Naranjo Causality Scale - Ephor
[Pages:2]Naranjo Causality Scale (adapted)
1. Are there previous conclusive reports on this reaction? Yes (+1) No (0) Do not know or not done (0)
2. Did the adverse event appear after the suspected drug was given? Yes (+2) No (-1) Do not know or not done (0)
3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given?
Yes (+1) No (0) Do not know or not done (0) 4. Did the adverse reaction appear when the drug was readministered?
Yes (+2) No (-1) Do not know or not done (0) 5. Are there alternative causes that could have caused the reaction?
Yes (-1) No (+2) Do not know or not done (0) 6. Did the reaction reappear when a placebo was given?
Yes (-1) No (+1) Do not know or not done (0) 7. Was the drug detected in any body fluid in toxic concentrations?
Yes (+1) No (0) Do not know or not done (0) 8. Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?
Yes (+1) No (0) Do not know or not done (0) 9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?
Yes (+1) No (0) Do not know or not done (0) Scoring
? > 9 = definite ADR ? 5-8 = probable ADR ? 1-4 = possible ADR ? 0 = doubtful ADR Naranjo et.al. Clin Pharmacol Ther. 1981 Aug;30(2):239-45
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