Rajiv Gandhi University of Health Sciences



RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, KARNATAKA, BANGALORE

ANNEXURE II

PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION

|1. |Name of the Candidate and Address (in block letters) |Dr. HARINI.S |

| | |POST GRADUATE STUDENT, |

| | |DEPARTMENT OF PHYSIOLOGY, |

| | |J.J.M. MEDICAL COLLEGE, |

| | |DAVANGERE-577004 |

|2. |Name of the Institution |J.J.M. MEDICAL COLLEGE, |

| | |DAVANGERE-577004, |

| | |KARNATAKA. |

|3. |Course of Study & Subject |M.D. PHYSIOLOGY |

|4. |Date of Admission to Course |31.05.2013 |

|5. |Title of the Topic |“A COMPARITIVE STUDY OF VISUAL EVOKED POTENTIAL AND EVENT RELATED |

| | |POTENTIAL P300 IN DIABETICS AND AGE MATCHED CONTROLS.” |

|6. |Brief resume of the intended work: |

| |6.1 Need for the study: |

| |Once regarded as a single disease entity, diabetes is now seen as a heterogenous group of diseases, characterised by a state of |

| |chronic hyperglycemia resulting from a diversity of aetiologies, environmental and genetics acting jointly.1 |

| |Diabetes mellitus refers to a group of common metabolic disorders that share the phenotype of hyperglycemia.1 The worldwide |

| |prevalence of diabetes has risen dramatically over the past two decades from an estimated 30million cases in 1985 to 285million |

| |in 2010.2Prevalance in adults is found to be 2.4% in rural and 4-11.6% in urban dwellers.1 |

| |Long standing metabolic derangement is associated with functional and structural changes in many organs, particularly vascular |

| |system. These characteristically seen in eye, kidney and nervous system. Hyperglycemia which, if untreated, is associated with |

| |significant risk of microvascular disease, and in particular diabetic retinopathy.3Nervous system involvement in diabetes has |

| |been amply documented. Important detectable changes in the higher functions appear to occur frequently in diabetics than |

| |commonly believed.4 |

| |Hence present study was conducted with an aim to observe VEPs and P300 abnormalities in diabetics of both sexes in comparison |

| |with a control group. |

| | |

| |6.2 Review of literature : |

| |A Study of Visual Evoked Potential Changes in Diabetes Mellitus shows that the mean P100 latencies in diabetics were |

| |significantly prolonged compared to controls. Similarly the P100 latencies recorded for individual eyes were also significantly |

| |delayed in diabetics. The interlatency difference in P100 latencies was also more in diabetics. The N75 amplitudes in diabetics |

| |had a lower mean value compared to controls. P100 amplitudes in test groups had a mean value lower than mean of controls. The |

| |delayed P100 latencies showed a positive correlation with the duration of disease. It also showed correlation with metabolic |

| |control of diabetes.5 |

| |A Study of Visual Evoked Potentials in Diabetic patients shows that P100 wave latencies were significantly longer in diabetic |

| |patients than those of the control group.45% had P100 wave latencies above normal range. Also significant positive correlation|

| |between P100 wave latency and duration of diabetes mellitus was found.6 |

| |A Study of Visual Evoked potentials in Patients with Type-2 Diabetes Mellitus shows, the mean value of N70 latency increased in |

| |all diabetic groups compared to that of healthy subjects. P100 latency was delayed in all diabetic groups as compared to that |

| |in healthy subjects. The mean values of the N70-P100 and the N70-P100 amplitudes showed a significant decrease in all diabetic |

| |patients with a duration of more than 10yrs.7 |

| |A Study of Effect of Type 2 Diabetes Mellitus On Cognitive Functions By Event Related Potential P300 shows that test group had |

| |significantly higher P300 latency than control group. Test group had significantly decreased P300 amplitude than control group.8|

| |A Study of Neurophysiological evidence for altered higher brain functions in NIDDM shows that, Diabetic patients had |

| |significantly longer P300 latencies than control subjects. There was a trend toward longer P300 latencies in diabetic patients |

| |with retinopathy and in those with HbA1 of ≥10%.9 |

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| | |

| |6.3. Objectives of the study: |

| |The present study was conducted to observe the pattern reversal stimulation in a group of subjects with NIDDM and IDDM without |

| |retinopathy and with normal visual acuity at baseline. The aim was to find whether the VEP-PR latencies are altered in diabetics|

| |or not and if altered whether it shows any correlation with the duration of diabetes in both sexes in comparison with control |

| |group. |

| |Also the study was conducted to investigate the influence of diabetes mellitus on the cognitive function as assessed by Event |

| |related potential P300 . |

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|7. |Materials and methods: |

| |7.1 Source of data: |

| |This study will be done in Department of Physiology, J.J.M. Medical College, Davangere. A total of 110 subjects are included in |

| |the study. A minimum of 60 diabetics attending medical out patient department from Bapuji hospital and Chigateri hospital |

| |davangere, satisfying the inclusion and exclusion criteria and a minimum of 50 age matched controls were included. |

| |Period of study: One year. |

| |Inclusion criteria: |

| |1. Males and Females in the age group of 25-55 years. |

| |2. All patients of NIDDM or IDDM were included. |

| |Exclusion criteria |

| |Retinopathy. |

| |Cataract. |

| |Glaucoma. |

| |Vitreous opacities. |

| |Optic atrophy. |

| |Visual acuity of ................
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