Lippincott Williams & Wilkins



Supplementary Tables

Table 1. Effect of Bevacizumab Added to Carboplatin and Paclitaxel Chemotherapy on Hazard Ratios for Overall Survival for Adults age less than 65 years with Stage IIIB/IV, Non-squamous NSCLC

|Models |Hazard Ratio (95% CI) |

| |Bevacizumab |Bevacizumab |

| |Carboplatin-Paclitaxel- vs |Carboplatin-Paclitaxel- vs |

| |Carboplatin-Paclitaxel |Carboplatin-Paclitaxel |

| |2005-2010 |2002-2004 |

| |Age < 65 Years |Age < 65 Years |

|Unadjusted modela |0.81 (0.65-1.02) |0.64 (0.50-0.81) |

|Multivariable-adjusted modela,b |0.78 (0.62-1.00) |0.62 (0.48-0.80) |

|Propensity score-adjusted modela,c |0.79 (0.63-1.01) |0.64 (0.50-0.83) |

|Weighting (stabilized IPW) a, d |0.81 (0.57-1.17) |0.62 (0.47-0.81) |

|Matching 1:1e |0.88 (0.61-1.29) |0.53 (0.39-0.72) |

|Multivariable-adjusted Subgroup analyses |0.73 (0.57-0.95) |0.55 (0.42-0.73) |

|Stage IV f,b | | |

| Estimated comorbidity score of 0 g,b |0.84 (0.63-1.12) |0.71 (0.52-0.96) |

| Females Only h,b |0.77 (0.55-1.09) |0.62 (0.43-0.90) |

a Sample sizes: BCP vs CP 2005-2010 = 126 and 444, BCP vs CP 2002-2004 = 126 and 254

b The model was adjusted for age at diagnosis, sex, race/ethnicity, health plan, tumor grading, census tract education, modified Charlson comorbidities, and AJCC stage.

c The propensity of receiving BCP was estimated using a multivariable logistic regression model that included age at diagnosis, sex, race/ethnicity, health plan, tumor grading, census tract education, modified Charlson comorbidities, and AJCC stage. The propensity score was then added as a predictor in the survival model.

d The propensity score was used to create stabilized weights

e Sample sizes: BCP vs CP 2005-2010 = 123 and 123, BCP vs CP 2002-2004= 118 and 118, BCP and CP patients were matched based on their propensity score.

f Sample sizes: BCP vs CP 2005-2010 = 109 and 378, BCP vs CP 2002-2004= 109 and 199

g Sample sizes: BCP vs CP 2005-2010 = 88 and 295, BCP vs CP 2002-2004= 88 and 192

h Sample sizes: BCP vs CP 2005-2010 = 68 and 239, BCP vs CP 2002-2004 = 58 and 131

Table 2. Effect of Bevacizumab Added to Carboplatin and Paclitaxel Chemotherapy on Hazard Ratios for Overall Survival for Adults age greater than or equal to 65 years with Stage IIIB/IV, Non-squamous NSCLC

|Models |Hazard Ratio (95% CI) |

| |Bevacizumab |Bevacizumab |

| |Carboplatin-Paclitaxel- vs |Carboplatin-Paclitaxel- vs |

| |Carboplatin-Paclitaxel |Carboplatin-Paclitaxel |

| |2005-2010 |2002-2004 |

| |Age > 65 Years |Age > 65 Years |

|Unadjusted modela |0.76 (0.57-1.01) |0.61 (0.46-0.83) |

|Multivariable-adjusted modela,b |0.74 (0.54-1.00) |0.64 (0.46-0.88) |

|Propensity score-adjusted modela,c |0.79 (0.59-1.07) |0.66 (0.48-0.90) |

|Weighting (stabilized IPTW) a, d |0.75 (0.40-1.41) |0.59 (0.37-0.92) |

|Matching 1:1e |0.57 (0.29-1.12) |0.63 (0.38-1.02) |

|Subgroup analyses |0.72 (0.51-.1.01) |0.71 (0.50-1.02) |

|Stage IV f, b | | |

| Estimated comorbidity score of 0 g, b |0.63 (0.40-0.99) |0.64 (0.41-1.02) |

| Females Only h,b |0.72 (0.45-1.15) |0.57 (0.34-0.94) |

a Sample sizes: BCP vs CP 2005-2010 = 72 and 467, BCP vs CP 2002-2004= 72 and 242

b The model was adjusted for age at diagnosis, sex, race/ethnicity, health plan, tumor grading, census tract education, modified Charlson comorbidities, and AJCC stage.

c The propensity of receiving BCP was estimated using a multivariable logistic regression model that included age at diagnosis, sex, race/ethnicity, healthplan, tumor grading, census tract education, modified Charlson comorbidities, and AJCC stage. The propensity score was then added as a predictor in the survival model.

d The propensity score was used to create stabilized weights

e Sample sizes: BCP vs CP 2005-2010 = 69 and 69, BCP vs CP 2002-2004= 67 and 67, BCP and CP patients were matched based on their propensity score.

f Sample sizes: BCP vs CP 2005-2010 = 59 and 344, BCP vs CP 2002-2004= 59 and 162

g Sample sizes: BCP vs CP 2005-2010 = 33 and 210, BCP vs CP 2002-2004= 33 and 137

h Sample sizes: BCP vs CP 2005-2010 = 34 and 224, BCP vs CP 2002-2004= 34 and 120

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