Specific information for Module 1



ECE491/NEU492, Spring 2019Instructor:Erin K. Purcell, PhDTel: (586)-202-4232Email: epurcell@egr.msu.eduOffice hours: Monday 2-3:30pm or by appointment. IQ/BME building room #2119. Course website: on D2LText:Background readings for each lecture are noted below. Additional articles will be distributed through the course website. No book purchase required.Class times/locations: Tuesday, Thursday 10:20-11:40am 1235 Anthony HallGrading:PointsPercentage 25 5%Quiz 75 15%Participation 75 15%Journal article presentation 75 15%Homework (3 assignments, 25 pts each)125 25%Mid-term exam125 25%Group project and presentation (final)500100%TOTALCourse organization: The course is divided into two units designed to give students background in the basic principles of excitable membranes and an introduction to topics in neural engineering. Textbook: Blaustein, Kao, and Matteson 2012. Cellular physiology and neurophysiology, 2nd Ed. (available on-line from MSU library). Contact the course instructor if you have difficulty accessing the text through the MSU library. Students also are expected to read supplied articles prior to class as indicated. Additionally, there are optional suggested reading from a textbook available during office hours from the instructor: Hille, Ion channels of excitable membranes (3rd edition, 2001).Participation (75 points): Students are expected to attend class regularly, and attendance will count toward the participation grade. If you cannot attend a discussion session/group presentation day, email the course instructor (epurcell@egr.msu.edu) with the reason within 24 hours of the absence. The participation points following an excused absence may be earned with a brief make-up assignment at the discretion of the instructor (for up to two absences). Attendance and participation in bolded discussion sessions and guest lectures in the syllabus count for 3 pts per session (15 sessions, 45 pts total). Peer evaluations of final proposals (filled out in class) will count for 15 points. General participation and attendance through the rest of the course, in addition to team feedback at the end of the semester, will count for the remaining 15 points. Mid-term Exam: The mid-term exam is closed-note and is currently scheduled during class. Quiz: One in-class quiz will be delivered on material covered after the mid-term exam.Individual and team work:Journal article presentation. Student groups will present a journal article describing an application of neural interface technology (15 min. presentation, 5 min. for questions). Groups will be assigned. The selected article must be submitted via email (epurcell@egr.msu.edu) for approval by Tuesday, February 26. The paper should be data- and/or design-driven, and may not be a review article, popular press article, or an article otherwise lacking scientific rigor. To minimize overlap, topics will be granted on a first-come, first-serve basis, and subsequent requests to present papers of similar content may be denied. Assessment will be as follows:Submit article for approval by Feb. 26 5 pointsDescription of neural interface technology20 pointsDescription of neural circuitry/physiology20 pointsExplanation of key paper results20 pointsEffective Q/As10 points 75 pointsHomework (#3) will be assigned to choose an article of interest presented by a peer, summarize and evaluate the article (details will be posted on course website). Group project. Teams of ~4 students will identify a problem in interfacing excitable tissue. Students will describe a potential solution and propose a research plan to assess efficacy. Teams will be assigned. The proposal should be ~10 pages and formatted as follows: Background and significance, ~2 pg.Describe the problem and its relevance to disease. Approach, ~4 pg.Detail the solution—describe the concept and highlight innovation. Include graphics. Assessment, ~3 pg.Describe a research plan for assessing the efficacy of your solution.Potential pitfalls and alternative strategies ~1 pg.Literature cited.Assessment will be as follows: Initial idea description (~1/2 page write-up due Feb 5): 10 pointsInterim report (~2 pg. general outline of final report and designated responsibilities, due Feb 19): 15 pointsFinal report 70 pointsFinal presentation 30 points 125 pointsProposals must be submitted by midnight on the due date (Tuesday, April 17). Late proposals will be penalized by 20% of points per day. Homework. Homeworks are due by the end of the class period on the due date assigned. Late homeworks are not accepted.DateInstructorTopicAssignment DueReading (additional articles on-line)UNIT 1: Bases of neural excitability.Tues Jan 8PurcellCourse intro, intro to neuro, excitable cells & membranes, equivalent circuits.n/aThurs Jan 10PurcellSolute movement across membranes. Email to instructorBlaustein Ch. 2. Hille Ch. 10. Tues Jan 15PurcellIonic basis of membrane potential, resting potential, introduction to ion channels.Blaustein Ch.4. Hille Ch. 14. Benzanilla (2005) Pts I-III, VI (A&B), VII-VIII. Thurs Jan 17PurcellAction potentials.Homework #1 assigned.Blaustein Ch. 7. Bean (2007) Nat Rev Neurosci 8: 451-465.Tues Jan 22PurcellHodgkin-Huxley model.Hille Ch. 2. McCormick, Naundorf (2007).Thurs Jan 24GuestDr. DuncanSingle channel analysis and ion channel gating, channel permeation and regulation.Homework #1 Due (25 pts).Franciolini & Petris (1988). Attendance taken.Tues Jan 29PurcellDiscussion session: A closer look at sodium and potassium channel structure.Discussion session #1 Jiang et al (2003).Attendance taken.Thurs Jan 31PurcellChannel diversity and encoding. Channelopathies.Homework #2 assigned.Ashcroft (2006). Tues Feb 5PurcellPropagation of signals, core conductor model, cable properties.Submit initial proposal idea.Blaustein Ch. 6&7.Thurs Feb 7PurcellSynapses, integration and intercellular communication.Homework #2 Due (25 pts).Yuste (2011).Tues Feb 12PurcellReview for exam.Thurs Feb 14PurcellMID-TERM EXAM Tues Feb 19NO CLASSSubmit interim report for project by midnight.Team project work day.Dr. Purcell will be available in class to meet with groups.Unit 2: Introduction to neural engineeringThurs Feb 21PurcellMotor encoding & extracellular recording techniques. Intro to brain-machine interface.Buzsaki (2012). Lebedev and Nicolelis (2017).Exams returned. Tues Feb 26PurcellSensory encoding & stimulation techniques. Somatosensation and “closed-loop” BMI.Submit journal article for approval.Merrill (2005), Bensmaia and Miller (2014).Discussion session #2: sensory substitution augmentation.Thurs Feb 28PurcellAuditory and visual prostheses, Part 1.QUIZ (in class). Covers material from 2/21-2/26Rauschecker and Shannon (2002), Weiland (2014).Discussion/activity #3: music and art appreciation with neuroprostheses.SPRING BREAK: MARCH 4-8Tues March 12PurcellAuditory and visual prostheses, Part 2.Rauschecker and Shannon (2002), Weiland (2014). Discussion session #4: neuroethics.Thurs March 14Paper presentationsSpecial topics in neural engineering.Articles presented.Attendance taken.Tues March 19Paper presentationsSpecial topics in neural engineering.Articles presented.Attendance taken.Thurs March 21GuestSetienOptogenetics: overview.Homework #3 assigned.Yizhar (2011). Canales (2015).Attendance taken.Tues March 26Paper presentationsSpecial topics in neural engineering.Articles presented.Attendance taken.Thurs March 28PurcellOptogenetics: unmasking circuits.Discussion session #5: Gradinaru (2009).Tues April 2GuestDr. PatelChallenges of neural interfaces and next-generation devices.Homework #3 due (25 pts).Reading TBD.Attendance taken.Thurs April 4GuestDr. SeymourDevice fabrication techniques.Minev (2015).Attendance taken.Tues April 9PurcellCognitive neural prostheses.Proposals due by midnight.Aflalo (2015).Attendance taken.Thurs April 11GuestDr. SortwellDeep brain stimulation and movement disorders.Elias (2016).Kringleback (2007).Attendance taken.Tues April 16PurcellDeep brain stimulation and movement disorders.Discussion session #6: Rosin (2011)Closing the loop.Thurs April 18Final presentationsIn class peer reviewParticipation required. Tues April 23Final presentationsIn class peer reviewParticipation required. Thurs April 25Final presentationsIn class peer reviewParticipation required. Course evaluations. ................
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