Antimicrobial resistance prevalence at the UKs first ...
Homogeneity of antimicrobial policy, yet heterogeneity of antimicrobial resistance: antimicrobial non-susceptibility among 108,717 clinical isolates from primary, secondary and tertiary care patients in London
Authors:
Moore, Luke SP 1,2
Freeman, Rachel 2
Gilchrist, Mark J 2
Gharbi, Myriam 1
Brannigan, Eimear T 2
Donaldson, Hugo 2
Livermore, David M 3,4
Holmes, Alison H 1,2*
1 National Centre for Infection Prevention and Management, Imperial College London, Hammersmith Campus, Du Cane Road, London. W12 0HS. United Kingdom.
2 Imperial College Healthcare NHS Trust, Fulham Palace Road, London.W6 8RF. United Kingdom.
3 Norwich Medical School, University of East Anglia, Norwich. NR4 7TJ. United Kingdom.
4 Antimicrobial Resistance & Healthcare Associated Infection Reference Unit, Public Health England, 61 Colindale Avenue, London NW9 5EQ
Corresponding author: *Professor Alison H Holmes, National Centre for Infection Prevention and Management, Imperial College London, Hammersmith Campus, London. W12 0HS. United Kingdom.
Email: alison.holmes@imperial.ac.uk, telephone: 02033131283, fax: 02083833394.
Running title:
Heterogeneity of antimicrobial resistance in London.
Keywords:
Antibiogram
Healthcare-associated infection
Multi-drug resistant organism
Antimicrobial stewardship
Antimicrobial policy
Synopsis:
Objectives: We examined the four-year trend in antimicrobial susceptibilities and prescribing across levels-of-care at two London teaching hospitals and their multisite renal unit, and for the surrounding community.
Methods: Laboratory and pharmacy information management systems were interrogated, with antimicrobial use and susceptibilities analysed between hospitals, within hospitals, and over time.
Results: 108,717 isolates from 71,687 patients were identified, with significant differences (at p ................
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