Mayo Medical Laboratories
6Mayo Medical Laboratories
Connective Tissue Diseases Cascade Test-Ordering Algorithm #2 (CTDC2)
Connective Tissue Diseases Cascade, Serum
-----------------------
Negative
( 20 Units
Antinuclear Antibodies (ANA), Serum
No further testing
< 1.0 U
Positive
> 20 Units
No further testing
( 1.0 U
( 10 IU/mL
< 5 IU/mL
#8178 DNA Double-Stranded (ds-DNA) Antibodies, IgG, Serum
< 1.0 U
( 1.0 U
< 1.0 U
( 1.0 U
CCP – Antibodies
(Order Separately – CCPB)
Supports diagnosis of
Rheumatoid Arthritis
#89035 Antibody to Extractable Nuclear Antigen Evaluation, Serum
automatically performs
the following tests
Positive result supports the diagnosis of LE
No further
testing
#9278 Centromere
Antibodies, IgG, Serum
#87837 Ribosome
P Antibodies, IgG, Serum
Positive result supports the diagnosis of
CREST syndrome
No further
testing
Positive result supports the diagnosis of LE and may indicate the presence of CNS involvement
No further
testing
SS-A/Ro Antibodies, IgG, Serum
SS-B/La Antibodies, IgG, Serum
Sm Antibodies,
IgG, Serum
RNP Antibodies,
IgG, Serum
Scl 70 Antibodies,
IgG, Serum
Jo 1 Antibodies,
IgG, Serum
Positive result supports the diagnosis of Sjögren syndrome or other CTD*
Positive result supports the diagnosis of Sjögren syndrome or other CTD*
Positive result supports the diagnosis of LE*
Positive result supports the diagnosis of mixed connective tissue disease*
Positive result supports the diagnosis of scleroderma*
Positive result supports the diagnosis of polymyositis*
* If negative, no further testing is performed.
Legend
CNS: central nervous system
CREST: calcinosis, Raynaud’s disease, oesophageal motility disorder, sclerodactyly, and telangiectasia
CTD: connective tissue disease
LE: lupus erythematosus
Cyclic Citrullinated Peptide Antibodies
5-9 IU/mL
Indeterminate
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