PHS 398 (Rev. 9/04), Continuation Page



Internal K application

NC TraCS KL2- Gene Orringer Career Development Award

UNC Oncology K12

Applications for 2020 cycle due by 8 am November 30, 2020

Instructions:

Use this format to complete the application keeping in mind the page limits.

• There are 2 mentoring agreements that require signatures by your lead mentor(s) and other mentors. Please do your best to have these signed and included within this application.

• Required letters of support:

o Department Chair or Division Chief

o All mentors

o Two letters from non-mentors who you will identify in a table at the end of the application

We understand that letters come at different times and writers may prefer to send a letter directly to us. You should include any letters you have at the end of the application (within the single PDF file). Otherwise, letters can go to Susan Pusek suspusek@med.unc.edu. No hard copy is needed.

Program Specific Instructions:

KL2:

• Budget: No budget is required with this application because the NIH rules for KL2 budgets state funds for research and training are determined after we confirm the final list of Scholars. However, you should design your project and training keeping in mind that each year you could receive between $10,000-$15,000 for training and research costs. If you anticipate your costs will exceed this amount, applicants will typically identify other funds (e.g. mentors or department funds).

• Individual Development Plan (IDP): The IDP in this application is populated with the required activities of the TraCS KL2 Program. You should add your own research, training, and career development goals to this table along with the proposed timelines and plan to obtain training.

Oncology K12:

• No budget is required for this application; however, you should design your research project with the expectation that approximately $15,000 will be awarded for training and research costs. If you anticipate that the total costs for your project will excess this amount, please include what additional funds are available to you to complete.

Once you are satisfied with the application, please send a Word file titled “Lastname, Firstname KApp2020” and email it to Allison Rorie at allison_rorie@med.unc.edu by the deadline.

Any questions:

Susan Pusek: susan_pusek@med.unc.edu

COVERSHEET

|Name of applicant: | |

|Degree(s): | |

|Department: | |

|School: | |

|Title of Project: (should match current or future IRB or IACUC materials): | |

Abstract (250 words) Include the research and training aims:

Mentors: Note it is a requirement of the KL2 Program (but not the Oncology K) that mentors come from different disciplines. If you are proposing mentors from the same department for the KL2, you should describe in the narrative the unique skills each mentor will bring to the research and training.

|Mentor name #1: | |

|Department: | |

|Organization: | |

|Has this mentor been on the mentoring team for prior institutional or individual K | |

|Scholars? | |

| | |

|Mentor name #2: | |

|Department: | |

|Organization: | |

|Has this mentor been on the mentoring team for prior institutional or individual K | |

|Scholars? | |

| | |

|(add same information for additional mentors) | |

|Applicant email: | |

|Applicant UNC ONYEN (if you are applying from a non-UNC school and need info on how| |

|to obtain an Onyen, contact Susan Pusek): | |

|Applicant ERA Commons ID: | |

|UNC PID number: | |

|Do you consider yourself to be Hispanic or Latino? | |

|What race do you consider yourself to be? | |

|American Indian or Alaska Native | |

|Asian | |

|Black or African American | |

|Native Hawaiian or Other Pacific Islander | |

|White | |

|Are you a US citizen? | |

|If you are not a citizen, do you have a permanent resident card or have an | |

|application pending? (must be approved before we can appoint you to KL2 grant) | |

|Requested start date of funding (when you can devote 75% time to research and | |

|training): | |

|Please list any other currently pending grants (ones that are already submitted) | |

|that allow for salary coverage: | |

|Is this a resubmission of a career development award application, either | |

|institutional or individual? | |

Application Narrative

Please assemble the application in the order below. Font size should be 11 or larger. Any other format questions contact Susan.

A. NIH Biosketch

B. Curriculum Vitae

C. Candidate background & career goals (up to 2 pages): Organize the narrative according to the following subsections:

C.1 Background and Research Training

C. 2 Research Interests

C. 3 Short and Long-Term Career Goals

D. Career Development/Training Plan (maximum 3 pages not including the table below)

D.1 Narrative of Career Development and Mentoring Activities Proposed (maximum 3 pages)

E. Research Project(s) (maximum 4 pages):

a. Specific Aims

b. Background and Clinical Significance

c. Research Plan

F. Description of translational components of the research project and training plan. According to the NIH, translation is “The process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public — from diagnostics and therapeutics to medical procedures and behavioral changes.” (1 paragraph).

G. Describe the relevance of anticipated results of the proposed research on other research fields and/or diseases (1 paragraph).

H. Resources available for the Research (maximum 1 page)

KEEP PAGE BREAK

I. 1 Individualized Development Plan. Using the Individualized Development Plan template below, identify your research, training and career development goals during the course of K funding. Activities that are already populated in the form are those that are required by the KL2 Program. If you are applying to another program, you can replace those activities with ones for that program. The narrative section should describe your rationale for the additional training proposed, including goals of any coursework.

Note:

For year 1: provide the month/year for national meetings you plan to attend

For any coursework: add semester and year for formal coursework (e.g. fall/2021)

|Skill/Activity |Proposed Mechanism |Format |Year 1 |Year 2 |

| | | |(mo./year when known) | |

|“what you want to learn” |“what way will you |“what kind of program” |“when” | |

| |learn it” | | | |

|Responsible Conduct of |TraCS 1-week RCR |3 morning workshop |07/21 | |

|Research (RCR) |course | | | |

|Mentoring skills |Mentor Training |In person workshop |X as participant |X as co-facilitator |

| |Workshop | | | |

|Proposal Development |K Seminar |2x/month workshop for 2 hours |x |x |

|Rigor and Reproducibility |K Seminar, and 2 |Selected Fridays when not in K |x |x |

| |dedicated sessions |Seminar | | |

|Required activities with timing to be determined |

|Networking |Translational Science|Annual national meeting |(x) must attend at least once during time on KL2 but may go more often, |

| |Meeting | |usually spring March/April |

|Peer Review |Participate in TraCS |In person meeting 1-2x/year |Invitation to come from TraCS once meeting dates are set. |

| |study section | | |

| | | | |

|Activities specific to your field/research and training goals |

|Skill/Activity |Proposed Mechanism |Format |Year 1 |Year 2 |

| | | | | |

| | | | | |

| | | | | |

| | | | | |

KEEP PAGE BREAK

J. Mentors

Proposed Mentors: (add more lines as necessary)

|Name |Department/School |Institution |If not UNC, provide organization |

| | | | |

| | | | |

| | | | |

Include for each mentor proposed:

NIH Biosketch

Mentor Training Table: An existing, but updated, NIH or other type of table may be used but make sure it includes the following information:

|Trainee Name, pre or |Dates of training |Previous Degree |Institution |Research topic |Current Position and |

|postdoc | | | | |sources of grant support |

(Note: Trainee tables that are not updated to reflect the current positions and sources of research support for former mentees may make it harder for reviewers to assess the strength of proposed mentors.)

LEAD Mentor Agreement

Applicant Name:      

You have been named as the Lead Mentor for the above applicant to a UNC internal K Program. The goal of these programs is to launch the careers of the next generation of clinical/translational researchers. Because the programs accept Scholars in diverse areas of science, it is absolutely essential that Scholars have mentors who can provide ongoing content expertise, networking assistance and strategic career planning in the Scholar’s specific field of research. Our experience tells us that, for Scholars to successfully transition to their own independent funding, there needs to be a single Lead Mentor who is primarily responsible for: (1) insuring that the Scholar makes progress on their research and training plans; (2) assisting the Scholar to identify an appropriate mentoring team and to work effectively with this team; (3) updating Program Leadership at least every 6 months regarding progress/changes in Scholars’ training or research activities (e.g., funding opportunities, mentors, direction of research, non-research commitments); and (4) working with Program Leadership to identify resources to facilitate the Scholar’s career development.

Specific functions of the Lead Mentor:

1. The Lead Mentor has primary responsibility for guiding the Scholar toward research independence. Together with the Scholar, the Lead Mentor will identify other investigators to serve on the Mentoring Team. This Mentoring Team will provide Scholars with the scientific and methodological expertise for each of their research projects.

2. The Lead Mentor has primary responsibility for helping the Scholar develop both hypotheses and research proposals by providing the initial "peer review" that helps assess the scientific merit of all proposals; helping the Scholar to obtain appropriate interdisciplinary consultations; and assisting with all phases of grant preparation and the development of effective presentations and publications.

3. The Lead Mentor, along with the Scholar and Mentoring Team, will develop: (a) clearly delineated specific expectations of the substantive learning/research skills to be achieved; and (b) specific milestones and timelines for achieving the Scholar’s career development goals.

4. The Lead Mentor, along with the Scholar and Mentoring Team, will define an appropriate schedule for the frequency of meetings. This plan should be included with the application and endorsed by each member of the Mentoring Team in their letters of support.

5. Lead Mentors are encouraged to attend meetings and seminars at which the Scholar is presenting their work. The Lead Mentor must attend the mock review(s) of the Scholar’s grant proposals.

6. The Lead Mentor will be responsible for submitting information about the Scholar’s progress when required by the NIH (at least annually). The Lead Mentor may also be contacted by evaluators working with NIH as part of ongoing evaluation efforts.

If you agree to accept these responsibilities please sign and return this document as a PDF or in hard copy to: Susan Pusek at susan_pusek@med.unc.edu or Room 223 TraCS Institute, CB #7064.

___________________________ (Lead Mentor’s signature)   date____/____/____

___________________________ (Scholar’s signature)   date____/____/____

Mentor-MENTEE TEAM Agreement

Applicant Name:      

The goal of the internal K career development programs is to launch the careers of the next generation of clinical/translational researchers. Because these programs accept Scholars in diverse areas of science it is absolutely essential that Scholars have mentors who can provide ongoing content expertise, networking assistance and strategic career planning in the Scholar’s specific field of research. Since the emphasis of the these programs is translational science, each Scholar is required to propose a mentoring team that consists of a Lead Mentor and other individuals who have defined roles in assisting the Scholar to achieve the goals set forth in their application to the programs. This document clarifies the expectations of the mentoring team and the mentee.

Mentors agree to:

1. Under the direction of the Lead Mentor, guide the Scholar toward research independence. The Mentoring Team will provide Scholars with the scientific and methodological expertise for each of their research projects.

2. Help the Scholar develop both hypotheses and research proposals by providing the initial "peer review" that helps assess the scientific merit of all proposals; help the Scholar to obtain appropriate interdisciplinary consultations; and assist with relevant phases of grant preparation and the development of effective presentations and publications.

3. Attend meetings and seminars at which the Scholar is presenting their work as their schedule allows.

4. Work in conjunction with faculty from the internal K Program for the benefit of the Scholar.

5. Submit information about the Scholar’s progress at the time of required progress reports by the NIH, or respond to requests for information as part of the ongoing NIH evaluation process.

Mentees agree to:

1. Define their career goals and priorities and work with the mentoring team to determine appropriate milestones and timelines.

2. Identify the most efficient method of communication with individual mentors and the mentoring team and to keep the mentoring team informed at regular intervals of their progress.

3. Maintain notes of communication with the mentoring team including formal meetings.

4. Inform the mentoring team of any challenges impacting the agreed upon research plan or milestones.

5. Agree to accept feedback from the mentoring team.

The mentee and members of the mentoring team agree to:

1. Develop: (a) clearly delineated specific expectations of the substantive learning/research skills to be achieved by the Scholar; and (b) specific milestones and timelines for achieving the Scholar’s career development goals while on the KL2/BIRCWH.

2. Define an appropriate schedule for the frequency of meetings. This plan should be included with the KL2/BIRCWH application and endorsed by each member of the Mentoring Team in their letters of support.

3. Keep discussions confidential and respectful.

4. Inform Program Leadership of changes to the research plan or other issues impacting the Scholar’s progress or change in composition of the mentoring team.

If you agree to accept these responsibilities please sign and return this document as a PDF or in hard copy to: Susan Pusek at susan_pusek@med.unc.edu or Room 223 TraCS Institute, CB #7064.

| | | |

|Applicant/Scholar Signature | |Date |

| | | |

|Mentor Signature | |Date |

| | | |

|Mentor Signature | |Date |

| | | |

|Mentor Signature | |Date |

J. References

K. Letters of support (may be sent with application or sent separately by the writer):

These letters should document the level of support you will receive and the resources you will have access to (e.g. time, protected schedule, start-up funds, etc.) while participating in the KL2 Program. Please place letters you are including in the order below. If the letters are PDF please just include them with the email submission- do not convert PDF letters to Word.

1. Department chair

2. Lead mentor

3. Other mentors

4. Additional letters of support (2): These letters can be from any individual who can speak to your potential to be an independently funded clinical/translational researcher.

|Names of individuals who will be providing 2 additional |Institution |Optional: Is there an administrative contact? (in case we need to |

|letters of support | |track down the letter) |

| | | |

| | | |

Application end

Please create a single Word file titled “Lastname, Firstname KApp2020” and email it to Allison Rorie at Allison_rorie@med.unc.edu by the deadline.

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