Gourion-Arsiquaud page 1/5 - Columbia University



Diane Bérengère Ré (aka Gourion-Arsiquaud) Ph.D,

E-mail : dr2240@cumc.columbia.edu

WORK EXPERIENCE

October 2014- Assistant Professor in the Department of Environmental Health Sciences at Columbia University. Principal Investigator of the Neurodegenerative disease and Neurotoxin Lab. Research work conducted on the cellular and molecular basis and the environmental causes of Amyotrophic lateral sclerosis and other adult-onset neurodegenerative disorders, especially at the level of neuro-glial interactions.

February 2008-September 2014 Associate Research Scientist, Junior Faculty, first in the Department of Neurology and then in the Department of Pathology and Cell Biology, Leader of the Motor Neuron Disease Team in Prof. Serge Przedborski’s Laboratory. Supervise and organize the work of two technicians, two post-doctoral scientists, one graduate student and multiple undergraduate students year-round.

Department of Pathology and Cell Biology at Columbia University. Research work conducted on the cellular and molecular basis of Amyotrophic lateral sclerosis and Spinal Muscular Atrophy, especially at the level of neuro-glial interactions.

TRAINING and education

January 2005-January 2008 Post-doctoral Research Scientist

in Prof. Serge Przedborski’s Laboratory, Department of Neurology at Columbia University. Research work conducted on the cellular and molecular basis of Amyotrophic lateral sclerosis.

July 2000-December 2004 Ph.D. thesis in Neuroscience. Awarded on September the 13th 2004

Title of thesis: “Astrocyte death linked to reverse glutamate transport: a novel cell death mechanism different from excitotoxicity and oxidative glutamate toxicity”.

Sponsors: French Ministry of Research and Technology (3 years fellowship)

France Parkinson Association (one year fellowship)

Publications: 4 scientific articles, 3 reviews.

IC2N laboratory (Cellular Interactions, Neurodegeneration and Neuroplasticity), CNRS, Marseille. Co-supervisors of thesis: Prof. André Nieoullon and Dr. Laurence Had-Aïssouni

July 1999-June 2000 DEA (Diplôme d’études approfondies) de Neurosciences (Master year 2+ Rotation), awarded on July 2000. One year of laboratory scientific experience at the laboratory of Cellular Interaction Neurodegeneration and Neuroplasticity (IC2N) (Faculté des Sciences de Luminy-Aix-Marseille II, Université de la Méditerranée, France) required to be admitted to a PhD course. This work has been summarized in a written report, with the title: “Consequences of glutamate transport alteration on survival of striatal astrocytes in primary cultures”.

September 1998-June 1999 Maîtrise de Biologie Cellulaire et Moléculaire (Master year 1), main option Neurosciences, awarded on July 1999. One year after the Licence de Neurosciences, at Faculté des Sciences de Luminy-Aix-Marseille II, Université de la Méditerranée, France. Including one month of training course at the Biochemistry Laboratory of Pr Rochat. This course is synthesized in a written report, with the title: “Characterization of monoclonal antibody clones against AahI neurotoxin of Androctonus Australis Hector scorpio”. 

September 1995-June 1998 Licence de Biologie Cellulaire et Moléculaire (Bachelor),

Neurosciences and Immunology options, awarded on July 1998. Three years of university

studies after the A-level (Baccalauréat), at Faculté des Sciences de Luminy-Aix-Marseille II,

Université de la Méditerranée, France.

HONORS

2014- Member to the Motor Neuron Center (MNC, Center for Motor Neuron Biology and Diseases), Oct. 1st 2014, Columbia University, New York, NY

2014- Member to the NIEHS Center for Environment Health in Northern Manhattan, Oct. 1st 2014, Columbia University, New York, NY

2014 Invited lecturer to the 37th Annual Meeting of the Japan Neuroscience Society, Challenge of Neuroscience against Amyotrophic Lateral Sclerosis Symposium (Sept 11-13, 2014 in Yokohama, Japan)

2013 Invited lecturer to the Stem Cell Seminar Series (Nov 11th, 2013 at Columbia University, in New York, NY)

2013 Invited Speaker at the Columbia High-Throughput Screening Day (Nov 1th, 2013 at the Columbia Genome Center, in New York, NY)

2013 Invited Lecturer at the Division of basic Neurosciences (June 10th 2013 at Biomedical Research Foundation, Academy of Athens, Greece)

2011-2014 Associate Member to the NIEHS Center for Environment Health in Northern Manhattan, Columbia University, New York, NY.

2011 Invited speaker at the Second Annual "Meeting of the Minds" symposium at the Wang Center, (Nov 4th, 2011 at Stony Brook University, NY).

2011 Invited lecturer at the WIP Seminar series of the New York State Psychiatric Institute (Oct 17th, 2011 in New York, NY).

2010 Invited speaker at the ribbon-cutting ceremony for the Motor Neuron Center (May 26th, 2010 at Columbia University, in New York, NY).

2010 Invited Speaker at the NIEHS Center for Environmental Health in Northern Manhattan External Advisory Meeting (May 24th, 2010 at Columbia University, in New York, NY).

2010 Recipient of the Career Development Award of the NIEHS Center for Environmental Health at Columbia University (awarded on April 1st, 2010, $100K for 2 years)

2008 Invited distinguished speaker at the 4th Neurodegenerative Diseases Drug Discovery conference (GTCBio, Oct 9-10, 2008 in Philadelphia, PA).

2007 Invited speaker at the Department of Neurology Grand Round (Columbia University, New York, NY).

2006 Recipient of the Philippe Foundation grant for exchange programs between France and the United States.

2004. 1 year fellowship for Ph.D. student from France Parkinson Association.

2002- 2003 Elected President of “Hippo’thèse” the association of Ph.D. students in Life Sciences of the Universities of Aix-Marseille, France. Association’s goals: informing, representing and improving the professional insertion of Ph.D. students.

2001- 2004 Elected Ph.D. student representative at the University of Mediterranee Luminy Faculty Council, Marseille, France.

2000-2003 3 years of Research Fellowship for Ph.D. student, obtained following the competitive examination of the French Ministry of Research and Technology (awarded to the top 10%

Ph.D. students).

PROFESSIONAL ORGANIZATIONS, SOCIETIES AND SERVICES

Memberships:

2005- Member of the Society for Neuroscience (SFN).

2000-2004 Member of the French Society for Neurosciences.

2000-2004 Member of the French Glial Cell Club.

Consultative:

2011- Reviewer for the Muscular Dystrophy Association (MDA) and MDA Venture Philanthropy USA

2011 External Referee for Università degli Studi di Milano (Italy) for scientific research

financing

2011 Reviewer for the Irving Institute 2010-11 Collaborative and Multidisciplinary Pilot Research (CaMPR) Award program.

2010- Scientific Reviewer for the Department of Defense U.S. Army Medical Research and Materiel Command, Congressionally Directed Medical Research Programs (CDMRP).

2010- Reviewer for the “Association France Myophathies” research grants (AFM, France).

2009 Consulting for ALS Biopharma, LCC headquartered at 3805 Old Easton Rd., Doylestown, PA.

2009 Reviewer for the Irish Health Research Board.

2008 & 2009 Reviewer for the Alzheimer's and Related Diseases Research Award Fund (ARDRAF).

Editorial:

2008- Reviewer for Journal of Clinical Investigation, Neurobiology of Disease, Journal of Neurochemistry, Human Molecular Genetics, Nature Genetics, Nature Neuroscience, PLOs One, Clinical Therapeutics, Molecular Neurobiology, Journal of Cellular and Molecular Medicine, Cellular and Molecular Life Sciences, and Brain Behavior.

FELLOWSHIPS AND GRANT SUPPORT

Present Support:

DOD W81XWH-14-1-0375 (PI Re) Therapeutic Idea Award

Title: Preclinical Testing of a Translocator Protein Ligand for the Treatment of Amyotrophic Lateral Sclerosis (ALS)

Time Commitment: PI @ 3.0 calendar months

Performance Period: 9/30/2014-9/29/2016

The aim of this project is to perform a preclinical study in a mutant superoxide dismutase 1 (SOD1) mouse model of ALS to validate the neuroprotective potential of a translocator protein (TSPO) ligand.

Starter Package from the EHS Department (PI Re)

Support for space and salary for 3 years, plus starter money for small and large equipment, and reagents.

Pilot Project from the NIEHS Center at Columbia University (PI Re):

Title: Manganese neurotoxicity in the spinal cord: amyloid precursor-like protein 1 and motor neuron death

The aim of this project is to investigate the neurotoxicity of manganese in the spinal cords of non-human primates chronically exposed to manganese.

IRSES 7PQ NO-MND project, no 612578, Staff exchange program between Italy, Greece, and USA (PI Corti). This program is supporting the travel cost and salary of Italian and Greek fellows who will participate to research in USA for 3 months to 1 year.

Title: Non-autonomous Motor Neuron Diseases.

Performance Period: 02/ 2014-02/ 2018

Role: US Coordinator.

The aim of this program is to exchange techniques, knowledge and coordinate an international effort to identify therapeutic targets against the motor neuron diseases amyotrophic lateral sclerosis and spinal muscular atrophy.

Past support:

04/01/10-03/31/12 Career Development Award of the NIEHS Center for Environmental Health at Columbia University.

Role: Principal Investigator.

TEACHING EXPERIENCE AND RESPONSABILITIES

Specific Courses:

2004. Teaching Assistant giving lectures on Human Physiology and supervising practical works in Physiology for students in Licence de Biologie Cellulaire (Last year of Bachelor degree) à la Faculté des Sciences de Luminy (120 hours per year).

Post-doctoral/Ph.D./Master's These Trainees:

2008- Daily supervision and mentoring in Prof. Serge Przedborski’s laboratory of two post-doctoral trainees and one graduate student enrolled in the Neuroscience and Behavior Ph.D. program (thesis defense planned on 08/23/12).

06/01/11-09/01/11 Supervision in Prof. Serge Przedborski’s laboratory of one MD/Ph.D rotation student.

06/01/10-09/01/10 Supervision in Prof. Serge Przedborski’s laboratory of one Ph.D rotation student.

2004. Supervision in Prof. Andre Nieoullon’s laboratory (Marseille, France) of student training courses (students in Master of Neuroscience).

Other trainee advisory roles and teaching activities:

Summers 2006-2013 Supervision in Przedborski’s laboratory of research training of three undergraduate students and four High school students. Mentoring of the High-school student for Science contests (2007 and 2010 semi-finalist of the Siemens Science Competition, and finalist of the Long Island Science and Engineering Fair (LISEF).

2002-2004 Science awareness communications in elementary schools and high schools during the French Brain awareness week and the Science week.

PUBLICATIONS

• Ikiz B., Alvarez M., Ré D.B., Le Verche V., Yu C., Croft G.F. Jacquier A., Phani S., Henderson C.E., Califano A. and Przedborski S. Dissecting the regulatory machinery of neurodegeneration in amyotrophic lateral sclerosis. Cell Report. 2015 Jul 14;12(2):335-45.

• Kariya S., Sampson J.B., Northrop L.E., Luccarelli C.M., Naini A.B., Ré D.B., Hirano, M., Mitsumoto H. Nuclear localization of SMN and FUS is not altered in fibroblasts from patients with sporadic ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2014 Dec;15(7-8):581-7.

• Ré DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, Henderson CE, Przedborski S. Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS. Neuron. 2014 Mar 5;81(5):1001-8

• Kariya S, Ré DB, Jacquier A, Nelson K, Przedborski S, Monani UR. Mutant superoxide dismutase 1 (SOD1), a cause of amyotrophic lateral sclerosis, disrupts the recruitment of SMN, the spinal muscular atrophy protein to nuclear Cajal bodies. Hum Mol Genet. (2012); May 22. 2012 Aug 1;21(15):3421-34

• Phani S., Ré DB., Przedborski S. The role of the innate immune system in ALS. Frontiers Pharmacology. (2012) 3:150. doi: 10.3389/fphar.2012.00150. Epub 2012 Aug 14.

• Le Verche V., Ikiz B., Jacquier A., Przedborski S., Ré D.B. Glutamate pathway implication in amyotrophic lateral sclerosis: what is the signal in the noise? Journal of Receptor Ligand and Channel Research (2010), 2011(4):1 – 22.

• Papadimitriou D., Le Verche V., Jacquier A., Ikiz B., Przedborski S., and Ré D.B Inflammation in ALS and SMA: Sorting out the good from the evil. Neurobiol Dis. 2010 Mar;37(3):493-502. Epub 2009 Oct 13.

• Nafia I., Ré D.B., Melon C., Shimamoto K., Kerkerian-Le Goff L., Had- Aïssouni L. Preferential vulnerability of mesencephalic dopamine neurons to glutamate transporter dysfunction. J Neurochem. (2008); Apr;105(2):484-96. 

• Nagai M*, Ré DB*, Nagata T*, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci. (2007) May;10(5):615-622.

*These authors contributed equally to this work. This work was Highlighted in Science and Nature.

• Ré DB and Przedborski S. Fractalkine: moving from chemotaxis to neuroprotection.

Nat Neurosci. (2006); 9(7):859-61.

• Wu D.C., Ré D.B., Nagai M., Ischiropoulos H., Przedborski S. The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. PNAS (2006); 103(32): 12132-7.

• Ré D.B., Nafia I., Melon C., Shimamoto K., Kerkerian-Le Goff L., Had- Aïssouni L. Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipooxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport. Glia (2006); 54(1):47-57. 

• Besson M.T., Ré D.B., Moulin M., Birman S. High affinity transport of taurine by the Drosophila aspartate transporter dEAAT2. J Biol Chem. (2005), 280(8):6621-6.

• Ré D.B., Nafia I., Nieoullon A., Kerkerian-Le Goff L., Had- Aïssouni L. Cerebral oxidative stress: are astrocytes vulnerable to low intracellular glutamate concentrations? Consequences for neuronal viability. Ann Fr Anesth Reanim. (2005),24(5):502-9

• Had-Aïssouni L., Ré D.B., Lortet S., Canolle B., Nafia I., Masmejean F., Guillet B., Pisano P., Nieoullon A. Contribution of excitatory amino acids to neurodegenerative disease: do the astrocytes have a key roles in the process? Advances in Cell and Molecular Biology. Kopp Publishing, (2005), pp13-26.

• Ré D.B., Boucraut J., Samuel D., Birman S., Kerkerian-Le Goff L., Had- Aïssouni L. Glutamate transport alteration triggers differentiation-state selective oxidative death of cultured astrocytes: a mechanism different from excitotoxicity depending on intracellular GSH contents. J Neurochem. (2003), 85: 1159-1170.

• Had-Aïssouni L., Ré D.B., Nieoullon A., Kerkerian-Le Goff L. Importance of astrocytic inactivation of synaptically released glutamate for cell survival in the central nervous system-Are astrocytes vulnerable to low intracellular glutamate concentrations ? J. Physiol. Paris. (2002) May-Aug; 96 (3-4): 317-22.

................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download