NIACIN HEX (NO FLUSH) - Anabolic Labs

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NIACIN HEX (NO FLUSH)

DESCRIPTION The form of niacin providing all of the traditional benefits of niacin without the flush and facial warmth that can sometimes accompany large doses. Niacin Hex delivers free niacin over several hours to keep bloodstream levels consistent.

FORMULA Each Vegetarian Capsule Provides:

amount

Niacin (from 500 mg inositol hexanicotinate)....................450 mg Inositol (from 500 mg inositol hexanicotinate).................... 50 mg

Other ingredients: cellulose, magnesium stearate (vegetable source), silica.

INDICATIONS Niacin Hex is for use to assist in the following:

? Healthy cholesterol support o Lowers free fatty acid levels in the bloodstream o Helps normalize the LDL/HDL ratio

? General cardiovascular health ? may reduce incidence of CV lesions

? For patients currently taking niacin complaining of facial flushing and skin warmth

? Individuals who do not want to take nicotinic acid as timed-release niacin

KEY FEATURES ? Provides the benefits of conventional niacin therapy without the side effects ? Slowly and continuously metabolized, not reaching maximum serum levels for up to 10 hours after ingestion ? Several decades of essentially risk-free clinical history

DIRECTIONS Take one capsule up to four times daily with meals

BENEFITS Most B vitamins are water soluble and many are eliminated from the body within hours after consumption. To counter this problem some people take large doses of niacin and a significant number experience the uncomfortable but harmless facial flushing. This is caused by histamine release as an immediate reaction to niacin ingestion. Due to this uncomfortable side effect, some people discontinue niacin therapy despite the many benefits. Inositol hexanicotinate (Niacin Hex) is a unique combination of niacin bound to inositol. Free niacin is only slowly released into the bloodstream from inositol in a slow reaction which may take up to 10 hours. Inositol hexanicotinate is not considered a timed release niacin, but rather a form that eliminates the side effects but with the same vascular supporting properties as simple niacin.

BACKGROUND

Niacin has been recognized as a vitamin since 1937 and is designated vitamin B3, nicotinic acid or

niacinamide. Once digested the body quickly transforms both nicotinic acid and niacinamide

(nutritionally equivalent) into the active coenzymes NicotinicAdenineDinucleotide (NAD) and



2008

ANABOLIC LABORATORIES,LLC

All rights reserved.

*These statements are for educational purposes and have not been

evaluated by the Food and Drug Administration. This product is not

intended to diagnose, treat, cure or prevent any disease.

Product no. 0080

NicotinicAdenineDinucleotide Phosphate (NADP). These coenzymes are vital for cellular metabolism of sugars and fats through their roles in many biochemical reactions, particularly within the mitochondria, by assisting the oxidation of sugars and fats into energy as ATP and GTP. As a portion of the reduced coenzymes, (NADH and NADPH) vitamin B3 cooperates in hundreds of biochemical reactions by donating reducing power to oxidizing agents, often in reactions with molecular oxygen. Important examples are the detoxifications of an array of noxious hydrocarbons and powerful steroids by various cytochrome P450 enzymes.

Niacin, as nicotinic acid, has long been used to address many circulatory conditions; the most common types being hyperlipidemia and dyslipidemia. It has been known for some time that ingestion of high doses of niacin decreases bloodstream cholesterol, free fatty acids and triglycerides, while raising the plasma level of HDL1. These powerful effects are due to the inhibition of lipolysis by nicotinic acid but not other forms of vitamin B3. Lipolysis is the biochemical reaction which releases free cholesterol and fatty acids (FFA) into the bloodstream.

Details of two important mechanisms for niacin inhibition of cholesterol deposition in arteries have been recently uncovered. The first is the finding that niacin interacts with the protein ABCA 1, which is responsible for releasing free cholesterol and FFA into the bloodstream from cholesterol esters in adipose tissues. ABCA 1 is a member of a huge family of transport proteins (ABC transporters) associated with cell membranes, especially adipose tissue cells. Nicotinic acid reduces the rate of ABCA 1 release of free cholesterol and FFA thus lowering total bloodstream cholesterol and keeping cholesterol esters in the adipose tissues. The concomitant reduction of bloodstream FFA lowers both VLDL and LDL levels by inhibiting the initial biosynthesis of VLDL. Better control of the patient's free cholesterol and FFA are the reasons why people taking niacin exhibit improved plasma HDL as well as lower LDL and VLDL parameters. These effects often combine to dramatically improve the patient's lipid ratio and the ability of vitamin B3 to reduce circulatory risk is published as a clinical recommendation2.

The second discovered mechanism of protection is the niacin dependence of G protein coupled receptor GPR-109A, found on the membranes of many cell types3. This key protein controls the activities of very important immune neutrophil cells. These cells underlie the common problem of uncomfortable side effects for those ingesting nicotinic acid. These include facial flushing, skin reddening and some rare gastrointestinal difficulties, which all pass a few minutes after ingestion. When bloodstream niacin levels are high, GPR-109A drastically modifies the internal neutrophil functions causing the harmless but irritating facial flushing via histamine release and in the presence of excessive nicotinic acid turns on controlled neutrophil death (apoptosis). These undesirable effects of high nicotinic acid concentrations can be avoided by ingesting inositolhexaniacinamide, Niacin Hex, which is quickly digested but only slowly releases the free and active nicotinic acid.

WARNINGS Pregnant women and lactating mothers should avoid inositol hexanicotinate. The clinician should monitor use by patients with Raynaud's disease1, diabetes, gout, renal dysfunction, unstable angina and myocardial dysfunction. Inositol hexanicotinate in very high doses may adversely affect glucose function. Niacin Hex should not be taken in large amounts to attempt avoiding the positive results of a drug screening test.

References

1 Carlson LA (2005). Nicotinic acid: the broad-spectrum lipid drug. J. Intern. Med. 258: 94-114. 2 Chapman MJ, et al. (2004). Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: the role of nicotinic acid ?position paper developed by the European Consensus Panel on HDL-C. Curr. Med. Res. Opin. 20: 1253-1268. 3 Benyo Z, et al. (2005). GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J. Clin. Invest. 115: 3634.



2008

ANABOLIC LABORATORIES,LLC

All rights reserved.

*These statements are for educational purposes and have not been

evaluated by the Food and Drug Administration. This product is not

intended to diagnose, treat, cure or prevent any disease.

Product no. 0080

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