Lippincott Williams & Wilkins
Most common in blacks, Hispanics, Mediterraneans, from Middle East . 2 million in US have SC trait. 30,000 in US have SCD. Etiology. Having 1 gene: sickle cell trait . Having 2 genes: sickle cell disease. Hemoglobin production is abnormal. RBCs have sickle shape. RBCs get caught at capillaries. RBC lifespan is shortened (Fig. 5.7) Complications ................
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