CURRICULUM VITAE - UCSF CME



CURRICULUM VITAE

Name: Keith Robert Yamamoto

Date of Birth: February 4, 1946

Place of Birth: Des Moines, Iowa

Education: B.Sc. 1968 Biochemistry and Biophysics

Iowa State University

Ph.D. 1973 Biochemical Sciences

Princeton University

Research and Professional Activities:

1973-1975 Postdoctoral Fellow

Department of Biochemistry and Biophysics

University of California, San Francisco (UCSF)

1976-1979 Assistant Professor of Biochemistry

Department of Biochemistry and Biophysics, UCSF

1979-1983 Associate Professor of Biochemistry

Department of Biochemistry and Biophysics, UCSF

1983-2003 Professor of Biochemistry

Department of Biochemistry and Biophysics, UCSF

1985-1994 Vice Chairman

Department of Biochemistry and Biophysics, UCSF

1988-2001 Director

Biochemistry and Molecular Biology Program

Program in Biological Sciences, UCSF

1994– Professor

Department of Cellular and Molecular Pharmacology, UCSF

1994-2003 Chairman

Department of Cellular and Molecular Pharmacology, UCSF

2002-2003 Vice Dean for Research

School of Medicine, UCSF

2004– Executive Vice Dean

School of Medicine, UCSF

2011– Vice Chancellor for Research, UCSF

Honors:

Iowa State University Special Merit Scholarship (1964-1968)

NSF Undergraduate Research Grant (1967-1968)

Helen Hay Whitney Postdoctoral Fellowship (1973-1976)

NIH Research Career Development Award (1977-1982)

UCSF Distinguished Teaching Award (1979-1980)

Dreyfus Teacher-Scholar Award (1982-1986)

Elected Fellow, American Academy of Arts and Sciences (1988)

NIH MERIT Award (1989-1998)

Elected Member, National Academy of Sciences (1989)

Gregory Pincus Medal (1990)

Elected Fellow, American Academy of Microbiology (1992)

Iowa State University Distinguished Achievement Award (1997)

Theodore Roosevelt High School Hall of Fame, Des Moines (1998)

Vanderbilt Medal of Merit, Vanderbilt University (1999)

Iowa State University D.Sc., honorary (2001)

Holly Smith Award for Exceptional Service to the School of Medicine, UCSF (2001)

Elected Fellow, American Association for the Advancement of Science (2002)

Elected Member, Institute of Medicine of the National Academy of Sciences (2003)

Allan Munck Prize, Dartmouth University (2004)

10 Influential People to Watch in Biomedical Policy, Nature Medicine (2008)

UCSF Postdoctoral Scholars Association Outstanding Faculty Mentorship Award (2010)

The Endocrine Society Edwin B. Astwood Award (2012)

The American Society for Cell Biology Public Service Award (2012)

Iowa State University John V. Atanasoff Discovery Award (2013)

Honorary Lectureships:

Swerling Lecturer, Harvard Medical School (1982)

Rudin Lecturer, Columbia University, College of Physicians and Surgeons (1983)

Weissberger Lecturer, University of Rochester (1983)

Keynote Speaker, Lost Pines Molecular Biology Conference, University of Texas System Cancer Center (1986)

Keynote Speaker, New Insights into the Regulation of Transcription, Stony Brook Symposium (1987)

Axelrod Lecturer, Purdue University (1988)

Plenary Lecturer, Cold Spring Harbor Symposium (1988)

Markey Lecturer, Harvard Medical School (1990)

Lindner Lecturer, Weizmann Institute (1990)

Keynote Speaker, West Central States Biochemistry Conference (1991)

Steenbock Lecturer, University of Wisconsin (1992)

Keynote Speaker, Transcription: Factors, Regulation and Differentiation, Keystone Symposium (1993)

Matrone Lecturer, North Carolina State University (1993)

Keynote Speaker, Steroid Receptor Superfamily Symposium, University of Wisconsin, Madison (1994)

Keynote Speaker, Whitehead Institute Symposium XII, Transcriptional Control (1994)

Sadler Lecturer, University of Colorado Health Sciences Center (1995)

duVigneaud Lecturer, Cornell University (1995)

Kosuge Lecturer, University of California, Davis (1995)

Keynote Speaker, 15th International Conference on Plant Growth Substances, Minneapolis, Minnesota (1995)

Harvey Lecturer, Rockefeller University (1995)

Monsanto Lecturer, Ohio State University (1996)

Ochoa Lecturer, New York University (1996)

Keynote Speaker, Regulation of Transcription, Translation, and Posttranslational Modifications, Howard Hughes Medical Institute Scientific Meeting (1996)

Faculty Research Lecturer, UCSF (1997)

Commencement Speaker, UC Berkeley Molecular and Cell Biology, Undergraduate (1997)

Taurog Lecturer, University of Texas Southwestern Medical Center (1998)

Flexner Lecturer, Vanderbilt University (1999)

Wells Lecturer, Michigan State University (2001)

The Chao Hao Li Memorial Lecturer, Institute of Biological Chemistry, Academia Sinica and National Taiwan University, Teipei (2004)

Allan Munck Prize Lecturer, Dartmouth University (2004)

Commencement Speaker, Watson School Biological Sciences, Cold Spring Harbor Lab (2004)

Ray A. and Robert L. Kroc Lecture, Joslin Diabetes Center, Harvard Medical School (2007)

Keynote Speaker, Opening Convocation, Van Andel Institute (2007)

Louis Sanford Goodman Lecture, Oregon Health and Sciences University (2007)

Christian Herter Lecture, New York University (2008)

8th Annual Doris Howes Calloway Memorial Lecture, Department of Nutritional Science &

Toxicology, UC Berkeley (2009)

Keynote Speaker, RNA & Society Dinner, RNA 2009 (14th Annual Meeting of the RNA Society), University of Madison, Wisconsin (2009)

Invited Guest Lecturer, Serbian Academy of Sciences and Arts, Belgrade, Serbia (2009)

Keynote Speaker, University of California Davis Molecular and Cellular Biology NIH Training Grant Retreat, Fallen Leaf Lake, CA (2009)

Keynote Speaker, NIH Graduate Research Symposium, Natcher Conference Center, NIH Campus (2009)

34th Annual Carl F. Schmidt Honorary Lecture, The University of Pennsylvania School of Medicine, Department of Pharmacology (2010)

Keynote Speaker, Jefferson College of Graduate Studies Fifth Annual Postdoctoral Research Symposium (2010)

Commencement Speaker, Biological Sciences, University of Chicago (2010)

9th Annual Fred Sherman Lecture, University of Rochester (2011)

Keynote Speaker, UCSF Breast Oncology Program Scientific Retreat (2012)

40th Annual Distinguished Schueler Lectureship, Tulane University (2012)

Martin Rodbell Memorial Lecture, NIH NIEHS (2012)

Arnold D. Welch Lecturer in Pharmacology, Danny Thomas Lecture Series, St. Jude Children’s Research Hospital (2012)

Commencement Speaker, Department of Molecular & Cell Biology (Graduate), UC Berkeley (2012)

Edwin B. Astwood Lecturer, Endocrine Society (2012)

Keynote Lecturer, US HUPO, The Future of Proteomics (2012)

IMED Lecturer, UCLA (2012)

Editorial Boards:

Biochemistry (1980-1982)

Journal of Biological Chemistry (1980-1985)

Biological Regulation and Development (Plenum Press) (1980-1985)

Cell Regulation, Associate Editor(1988-1991)

Journal of Molecular Biology, Associate Editor (1988-2001)

Current Biology Journal Group (1989-1998)

Journal of NIH Research (1989-1997)

Genes and Development (1990-1992)

Science, Board of Reviewing Editors (1990-1994)

Mechanisms of Development (1990-1995)

Protein Science (1990-1993)

Molecular Biology of the Cell, Editor (1991-2001), Editor-in-Chief (2001-2003)

UCSF Magazine (1992–1999)

Advances in Second Messenger and Phosphoprotein Research (Raven Press) (1993–1997)

Chemistry & Biology (1994-2003)

Annual Review of Biochemistry (1996-2000)

Proceedings of the National Academy of Sciences (2001)

Encyclopedia of Transcription (Academic Press) Advisory Board (2001–2005)

Societies:

American Society for Microbiology

American Society for Biochemistry and Molecular Biology

Publications Committee (1990-1993)

Chairman, Nominations Committee (1994-1997)

Public Affairs Advisory Committee (1997-2010)

American Society for Developmental Biology

American Society for Cell Biology

Program Committee (1989; 1992-1993; 1997)

Nominations Committee (1990)

Council (1991-1994)

Public Policy Committee (1992-2001)

The Endocrine Society

Genetics Society of America

American Association for the Advancement of Science

Committee on Nominations (1994-1996) (2012-)

American Society for Pharmacology and Experimental Therapeutics

Conferences Chaired, Organized:

Co-Chairman, Gordon Conference on Biological Regulatory Mechanisms (1979)

Co-Chairman, Conference on “Regulation of mRNA Transcription,” Cold Spring Harbor Lab (1989)

Organizer, NIH Workshop “New Approaches to Understanding Cell Cycle Regulation” (1989)

Co-Chairman, Conference on “Regulation of Eukaryotic mRNA Transcription,” Cold Spring Harbor lab (1991)

Co-Chairman, Gordon Conference on Animal Cells and Viruses (1992)

Co-Chairman, Conference on “Regulation of Eukaryotic Transcription,” Cold Spring Harbor Lab (1993)

Co-Chairman, UCSF Symposium "Wondrous Voyages: Science and Health for a New Century" (1994)

Co-Organizer, "Reviewing Peer Review: An Assessment of NIH Study Sections” (1994)

Co-Chairman, Conference on “Cancer Cells: Mechanisms of Eukaryotic Transcription,” Cold Spring Harbor Lab (1995)

Co-Organizer, Jane Coffin Childs Memorial Fund for Medical Research Symposium on "Intersection of Transcription, Cancer and Growth Regulation" (1995)

Co-Organizer, Banbury Conference on "Mechanisms of Transcriptional Initiation," Cold Spring Harbor Lab (1996)

Co-Organizer, Conference on "Mechanisms of Eukaryotic Transcription," Cold Spring Harbor Lab (1997)

Co-Organizer, Jane Coffin Childs Memorial Fund for Medical Research Symposium on "Cellular Machines" (1999)

Co-Organizer, Banbury Center Workshop on "Nuclear Receptors," Cold Spring Harbor Lab(2002)

Co-Organizer, "Nuclear Receptors: Bench to Bedside, " Cold Spring Harbor Lab (2006)

Co-Organizer, "Nuclear Receptors: Bench to Bedside, " Cold Spring Harbor Lab (2008)

Co-Organizer, "Nuclear Receptors from Molecular Mechanism to Molecular Medicine," EMBO Conference, Croatia (2009)

Co-Organizer, "Nuclear Receptors & Disease," Cold Spring Harbor Lab (2010)

Co-Organizer, “Nuclear Receptors & Disease,” Cold Spring Harbor Lab (2012)

Institute/Department Review Committees:

External Review Committee, University of Toronto, Banting and Best Institute (1985)

External Review Committee, Northwestern University, Department of Biochemistry, Molecular Biology, and Cell Biology (1987)

Chairman, External Review Committee, Indiana University, Department of Biology (1992)

External Review Committee, Rutgers University, Department of Molecular Biology and Biochemistry; Waksman Institute of Microbiology; Joint Graduate Program in Biochemistry (1993)

External Review Committee, Northwestern University, Departments of Microbiology and Immunology; Cell, Molecular and Structural Biology; Biochemistry, Molecular Biology and Cell Biology (1994)

External Review Committee, Univ of Massachusetts Medical Center, Department of Biochemistry and Molecular Biology (1994)

Chairman, External/Internal Review Committee, UCSF, Cardiovascular Research Institute (1994)

External Review Committee, University of California, Santa Cruz, Department of Biology (1995)

External Review Committee, University of California, Los Angeles, ACCESS Graduate Programs in the Molecular and Life Sciences (1996)

Chairman, External Review Committee, Cold Spring Harbor Lab, proposed Graduate Program in Biological Sciences (1998-99)

Chairman, External Review Committee, Watson School of Biological Sciences, Cold Spring Harbor Lab (2000- )

External Review Committee, University of Southern California School of Medicine, Basic Sciences (2002)

External Review Committee, University of Utah, Department of Oncological Sciences (2002)

Chairman, External Review Committee, Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology (2004)

Chairman, External Review Committee, Columbia University Medical Center, Department of Pharmacology (2005)

External Review Committee, Duke University Medical Center, Department of Pharmacology and Cancer Biology (2005)

External Review Committee, Northwestern University, Searle Leadership Fund (2005)

External Review Committee, Iowa State University, Department of Genetics (2007)

External Review Committee, Iowa State University, Department of Biochemistry, Biophysics, and Molecular Biology (2008)

Government, Public and Non-profit Advisory Boards:

°NIH

NIH Molecular Biology Study Section (1986-1990, 1996); Chairman (1987-1990)

NIH Director's Subcommittee on Intramural Research

Program Review Procedures (1989)

NIH National Advisory Council for Human Genome Research (1990-1992)

NIH Strategic Plan National Task Force (1992)

National Advisory Council, National Institute for General Medical Sciences, NIH (1993, 1994)

NIH Director's Working Group on the Division of Research Grants (1994-1995)

NIH Reinvention Roundtable on Peer Review (1994)

NIH Center for Scientific Review (formerly DRG) Advisory Committee (1995-1996); Chairman (1996-2000)

NIH Director's Peer Review Oversight Group, (1996-1999)

NIH Advisory Committee to the Director, ad hoc member (1996-1997)

NIH National Advisory Council and Board Representatives (1996-2000)

NIH National Cancer Institute Prostate Cancer Progress Review Group (1997-1998)

NIH Center for Scientific Review, Panel on Scientific Boundaries for Review (1998-2000)

NIH CSR Special Review Panel: Bioengineering Research Partnerships (2000)

NIH Study Section Boundaries Team: Digestive Sciences IRG (2002)

NIH Center for Scientific Review, Roadmap Focus Group (2002)

NIH Study Section Boundaries Team: Molecular Approaches to Cell Function and Interactions IRG (2003)

NIH Director's Pioneer Award reviewer (2006, 2007)

NIH National Center for Research Resources, Director Search Committee (2006)

NIH Advisory Committee to the Director (2007-2010)

NIH ACD Working Group on Enhancing Peer Review, Co-Chair (2007-2008)

NIH CSR Intercellular Interactions Study Section, ad hoc reviewer (2007)

NIH Office of Portfolio Analysis and Strategic Initiatives: Innovation Workshop, Co-Organizer (2007)

NIH Transformational R01 Study Section, Co-Chair (2009)

NIH NCI National Cancer Advisory Board ad hoc Working Group: Creating a Strategic Scientific Vision for the National Cancer Program and Review of the National Cancer Institute (2010)

NIH Center for Scientific Review Advisory Council (2011-)

NIH Advisory Committee to the Director Biomedical Workforce (2011-)

NIH Advisory Committee to the Director Working Group on Diversity in the Biomedical Workforce (2011-)

°Other Federal Agencies

NSF Genetic Biology Review Panel (1984-1987)

NSF Division of Molecular and Cellular Biosciences, Committee of Visitors (1995)

NSF National Science Board Task Force on Transformative Research, ad hoc member (2005-2006)

°National Academy of Sciences/National Research Council

National Academy of Sciences Panel on Scientific Responsibility and the Conduct of Research (1990-1991)

National Academy of Sciences, International Science Foundation Biology Review Panel (1993)

National Academy of Sciences, Committee on Publications (2003-2008)

National Academy of Sciences, Board on Life Sciences (2003-2006); Chairman (2006-2012)

National Research Council Committee "Bridges to Independence: Identifying Opportunities for and Fostering the Independence of Young Investigators in the Life Sciences" (2004-2005)

National Research Council Committee "A New Biology for the 21st Century: Ensuring the United States Leads the Coming Biology Revolution" (2009)

National Research Council Committee "Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease" (2011)

Institute of Medicine Council (IOM) (2012 - )

National Academy of Sciences, Division on Earth and Life Sciences (DELS) Advisory Committee (2012 - )

°Other Private (Not for Profit) Agencies

Foundation for Research in Hereditary Disease (1974)

Damon Runyon-Walter Winchell Cancer Fund, Scientific Advisory Committee (1977-1981)

UC Biotechnology Research and Education Program

Executive Committee (1986-1988)

Fox Chase Cancer Center Scientific Advisory Committee (1990-1994)

American Academy of Microbiology Colloquium on Ethics in Science Steering Committee (1992-1994)

The Jane Coffin Childs Memorial Fund for Medical Research, Board of Scientific Advisors (1992-1999)

Forum on Science in the National Interest, White House Office of Science and Technology Policy (1993)

FASEB Consensus Conference on Federal Research Funding for the Biomedical and Life Sciences FY 96, NIH Subcommittee (1994), FY 99 (1997)

Joint Steering Committee for Public Policy (1996–2009) [Renamed in 2007: Coalition for the Life Sciences]; Chairman (2009- )

Vollum Institute, Oregon Health Sciences University, Scientific Advisory Board (1997–2001)

Cold Spring Harbor Laboratory, Watson School of Biological Sciences, External Advisory Committee (1998–)

Dean and Betty Gallo Prostate Cancer Institute, External Advisory Board (1999–2005)

Northern California Institute for Research and Education, Inc., Board of Directors (2002–)

Lasker Foundation Forum on Ethical Challenges in Biomedical Research and Practice (2003)

American Academy of Arts and Sciences, Committee on Alternative Mechanisms for Federal Funding of Research (2007-2008)

American Society for Biochemistry and Molecular Biology, Public Affairs Advisory Committee (2007-2010)

American Society for Biochemistry and Molecular Biology, President's Advisory Committee (2007)

UCSF NIH HIV Accessory and Regulatory Complexes Center, Scientific Advisory Board (2007-)

Bill and Melinda Gates Foundation Grand Challenges Explorations Review Panel (2008-2009)

American Academy of Arts and Sciences, Chair of ARISE II Study: The Role of Academia, Industry, and Government in the 21st Century (2009-)

Lawrence Berkeley National Laboratory (LBNL) Advisory Board (2011-)

Research!America Board of Directors (2012-)

National Centers for Biomedical Computing (NCBC) Scientific Advisory Board (2012-)

American Association for the Advancement of Science (AAAS), Committee on Nominations (2012 - )

Research!America Membership Committee (2013-)

Corporate Advisory Boards:

Tularik Inc. Scientific Advisory Board (1992-2004)

Morphogenesis, Inc. Scientific Advisory Board (1994)

Burrill & Company Scientific Advisory Board (1997–)

CIStem Corporation Scientific Board (2000–2001)

Zorphion Therapeutics, Scientific Advisory Board (2003 – 2006)

BiPar Sciences, Inc. Scientific Advisory Board (2004–2009)

Amgen, Inc. Scientific Advisory Board (2005–2006)

Sirna Therapeutics, Inc. Scientific Advisory Board, Chair (2005 – 2007)

Merck & Co., Inc. Research Strategy Review Committee (2007 – 2010)

Sangamo Biosciences, Inc., Scientific Advisory Board (2007 – 2012)

Extramural Courses:

Faculty, NATO course on Cellular and Molecular Aspects of Developmental Biology, Les Houches, France (1984)

Faculty, MBL Embryology Course, Woods Hole, Massachusetts (1988)

Lecturer, Cold Spring Harbor Courses:

Advanced Molecular Cloning (1983, 1987, 1990, 1991, 1992, 1993)

Neurobiology (1984)

Yeast Molecular Biology (1988)

Eukaryotic Gene Expression (1996, 2002, 2003, 2007, 2011)

SCIENTIFIC PUBLICATIONS

1. Johnson, J.L., Yamamoto, K.R., Weislogel, P.O., and Horowitz, J. (1969) Some properties of transfer ribonucleic acids from 5-fluorouracil-treated Escherichia coli. Biochem. 8, 1901-1908.

2. Yamamoto, K.R., Alberts, B.M., Benzinger, R., Lawhorne, L., and Treiber, G. (1970) Rapid bacteriophage sedimentation in the presence of polyethylene glycol and its application to large scale virus purification. Virology 40, 734-744.

3. Yamamoto, K.R., and Alberts, B.M. (1972) In vitro conversion of estradiol-receptor protein to its nuclear form: dependence on hormone and DNA. Proc. Natl. Acad. Sci. USA 69, 2105-2109.

4. Yamamoto, K.R. (1973) In vitro studies on the estradiol receptor protein and its interaction with DNA. Ph.D. Dissertation, Princeton University.

5. Yamamoto, K.R., and Alberts, B.M. (1974) On the specificity of the binding of the estradiol receptor protein to deoxyribonucleic acid. J. Biol. Chem. 249, 7076-7086.

6. Yamamoto, K.R. (1974) Characterization of the 4 S and 5 S forms of the estradiol receptor protein and their interaction with deoxyribonucleic acid. J. Biol. Chem. 249, 7068-7075.

7. Yamamoto, K.R., Stampfer, M.R., and Tomkins, G.M. (1974) Receptors from glucocorticoid- sensitive lymphoma cells and two classes of insensitive clones: physical and DNA-binding properties. Proc. Natl. Acad. Sci. USA 71, 3901-3905.

8. Yamamoto, K.R., and Alberts, B.M. (1975) The interaction of estradiol-receptor protein with the genome: an argument for the existence of undetected specific sites. Cell 4, 301-310.

9. Ringold, G.M., Yamamoto, K.R., Tomkins, G.M., Bishop, J.M., and Varmus, H.E. (1975) Dexamethasone mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action. Cell 6, 299-305.

10. Yamamoto, K.R., and Alberts, B.M. (1976) Steroid receptors: elements for modulation of eukaryotic transcription. Ann. Rev. Biochem. 45, 721-746.

11. Yamamoto, K.R., Gehring, U., Stampfer, M.R., and Sibley, C.H. (1976) Genetic approaches to steroid hormone action. Rec. Prog. Horm. Res. 32, 3-32.

12. Coffino, P., and Yamamoto, K.R. (1976) Somatic genetic studies of steroid and cyclic AMP receptors. In: “Control Mechanisms in Cancer,” (W.E. Criss, T. Ono, and J.R. Sabine, eds.), Raven Press, New York, pp. 57-66.

13. Ringold, G.M., Cardiff, R.D., Varmus, H.E., and Yamamoto, K.R. (1977) Infection of cultured rat hepatoma cells by mouse mammary tumor virus. Cell 10, 11-18.

14. Ringold, G.M., Yamamoto, K.R., Shank, P.R., and Varmus, H.E. (1977) Mouse mammary tumor virus DNA in infected rat cells: characterization of unintegrated forms. Cell 10, 19-26.

15. Ringold, G.M., Yamamoto, K.R., Bishop, J.M., and Varmus, H.E. (1977) Glucocorticoid stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA. Proc. Natl. Acad. Sci. USA 74, 2879-2883.

16. Yamamoto, K.R., and Ringold, G.M. (1978) Glucocorticoid regulation of mammary tumor virus gene expression. In: “Receptors and Hormone Action,” Vol. 2, (B.W. O'Malley and L. Birnbaumer, eds.), Academic Press, New York, pp. 297-322.

17. Yamamoto, K.R., Ivarie, R.D., Ring, J., Ringold, G.M., and Stallcup, M.R. (1978) Integrated mammary tumor virus genes: transcriptional regulation by glucocorticoids and specific effects on host gene expression. In: “Biochemical Actions of Hormones,” Vol. 5, (G. Litwack, ed.), Academic Press, New York, pp. 373-395.

18. Sibley, C.H., and Yamamoto, K.R. (1979) Mouse lymphoma cells: mechanisms of resistance to glucocorticoids. In: “Glucocorticoid Hormone Action,” (J.D. Baxter and G.G. Rousseau, eds.), Springer-Verlag, Berlin, Heidelberg, pp. 253-278.

19. Varmus, H.E., Ringold, G.M., and Yamamoto, K.R. (1979) Regulation of mouse mammary tumor virus gene expression by glucocorticoid hormones. In: “Glucocorticoid Hormone Action,” (J.D. Baxter and G.G. Rousseau, eds.), Springer-Verlag, Berlin, Heidelberg, pp. 253-278.

20. Yamamoto, K.R., Stallcup, M.R., Ring, J., and Ringold, G.M. (1978) Mammary tumor virus DNA: a glucocorticoid-responsive transposable element. Cold Spring Harb. Symp. Quant. Biol. 42, 625-638.

21. Ringold, G.M., Cohen, J.C., Ring, J., Shank, P.R., Varmus, H.E., and Yamamoto, K.R. (1978) Mouse mammary tumor virus genes: regulation of expression by glucocorticoids and structural analysis with restriction endonucleases. J. Toxicol. and Environ. Health 4, 457-470.

22. Ringold, G.M., Shank, P.R., and Yamamoto, K.R. (1978) Production of unintegrated mouse mammary tumor virus DNA in infected rat hepatoma cells is a secondary action of dexamethasone. J. Virol. 26, 93-101.

23. Stallcup, M.R., Ring, J., and Yamamoto, K.R. (1978) Synthesis of mouse mammary tumor virus ribonucleic acid in isolated nuclei from cultured mammary tumor cells. Biochem. 17, 1515-1521.

24. Shank, P.R., Cohen, J.C., Varmus, H.E., Yamamoto, K.R., and Ringold, G.M. (1978) Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: evidence for a large specific deletion occurring at high frequency during circularization. Proc. Natl. Acad. Sci. USA 75, 2112-2116.

25. Varmus, H.E., Cohen, J.C., Shank, P.R., Ringold, G.M., Yamamoto, K.R., Cardiff, R., and Morris, V.L. (1978) The endogenous and acquired proviruses of mouse mammary tumor virus. In: “Persistent Viruses,” Vol. 2, ICN-UCLA Symposia on Molecular and Cellular Biology, (J. Stevens, G.J. Todaro, and C.F. Fox, eds.), Academic Press, New York, pp. 161-179.

26. Stallcup, M.R., Ring, J.C., Ucker, D.S., and Yamamoto, K.R. (1979) Mammary tumor virus genes: probes for mechanisms of transcriptional regulation. In: “Hormones and Cell Culture,” Vol. 6, Cold Spring Harbor Conference on Cell Proliferation, (G. Sato and R. Ross, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 919-936.

27. Ringold, G.M., Shank, P.R., Varmus, H.E., Ring, J., and Yamamoto, K.R. (1979) Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma cells. Proc. Natl. Acad. Sci. USA 76, 665-669.

28. Yamamoto, K.R., Chandler, V.L., Ross, S.R., Ucker, D.S., Ring, J.C., and Feinstein, S.C. (1981) Integration and activity of mammary tumor virus genes: regulation by hormone receptors and chromosomal position. Cold Spring Harbor Symp. Quant. Biol. 45, 687-697.

29. Payvar, F., Wrange, Ö., Carlstedt-Duke, J., Okret, S., Gustafsson, J.-Å., and Yamamoto, K.R. (1981) Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo. Proc. Natl. Acad. Sci. USA 78, 6628-6632.

30. Ucker, D.S., Ross, S.R., and Yamamoto, K.R. (1981) Mammary tumor virus DNA contains sequences required for its hormone regulated transcription. Cell 27, 257-266.

31. Feinstein, S.C., Ross, S.R., and Yamamoto, K.R. (1982) Chromosomal position effects determine transcriptional potential of integrated mammary tumor virus DNA. J. Mol. Biol. 156, 549-565.

32. Firestone, G.L., Payvar, F., and Yamamoto, K.R. (1982) Glucocorticoid regulation of protein processing and compartmentalization. Nature 300, 221-225.

33. Payvar, F., Firestone, G.L., Ross, S.R., Chandler, V.L., Wrange, Ö., Carlstedt-Duke, J., Gustafsson, J.-Å., and Yamamoto, K.R. (1982) Multiple specific binding sites for purified glucocorticoid receptors on mammary tumor virus DNA. J. Cell. Biochem. 19, 241-247.

34. Yamamoto, K.R., Payvar, F., Firestone, G.L., Maler, B., Wrange, Ö., Carlstedt-Duke, J., Gustafsson, J.-Å., and Chandler, V.L. (1983) Biological activity of cloned mammary tumor virus DNA fragments that bind purified glucocorticoid receptor protein in vitro. Cold Spring Harbor Symp. Quant. Biol. 47, 977-984.

35. Ucker, D.S., Firestone, G.L., and Yamamoto, K.R. (1983) Glucocorticoids and chromosomal position modulate MTV transcription by affecting the efficiency of promoter utilization. Molec. Cell. Biol. 3, 551-561.

36. Chandler, V.L., Maler, B.A., and Yamamoto, K.R. (1984) Are glucocorticoid receptor binding domains regulable “enhancer” elements? In: “Gene Transfer and Cancer,” (M.L. Pearson and N.L. Sternberg , eds.), Raven Press, New York, pp. 303-310.

37. Baumann, H., Firestone, G.L., Burgess, T.L., Gross, K.W., Yamamoto, K.R., and Held, W.A. (1983) Dexamethasone regulation of a1-acid glycoprotein and other acute phase reactants in rat liver and hepatoma cells. J. Biol. Chem. 258, 563-570.

38. Firestone, G.L., and Yamamoto, K.R. (1983) Two classes of mutant mammary tumor virus- infected HTC cells with defects in glucocorticoid-regulated gene expression. Molec. Cell. Biol. 3, 149-160.

39. Chandler, V.L., Maler, B.A., and Yamamoto, K.R. (1983) DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo. Cell 33, 489-499.

40. Yamamoto, K.R., Maler, B.A., and Chandler, V.L. (1983) Fusions of a glucocorticoid response element to the tk promoter region: hormone regulated enhancement of transcription initiation. In: “Enhancers and Eukaryotic Gene Expression,” (Y. Gluzman and T. Shenk, eds.), Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp. 165-169.

41. Yamamoto, K.R. (1983) Transcriptional enhancement by specific regulatory protein: DNA complexes. In: “Transfer and Expression of Eukaryotic Genes,” (H.S. Ginsberg and H.J. Vogel, eds.), Academic Press, New York, pp. 79-92.

42. Payvar, F., DeFranco, D., Firestone, G.L., Edgar, B., Wrange, Ö., Okret, S., Gustafsson, J.-Å., and Yamamoto, K.R. (1983) Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region. Cell 35, 381-392.

43. Yamamoto, K.R. (1983) On steroid receptor regulation of gene expression and the evolution of hormone-controlled gene networks. In: “Steroid Hormone Receptors: Structure and Function,” Nobel Symposium 57, (H. Eriksson and J.-Å. Gustafsson, eds.), Elsevier/North Holland Biomed. Press, Amsterdam, pp. 285-304.

44. Ucker, D.S., and Yamamoto, K.R. (1984) Early events in the stimulation of MTV RNA synthesis by glucocorticoids: novel assays of transcription rates. J. Biol. Chem. 259, 7416-7420.

45. Zaret, K.S., and Yamamoto, K.R. (1984) Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element. Cell 38, 29-38.

46. DeFranco, D., Wrange, Ö., Merryweather, J., and Yamamoto, K.R. (1985) Biological activity of a glucocorticoid regulated enhancer: DNA sequence requirements and interactions with other transcriptional enhancers. In: “Genome Rearrangement,” UCLA Symposium on Molecular and Cellular Biology, New Series, (I. Herskowitz and M. Simon, eds.), Alan R. Liss, Inc., New York, pp. 305-321.

47. Miesfeld, R., Okret, S., Wikstrom, A.-C., Wrange, Ö., Gustafsson, J.-Å., and Yamamoto, K.R. (1984) Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells. Nature 312, 779-781.

48. Yamamoto, K.R. (1986) Hormone-dependent transcriptional enhancement and its implications for mechanisms of multifactor gene regulation. In: “Molecular Developmental Biology: Expressing Foreign Genes,” 43rd Symposium of the Society for Developmental Biology, (L. Bogorad and G. Adelman, eds.), Alan R. Liss, Inc., New York, pp. 131-148.

49. DeFranco, D., Miesfeld, R., Rusconi, S., and Yamamoto, K.R. (1985) Additive effects of two distinct activators upon a single enhancer element. In: “Eukaryotic Transcription: The Role of cis and trans-acting Elements in Initiation,” (Y. Gluzman, ed.), Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp. 132-137.

50. Yamamoto, K.R. (1985) Steroid receptor regulated transcription of specific genes and gene networks. Ann. Rev. Genetics 19, 209-252.

51. Miesfeld, R., Rusconi, S., Okret, S., Wikstrom, A.-C., Gustafsson, J.-Å., and Yamamoto, K.R. (1985) Preliminary analyses of the glucocorticoid receptor gene and its expression: a DNA-binding protein essential for hormone-dependent transcriptional enhancement. In: “Sequence Specificity in Transcription and Translation,” UCLA Symposium on Molecular and Cellular Biology, New Series, Vol. 30, (R. Calender and L. Gold, eds.), Alan R. Liss, Inc., New York, pp. 535-545.

52. Jones, K.A., Yamamoto, K.R., and Tjian, R. (1985) Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro. Cell 42, 559-572.

53. DeFranco, D., and Yamamoto, K.R. (1986) Two different factors act separately or together to specify functionally distinct activities at a single transcriptional enhancer. Molec. Cell. Biol. 6, 993-1001.

54. Miesfeld, R., Rusconi, S., Godowski, P.J., Maler, B.A., Okret, S., Wikstrom, A.-C., Gustafsson, J.-Å., and Yamamoto, K.R. (1986) Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA. Cell 46, 389-399.

55. Firestone, G.L., and Yamamoto, K.R. (1986) Glucocorticoid regulated glycoprotein maturation in wild type and mutant rat cell lines. J. Cell Biol. 103, 2323-2331.

56. Rusconi, S., Miesfeld, R., Godowski, P.J., Vanderbilt, J.N., Maler, B.A., and Yamamoto, K.R. (1987) Functional analysis of cloned glucocorticoid receptor sequences. In: “RNA Polymerase and the Regulation of Transcription,” Sixteenth Steenbock Symposium, Elsevier Science Publishing, New York, pp. 257-266.

57. Vanderbilt, J.N., Miesfeld, R., Maler, B.A., and Yamamoto, K.R. (1987) Intracellular receptor concentration limits glucocorticoid-dependent enhancer activity. Mol. Endocrinol. 1, 68-74.

58. Godowski, P.J., Rusconi, S., Miesfeld, R., and Yamamoto, K.R. (1987) Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature 325, 365-368.

59. Parslow, T.G., Jones, S.D., Bond, B., and Yamamoto, K.R. (1987) The immunoglobulin octa-nucleotide: independent activity and selective interaction of enhancers. Science 235, 1498-1501.

60. Miesfeld, R., Godowski, P.J., Maler, B.A., and Yamamoto, K.R. (1987) Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation. Science 236, 423-427.

61. Rusconi, S., and Yamamoto, K.R. (1987) Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor. EMBO J. 6, 1309-1315.

62. Miesfeld, R., Sakai, D., Inoue, A., Schena, M., Godowski, P.J., and Yamamoto, K.R. (1988) Glucocorticoid receptor sequences that confer positive and negative transcriptional regulation. In: “Steroid Hormone Action,” UCLA Symposium on Molecular and Cellular Biology, Vol. 75, (G. Ringold, ed.), Alan R. Liss, Inc., New York, 193-200.

63. Picard, D., and Yamamoto, K.R. (1987) Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J. 6, 3333-3340.

64. Bond, B., Jones, S.D., Elcock, M., Yamamoto, K.R., and Parslow, T.G. (1988) Immunoglobulin promoter structure: the octamer and TATA homologies alone are not sufficient for accurate promoter function. Cell Reg., 13-17.

65. Sakai, D.D., Helms, S., Carlstedt-Duke, J., Gustafsson, J.-Å., Rottman, F.M., and Yamamoto, K.R. (1988) Hormone-mediated repression of transcription: a negative glucocorticoid response element from the bovine prolactin gene. Genes Dev. 2, 1144-1154.

66. Schena, M., and Yamamoto, K.R. (1988) Mammalian glucocorticoid receptor derivatives enhance transcription in yeast. Science 241, 965-67.

67. Freedman, L.P., Luisi, B.F., Korszun, Z.R., Basavappa, R., Sigler, P.B., and Yamamoto, K.R. (1988) The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain. Nature 334, 543-546.

68. Godowski, P.J., Picard, D., and Yamamoto, K.R. (1988) Signal transduction and trans-criptional regulation by glucocorticoid receptor-LexA fusion proteins. Science 241, 812-816.

69. Godowski, P.J., Sakai, D.D., and Yamamoto, K.R. (1989) Signal transduction and transcriptional regulation by the glucocorticoid receptor. In: “DNA-Protein Interactions in Transcription,” UCLA Symposium on Molecular and Cellular Biology, New Series, Vol. 95, (J. Gralla, ed.), Alan R. Liss, Inc., New York, 197-210.

70. Freedman, L.R., Yamamoto, K.R., Luisi, B.F., and Sigler, P.B. (1988) More fingers in hand. Cell 54, 444.

71. Picard, D., Salser, S. J., and Yamamoto, K.R. (1988) A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor. Cell 54, 1073-1080.

72. Yamamoto, K.R., Godowski, P.J., and Picard, D. (1988) Ligand regulated nonspecific inactivation of receptor function: a versatile mechanism for signal transduction. Cold Spring Harb. Symp. Quant. Biol. 53, 803-811.

73. Yamamoto, K.R. (1989) A conceptual view of transcriptional regulation. Am. Zool. 29, 537-547.

74. Eilers, M., Picard, D., Yamamoto, K.R., and Bishop, J.M. (1989) Chimeras of the MYC oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature 340, 66-68.

75. Freedman, L.P., Yoshinaga, S.K., Vanderbilt, J.N., and Yamamoto, K.R. (1989) In vitro transcriptional enhancement by purified derivatives of the glucocorticoid receptor. Science 245, 298-301.

76. Schena, M., Freedman, L.P., and Yamamoto, K.R. (1989) Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activites. Genes Dev. 3, 1590-1601.

77. Picard, D., Schena, M., and Yamamoto, K.R. (1990) An inducible expression vector for both fission and budding yeasts. Gene 86, 257-261.

78. Schena, M., Picard, D., and Yamamoto, K.R. (1991) Vectors for constitutive and inducible gene expression in yeast. Meth. Enz. 194, 389-398.

79. Picard, D., Kumar, V., Chambon, P., and Yamamoto, K.R. (1990) Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors. Cell Reg. 1, 291-299.

80. Debs, R.J., Freedman, L.P., Edmunds, S., Gaensler, K.L., Düzgünes, N., and Yamamoto, K.R. (1990) Regulation of gene expression in vivo by liposome-mediated delivery of a purified transcription factor. J. Biol. Chem. 265, 10189-10192.

81. Howard, K.J., Holley, S.J., Yamamoto, K.R., and Distelhorst, C.W. (1990) Mapping the hsp90 binding region of the glucocorticoid receptor. J. Biol. Chem. 265, 11928-11935.

82. Härd, T., Kellenbach, E., Boelens, R., Maler, B.A., Dahlman, K., Freedman, L.P., Carlstedt-Duke, J., Yamamoto, K.R., Gustafsson, J.-Å., and Kaptein, R. (1990) Solution structure of the glucocorticoid receptor DNA-binding domain. Science 249, 157-160.

83. Härd, T., Kellenbach, E., Boelens, R., Kaptein, R., Dahlman, K., Carlstedt-Duke, J., Freedman, L.P., Maler, B.A., Hyde, E.I., Gustafsson, J.-Å., and Yamamoto, K.R. (1990) 1H-NMR studies of the glucocorticoid receptor DNA-binding domain: sequential assignments and identification of secondary structure elements. Biochem. 29, 9015-9023.

84. Picard, D., Khursheed, B., Garabedian, M.J., Fortin, M.G., Lindquist, S., and Yamamoto, K.R. (1990) Reduced levels of HSP90 compromise steroid receptor action in vivo. Nature 348, 166-168.

85. Diamond, M., Miner, J.N., Yoshinaga, S.K., and Yamamoto, K.R. (1990) Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249, 1266-1272.

86. Privalsky, M.L., Sharif, M., and Yamamoto, K.R. (1990) The viral erb A oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast. Cell 63, 1277-1286.

87. Kellenbach, E., Härd, T., Boelens, R., Dahlman, K., Carlstedt-Duke, J., Van der Marel, G.A., Van Boom, J.H., Maler, B., Yamamoto, K.R., and Kaptein, R. (1991) Photo-CIDNP study of the interaction between the glucocorticoid receptor DNA-binding domain and glucocorticoid response elements. J. Biomol. NMR, 105-110.

88. Yoshinaga, S.K., and Yamamoto, K.R. (1991) Signaling and regulation by a mammalian glucocorticoid receptor in Drosophila cells. Mol. Endocrinol. 5, 844-853.

89. Luisi, B.F., Xu, W.X., Otwinowski, Z., Freedman, L.P., Yamamoto, K.R., and Sigler, P.B. (1991) Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352, 497-505.

90. Miner, J.N., Diamond, M.I., and Yamamoto, K.R. (1991) Joints in the regulatory lattice: composite regulation by steroid receptor-AP1 complexes. Cell Growth Diff. 2, 525-530.

91. Miner, J.N., and Yamamoto, K.R. (1991) Regulatory crosstalk at composite response elements. Trends Biochem. Sci. 16, 423-426.

92. Chakraborti, P.K., Garabedian, M.J., Yamamoto, K.R., and Simons, S.S. Jr. (1991) Creation of “super” glucocorticoid receptors by point mutations in the steroid binding domain. J. Biol. Chem. 266, 22075-22078.

93. Amero, S.A., Kretsinger, R.H., Moncrief, N.D., Yamamoto, K.R., and Pearson, W.R. (1992) The origin of nuclear receptor proteins: a single precursor distinct from other transcription factors. Mol. Endocrinol. 6, 3-7.

94. Kellenbach, E., Maler, B.A., Yamamoto, K.R., Boelens, R., and Kaptein, R. (1991) Identification of the metal coordinating residues in the DNA binding domain of the glucocorticoid receptor by 113Cd-1H heteronuclear NMR spectroscopy. FEBS Lett. 291, 367-370.

95. Remerowski, M.L., Kellenbach, E., Boelens, R., Van der Marel, G.A., Van Boom, J.H., Maler, B.A., Yamamoto, K.R., and Kaptein, R. (1991) 1H NMR studies of DNA recognition by the glucocorticoid receptor: complex of the DNA binding domain with a half-site response element. Biochem. 30, 11620-11625.

96. Yamamoto, K.R. (1993) Eukaryotic gene transcription: big leaps, no bounds. In: “Practical Approaches to Eukaryotic Gene Transcription,” (B.D. Hames and S. Higgins, eds.), IRL Press, Oxford, U.K., pp. 1-3.

97. Chakraborti, P.K., Garabedian, M.J., Yamamoto, K.R., and Simons, S.S. (1992) Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors. J. Biol. Chem. 267, 11366-11373.

98. Garabedian, M.J., and Yamamoto, K.R. (1992) Genetic dissection of the signaling domain of a mammalian steroid receptor in yeast. Molec. Biol. Cell 3, 1245-1257.

99. Miner, J.N., and Yamamoto, K.R. (1992) The basic region of AP1 specifies glucocorticoid receptor activity at a composite response element. Genes Dev. 6, 2491-2501.

100. Pearce, D., and Yamamoto, K.R. (1993) Mineralocorticoid and glucocorticoid receptor activities are distinguished by nonreceptor factors at a composite response element. Science 259, 1161-1165.

101. Yoshinaga, S.K., Peterson, C.L., Herskowitz, I., and Yamamoto, K.R. (1992) Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors. Science 258, 1598-1604.

102. Yamamoto, K.R., Pearce, D., Thomas, J., and Miner, J.N. (1992) Combinatorial regulation at a mammalian composite response element. In: “Transcriptional Regulation,” (S.L. McKnight and K.R. Yamamoto, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 1169-1192.

103. Imai, E., Miner, J.N., Mitchell, J.A., Yamamoto, K.R., and Granner, D.K. (1993) Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J. Biol. Chem. 268, 5353-5356.

104. Scherrer, L.C., Picard, D., Massa, E., Harmon, J.M., Simons, S.S. Jr., Yamamoto, K.R., and Pratt, W.B. (1993) Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimaeric proteins by determining their hormone-regulated binding to hsp90. Biochem. 32, 5381-5386.

105. Bohen, S.P., and Yamamoto, K.R. (1993) Isolation of Hsp90 mutants by screening for decreased steroid receptor function. Proc. Natl. Acad. Sci. USA 90, 11424-11428.

106. Bohen, S.P., and Yamamoto, K.R. (1994) Modulation of Steroid Receptor Signal Transduction by Heat Shock Proteins. In: “The Biology of Heat Shock Proteins and Molecular Chaperones,” (R.I. Morimoto, A. Tissieres and C. Georgopoulos, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 313-334.

107. LaBaer, J., and Yamamoto, K.R. (1994) Analysis of the DNA-binding affinity, sequence specificity and context dependence of the glucocorticoid receptor zinc finger region. J. Mol. Biol. 239, 664-688.

108. Lefstin, J.A., Thomas, J.R., and Yamamoto, K.R. (1994) Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions. Genes Dev. 8, 2842-2856.

109. Kralli, A., Bohen, S.P., and Yamamoto, K.R. (1995) LEM1, An ATP-binding-cassette transporter, selectively modulates the biological efficacy of steroid hormones. Proc. Natl. Acad. Sci. USA 92, 4701-4705.

110. van Tilborg, M.A.A., Bonvin, A.M.J.J., Hård, K., Davis, A.L., Maler, B., Boelens, R., Yamamoto, K.R. and Kaptein, R. (1995) Structure refinement of the glucocorticoid receptor-DNA binding domain from NMR data by relaxation matrix calculations. J. Mol. Biol. 247, 689-700.

111. Vivanco, M.d.M., Johnson, R., Galante, P., Hanahan, D. and Yamamoto, K.R. (1995) A transition in transcriptional activation by the glucocorticoid and retinoic acid receptors at the tumor stage of dermal fibrosarcoma development. EMBO J. 14, 2217-2228.

112. Bohen, S.P., Kralli, A. and Yamamoto, K.R. (1995) Hold’em and Fold’em: Molecular chaperones and signal transduction. Science 268, 1303-1304.

113. Holley, S.J. and Yamamoto, K.R. (1995) A role for Hsp90 in retinoid receptor signal transduction. Molec. Biol. Cell 6, 1833-1842.

114. Starr, D.B., Matsui, W., Thomas, J.R. and Yamamoto, K.R. (1996) Intracellular receptors use a common mechanism to interpret signaling information at response elements. Genes Dev. 10, 1271-1283.

115. Kralli, A. and Yamamoto, K.R. (1996) An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones. J. Biol. Chem. 271, 17152-17156.

116. Xu, M., Chakraborti, P.K., Garabedian, M.J., Yamamoto, K.R. and Simons, S. Jr. (1996) Modular structure of glucocorticoid receptor domains is not equivalent to functional independence. Stability and and activity of the steroid binding domain are controlled by sequences in separate domain. J. Biol. Chem. 271, 21430-21438.

117. Miller, M.E., Cairns, B.R., Levinson, R.S., Yamamoto, K.R., Engel, D.A. and Smith, M.M. (1996) Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation. Mol. Cell. Biol. 16, 5737-5743.

118. Cairns, B.R., Levinson, R.S., Yamamoto, K.R. and Kornberg, R.D. (1996) Essential role of Swp73p in the function of yeast Swi/Snf complex. Genes Dev. 10, 2131-2144.

119. Yamamoto, K.R. (1997) Multilayered control of intracellular receptor function. The Harvey Lectures 91, 1-19.

120. Iñiguez-Lluhi, J.A., Lou, D.Y. and Yamamoto, K.R. (1997) Three amino acid substitutions selectively disrupt the activation but not the repression function of the glucocorticoid receptor n-terminous. J. Biol. Chem. 272, 4149-4156.

121. Krstic, M.D., Rogatsky, I., Yamamoto, K.R. and Garabedian, M.J. (1997) Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor. Mol. Cell. Biol. 17, 3947-3954.

122. Lichtarge, O., Yamamoto, K.R. and Cohen, F. (1997) Identification of functional surfaces of the zinc binding domains of intracellular receptors. J. Mol. Biol. 274, 325-337.

123. Yamamoto, K.R. (1997) Intracellular receptors: New instruments for a symphony of signals. In: "The Molecular Biology of Steroid and Nuclear Hormone Receptors," (L.P. Freedman, ed.), Birkhauser Press, Boston, pp. vii-x.

124. Lefstin, J.A. and Yamamoto, K.R. (1998) Allosteric effects of DNA on transcriptional regulators. Nature 392, 885-888.

125. Pearce, D., Matsui, W., Miner, J.N. and Yamamoto, K.R. (1998) Glucocorticoid receptor transcriptional activity determined by spacing of receptor and non-receptor DNA sites. J. Biol. Chem. 273, 30081-30085.

126. Darimont, B.D., Wagner, R.L., Apriletti, J.W., Stallcup, M.R., Kushner, P.J., Baxter, J.D., Fletterick, R.L. and Yamamoto, K.R. (1998) Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 12, 3343-3356.

127. Yamamoto, K.R., Darimont, B.D., Wagner, R.L. and Iniguez-Lluhi, J.A. (1998) Building transcriptional regulatory complexes: Signals and surfaces. Cold Spring Harb. Symp. Quant. Biol. 63, 587-598.

128. Hong, H., Darimont, B.D., Ma, H., Yang, L., Yamamoto, and K.R. and Stallcup, M.R. (1999) An additional region of coactivator GRIP1 required for interaction with the hormone binding domains of a subset of nuclear receptors. J. Biol. Chem. 274, 3496-3502.

129. Diamond, M.I., Robinson, M.R. and Yamamoto, K.R. (1999) Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 97, 657-661.

130. Freeman, B.C., Felts, S.J., Toft, D.O. and Yamamoto, K.R. (2000) The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies. Genes Dev. 14, 422-434.

131. Sitcheran, R., Emter, R., Kralli, A. and Yamamoto, K.R. (2000) A genetic analysis of glucocorticoid receptor signaling: identification and characterization of ligand-effect modulators in Saccharomyces cerevisiae. Genetics 156, 963-972.

132. Jamieson, C.A.M. and Yamamoto, K.R. (2000) Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T-cell receptor signaling. Proc. Natl. Acad. Sci. USA 97, 7319-7324.

133. Nissen, R.M. and Yamamoto, K.R. (2000) The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxyl-terminal domain. Genes Dev. 14, 2314-2329.

134. van Tilborg, M.A.A., Lefstin, J.A., Kruiskamp, M., Teuben, J-M., Boelens, R., Yamamoto, K.R. and Kaptein, R. (2000) Mutations in the glucocorticoid receptor DNA-binding domain mimic an allosteric effect of DNA. J. Mol Biol. 301, 947-958.

135. Freeman, B.C. and Yamamoto, K.R. (2001) Continuous recycling: A mechanism for modulatory signal transduction. Trends Biochem. Sci. 26, 285-290.

136. Rogatsky I., Zarember K.A. and Yamamoto K.R. (2001) Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO J. 20, 6071-6083.

137. Freeman, B.C. and Yamamoto, K.R. (2002) Disassembly of transcriptional regulatory complexes by molecular chaperones. Science 296, 2232-2235.

138. Rogatsky, I., Luecke, H.F., Leitman, D.C. and Yamamoto, K.R. (2002) Alternate surfaces of transcriptional co-regulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc. Natl. Acad. Sci. USA, 99, 16701-16706.

139. Rogatsky, I., Wang, J-C., Derynck, M.K., Nonaka, D., Khodabakhsh, D.B., Haqq, C.M., Darimont, B.D., Garabedian, M.J., and Yamamoto, K.R. (2003) Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 100, 13845-13850.

140. Kian Tee, M., Rogatsky, I., Tzagarakis-Foster, C., Cvoro, A., An, J., Christy, R.J., Yamamoto, K.R. and Leitman, D.C. (2004) Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors α and β. Mol. Biol. Cell 15, 1262-1272.

141. Freedman, N.D. and Yamamoto, K.R. (2004) Importin 7 and Importin α/Importin β Are Nuclear Import Receptors for the Glucocorticoid Receptor. Mol. Biol. Cell. 15, 2276-2286.

142. Wang, J-C., Walker, A., Blackwell, T.K., and Yamamoto, K.R. (2004) The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J. Biol. Chem. 279, 29270-29277.

143. Shostak, Y., Van Gilst, M.R., Antebi, A., and Yamamoto, K.R. (2004). Identification of C. elegans DAF-12 binding sites, response elements and target genes. Genes Dev. 18, 2529-2544.

144. Wang, J.-C., Derynck, M.K., Nonaka, D.F., Khodabakhsh,D.B., Haqq, C., Yamamoto, K.R. (2004) Chromatin Immunoprecipitation (ChIP) Scanning Identifies Primary Glucocorticoid Receptor Target Genes. Proc. Natl. Acad. Sci. USA 101, 15603-15608.

145. Van Gilst, M.R., Hadjivassiliou, H., Jolly, A., and Yamamoto, K.R. (2005) Nuclear Hormone Receptor NHR-49 Controls Fat Consumption and Fatty Acid Composition in C. elegans. PLoS Biol. 3, e53.

146. Shostak, Y. and Yamamoto, K.R. (2005) Overlapping but Separable Determinants of DNA Binding and Nuclear Localization Map to the C-terminal End of the C. elegans DAF-12 DNA Binding Domain. J. Biol. Chem. 280, 6554-6560.

147. Luecke, H.F. and Yamamoto, K.R. (2005). The Glucocorticoid Receptor blocks P-TEFb recruitment by NFκB to effect promoter specific transcriptional repression. Genes Dev. 19, 1116-1127.

148 Van Gilst, M.R., Hadjivassiliou, H. and Yamamoto, K.R. (2005) A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Proc. Natl. Acad. Sci. USA 102, 13496-13501.

149. Wang, J-C., Shah, N., Pantoja, C., Meijsing, S.H., Ho, J.D., Scanlan, T.S., Yamamoto, K.R. (2006) Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev. 20, 689-699.

150. Taubert, S., Van Gilst, M.R., Hansen, M., Yamamoto, K.R. (2006) A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev. 20, 1137-1149.

151. Feldman, B.F., Streeper, R.S., Farese, R.V. Jr. and Yamamoto, K.R. (2006) Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc. Natl. Acad. Sci. USA 103, 15675-15680.

152 Meijsing, S.H., Elbi, C., Luecke, H.F., Hager, G.L., and Yamamoto, K.R. (2007) The ligand binding domain controls glucocorticoid receptor dynamics independent of ligand release. Mol. Cell. Biol. 27, 2442-2451.

153. Ricketson, D., Hostick, U., Fang, L., Yamamoto, K.R., and Darimont, B. (2007) A conformational switch in the ligand binding domain regulates the dependence of the glucocorticoid receptor on Hsp90. J. Mol. Biol. 368, 729-741.

154. So, A.Y., Chaivorapol, C., Bolton, E.C., Li, H., and Yamamoto, K.R. (2007) Determinants of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor. PloS Genetics 3, e94.

155. Bolton, E.C., So, A.Y., Chaivorapol, C., Haqq, C.M., Li, H. and Yamamoto. K.R. (2007) Cell- and Gene-Specific Regulation of Primary Target Genes by the Androgen Receptor. Genes Dev. 21, 2005-2017.

156. Woodruff, P.G., Boushey, H.A., Dolganov, G.M., Barker, C.S., Yang, Y.H., Donnelly, S., Ellwanger, A., Sidhu, S.S., Dao-Pick, T.P., Pantoja, C., Erle, D.J., Yamamoto, K.R., Fahy,. J.V. (2007) Genome-Wide Profiling Identifies Epithelial Cell Genes Associated With Asthma and With Treatment Response to Corticosteroids. Proc. Natl. Acad. Sci. USA 104, 15858-15863.

157. Taubert, S., Hansen, M., Van Gilst, M.R., Cooper, S.M., Yamamoto, K.R. (2008) The Mediator Subunit MDT-15 Confers Metabolic Adaptation to Ingested Material. PLoS Genetics 4, e1000021.

158. So, A.Y., Cooper, S.B., Feldman, B.J., Manuchehri, M., Yamamoto, K.R. (2008) Conservation Analysis Predicts In Vivo Occupancy of Glucocorticoid Receptor Binding Sequences at Glucocorticoid-Induced Genes. Proc. Natl. Acad. Sci. USA 105, 5745-5749.

159. Pantoja, C., Huff, J.T., Yamamoto, K.R. (2008) Glucocorticoid Signaling Defines a Novel Commitment State during Adipogenesis In Vitro. Mol. Biol. Cell. 19, 4032-41.

160. Meijsing, S.H., Pufall, M.A., So, A.Y., Bates, D.L., Chen, L., Yamamoto, K.R. (2009) DNA-binding site sequence directs glucocorticoid receptor structure and activity. Science 324, 407-410.

161. Jones, J.O., Bolton, E.C., Huang, Y., Feau, C., Guy, R.K., Yamamoto, K.R., Hann B., Diamond M.I. (2009) Non-competitive androgen receptor inhibition in vitro and in vivo. Proc. Natl. Acad. Sci. U S A. 106, 7233-7238.

162. Beck, I.M.E., Vanden Berghe, W., Vermeulen, L., Yamamoto, K.R., Haegeman, G.*, De Bosscher, K*. (*Share senior authorship) (2009) Crosstalk in Inflammation: The interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocrine Reviews 30, 830-82.

163. So, A.L., Bernal, T.U., Pillsbury, M.L., Yamamoto, K.R., Feldman, B.J. (2009) Glucocorticoid Regulation of the Circadian Clock Modulates Glucose Homeostasis. Proc. Natl. Acad. Sci. U S A. 106, 17582-7.

164. Taubert, S., Ward, J.D., Yamamoto, K.R. (2010) Nuclear Hormone Receptors in Nematodes: Evolution and Function. Mol. Cell. Endocrinol. 334, 49-55.

165. Arda, H.E., Taubert, S., MacNeil, L.T., Conine, C., Tsuda, B., van Gilst, M., Sequerra, R., Doucette-Stamm, L., Yamamoto, K.R., Walhout, A.J.M. (2010) Functional modularity of nuclear hormone receptors in a C. elegans metabolic gene regulatory network. Molecular Systems Biology 6: 367.

166. Dekelver, R.C., Choi, V.M., Moehle, E.A., Paschon, D.E., Hockemeyer, D., Meijsing, S.H., Sancak, Y., Cui, X., Steine, E.J., Miller, J.C., Tam, P., Bartsevich, V.V., Meng, X., Rupniewski, I., Gopalan, S.M., Sun, H.C., Pitz, K.J., Rock, J.M., Zhang, L., Davis, G.D., Rebar, E.J., Cheeseman, I.M., Yamamoto, K.R., Sabatini, D.M., Jaenisch, R., Gregory, P.D., Urnov, F.D. (2010) Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res. 20, 1133-42.

167. Huff, J.T., Plocik, A.M., Guthrie, C., Yamamoto, K.R. (2010) Reciprocal intronic and exonic histone modification regions in humans. Nat. Struct. Mol. Biol. 17, 1495-9.

168. Costa, M.J., So, A.Y., Kaasik, K., Krueger, K.C., Pillsbury, M.L., Fu, Y.H., Ptacek, L.J., Yamamoto, K.R., Feldman, B.J. (2011) Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. J. Biol. Chem. 286, 9063-70.

169. Cvoro, A., Yuan, C., Paruthiyil, S., Miller, O.H., Yamamoto, K.R., Leitman, D.C. (2011) Cross Talk between Glucocorticoid and Estrogen Receptors Occurs at a Subset of Proinflammatory Genes. J Immunol. 186, 4354-60.

170. Ou, C.-Y., LaBonte, M.J., Manegold, P.C., So, A. L., Ianculescu, I., Gerke, D.S., Yamamoto, K.R., Ladner, R.D., Kahn, M., Kim, J.-H., Stallcup, M.R. (2011) A coactivator role of CARM1 in the dysregulation of β-catenin activity in colorectal cancer cell growth and gene expression. Mol. Cancer Res. 9, 660-70.

171. Holdorf, M.M., Cooper, S.B., Yamamoto, K.R., Miranda, J.J. (2011) Occupancy of chromatin organizers in the Epstein-Barr virus genome. Virology. 415, 1-5.

172. Engel K.B., Yamamoto K.R. (2011) The glucocorticoid receptor and the coregulator Brm selectively modulate each other’s occupancy and activity in a gene-specific manner. Mol. Cell. Biol. 31, 3267-76.

173. Ziv, L., Muto, A., Schoonheim, P.J., Meijsing, S.H., Strasser, D., Ingraham, H.A., Schaaf, M.J.M., Yamamoto, K.R., Baier, H. (2012) An affective disorder in zebrafish with mutation of the glucocorticoid receptor. Mol. Psychiatry. doi: 10.1038/mp.2012.64. [epub ahead of print]

174. Chen, S.-H., Masuno, K., Cooper, S., Yamamoto, K.R. (2013) An incoherent feed-forward regulatory logic underpinning glucocorticoid receptor action. Proc Natl Acad Sci USA. 110, 1964-9.

175. Watson, L.C., Kuchenbecker, K.M., Schiller, B.J., Gross, J.D., Pufall, M.A., Yamamoto, K.R. (2013) The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nature Struc Mol Biol. 20, 876-83.

CO-WORKER PUBLICATIONS FROM THE YAMAMOTO LABORATORY

1. Compton, J.L. and Bonner, J.J. (1978) An in vitro assay for the specific induction and regression of puffs in isolated polytene nuclei of Drosophila melanogaster. Cold Spring Harb. Symp. Quant. Biol. 42, 835-838.

2. Bonner, J.J. (1981) Induction of Drosophila heat shock puffs in isolated polytene nuclei. Dev. Biol. 86, 409-418.

3. Firestone, G.L. (1983) The role of protein glycosylation in the compartmentalization and processing of mouse mammary tumor virus glyco-proteins in MTV-infected rat hepatoma cells. J. Biol. Chem. 258, 6155-6161.

4. Goldfeld, A.E., Firestone, G.L., Shaw, P.A. and Gluecksohn-Waelsch, S. (1983) A recessive lethal deletion on mouse chromosome 7 affects glucocorticoid receptor binding activities. Proc. Natl. Acad. Sci. USA 80, 1431-1434.

5. Danielsen, M., Peterson, D.O. and Stallcup, M.R. (1983) Immunological selection of variant mouse lymphoid cells with altered glucocorticoid responsiveness. Molec. Cell. Biol. 3, 1310-1316.

6. Payvar, F. and Wrange, Ö. (1983) Relative selectivities and efficiencies of DNA binding by purified intact and protease-cleaved glucocorticoid receptor. In: “Steroid Hormone Receptors: Structure and Function,” Nobel Symposium 57, (H. Erikkson and J.-Å. Gustafsson, eds.), Elsevier/North Holland Biomedical Press, Amsterdam, pp. 267-282.

7. Distelhorst, C. and Miesfeld, R. (1987) Characterization of glucocorticoid receptors and glucocorticoid receptor mRNA in human leukemia cells: stabilization of the receptor by diisopropylfluorophosphate. Blood 69, 750-756.

8. Rosewicz, S., McDonald, A.R., Maddux, B.A., Goldfine, I.D., Miesfeld, R.L. and Logsdon, C.D. (1988) Mechanism of glucocorticoid receptor down-regulation by glucocorticoids. J. Biol. Chem. 263, 2581-2584.

9. Miesfeld, R.L. (1989) The structure and function of steroid receptor proteins. CRC Crit. Rev. Biochem. 24, 101-117.

10. Schena, M. (1989) The evolutionary conservation of eukaryotic gene transcription. Experientia 45, 972-983.

11. Godowski, P.J. and Picard, D. (1989) Steroid receptors: how to be both a receptor and a transcription factor. Biochem. Pharmacol. 38, 3135-3143.

12. Pan, T., Freedman, L.P. and Coleman, J.E. (1990) 113Cd NMR studies of the DNA binding domain of the mammalian glucocorticoid receptor. Biochem. 29, 9218-9225.

13. Superti-Furga, G., Bergers, G., Picard, D., and Busslinger, M. (1991) Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins. Proc. Natl. Acad. Sci. USA 88, 5114-5118.

14. Byravan, S., Milhon, J., Rabindran, S.K., Olinger, B., Garabedian, M.J., Danielsen, M. and Stallcup, M.R. (1991) Two point mutations in the hormone-binding domain of the mouse glucocorticoid receptor that dramatically reduce its function. Mol. Endocrinol. 5, 752-758.

15. DeFranco, D.B., Qi, M., Borror, K.C., Garabedian, M.J. and Brautigan, D.L. (1991) Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors. Mol. Endocrinol. 5, 1215-1228.

16. Garabedian, M.J., LaBaer, J., Liu, W.-H. and Thomas, J.R. (1993) Analysis of protein-DNA interactions. In: “Practical Approaches to Eukaryotic Gene Transcription,” (B.D. Hames and S. Higgins, eds.), IRL Press, Oxford, U.K., pp. 243-293.

17. Pearce, D. (1994) A mechanistic basis for distinct mineralocorticoid and glucocorticoid receptor transcriptional specificities. Steroids 159, 153-159.

18. Garabedian, M.J. (1993) Genetic approaches to mammalian nuclear receptor function in yeast. Methods 6, 1-9.

19. Bohen, S.P. (1995) HSP90 Mutants disrupt glucocorticoid receptor ligand binding and destabilize aporeceptor complexes. J. Biol. Chem. 270, 29433-29438.

20. Lamarco, K. and Vivanco, M.D.M. (1996) Steroid hormone and nuclear receptors. In: "Signal Transduction," (C-H. Helden and M. Purtin, eds.), Chapman & Hall, London, pp. 305-320.

21. Meyer, T., Starr, D.B. and Carlstedt-Duke, J. (1997) The rat glucocorticoid receptor mutant K461A differentiates between two different mechanisms of transrepression. J. Biol. Chem. 272, 21090-21095.

22. Meyer, T., Carlstedt-Duke and J., Starr, D.B. (1997) A weak TATA box is a prerequisite for glucocorticoid-dependent repression of the osteocalcin gene. J. Biol. Chem. 272, 30709-30714.

23. Tang, Y., Ramakrishnan, C., Thomas, J. and DeFranco, D.B. (1997) A role for HDJ-2/HSDJ in correcting subnuclear trafficking, transactivation, and transrepression defects of a glucocorticoid receptor zinc finger mutant. Mol. Biol. Cell. 8, 795-809.

24. Pocuca, N., Ruzdijic, S., Demonacos, C., Kanazir, D. and Krstic-Demonacos, M. (1998) Using yeast to study glucocorticoid receptor phosphorylation. J. Steroid Biochem. Molec. Biol. 66, 303-318.

25. Hammer,G.D., Krylova, I., Zhang, Y., Darimont, B.D., Simpson, K., Weigel, N.L. and Ingraham, H.A. (1999) Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol Cell 3, 521-526.

26. Darimont, B.D. (1999) The Hsp90 chaperone complex–A potential target for cancer therapy? World Journal of Gastroenterology 5, 195-198.

27. Hittelman, A.B., Burakov, D., Iñiguez-Lluhí, J.A., Freedman, L.P. and Garabedian, M.J. (1999) Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. EMBO J. 18, 5380-5388.

28. Iniguez-Lluhi, J.A. and Pearce, D. (2000) A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol. Cell. Biol. 15, 6040-6050.

29. Bland, M.L., Jamieson,C.A.M., Akana,S.F., Bornstein,S.R., Eisenhofer,G., Dallman,M.F. and Ingraham,H.A. (2000) Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impared stress response. Proc. Natl. Acad. Sci. USA 97, 14488-14493.

30. Barboric, M., Nissen, R.M., Kanazawa, S., Jabrane-Ferrat, N. and Peterlin, B.M. (2001) NF-κB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. Mol. Cell. 8, 327-337.

31. Welch, W.J. and Diamond, M.I. (2001) Glucocorticoid modulation of androgen receptor nuclear aggregation and cellular toxicity is associated with distinct forms of soluble expanded polyglutamine protein. Human Molecular Genetics 10, 3063-3074.

32. Rogatsky, I. (2003) Drug discovery for inflammatory diseases. Expert Opin. Biol. Ther. 3, 1-4.

33. Van Gilst, M., Gissendanner, C.R., Sluder, A.E. (2002) Diversity and function of orphan nuclear receptors in nematodes. Crit Rev Eukaryot Gene Expr. 12, 65-88.

34. Wang, J-C. (2005) Finding Primary Targets of Transcriptional Regulators. Cell Cycle 4, 356-358.

35. Reily, M.M., Pantoja, Hu, C.X., Chinenov, Y. and Inez Rogatsky (2006) The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression. EMBO J. 25, 108–117.

36. Takayama, S., Rogatsky, I., Schwarcz, L.E. and Darimont, B.D. (2006) The glucocorticoid receptor represses cyclin D1 by targeting the Tcf-beta-catenin complex. J. Biol. Chem. 281, 17856-17863.

37. Feldman, B.J. (2007) Is Your Metabolism Determined By (Cell) Fate? Pediatric Research 61, 636-639.

38. Pathare, P.P., Lin, A., Bornfeldt, K.E., Taubert, S., Van Gilst, M.R. (2012) Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships. PLoS Genetics 8, e1002645.

BOOKS EDITED

1. Goldberger, R.F., and Yamamoto, K.R., eds. (1982) “Biological Regulation and Development, Vol. 3A, Hormone Action,” Plenum Press, New York.

2. Goldberger, R.F., and Yamamoto, K.R., eds. (1984) “Biological Regulation and Development, Vol. 3B, Hormone Action,” Plenum Press, New York.

3. McKnight, S.L., and Yamamoto, K.R., eds. (1992) “Transcriptional Regulation,” Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

SCIENCE AND PUBLIC POLICY PUBLICATIONS

1. Yamamoto, K.R. (1982) Faculty members as corporate officers: does cost outweigh benefit? In: “From Genetic Experimentation to Biotechnology — The Critical Transition,” (W.J. Whelan and S. Black, eds.), John Wiley & Sons, Limited, Chichester, Sussex, England, pp. 195-201.

2. Piller, C., and Yamamoto, K.R. (1988) “Gene Wars: Military Control Over the New Genetic Technologies,” Beech Tree/William Morrow, New York.

3. Yamamoto, K.R. (1989) Retargeting research on biological weapons. Technol. Rev. 92, 23-24.

4. Yamamoto, K.R. (1989) Should germ warfare defense funds be transferred to NIH? J. NIH Research 1, 18-20.

5. Yamamoto, K.R. (1992) Second thoughts on misconduct. J. NIH Res. 4, 18.

6. Yamamoto, K.R., and Marincola, E. (1993) NIH’s strategic plan: From whom? To whom? Why now? J. NIH Res. 5, 26-28.

7. Yamamoto, K.R. (1997) Placing the Ph.D. at the hub of career development in the biological sciences. In: "Graduate Education in the Biological Sciences in the 21st Century: Meeting the Challenge," (S. Huttner and J. Rubaloff, eds.) University of California Systemwide Biotechnology Research and Education Program, Berkeley, California, pp. 144-155.

8. Alberts, B.M., Ayala, F.J., Botstein, D., Frank, E., Holmes, E.W., Lee, R.D., Macagno, E.R., Marrack, P., Oparil, S., Orkin, S.H., Rubenstein, A.H., Slayman, C.W., Sparling, P.F., Squire, L.R., von Hippel, P.H. and Yamamoto, K.R. (1999) Proposed changes for NIH's Center for Scientific Review. Science 285, 666-667.

9. Yamamoto,K.R. (interview) (2000) How to use electroninc publishing to enhance your science. ASCB Newsletter 23 (10), 3-5.

10. Lo, B., Chou,V., Cedars, M.I., Gates, E., Taylor, R.N., Wolf, L., Wagner, R.M. and Yamamoto, K.R. (2003) Informed consent from gamete donors. Science 301, 921.

11. Walter, P. and Yamamoto, K.R. (2003) In memory of Ira Herskowitz. The ASCB Newsletter 26 (6), 18.

12. Lo, B., Chou, V., Cedars, M.I., Gates, E., Taylor, R.N., Wagner, R.M., Wolf, L. and Yamamoto, K.R. (2004) Informed consent in human oocyte, embryo, and embryonic stem cell research. Fertil Steril 82, 559-563.

13. Yamamoto, K.R. (2004) Bankrolling Stem-Cell Research with California Dollars. NEJM 351, 1711-1713.

14. Lo, B., Zettler, P., Cedars, M.I., Gates, E. Kriegstein, A.R., Oberman, M., Reijo Pera, R., Wagner, R.M., Wuerth, M.T., Wolf, L.E., Yamamoto, K.R. (2005) A New Era in the Ethics of Human Embryonic Stem Cell Research. Stem Cells 23, 1454-1459.

15. Kriegstein, A. and Yamamoto, K.R. (2006) Op-Ed: Stem-cell research on the rise, even lacking government funds. San Francisco Chronicle, February 3, 2006.

16. Committee on Bridges to Independence, National Research Council (US). 2005. Bridges to Independence: Fostering the Independence of New Investigators in Biomedical Research. National Academies Press. Washington, DC, USA. 172 pp.

17. Committee on Alternative Models for the Federal Funding of Science (US). 2008. ARISE (Advancing Research in Science and Engineering): Investing in Early-Career Scientists and High-Risk, High-Reward Research. White paper.

18. Committee on a New Biology for the 21st Century: Ensuring the United States Leads the Coming Biology Revolution, National Research Council of the National Academies (US). 2009. A New Biology for the 21st Century. The National Academies Press.

19. Labov, J.B., Reid, A.H., Yamamoto K.R. (2010) Integrated Biology and Undergraduate Science Education: A New Biology for the Twenty First Century? CBE Life Sci Educ 9, 10-6.

20. Norman, T.C., Bountra, C., Edwards, A.M., Yamamoto, K.R., Friend, S.H. (2011) Leveraging crowdsourcing to facilitate the discovery of new machines. Sci. Transl. Med. 3, 88mr1.

21. Hood, L.E., Omenn, G.S., Moritz, R.L., Aebersold, R., Yamamoto, K.R., Amos, M., Hunter-Cevera, J., Locascio, L. (2012) New and improved proteomics technologies for understanding complex biological systems: Addressing a grand challenge in the life sciences. Proteomics 12, 2773-2783.

22. O’Brien, T.C., Yamamoto, K.R., Hawgood, S. (2013) Team Science (Commentary). Academic Medicine 88, 156-7.

23. Yamamoto, K.R. (2013) “Time to Play Ball.” Editorial. Science 340:1375.

PATENTS

U.S. Patent No. 4,889,802 Enhanced Production of Recombinant Proteins in Myeloma Cells (T.J. Parslow, K.R. Yamamoto) December 26, 1989.

U.S. Patent No. 5,215,916 Super glucocorticoid receptors: receptors with increased affinity and specificity for glucocorticoid steriods. S.S Simons, Jr., P.K. Chakraborti, K.R. Yamamoto, M.J. Garabedian. June 1, 1993.

U.S. Patent No. 5,631,133 Transition in Transcriptional Activation by Intracellular Hormone Receptors at the Tumor Stage of Dermal Fibrosarcoma Development (D. Hanahan, M.d.M. Vivanco, K.R. Yamamoto) May 20, 1997.

U.S. Patent Application No. 20020061539 Methods and Compounds for Modulating Nuclear Receptor Coactivator Binding. (J.D. Baxter, B.D. Darimont, W. Feng, R.J. Fletterick P.J. Kushner, R.L. Wagner, B.L. West, K.R. Yamamoto). Filed March 30, 1999.

Canadian Patent Application No. 2323575 Methods and Compounds for Modulating Nuclear Receptor Coactivator Binding. (B.D. Darimont, R.J. Fletterick, J.D. Baxter, W. Feng, P.J. Kushner, B.L. West, R.L. Wagner, K.R. Yamamoto). March 30, 1999.

Canadian Patent Application No. 2415103 Methods and Compounds for Modulating Nuclear Receptor Coactivator Binding. (B.D. Darimont, R.J. Fletterick, T.R. Geistlinger, J.D. Baxter, W. Feng, I. Kuntz, J.R. Arnold, R. K. Guy, P.J. Kushner, B.L. West, R.L. Wagner, K.R. Yamamoto). June 29, 2001.

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