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Appendix 2: attributes and levels for the included studies. Osteoarthritis characteristicsTreatment characteristicsTreatment benefitsTreatment complicationCostAl-Omari, (2017)Al-Omari et al., (2017)Al-Omari et al., (2015)Way of taking the medication Cream/gelOralFrequency Once a dayTwice a day3-4 times a dayAs neededAvailabilityInternet purchaseOver the counterPrescriptionHow much you would expect to beneift Expect 25%Expect 50%Expect 75%Risk of heart attacks and strokesNo risk Low risk Moderate risk High riskRisk of kidney and liver side effectsNo risk Low risk Moderate risk High riskRisk of stomach side effects No risk Low risk Moderate risk High riskRisk of addiction No risk Low risk Moderate risk High riskByrne et al., (2006)Pain: No painMildModerateWalking:Able to walk and climb stairs without difficultyAble to walk without difficulty for 10 blocks. A little difficulty climbing stairsAble to walk for five to six blocks, then need to stop. Some difficulty climbing stairsComplications:5% chance of complications from surgery such as blood clots or infections25% chance of complications40% chance of complicationsDeath:1 in 5,000 chance of death from surgery1 in 1,000 chance of death1 in 100 chance of deathFailure:1% chance of reoperation needed in the next 10 years10% chance of reoperation needed in the next 10 yearsChang et al., (2005)Severity of pain:NoneMildModerateSevereExtremeDaily activities:NoneMildModerateSevereExtremeStiffness:NoneMildModerateSevereExtremeLevel of functioning:NoneMildModerateSevereExtremeMedication use (if any):NoneMildModerateSevereExtremeGastrointestinal side effects:No side effectsMild side effects, treatable with over-the-counter medicationMild side effects, treatable with prescription medicationUlcer, treatable with prescription medicationBleeding ulcer, treatable with prescription medicationBleeding ulcer requiring surgery.Fraenkel and Fried, (2008)Route of administration:Cream applied up kneePillsInjections into the knee (up to four times per year)Exercise (low impact aerobic/strength training for minimum of 30 minutes 3 times per week)Improved strength:Improves strength and enduranceDoes not improve strength and enduranceDecrease in pain:8 out of 10 people have less pain5 out of 10 people have less pain3 out of 10 people have less painRisk of dyspepsia:Causes stomach upset or heartburn in 3 out of 10 peopleDoes not cause stomach upset or heartburnRisk of bleeding ulcer:Causes a bleeding ulcer in 1 in 100 peopleDoes not cause bleeding ulcersFraenkel et al., (2014)The way the medication is taken: A pill taken once a day An injection once a week An infusion once a monthHow well the medication worksPreventing the progression of arthritis in 80% of people.Preventing the progression of arthritis in 60% of people.Preventing the progression of arthritis in 40% of people.The possible risksMild side effectsModerate side effectsSerious side effectsCostEasily affordable. No changes in budget neededSomewhat affordable. Minor changes in budget neededHard to afford. Major changes in budget needed.Fraenkel et al., (2004A)Fraenkel et al., (2004B)Fraenkel et al., (2004C)Route of administration:Natural supplementOne pill by mouth; every dayOne pill by mouth; twice a dayOne pill by mouth; 4 times a dayCream applied to knee(s) 3 times a dayLabel:Prescription medicationOver-the-counter medicationOnset of action:1–2 hoursWithin 1 weekWithin 2 weeksWithin 4 weeksPercent of patients who benefit:25%50%75%100%Annual risk of ulcer:No added risk of ulcer1%2%8%Common adverse effects:Nausea, diarrhea, heartburnWell toleratedNausea, constipation, dizzinessHarris et al., (2018)Your recovery will last10 Weeks12 WeeksYou will needfuture surgery toremove your jointhardwareYesNoAfter surgery, your joint stiffness will beMildModerateSevereAfter Surgery, your grip strength willImproveDecreaseSurgery will costyou (out-of pocket)$2,000$4,000$6,000Hauber et al., (2013)Pain while moving around 1 h after taking the MedicineNoneMildModerateSeverePain while sitting, lying down, or sleeping 1 h after taking the medicineNoneMildModerateSevereStiffness 1 h after taking the medicine NoneMildModerateSevereDifficulty doing your daily activities 1 h after taking the medicineNoneMildModerateSevereChance of a bleeding ulcer requiring an operation within the next year because of the medicineNone10 out of 1,000 (1.0%)50 out of 1,000 (5.0%)y100 out of 1,000 (10.0%)yAdditional chance of a heart attack or stroke within the next 5 years because of the medicineNo chanceout of 1,000 (0.5%)15 out of 1,000 (1.5%)30 out of 1,000 (3.0%)Laba et al., (2013)Dose frequency13 (Base)Mode of actionQuick pain relief (Base)Slow OsteoarthritisTreatment ScheduleWhen needed (Base)DailyPrescriptionYesNoPain Efficacy1347Side effectsNo side effects (Base)Drowsy/constipatedHeartburn/reflux, stomach ulcersHigh blood pressure, heart/kidney/liver problemsMonthly cost$AUS 5, $AUS 20, $AUS 35 $AUS 50Moorman et al. (2017)How much cutting and removal of existing bone is requiredNone1 leg bone cut2 leg bones cut with partial bone removal2 leg bones cut with extensive bone removalLength of hospital stay requiredNone, outpatient procedure1 night stay typical2 night typicalRecovery time needed before standing, bearingweight without crutchesImmediately after procedurewkwk12 wkTime before resuming daily activities1-2 mo3-4 mo5-6 moPostrecovery activity restrictionsNo restrictions, even running and jumping allowedModerate activity allowed, excluding running and jumpingOnly low-impact activities allowedChance of additional surgeryNone25% require surgical removal of original implant within 2 y5% require surgical removal of original implant and progression to surgery with bonecuts and extensive bone removal within 2 yMaintains natural knee motionYesNoAmount of pain reliefComplete relief5% experience some minor pain10% experience some minor pain30% experience some minor painLimits or complicates any future treatment needs on the kneeAllows all future knee surgical optionsAllows for limited future knee surgical options (with bone cuts and partial bone removal)Allows for only end-stage knee surgical options (with bone cuts and extensive bone removal)Pinto et al., (2019)Time per physical activity occasionLowMediumHighHealth benefitsLowMediumHighEnjoymentLowMediumHighConvenienceLowMediumHighPhysical activity effortLowMediumHighMonthly cost$20 per month$50 per month$80 per monthRatcliffe et al., (2004)Joint pain:Occasionally2-3 times per week Most daysJoint aches:Very slightModerateSeverMobility:Normal Some difficultyConfined to a chairRisk of mild/moderate side effects:25%50%75%Risk of serious side effects:0.2%0.5%2% ................
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