NICARDIPINE (CARDENE )
NICARDIPINE (CARDENE()
Indications:
• Hypertension
Mechanism of Action:
• Calcium channel blocker
Contraindications:
• Hypersensitivity to nicardipine or other calcium channel blockers
• Aortic Stenosis
Dosage and Administration:
Start with 5 mg/hr then increase by 2.5 mg/hr every 15 minutes as needed up to a maximum of 15 mg/hr. If hypotension occurs, the infusion should be stopped. When the blood pressure has stabilized, nicardipine can be restarted at a lower dose and titrated as needed. The infusion site should be changed every 12 hours if nicardipine is administered via a peripheral vein.
Equivalent Oral vs. IV Infusion Doses
|Oral Dose |Equivalent IV Infusion |
|20 mg q 8 hr |0.5 mg/hr |
|30 mg q 8 hr |1.2 mg/hr |
|40 mg q 8 hr |2.2 mg/hr |
Precautions:
• May need lower dose in the elderly and in patients with renal or hepatic insufficiency
Adverse Effects:
• Flushing
• Palpitations
• Tachycardia
• Peripheral Edema
• Headache
• Dizziness
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