RAMPART Trial



RAMPART Pre-Surgery FactsheetWe are aware you have just been told you have kidney cancer. This can be a very daunting and anxious time for both you and your family. You will have been given lots of information to take on board about what happens next. Your surgeon will have explained that the next step for you is to have surgery to remove all or part of your kidney. After surgery, your surgeon and a team of doctors will review all the available information and will give you their best estimate of the chance the cancer could come back at some point.The current best practice or ‘standard-of-care’ that patients receive after surgery for kidney cancer like yours is to have regular reviews in clinic and CT scans to check for evidence of cancer coming back. This is known as observation or active monitoring. The cancer does not come back in everyone, and if it does then there are treatments available.center408305Cancer is estimated to be at intermediate or high risk of coming back?Randomised between arms A, B and CArm CDurvalumab & Tremelimumab Arm B?Durvalumab Arm A?Active MonitoringSurgery00Cancer is estimated to be at intermediate or high risk of coming back?Randomised between arms A, B and CArm CDurvalumab & Tremelimumab Arm B?Durvalumab Arm A?Active MonitoringSurgeryWe would like to make you aware that depending on the findings of your surgery you might be eligible to take part in a clinical trial called “RAMPART”. The RAMPART study is investigating whether giving additional treatment after surgery stops or delays kidney cancer coming back. Two drugs known as “immune checkpoint inhibitors” are being tested in RAMPART. An immune checkpoint inhibitor drug is a type of immunotherapy designed to ‘wake up’ a patient’s own immune system so that it can fight cancer. These new drugs will be compared against current practice, which is active monitoring. This means some patients who agree to take part in the RAMPART trial will receive the new drugs and some will have active monitoring. We do not know yet whether the new drugs will be helpful or not for people in your situation. The duration of treatment in each of the trial arms B and C is one year. If a benefit from taking these drugs is shown, the results will improve treatment options and outcomes for people with kidney cancer. After your surgery you may be asked if you are interested in taking part in the RAMPART trial. A research nurse or doctor will discuss the study with you and provide you with more detailed information that you are able to take home with you. It will be up to you to decide if you want to take part. You can find out more about the study here: you have any questions at all about the Rampart trial please contact <contact name>, <phone number>Thank you,The RAMPART Trial Team ................
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