Kinetic and intrinsic solubility determination of some b ...
described by Avdeef [5]. The intrinsic solubility is the equilibrium solubility of the free acid or base form of an ionizable compound at a pH where it is fully unionized [6]. Kinetic-based methods have been introduced to meet the needs of drug discovery teams. These methods use solutions prepared from DMSO stocks and attempt to rank or classify ................
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