Pharma 2020: Marketing the future - Which path will you take?
[Pages:32]Pharmaceuticals and Life Sciences
Pharma 2020: Marketing the future Which path will you take?
Table of contents
Previous publications in this series include:
Pharmaceuticals
Pharmaceuticals and Life Sciences
Pharma 2020: The vision Which path will you take?*
Pharma 2020: Virtual R&D Which path will you take?
*connectedthinking
Pharma 2020: The vision
#
Published in June 2007 this paper highlights a number of issues that will have a major bearing on the industry over the next 11 years. The publication outlines the changes we believe will best help pharmaceutical companies realise the potential the future holds to enhance the value they provide to shareholders and society alike.
Pharma 2020: Virtual R&D
1
This report published in June 2008 explores opportunities to improve the R&D process. It proposed that new technologies will enable the adoption of virtual R&D; and by operating in a more connected world the industry, in collaboration with researchers, governments, healthcare payers and providers, can address the changing needs of society more effectively.
"Pharma 2020: Marketing the future" is the third in this series of papers on the future of the pharmaceutical industry published by PricewaterhouseCoopers. It discusses the key forces reshaping the pharmaceutical marketplace, including the growing power of healthcare payers, providers and patients, and the changes required to create a marketing and sales model that is fit for the 21st century. These changes will enable the industry to market and sell its products more cost-effectively, to create new opportunities and to generate greater customer loyalty across the healthcare spectrum.
Table of contents
Introduction
2
What will the healthcare landscape look like in 2020?
4
Recognising the interdependence of the pharmaceutical and
healthcare value chains
8
Investing in the development of medicines the market wants to buy
10
Forming a web of alliances to offer supporting services
12
Developing a plan for marketing and selling specialist therapies
13
Creating a culture that is suitable for marketing specialist healthcare packages 15
Managing multi-country launches and live licensing
18
Adopting a much more flexible approach to pricing
18
Creating a marketing and sales function that is fit for the future
19
Conclusion
22
Pharma 2020: Marketing the future
Introduction
The social, demographic and economic context in which the pharmaceutical industry (Pharma) operates is changing dramatically, as we noted in "Pharma 2020: The vision", the White Paper PricewaterhouseCoopers* published in June 2007 (see sidebar, Seven major
trends reshaping the pharmaceutical marketplace).1 All these challenges have major ramifications for the way in which Pharma markets and sells the medicines it develops ? the subject on which we shall focus here.
The industry has traditionally relied on aggressive marketing to promote its products. One recent study estimates
that, between 1996 and 2005, total real spending on pharmaceutical promotions rose from US$11.4 billion to US$29.9 billion in the US (the only country for which expenditure on all major marketing and sales activities is available).2 Another study suggests that the true figure (including meetings and e-promotions) is closer to US$57.5 billion in real terms.3
Seven major trends reshaping the pharmaceutical marketplace
The pharmaceutical marketplace is changing dramatically, with huge implications for the industry as a whole. We have identified seven major socio-economic trends.
The burden of chronic disease is soaring. The prevalence of chronic diseases like diabetes is growing everywhere. As greater longevity forces many countries to lift the retirement age, more people will still be working at the point at which these diseases start. The social and economic value of treatments for chronic diseases will rise accordingly, but Pharma will have to reduce its prices and rely on volume sales of such products because many countries will otherwise be unable to afford them.
Healthcare policy-makers and payers are increasingly mandating or influencing what doctors can prescribe. As treatment protocols replace individual prescribing decisions, Pharma's target audience is also becoming more consolidated and more powerful, with profound implications for its sales and marketing model. The industry will have to work much harder for its dollars, collaborate with healthcare payers and providers, and improve patient compliance.
Pay-for-performance is on the rise. A growing number of healthcare payers are measuring the pharmacoeconomic
performance of different medicines. Widespread adoption of electronic medical records will give them the outcomes data they need to determine best medical practice, discontinue products that are more expensive or less effective than comparable therapies and pay for treatments based on the outcomes they deliver. So Pharma will have to prove that its medicines really work, provide value for money and are better than alternative forms of intervention.
The boundaries between different forms of healthcare are blurring. The primary-care sector is expanding as clinical advances render previously fatal diseases chronic. The self-medication sector is also increasing as more prescription products are switched to over-the-counter status. The needs of patients are changing accordingly. Where treatment is migrating from the doctor to ancillary care or self-care, patients will require more comprehensive information. Where treatment is migrating from the hospital to the primary-care sector, patients will require new services such as home delivery.
The markets of the developing world,
where demand for medicines is likely to grow most rapidly over the next 13 years, are highly varied. Developing countries have very different clinical and economic characteristics, healthcare systems and attitudes towards the protection of intellectual property. Any company that wants to serve these markets successfully will therefore have to devise strategies that are tailored to their individual needs.
Many governments are beginning to focus on prevention rather than treatment, although they are not yet investing very much in pre-emptive measures. This change of emphasis will enable Pharma to enter the realm of health management. But if it is to do so, it will have to rebuild its image, since healthcare professionals and patients will not trust the industry to provide such services unless they are sure it has their best interests at heart.
The regulators are becoming more risk-averse. The leading national and multinational agencies have become much more cautious about approving truly innovative medicines, in the wake of problems with medicines like Vioxx.
*`PricewaterhouseCoopers' refers to the network of member firms of PricewaterhouseCoopers International Limited, each of which is a separate and independent legal entity.
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Much of this increase in spending has gone on the expansion of the sales force. However, many of the industry's biggest markets are now saturated with sales representatives, and its selling techniques are becoming increasingly ineffective (see sidebar, Too many cooks spoil the broth).4
Hence the fact that returns on detailing (sales visits to doctors) have begun to decline in the developed world. Between 2004 and 2005, there was a 23% drop in dollar growth per detail in the US, although detailing still accounts for more than half the market share new brands win during their first year of life. The picture is rather more varied in Western Europe, but detailing plays a much smaller role in stimulating sales in these countries.5
Conversely, detailing is still very important in many developing nations. In China, for example, nearly three-quarters of the information doctors receive about new medicines comes from meetings with sales representatives and conferences.6 But here, too, resistance to "irresponsible" marketing practices is growing,7 and, in May 2007, the member governments of the World Health Organisation passed a resolution to enact or enforce legislation banning the "inaccurate, misleading or unethical promotion of medicines".8
Direct-to-consumer (DTC) advertising ? the other big weapon in Pharma's marketing artillery ? has also failed to deliver all that the industry expected. Only two countries ? the US and New Zealand ? currently allow companies to market their medicines directly to consumers, although the European Commission is considering a proposal to lift the ban on direct communications that provide "objective...non-
Too many cooks spoil the broth
Between 1996 and 2005, the number of US sales representatives nearly doubled to 100,000, although the number of practising physicians rose by just 26%. The market is getting very crowded in other countries, too. In a recent poll of British general practitioners, respondents reported receiving an average of four visits a month and five promotional mailings a week. Similarly, one Malaysian doctor participating in a study of promotional practices in emerging countries was approached by 16 multinationals and nine local generics companies within a fiveweek time span.
The battle for market share has triggered considerable alarm. Some 20% of US and British doctors now refuse to see any sales representatives. The regulations governing the behaviour of sales representatives are also getting tougher. Various US states have passed laws requiring pharmaceutical companies to report all gifts or payments to healthcare professionals exceeding $25, while Australia has banned pharmaceutical companies from providing doctors with personal gifts, entertainment or lavish hospitality.
Several industry trade groups have likewise introduced new codes of practice ? and they are actively enforcing the rules. The Prescription Medicines Code of Practice Authority (PMCPA), which administers the code of practice laid down by the Association of the British Pharmaceutical Industry, is one such instance. The PMCPA "names and shames" the most serious offenders, by reprimanding them publicly and publicising the violations they have committed in advertisements in the medical and pharmaceutical press.
promotional" information.9 And Pharma's spending on DTC advertising only accounts for about US$5 billion, which is just 14% of its total marketing budget.10 However, the jury is still out on just what this expenditure provides.
In the early days, the returns appeared to be substantial. Between 1999 and 2000, sales of the 50 products that were most heavily advertised in the US soared by 32%, compared with an average increase of 13.6%.11 But more recent research suggests that DTC advertising has little, if any, longterm impact on demand. In one study published in the British Medical Journal, the researchers compared the uptake of three medicines in two populations ? English-speaking Canadians exposed
to US advertising and French-speaking Canadians, who primarily watch Frenchlanguage media ? over a five-year period. They found that DTC advertising had no effect on sales of two of the three products and that, although sales of the third spiked by more than 40% when the campaign began, the spike was quite brief.12
Much of the industry's expenditure on DTC advertising may have been pointless, but the damage to its reputation is arguably a more serious problem. In January 2008, the US House of Representatives Committee on Energy and Commerce initiated an investigation into the misleading and deceptive advertising of medicines, after several particularly flagrant abuses of the rules.13
Pharma 2020: Marketing the future
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Table 1: Big Pharma has been slashing its workforce
Company Pfizer AstraZeneca Merck & Co. Bayer Schering-Plough Johnson & Johnson GlaxoSmithKline Amgen Novartis Wyeth sanofi-aventis Total
Announced Job Cuts 10,000 7,600 7,200 6,000 5,500 5,000 5,000 2,600 2,500 1,200 700 53,300
Source: PricewaterhouseCoopers
In short, aggressive marketing ? whether it be to doctors or patients ? is becoming increasingly ineffective as a means of stimulating demand for new therapies and overcoming reluctance to pay premium prices for products that are deemed to offer only minor clinical improvements. Industry critics are also becoming increasingly vociferous in their complaints that it is wasteful or even unethical.
Big Pharma has responded with various cost-cutting measures. Pfizer set the pace in late 2006, when it said that it would cut 20% of its US sales force.14 Other companies rapidly followed suit and, by October 2008, the industry leaders had announced plans to shed another 53,300 jobs, many of them in marketing and sales (see Table 1).15 They are now turning their attention to developing countries like India, where 10 multinationals are reported to be trimming the number of sales representatives they employ.16
However, both industry executives and commentators recognise that the failings of the current marketing and sales model cannot be addressed simply by reducing the size of the sales force; the problems go very much deeper. We believe that they stem from three incorrect assumptions, namely that:
? Pharma alone determines the value of its products
? Products alone create value; and
? The buying and selling of medicines is based solely on technical data like safety and efficacy, as distinct from subjective criteria like quality of life.
We shall discuss the changes that have invalidated these assumptions in more detail in the next chapter.
What will the healthcare landscape look like in 2020?
For many years, pharmaceutical companies decided what their products were worth, and priced them accordingly. But healthcare policy-makers, payers and patient groups are now playing an increasingly important role in the valuation process ? and this trend will accelerate, as healthcare expenditure everywhere continues to soar.
The aging of the population, together with dietary changes and more sedentary lifestyles, is driving up the disease burden in both developed and developing countries.17 People's expectations are also rising as new therapies for treating serious illnesses like cancer reach the market. The global healthcare bill has risen commensurately; between 2000 and 2006, expenditure on healthcare as a percentage of gross domestic product (GDP) climbed in every country in the OECD.18
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Many policy-makers and payers have therefore started trying to measure exactly what they are getting for their money. A number of countries, including Australia, Canada, Finland, New Zealand and the UK, have established agencies specifically to conduct formal clinical and economic evaluations of medicines. The US Senate is also considering a bill to create a Health Care Comparative Effectiveness Research Institute, which would perform a similar function.19
Similarly, some governments are actively encouraging the use of e-prescribing (see sidebar, The push for e-prescribing).20 The main aim of these efforts is to reduce prescribing errors. But e-prescribing will also enable healthcare payers to influence the prescribing decision much more easily, by providing doctors with clinical and financial information at the very point at which they are choosing which products to prescribe.
This will have a major impact on the decisions doctors make. In one recent survey, for example, two-thirds of the physicians participating in a US e-prescribing initiative reported that they were more likely to prescribe a generic or plan-preferred medicine when using an e-prescribing system. Analysis of some 3.3m e-prescriptions bore out their claims; 39% of those that failed to comply with the formulary requirements were changed when the
doctor was electronically notified that the product concerned was off plan.21
E-prescribing has enormous commercial implications for Pharma. Most of the activities it performs to market its medicines to doctors take place before the prescribing decision is made ? and e-prescribing could mitigate that influence, unless the industry can collaborate with healthcare payers to shape the information doctors receive. However, healthcare payers will want hard proof that a product really is safer, more effective or more economical than its rivals, and they will have many more resources to investigate such claims than any individual doctor or practice.
With greater use of pharmacoeconomics, strict formularies and e-prescribing, healthcare policy-makers and payers are increasingly assessing the relative value of different medicines. Patients are playing a bigger part in the process, too. Indeed, they are even helping to decide which products should reach, or remain on, the market. Patient power was a critical factor in the decision to approve Herceptin for use on the British National Health Service (NHS) in the treatment of early-stage breast cancer, for example.22
Patients will become even more influential, as access to reliable healthcare information increases, the use of co-payments proliferates and the trend towards self-medication
The push for e-prescribing
More than 70% of all doctors in Denmark, the Netherlands and Sweden write prescriptions electronically, and the European Union is promoting the practice in other member states. Doctors in Darwin, Australia, are also testing a new system that, if successful, could be rolled out nationwide, and the US has just passed a new law to increase e-prescribing among doctors participating in the Medicare programme. Eligible physicians will receive a 2% bonus for writing electronic scripts in 2009 and 2010, dropping to 1% in 2011 and 2012, and 0.5% in 2013. But penalties will be imposed on those who do not use e-prescribing by 2012.
Interest in e-prescribing is not confined to the developed world. India's largest retail pharmacy chain, Apollo Pharmacies, has recently started offering doctors and patients an e-prescription service. Similarly, the Turkish government has launched several e-prescribing pilot programmes as part of a bigger initiative to establish a national health network, and the Russian Ministry of Health and Social Development introduced new prescribing rules, including computerreadable prescription forms for the beneficiaries of federal and regional insurance schemes, in 2007.
Pharma 2020: Marketing the future
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Table of contents
grows (see sidebar, Health 2.0 hits the headlines).23 Public expenditure still accounts for the bulk of healthcare spending in every G7 country except the US, but patients in the E7 countries typically foot more than half the bill themselves (see Figure 1).
The split between public and private healthcare spending is also changing in some G7 countries, as they try to reduce the burden on the public exchequer. In Britain, for example, the government recently gave permission for cancer patients to buy "top-up" drugs privately, without losing their right to free care under the NHS.24
Conversely, in the US, President Barack Obama plans to put a bigger share of healthcare costs on the public tab, by expanding coverage to uninsured Americans. He has also promised to lower the cost of medicines by allowing the importation of safe products from other developed countries, increasing the use of generics in public programmes, taking on pharmaceutical companies that block cheaper generics from the market and eliminating the ban on the federal government negotiating drug prices.25 But, whether it is patients, governments or health insurers who are picking up the costs, one thing is clear: the days when pharmaceutical companies could dictate how much their medicines should fetch, without regard for the other stakeholders in the healthcare arena, are over.
The opportunities for generating value from pure product offerings are also rapidly diminishing. In the past 15 months, at least three companies have started offering personal genome
Health 2.0 hits the headlines
The number of people using the Internet to find healthcare information has increased dramatically over the last decade. Some 66% of US adults go online to research their conditions, as do more than half of all Europeans. Numerous blogs and online forums have also sprung up to cater for increasingly information-hungry patients. They include sites such as , which enables patients to compare symptoms and side effects; , where doctors and patients work together to create "wikis"; and various disease-specific forums for patients with conditions like cancer and epilepsy.
The next stage in the so-called Health 2.0 revolution is the proliferation of electronic personal health records. Microsoft and Google have both launched services to help people create and store their own personal health records on the World Wide Web. But there are many other, smaller companies offering similar services, including , and .
Figure 1: Private expenditure on health as a percentage of total healthcare spending in the G7 and E7 countries
90%
G7 Countries
E7 Countries
80%
70% 60% 50%
40%
30% 20% 10%
0% Canada FrancGeermany
Italy Japan
Uk US
Brazil China
Source: World Health Organisation, "World Health Statistics 2008"
IndIniadonesiaMexico Russia Turkey
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