healthcare Associated Infection Reference Unit, Public Health England, 61 Colindale Avenue, London NW9 5EQ

Corresponding author: *Professor Alison H Holmes, National Centre for Infection Prevention and Management, Imperial College London, Hammersmith Campus, London. W12 0HS. United Kingdom.

Email: alison.holmes@imperial.ac.uk, telephone: 02033131283, fax: 02083833394.

Running title:

Heterogeneity of antimicrobial resistance in London.

Keywords:

Antibiogram

Healthcare-associated infection

Multi-drug resistant organism

Antimicrobial stewardship

Antimicrobial policy

Synopsis:

Objectives: We examined the four-year trend in antimicrobial susceptibilities and prescribing across levels-of-care at two London teaching hospitals and their multisite renal unit, and for the surrounding community.

Methods: Laboratory and pharmacy information management systems were interrogated, with antimicrobial use and susceptibilities analysed between hospitals, within hospitals, and over time.

Results: 108,717 isolates from 71,687 patients were identified, with significant differences (at p ................
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