Pinin Interacts with C-terminal Binding Proteins for RNA ...



Joint Symposium of the Dana-Farber/Harvard Cancer Center Programs in Breast and Gynecologic CancersMarch 4, 2016GENETICS AND GENOMICSGenome-scale Screening for New OncogenesAllison P Clark, Manish Neupane, Dave E Hill, Marc Vidal and Daniel P Silver Integrated analysis of mRNA, copy number and proteomics profiles of TCGA high-grade serous ovarian cancer reveals new markers of prognosis.Aedin CulhaneThe genomic evolution of endometrial carcinoma progression and abdominopelvic metastasis.William J. Gibson, Erling A. Hoivik, Mari K. Halle, Amaro Taylor-Weiner, Andrew D. Cherniack, Anna Berg, Frederik Holst, Travis I. Zack, Henrica M. J. Werner, Kjersti M. Staby, Mara Rosenberg, Ingunn M Stefansson, Kanthida Kusonmano, Aaron Chevalier, Karen K. Mauland, Jone Trovik, Camilla Krakstad, Marios Giannakis, Eran Hodis, Kathrine Woie, Line Bjorge, Olav K. Vintermyr, Jeremiah Wala, Michael S Lawrence, Gad Getz , Scott L. Carter , Rameen Beroukhim , Helga B. SalvesenIdentification of subtype-specific gene regulation in high-grade serous ovarian cancerKuijjer ML, Glass K, Quackenbush JFeasibility and efficacy of a precision treatment approach for triple-negative breast cancer in mouse models Hui Liu, Charlie Murphy, Florian Karreth, Kang Kang Yang, Olivier Elemento, Gerburg M. Wulf, Lewis C. CantleyAnalysis of Resistance to the Combination of a PI3K- and Parp-InhibitorUsing a Genomic Sequencing ApproachSheida Nabavi, Ashish Juvekar, Nicholas Wang, Lewis C. Cantley, and GerburgWulfUnderstanding the genomic underpinnings of breast cancer in young womenC Oh, N Wagle, E Morgan, B Larsen1, K Ruddy, T Cederroth, E Brachtel, L Schapira, SE Come, V Borges, E Warner, E Winer, LC Collins and A PartridgeEpigenomic changes induced by PI3K/AKT inhibitors are mediated by the dephosphorylation of the H3K4 demethylase KDM5ASpangle, JM, Dreijerink, KM, Groner, AC, Cheng, H, Ohlson C, Reyes, J, Lin, CY, Bradner, J,Zhao, JJ, Roberts, TM, and Brown, M.An open-reading frame overexpression screen to identify genes mediating cisplatin and paclitaxel response in high-grade serous ovarian cancer cell lines.Elizabeth Stover, Cory Johanessen, Federica Piccioni, Mukta Bagul, Ursula Matulonis, Levi GarrawayMechanisms of resistance (MoR) to DNA damaging therapy in BRCA1/2-deficient metastatic breast cancer (MBC)Adrienne G. Waks, Ofir Cohen, Karla Helvie, Max Lloyd, Lori Marini, Coyin Oh, Nelly Oliver, Neal I. Lindeman, Ursula Matulonis, Ian Krop, Levi A. Garraway, Eric P. Winer, Nancy U. Lin, Nikhil WagleBCL6 and MYC cooperate to promote high grade serous ovarian cancerSarah R. Walker, Marieke Kuijjer, Yixi Zhang, John Quackenbush, and David A. FrankCDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer Yubao Wang, Tinghu Zhang, Nicholas Kwiatkowski, Brian J. Abraham, Tong Ihn Lee, Shaozhen Xie, Haluk Yuzugullu, Thanh Von, Heyuan Li, Ziao Lin, Daniel G. Stover, Elgene Lim, Zhigang C. Wang, J. Dirk Iglehart, Richard?A. Young, Nathanael S. Gray and Jean J. ZhaoChromosomal scars and response to PARP inhibitor-based therapy in ovarian caner Zhigang C. Wang, Nicolai Juul Birkbak, William T. Barry, Thomas M. Roberts, Eric P. Winer, J Dirk Iglehart, Ursula A. Matulonis, and Joyce F. LiuTumor-Stroma Cross-Talk in High Grade Serous Ovarian CancerOana A. Zeleznik, Shelley S. Tworoger, Aedin C. Culhane CLINICAL AND TRANSLATIONAL STUDIESThe combination of bazedoxifene and palbociclib in the treatment of ER+ breast cancerMacintosh Cornwell, Matthew Pun, Mai Nguyen, Gilles Buchwalter, Myles Brown, Rinath JeselsohnPatterns of utilization of imaging and tumor markers (TM) among metastatic breast cancer (MBC) patients (pts).Antonio Di Meglio, Nancy U Lin, Rachel A Freedman, William T Barry, Eric P Winer,Ines Vaz-LuisICAM-1-Targeted, Lcn2 siRNA-Encapsulating Liposomes are Potent Anti-angiogenic Agents for Triple Negative Breast CancerPeng Guo, Jiang Yang, Marsha A. Moses and Debra T. AugusteDesign of effective combination therapies for high-grade serous ovarian cancer using patient-derived xenograft modelsClaudia Iavarone, Ioannis Zervantonakis, Laura Selfors, Hsing-Yu Chen, Sangeetha S. Palakurthi, Joyce Liu, Ursula Matulonis, Ronny Drapkin, Gordon Mill, Joel Leverson, Deepak Sampath, and Joan S. BruggeIn vivo synergism between PARP-inhibitor olaparib and HSP90-inhibitor AT13387 in high grade serous ovarian cancer patient derived xenograftsPanagiotis A. Konstantinopoulos, Sangeetha Palakurthi, Qing Zeng, Shan Zhou, Joyce F. Liu, Naveen Kommajosyula, Alan D. D’Andrea, Geoffrey I. Shapiro, Ursula A. MatulonisMicroRNA profiling to identify novel determinants of platinum resistance in BRCA1/2-mutated high grade serous ovarian cancerKhyati Meghani, Yizhou He, Elizabeth Swisher, Ursula Matulonis, Panagiotis A Konstantinopoulos and Dipanjan ChowdhuryOrthotopic PDX models of HER2+ breast cancer brain metastases facilitate discovery of a therapeutic strategy yielding durable remissionsJing Ni, Shakti H. Ramkissoon, Shaozhen Xie, Shom Goel, Daniel G. Stover, Hanbing Guo, Victor Luu, Eugenio Marco, Lori A. Ramkissoon, Yun Jee Kang, Marika Hayashi, Quang-De Nguyen, Azra H. Ligon, Rose Du, Elizabeth B. Claus, Brian M. Alexander, Guo-Cheng Yuan, Zhigang C. Wang, J. Dirk Iglehart, Ian E. Krop, Thomas M. Roberts, Eric P. Winer, Nancy U. Lin, Keith L. Ligon, Jean J. ZhaoA Reversible Contraceptive that Protects the Ovarian Reserve During Chemotherapy.David Pépin, Motohiro Kano, Amanda Sosulski, Lihua Zhang, Fotini Nicolaou, Nicholas Nagykery, Guangping Gao, Patricia K. DonahoeCost-effectiveness of the Oncotype Dx DCIS Score for Guiding Treatment of Patients with Ductal Carcinoma In SituAnn C. Raldow, MD MPH, David Sher, MD MPH, Aileen B. Chen, MD MPP, Abram Recht, MD, Rinaa S. Punglia, MD MPHImmune Activation Signatures Identify a Subset of ER+ Breast Cancers with Increased Pathologic Complete Response to Neoadjuvant ChemotherapyDaniel G. Stover, Adrienne G. Waks, Sara M. Tolaney, Joan S. Brugge, Eric P. Winer, and Laura M. SelforsImmunogenicity of clear cell ovarian cancer: association with ARID1A loss, microsatellite instability and endometriosis Kyle C. Strickland, Brooke E. Howitt, Scott Rodig, Ursula A. Matulonis, Panagiotis A. KonstantinopoulosNipple Changes During and After Pregnancy in Women who Have Undergone Nipple Sparing Mastectomy Rong Tang MD, Suzanne B. Coopey MD, Jennifer Plichta MD, Upahvan Rai, Amy S. Colwell MD, Michele A. Gadd MD, Michelle C. Specht MD, William G. Austen, Jr. MD, Barbara L. Smith MD, PhDFactors associated with non-use of adjuvant trastuzumab in older patients with HER2-positive breast cancer: a population-based study Ines Vaz-Luis, Nancy U. Lin, Nancy L. Keating, William T. Barry, Joyce Lii, Harold J. Burstein, Eric P. Winer, Rachel A. FreedmanNeutralization of BCL2/XL enhances the cytotoxicity of T-DM1 in vivo.Jason J. Zoeller, Roderick T. Bronson, Deepak Sampath, Joel Leverson, Joan S. BruggeRISK AND PREVENTIONQUALITY OF BREAST CANCER SCREENING IN BRAZIL: EXTERNAL ASSESSMENT FOR IMPROVING ACCESS AND QUALITY PROGRAMMara Rejane Barroso Barcelos, Rita de Cássia Duarte Lima, Elaine Tomasi, Bruno Nunes, Suele Manjourany Silva Duro, Malgorzata Chalupowski, Timothy Rebbeck, Luiz Augusto FacchiniQUALITY OF CERVICAL CANCER SCREENING IN BRAZIL: EXTERNAL ASSESSMENT OF IMPROVING ACCESS AND QUALITY PROGRAMMara Rejane Barroso Barcelos, Rita de Cássia Duarte Lima, Elaine Tomasi, Bruno Nunes, Suele Manjourany Silva Duro, Malgorzata Chalupowski , Timothy Rebbeck, Luiz Augusto Facchini Caregiver burden and risk of epithelial ovarian cancer in the Nurses’ Health StudiesMollie E. Barnard, Tianyi Huang, Elizabeth M. Poole, Laura D. Kubzansky, Shelley S. TworogerAir pollution at breast cancer diagnosis and survival from breast cancerNatalie DuPre SM, Jaime E Hart ScD, Kimberly Bertrand ScD, Francine Laden ScD, Rulla Tamimi ScDAltered Progenitor Function and Breast Cancer PredispositionMihriban Karaayvaz, Kenneth Ross, Leif W. Ellisen Breast cancer knowledge, behaviors, and preferences in Malawi: implications for early detection Racquel E. Kohler, PhD; Satish Gopal, MD MPH; Clara N. Lee, MD MPP; Bryan J. Weiner, PhD; Bryce B. Reeve, PhD; Stephanie B. Wheeler, PhD MPHCirculating Lipids and Mammographic DensitySarah Lucht, Heather Eliassen, Rulla TamimiPre- and post-diagnosis analgesic use and ovarian cancer survivalMelissa A. Merritt, Megan S. Rice, Shelley S. Tworoger, and Elizabeth M. PooleTexture variation on a mammogram and risk of breast cancerMegan Rice, Kimberly Bertrand, John Heine, Bernard Rosner, Rulla TamimiSingle-cell analysis using CyTOF and DNA-Exchange-ImagingRon C.J. Schackmann, Jesse L. Silverberg, Sarit S. Agasti, Yu Wang, Peng Yin, Joan S. BruggeMammography Decision-Making: Trends, Predictors and Effects of Provider Communication in the Health Information National Trends Survey 2011-2014Laura Spring, MD, Megan Marshall BS, and Erica T. Warner, ScDSleep duration and difficulty in relation to breast cancer survival: Results from the Nurses’ Health Study Claudia Trudel-Fitzgerald, PhD; Eric S. Zhou, PhD; Elizabeth M. Poole, PhD; Xuehong Zhang, MD, ScD; Shelley S. Tworoger, PhD; Eva Schernhammer, MD, DrPHRotating Night Shift Work and Mammographic Breast Density in Premenopausal and Postmenopausal Women in the Nurses’ Health StudiesWegrzyn LR, Rosner BA, Tamimi RM, Schernhammer ESTUMOR BIOLOGYmiR-34a Silences c-SRC to Attenuate Tumor Growth in Triple Negative Breast CancerAdams BD, Wali VB, Cheng CJ, Inukai S, Booth CJ, Agarwal S, Rimm DL, Gy?rffy B, Santarpia L, Pusztai L, Saltzman WM, and Slack FJInnovative therapeutic strategy to eradicate cancer stem cells and to prevent OvCa recurrenceChiara Bellio, Rosemary Foster, Whitfield B. Growdon and Bo R. Rueda The dual roles of microRNA-200: From inclusion cyst formation to cell migration.?Pui Wah Choi, Junzheng Yang, Wing Ping Fong, Ross S. Berkowitz, William R. Welch, Gregory J. Goodall, Shu-Wing NgCDK4/6 inhibition sensitizes HER2-positive breast cancers to anti-HER2 therapyShom Goel, April C. Watt, Qi Wang, Sara M. Tolaney, Deborah A. Dillon, Wei Li, Haluk Yuzugullu, X. Shirley Liu, Piotr Sicinski, Eric P. Winer, Ian E. Krop, Jean J. ZhaoClass IIa HDAC inhibition promotes an anti-tumor macrophage phenotype that induces breast tumor regression and inhibits metastasis Jennifer L. Guerriero, Alaba Sotayo, Holly E. Ponichtera, Alexandra Pourzia, Sara Schad, Ruben D. Carrasco, Suzan Lazo, Roderick T. Bronson, Anthony LetaiPhosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin cytoskeletonHai Hu, Ashish Juvekar, Costas A. Lyssiotis, Evan C. Lien, John G. Albeck, Doogie Oh, Gopal Varma, Yin Pun Hung, Soumya Ullas, Josh Lauring, Pankaj Seth, Mark R. Lundquist, Dean R. Tolan, Aaron K. Grant, Daniel J. Needleman, John M. Asara, Lewis C. Cantley and Gerburg M. WulfA Role for FANCD2 in Fork Stability and Alternative End-JoiningZeina Kais, Beatrice Rondinelli, Amie Holmes, Colin O'Leary, David Kozono, Alan D. D'Andrea and Raphael CeccaldiEstrogen receptor-negative breast cancer cell lines exhibit hypersensitivity to the CHK1 inhibitor LY2606368Jean-Bernard Lazaro, Elizaveta Reznichenko, Kalindi Parmar, Geoffrey I. Shapiro, Alan D. D’AndreaMECP2 is a frequently amplified oncogene with a novel epigenetic mechanism which mimics the role of activated RAS in cancersManish Neupane, Allison P. Clark, Serena Landini, Nicolai J. Birkbak, Aron C. Eklund, Elgene Lim, Aedin C. Culhane, William T. Barry, Steven E. Schumacher, Rameen Beroukhim, Zoltan Szallasi, Marc Vidal, David E. Hill, Daniel P. SilverCellular Origin for Epithelial Ovarian CancerEun-Sil Park and Zhe LiSentinel lymph node metastases in breast cancer: A contributor to distant metastases?Ethel R. Pereira, Dmitriy Kedrin, Dennis Jones, Elizabeth Beech, Alphonse G. Taghian and Timothy P. PaderaDeciphering the alterations of the ER cistrome with the acquisition of tamoxifen resistanceMatthew Pun, Macintosh Cornwell, Myles Brown, Rinath JeselsohnTreatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen sialyl TnK. Starbuck, D. Eavarone, J. Prendergast, A.P.G. da Silva, J. DeSander, J. Behrens2, B. Rueda, R. FosterThe Jak/STAT3 signaling pathway promotes 3D growth of ovarian cancerSarah R. Walker, Yixi Zhang, Suhu Liu, and David A. FrankBRCA1 suppresses tandem duplications at Tus/Ter-stalled replication forks.Nicholas A. Willis, Richard L. Frock, Frederick W. Alt, Ralph ScullyDistinct EMT Programs Control Normal Stem Cells and Cancer Stem Cells of Mammary TissueXin Ye, Wai Leong Tam, Tsukasa Shibue, Yasemin Kaygusuz, Ferenc Reinhardt, and Robert A. Weinberg1Pinin Interacts with C-terminal Binding Proteins for RNA Alternative Splicing and Epithelial Cell Identity of Human Ovarian Cancer CellsYanli Zhang, Jamie Sui-Lam Kwok, Pui-Wah Choi, Minghua Liu, Junzheng Yang, Margit Singh, Shu-Kay Ng, William R. Welch, Michael G. Muto, Stephen KW Tsui, Stephen P. Sugrue, Ross S. Berkowitz, and Shu-Wing Ng ................
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