C&P Service Clinician's Guide - Veterans Affairs

Another gene, the apolipoprotein E (APOE) gene has three common alleles: epsilon 2 or e2, epsilon 3 or e3, and epsilon e4 or e4; Those individuals with one e4 allele have a 2-3-three-fold increased risk of AD; further, those with two e4 alleles have an 8-12-fold increased risk; it appears that the mutant e4 allele leads to the impaired ... ................
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