GCRC Hypothesis Testing
HYPOTHESIS TESTING
? The logic of hypothesis testing ? One-sample vs. two-sample problem ? Null vs. alternative hypothesis ? Type I and type II error ? Significance level ? Power 1- ? One-sided vs. two-sided test ? Test statistic ? P-value ? Statistical tests and diagnostic tests ? Power and sample size
Decisions under uncertainty: A choice between two conflicting theories
? A court psychiatrist is called upon to pronounce an accused murderer "sane" or "insane"
? The FDA "approves" or "rejects" an application by a pharmaceutical house to get a flu vaccine licensed
? A stockbroker "buys" or "sells" a certain stock
To make controlled decisions we need:
? A formal decision rule (a test) ? Characterize the performance of the decision procedure ? Compare decision rules
Using statistical testing => Evidence based decisions
A DIAGNOSTIC TEST FOR RESIDUAL DISEASE IN BREAST CANCER PATIENTS
A treated breast cancer patient
Question: Is there any residual disease in the patient? The answer is important for further treatment or screening for relapse
Null hypothesis and the alternative one H0 = No residual disease H1 = Residual disease present
Bills, A.C., Green, W.F., Tsodikov, A., Carey, M., Perkins, S., Petersen, F.B., Kelley, L. (1999) Cytokeratin positive cells in peripheral blood stem cell collections from normal donors and patients with non-epithelial cell-derived tumors, Cytotherapy, Vol.1, 389-399.
Quantify the effect: Measure residual disease
Marker of a cancer cell: Cytokeratin
A breast cancer cell is more likely to be Cytokeratine-positive than a normal cell. Nothing is perfect.
Measure of residual disease T (test statistic) Proportion of cytokeratin-positive cells in peripheral blood stem cell collection
Rcmdr
Put variable names on top of the file Data/Import data/From textfile Give a name: Dataset View dataset to check what happened Data/Active dataset/Subset active dataset/ Expression: (BC==1) Name: BC1; Data/Active dataset/Select active dataset
or press name -> Dataset Data/Active dataset/Subset active dataset/ Expression: (BC==0) Name: BC0 Graphs/Histograms -> IHC with BC0 and BC1
................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related download
- ricoh quick reference guide
- sas stat 9 2 user s guide the ttest procedure book excerpt
- effect of involvement on message sidedness
- chapter 208 paired t test
- appendix a glossary core learning
- questions and answers
- need additional statistics in your report sas support
- stat 571 statistical methods list of topics
- chapter 6 confidence intervals and hypothesis testing
- gcrc hypothesis testing
Related searches
- hypothesis testing for regression
- hypothesis testing for linear regression
- p value hypothesis testing calculator
- hypothesis testing p value calculator
- hypothesis testing examples
- real world hypothesis testing examples
- hypothesis testing in nursing example
- t test hypothesis testing example
- hypothesis testing examples and solutions
- hypothesis testing in daily life
- hypothesis testing questions and answers
- hypothesis testing statistics pdf