Mayo Medical Laboratories



6Mayo Medical Laboratories

Connective Tissue Diseases Cascade Test-Ordering Algorithm #2 (CTDC2)

Connective Tissue Diseases Cascade, Serum

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Negative

( 20 Units

Antinuclear Antibodies (ANA), Serum

No further testing

< 1.0 U

Positive

> 20 Units

No further testing

( 1.0 U

( 10 IU/mL

< 5 IU/mL

#8178 DNA Double-Stranded (ds-DNA) Antibodies, IgG, Serum

< 1.0 U

( 1.0 U

< 1.0 U

( 1.0 U

CCP – Antibodies

(Order Separately – CCPB)

Supports diagnosis of

Rheumatoid Arthritis

#89035 Antibody to Extractable Nuclear Antigen Evaluation, Serum

automatically performs

the following tests

Positive result supports the diagnosis of LE

No further

testing

#9278 Centromere

Antibodies, IgG, Serum

#87837 Ribosome

P Antibodies, IgG, Serum

Positive result supports the diagnosis of

CREST syndrome

No further

testing

Positive result supports the diagnosis of LE and may indicate the presence of CNS involvement

No further

testing

SS-A/Ro Antibodies, IgG, Serum

SS-B/La Antibodies, IgG, Serum

Sm Antibodies,

IgG, Serum

RNP Antibodies,

IgG, Serum

Scl 70 Antibodies,

IgG, Serum

Jo 1 Antibodies,

IgG, Serum

Positive result supports the diagnosis of Sjögren syndrome or other CTD*

Positive result supports the diagnosis of Sjögren syndrome or other CTD*

Positive result supports the diagnosis of LE*

Positive result supports the diagnosis of mixed connective tissue disease*

Positive result supports the diagnosis of scleroderma*

Positive result supports the diagnosis of polymyositis*

* If negative, no further testing is performed.

Legend

CNS: central nervous system

CREST: calcinosis, Raynaud’s disease, oesophageal motility disorder, sclerodactyly, and telangiectasia

CTD: connective tissue disease

LE: lupus erythematosus

Cyclic Citrullinated Peptide Antibodies

5-9 IU/mL

Indeterminate

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