CURRICULUM VITAE



Curriculum vitae

[pic]

Mert Erkan, M.D., Associate Professor of Surgery

Current affiliation: Department of Surgery, Koc School of Medicine, Istanbul Turkey

h-Index (Thomson Web of Science - September 2015): 21

Total citations (Web of Science): 1549

Total impact factor: 387

Total impact factor as 1st or equally contributing 1st author: 144

Languages

English, German, Turkish

Qualifications

September 1995 Medical Doctor, University of Istanbul, Istanbul, Turkey

March 2001 Qualified Surgeon, Thesis: Retrospective analysis of 177 patients treated due to iatrogenic biliary injury. University of Istanbul, Istanbul, Turkey,

December 2007 2nd Doctaral degree, “summa cum laude”, Thesis: The influence of tumor modulated microenvironment on pancreatic cancer behavior. University of Heidelberg

August 2010 Abdominal Surgeon / Speciality in Digestive Surgery, Klinikum r.d. Isar, Technische Universität München / Bayerische Landesärstekammer (Chamber of medicine of Bavaria)

December 2011 Associate Professor of Surgery, Chirurgische Klinik, Klinikum r.d.Isar, Technische Universität München, Munich, Germany

Professional Appointments

10/1995 – 08/2000 Surgical resident. Department of Surgery, Istanbul Faculty of Medicine, University of Istanbul, Istanbul, Turkey

02/1998 Visiting Surgeon. Cleveland Clinic Florida, Fort Lauderdale, Florida, USA

03/2001 – 04/2002 Consultant Surgeon (Hepato-Pancreato-Biliary Surgery Unit) Department of Surgery, Istabul Faculty of Medicine, University of Istanbul, Istanbul, Turkey

06/2002 – 08/2002 Training in endoscopy. Surgical Endoscopy Unit. Department of Surgery, Istabul Faculty of Medicine, University of Istanbul, Istanbul, Turkey

07/2003 Visiting Surgeon. Department of Surgery, University of Heidelberg, Heidelberg, Germany

10/2003 – 06/2007 Post doctoral research fellow in the European Pancreatic Center. Department of Surgery, University of Heidelberg, Heidelberg, Germany

07- 10/2007 Post doctoral research fellow. Department of Surgery, Klinikum r.d.Isar, Technische Universität München, Munich, Germany

10/2007 – 08/2010 Surgical resident, Department of Surgery, Klinikum r.d.Isar, Technische Universität München, Munich, Germany

08/2010 Qualified Abdominal Surgeon (Medical Board of Bavaria) Department of Surgery, Klinikum r.d.Isar, Technische Universität München, Munich, Germany

01/2011 Consultant Surgeon, Department of Surgery, Klinikum r.d.Isar, Technische Universität München, Munich, Germany

03/2013 – 03/2014 Head of Pancreatic Surgery, Department of Surgery, Klinikum r.d.Isar, Technische Universität München, Munich, Germany

06/2014 - Associate Professor of Surgery, Koc University School of Medicine, Istanbul, Turkey

Awards and Scholarships

05/ 2001 Presentation in the Excellent Paper Session: “Negative prognostic markers in iatrogenic biliary injuries”, 4rd Congress of the European Chapter of the IHPBA, Amsterdam, The Netherlands

05/ 2005 Best Poster Prize: “Loss of BNIP3 expression is a late event in pancreatic carcinogenesis contributiong to chemoresistance and worse prognosis”, 6th Congress of the EHPBA, Heidelberg

09/ 2006 Deutsche Forschungsgemeinschaft: Travel grant to the “IHPBA World Congress, Edinburgh, UK, 03-07.09.2006, GZ: ER 563/1-1 AOBJ:531063. €1000 travel grant

11/ 2007 Deutsche Forschungsgemeinschaft: Travel grant to the “APA annual meeting, Chicago, USA, 01-03.11.2007, GZ: ER 563/2-1 AOBJ:546263. €1200 travel grant

04/ 2008 Presentation in “Die Besten für die Allgemein- und Viszeral Chirurgie” session: The influence of tumor modulated microenvironment on pancreatic cancer behaviour”, DGVC Chirurgenkongress 2008, April 22-25, 2008, Berlin, Germany. €1000 travel grant

11/ 2009 Presentation in “Distinct Poster” session: APA/JPS meeting 2009 Hawaii. $800 Travel Grant

11/ 2010 DAAD: € 1500 Travel grant to 41st Annual Meeting of the American Pancreatic Association, APA 2010, November 3-6, 2010, Chicago, USA

11/2011 DAAD: € 1800 Travel grant to 42nd Annual Meeting of the American Pancreatic Association, APA 2011, November 2-5, 2011, Chicago, USA

11/2011 EDS: € 500 Travel Grant to EDS Postgraduate Course – Advances in Gastro-Intetinal Surgery, November 24-26, 2011, Lublin, Poland

04/2012 EDS: €500 Travel Grant to EDS Postgraduate Course – Advances in Gastro-Intetinal Surgery, April 19-21, 2012, Thessaloniki, Greece

04/ 2012 Presentation in “Die Besten für die Allgemein- und Viszeral Chirurgie” session: Die Beste Habilitation 2011: “The influence of the activated stroma on the evolution of pancreatic cancer”, 129. Kongresses der Deutschen Gesellschaft Für Chirurgie, Berlin, Germany. €1000 travel grant

Grants

2008 BMBF: NGFNplus. Subproject: Cancer specific activation of stroma. Project number: 01GS08115. Dr. J. Kleeff, Dr. M. Erkan, Dr. C.W. Michalski, Dr. H. Friess.

€509.250

2010 DFG: International scientific organisation: Dr. M. Erkan: “Pancreatic star alliance: Consensus criteria on PSC – StellaTUM-“, München 30.01.2011 – 01.02.2011. GZ: ER 563/3-1, AOBJ: 577801.

€ 11.330

Else-Kröner-Fresenius Stiftung: Molecular mechanisms of cannabinoid-mediated tumor-stroma interactions in pancreatic cancer: Dr. CW Michalski, Dr. M Erkan, Prof. I. Esposito, Prof. J. Kleeff,

€300.000

2011 KKF: Kommission für Klinische Forschung TUM: Stellate cells as antigen presenting cells of the pancreas: Characterization of class II MHC and CD83 or CD163 positive sub-populations: Dr. M. Erkan, Dr. D. Stangel,

€60.000

EU FP7: Targeting the tumour microenvironment to improve pancreatic cancer prognosis (EPC-TM-Net); EU FP7; 2011-2013; €270.000. Prof. J Kleeff, Dr. M. Erkan, Dr. C.W. Michalski, Prof. I. Esposito, Prof. H. Friess.

2015 Seed fund (Koc University): Circulating cancer-stem-cell detection in adenocarcinomas as a novel tumor marker: Associate Prof. M. Erkan. €10.000

Memberships

• International Hepato-Pancreato-Biliary Associaton (IHPBA / E-AHPBA)

• International Association of Pancreatology (IAP)

• European Pancreatic Club (EPC)

• Deutscher Pankreasclub (DPC)

• COST action BM1204 on pancreatic cancer

• Istanbul Chamber of Medicine

• Turkish Association of Hepato-Pancreato-Biliary Surgery

• Istanbul University Graduates Association

• EDS – European Digestive Surgery

• DGAV – Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie

• Deutscher Modellflieger Verband e.V.

Congress Organisations

• 5th European Congress of the International Hepato-Pancreato-Biliary Association (IHPBA). 28.-31. May 2003, Istanbul, Turkey

• 6th Congress of the European Hepato-Pancreato-Biliary Association (EHPBA). 25.-28. May 2005, Heidelberg

• 31. Deutscher Pankreasclub, 18.-20. November 2010, Munich

• 1st meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate Cells. 04. März 2011, Munich- Congress Preisdent

• Pankreas-Symposium. 16 May 2013. Klinikum rechts der Isar, Tecnische Universität München. Munich, Germany.

• Consensus Workshop on Defining and Standardizing Pancreatic Texture. 30.05.13 – 14:00 – 17:30, Room III. 10th Congress of the E-AHPBA, 29th – 31st May, 2013, Belgrade, Serbia. Belgrade

• United European Gastroenterology (UEG) Basic Science Course 17th – 19th July, 2014, Klinikum r.d. Isar, Technische Universität München, Munich, Germany

• 1st nEUROgastro TANDEM Young Investigator Meetingç 1-3 June, 2015ç Koç University, Istanbul, Turkey

Invited Faculty and Chair

• 5th European Congress of the IHPBA, 28.-31. May 2003, Istanbul, Turkey.

Poster-Session: Hepato-Pancreato-Biliary, Chairman

• 6th Congress of the European Hepato-Pancreato-Biliary Association (EHPBA)

25.-28. May 2005, Heidelberg. Session: Hydatid Liver Disease, State of the art lecture: “Laparoscopic cyst- and pericystectomy”

• 31. Deutscher Pankreasclub, 18.-20. November 2010, Munich, State of the art lecture: “Microenvironment of the pancreatic cancer”

• First meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate Cells: Does EMT contribute to the population of PSC?

• First meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate Cells: Purity and contaminants of PSC isolated by different methods

• 32. Deutscher Pankreasclub, 17.-19. November 2011, Marburg, Importance of Stroma in inflammation and tumorigenesis. Chairmen: C. Pilarsky, M. Erkan

• EDS Postgraduate Course – Advances in Gastro-Intetinal Surgery, November 24-26, 2011, Lublin, Poland. Video Session: Surgical options in Klatskin tumors

• 6th EDS Postgraduate Course – Advances in Gastro-Intetinal Surgery, April 19-21 2012, Thessaloniki, Greece. Incidental carcinoma of the gallbladder: How to deal with it?

• Viszelmedizin 2012, Gastroenterologie-Viszeralchirurgie 19.-22. September 2012, Hamburg, Germany. AG Pankreas: StellaTUM: Report about the consensus conference

• Viszelmedizin 2012, Gastroenterologie-Viszeralchirurgie 19.-22. September 2012, Hamburg, Germany. Interactions of pancreatic stellate cells with cancer cells

• 2012 Joint APA/IAP Annual Meeting, October 31 - November 3, 2012 – Miami, Florida, USA: Mini Symposium: Pancreatic stellate cells and cancer

• XVI. Annual Meeting of the European Society of Surgery, November 22-24, 2012 Istanbul. Chair: Invited Presentations, 08:00-09:30, 23.11.12

• XVI. Annual Meeting of the European Society of Surgery, November 22-24, 2012 Istanbul. Chair: An Ordinary Day in the Theatre, 16:00-17:00, 24.11.12

• 7th EDS Postgraduate Course – Pitfalls in Gastro-Intestinal Surgery, May 9-11 2013, Istanbul, Turkey. Colorectal cancer management. Case presentations. 10:30-11:30, 11.05.13

• 10th Congress of the E-AHPBA, 29th – 31st May, 2013, Belgrade, Serbia

Breakfast Session: How to do a pancreatic anastomosis? Helmut Friess and Mert Erkan 07:45 – 08:45, 30.05.13

• 10th Congress of the E-AHPBA, 29th – 31st May, 2013, Belgrade, Serbia: Chair: Session 8: Oral presentations – Pancreas: 30.05.13, 09:00 – 10:00, Amfiteatar, Alain Sauvanet, Mo Hilal, Mert Erkan

• 10th Congress of the E-AHPBA, 29th – 31st May, 2013, Belgrade, Serbia: Chair: Session 29: Oral presentations – Pancreas: 14:00 – 15:30 , Room IV-1 , Helmut Friess, Mert Erkan, Takashi Hatori

• 10th Congress of the E-AHPBA, 29th – 31st May, 2013, Belgrade, Serbia. Belgrade Consensus Workshop on Defining and Standardizing Pancreatic Texture. 30.05.13 – 14:00 – 17:30, Room III.

• Onkologisch-chirurgische Viszeralmedizin Kompetenz unter einem Dach. 29.06.2013. Klinkum rechts der Isar, Technische Universität München, Munich, Germany. Grenzwertig resektable Pankreaskarzinome - Grenzen der chirurgischen Therapie

• East China Surgery Congress, June 6th-8th, 2014, Hefei, Anhui Province in P.R. of China - Surgical Treatment of Borderline Resectable Pancreatic Cancer.

• United European Gastroenterology (UEG) Basic Science Course 17th – 19th July, 2014, Klinikum r.d. Isar, Technische Universität München, Munich, Germany: The impact of stroma on carcinogenesis. 18th July, 2014, 08:30 – 09:00.

• 6. Onkoloji Günleri, Gastrointestinal Sistem Kanserleri, 5 – 6 / Aralik, 2014, Büyük Abant Oteli & Kongre Merkezi, Abant, Bolu, Türkiye. Biyolojik ajan kullanılan hastalarda metastaz cerrahisi ne kadar güvenlidir?

• Pankreas Kanserinde Yeni Ufuklar Sempozyumu 6 Subat, 2015. Medipol Üniversitesi Tıp Fakültesi. Pankreas Kanserinde Majör Vasküler Rezeksiyonun Prognoza Etkileri 6. Subat, 2015, 13:30 – 14:30.

• Expert Tumour Hypoxia Steering Committee Meeting, Merck Serono, London & New York, Friday 20 March 2015

• 12. Hepatopankreatobilier Cerrahi Kongresi. 1-4 Nisan 2015, Antalya, Türkiye. Kanıta Dayalı Tıp Kursu: Kanıtlar nasıl değerlendirilir? 1 Nisan 2015, 14.30 - 15.00

• 12. Hepatopankreatobilier Cerrahi Kongresi. 1-4 Nisan 2015, Antalya, Türkiye. Tıbbi istatistik Kursu: Makale yazımında sonuçlar nasıl ifade edilmelidir? 1 Nisan 2015, 15.30 - 16.00

• 12. Hepatopankreatobilier Cerrahi Kongresi. 1-4 Nisan 2015, Antalya, Türkiye. Pankreas kanseri tedavisinde arayışlar. 2 Nisan 2015, 15.30 - 16.00

• 11th International Congress of the European-African Hepato-Pancreato-Biliary Association. Manchester Central. Tuesday 21st to Friday 24th April. Manchester, UK. E-AHPBA Free Papers 18: LIVER HCC. Friday 24th April 2015. 11.00 – 12.30. Professor Mert Erkan and Professor Christos Agalianos.

• 1. GISTANBUL Meeting. Hilton Kozyatagi. 28 – 30.08.2015. Surgical approach to the liver metastasis. 30.08.2015 – 11:30-11:50

Editorial Board Member and ad hoc Reviewer For: (among others)

• BMC Gastroenterology

• Carcinogenesis

• Frontiers Gastrointestinal Sciences (Editorial Board Member)

• Gastric Cancer (Editorial Board Member)

• Gastroenterology

• Gut

• Journal of Pancreatology

• Lancet Oncology

• Molecular Oncology

• Pancreatology

• The Journal of Pathology

• Türkiye Klinikleri Journal of Medical Sciences

• Trials

Publications

1. Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Buchler MW, Giese NA, Friess H. Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene. 2005 Jun 23;24(27):4421-32.

2. Erkan M, Tekant Y. Molecular aspects of pancreatic cancer and new threapeutic targets (review in Turkish). Türk HPB 2005;1(2):1-5.

3. Ceyhan GO, Giese NA, Erkan M, Kerscher AG, Wente MN, Giese T, Büchler MW, Friess H. The neurotrophic factor Artemin promotes pancreatic cancer invasion: Ann surg. 2006; 244: 274-281.

4. Ceyhan GO, Bergmann F, Kadihasanoglu M, Erkan M, Park W, Gorbachevski A, Buchler MW, Giese N, Friess H. The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis. Gut. 2007; 56:534-44.

5. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Buchler MW, Giese NA, Friess H. Periostin creates a tumor supportive microenvironment in the pancreas by sustaining fibrogenic steallate cell activity. Gastroenterology. 2007; 132:1447-64.

6. Weiwei Zhang, Mert Erkan, Ivane Abiatari, Nathalia A. Giese, Klaus Felix, Hany Kayed, Markus W. Büchler, Helmut Friess, Jörg Kleeff. Expression of Extracellular

Matrix Metalloproteinase Inducer (EMMPRIN/CD147) in Pancreatic Neoplasm and

Pancreatic Stellate Cells. Cancer Biol Ther. 2007; 6:218-27.

7. Kussumawidjaja G, Kayed H, Bauer A, Giese N, Erkan M, Friess H, Kleeff J. Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells. Cancer Biol Ther. 2007; 6:367-76.

8. Michalski CW*, Oti FE*, Erkan M*, Bergmann F, Pacher P, Batkai S, Müller MW, Giese NA, Friess H, Kleeff J. Cannabinoids in pancreatic cancer: correlation with survival and pain. Int J Cancer. 2008;122(4):742-50.

* Equally contributing first author

9. Erkan M, Kleeff J, Reiser C, Hinz U, Esposito I, Friess H, Büchler MW. Pre-operative acute pancreatitis in periampullary tumors: Implications for surgical management. Digestion. 2007 Aug 7; 75:165-171

10. Michalski CW, Kleeff J, Bachmann J, lKhatib J, Erkan M , Esposito I, Friess H, Büchler MW. Second-look operation for unresectable pancreatic ductal adenocarcinoma at a high-volume center. Ann Surg Oncol. 2008; 15(1):186-92. Epub 2007 Oct 18.

11. Michalski CW*, Gorbachevski A*, Erkan M*, Reiser C, Deucker S, Bergmann F, Giese T, Weigand M, Giese NA, Friess H, Kleeff J. Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis. J Transl Med. 2007 Dec 5;5(1):63

* Equally contributing first author

12. Hüser N, Michalski CW, Erkan M, Schuster T, Rosenberg R, Kleeff J, Friess H. Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery. Ann Surg. 2008 Jul;248(1):52-60. Review.

13. Michalski CW*, Maier M* Erkan M*, Sauliunaite D, Bergmann F, Pacher P, Batkai S, Giese NA, Giese T, Friess H, Kleeff J. Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells. PLoS ONE. 2008 Feb 27;3(2):e1701.

* Equally contributing first author

14. Reiser-Erkan C, Erkan M, Michalski CW, Bekasi S, Giese NA, Giese T, Friess H, Kleeff J. Expression of hypoxia-inducible proto-oncogene Pim-1 in pancreatic neoplasms. Cancer Biol Ther. 2008; 9:1353-1360

15. Erkan M, Michalski CW, Rieder S, Reiser-Erkan C, Abiatari I, Kolb A, Giese NA, Esposito I, Friess H, Kleeff J. Activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol. 2008 Oct;6(10):1155-61. Epub 2008 Jul 17

16. Michalski CW, Erkan M, Hüser N, Müller MW, Hartel M, Friess H, Kleeff J. Resection of primary pancreatic cancer and liver metastasis: a systematic review. Dig Surg. 2008;25(6):473-80. Epub 2009 Feb 12.

17. Michalski CW*, Erkan M*, Sauliunaite D, Giese T, Stratmann R, Sartori C, Giese NA, Friess H, Kleeff J. Ex vivo chemosensitivity testing and gene expression profiling predict response towards adjuvant gemcitabine treatment in pancreatic cancer. Br J Cancer. 2008 Sep 2;99(5):760-7.

* Equally contributing first author

18. Jiang X, Abiatari I, Kong B, Erkan M, De Oliveira T, Giese NA, Michalski CW, Friess H, Kleeff J. Pancreatic Islet and Stellate Cells Are the Main Sources of Endocrine Gland-Derived Vascular Endothelial Growth Factor/Prokineticin-1 in Pancreatic Cancer. Pancreatology. 2008 Dec 13;9(1-2):165-172.

19. Streit S, Michalski CW, Erkan M, Kleeff J, Friess H. Northern blot analysis for detection and quantification of RNA in pancreatic cancer cells and tissues. Nat Protoc. 2009;4(1):37-43.

20. Ceyhan GO, Deucker S, Demir IE, Erkan M, Schmelz M, Bergmann F, Müller MW, Giese T, Büchler MW, Giese NA, Friess H. Neural fractalkine expression is closely linked to pain and pancreatic neuritis in human chronic pancreatitis. Lab Invest. 2009 Mar;89(3):347-61.

21. Erkan M, Reiser-Erkan C, Michalski CW, Deucker S, Sauliunaite D, Streit S, Esposito I, Friess H, Kleeff J. Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. Neoplasia. 2009 May;11(5):497-508.

22. Streit S, Michalski CW, Erkan M, Friess H, Kleeff J. Confirmation of DNA Microarray-Derived Differentially Expressed Genes in Pancreatic Cancer Using Quantitative RT-PCR. Pancreatology. 2009 Aug 4;9(5):577-582.

23. Pan Z, Erkan M, Streit S, Friess H, Kleeff J. Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells. Int J Oncol. 2009 Oct;35(4):823-8.

24. Erkan M, Tekant Y. Intraductal Papillary Mucinous Neoplasms of the Pancreas. (Review in Turkish). Türk HPB. 2009;5:15-20

25. Michalski CW, Erkan M, Friess H, Kleeff J. Tumor metabolism to blood flow ratio in pancreatic cancer: helpful in patient stratification. Future Oncol. 2010 Jan;6(1):13-5.

26. Ceyhan GO, Schäfer KH, Kerscher AG, Rauch U, Demir IE, Kadihasanoglu M, Böhm C, Müller MW, Büchler MW, Giese NA, Erkan M, Friess H. Nerve growth factor and artemin are paracrine mediators of pancreatic neuropathy in pancreatic adenocarcinoma. Ann Surg. 2010 May;251(5):923-31.

27. Erkan M, Weis N, Pan Z, Schwager C,Jiang X, Wirkner X, Giese NA, Ansorge W, Debus J, Huber PE, Friess H, Abdollahi A, Kleeff J. Organ-, Inflammation- and Cancer Specific Transcriptional Fingerprints of Pancreatic and Hepatic Stellate Cells. Mol Cancer, 2010 Apr 23;9:88.

28. Holzapfel K, Reiser-Erkan C, Fingerle AA, Erkan M, Eiber MJ, Rummeny EJ, Friess H, Kleeff J, Gaa J. Comparison of diffusion-weighted MR imaging and multidetector-row CT in the detection of liver metastases in patients operated for pancreatic cancer. Abdom Imaging. 2011 Apr;36(2):179-84.

29. Reiser-Erkan C, Erkan M, Ulbrich E, Nahrig J, Kleeff J. Cystic colon duplication causing intussusception in a 25-year-old man: report of a case and review of the literature. BMC Surg. 2010 Jun 23;10(1):19.

30. Kong B, Michalski CW, Hong X, Valkovska N, Rieder S, Abiatari I, Streit S, Erkan M, Esposito I, Friess H, Kleeff J. AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGFbeta-mediated ERK signaling. Oncogene. 2010 Sep 16;29(37):5146-58.

31. Wang W, Reiser-Erkan C, Raggi MC, Michalski CW, Quan L, Yupei Z, Friess H, Erkan M , Kleeff J. BHLHB2 overexpression is a positive prognostic factor indicating gemcitabine responsiveness in pancreatic cancer. Biochem Biophys Res Commun. 2010 Oct 22;401(3):422-8

32. Samkharadze T*, Erkan M*, Reiser-Erkan C, Demir IE, Bo K, Ceyhan GO, Michalski CW, Esposito I, Friess H, Kleeff J. Pigment Epithelium-Derived Factor Increases Neuropathy and Fibrosis in Pancreatic Cancer. Am J Gastroenterol. 2011 Jan 11 [Epub ahead of print].

* Equally contributing first author

33. Erkan M, Reiser-Erkan C, Michalski CW, Friess H, Kleeff J. Tumor microenvironment and progression of pancreatic cancer. Exp Oncol. 2010 Sep;32(3):128-31

34. Paron I, Berchtold S, Vörös J, Shamarla M, Erkan M, Höfler H, Esposito I. Tenascin-C Enhances Pancreatic Cancer Cell Growth and Motility and Affects Cell Adhesion through Activation of the Integrin Pathway. PLoS One. 2011;6(6):e21684. Epub 2011 Jun 29.

35. Kong B, Michalski CW, Erkan M, Friess H, Kleeff J. From tissue turnover to the cell of origin for pancreatic cancer. Nat Rev Gastroenterol Hepatol. 2011 Jul 12;8(8):467-72.

36. Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, EspositoI, Friess H, Gress T, Habisch HJ, Hwang RF, Jaster R, Kleeff J, Klöppel G, Kordes C, Logsdon CD, Masamune A, Michalski CW, Oh J, Phillips PA, Pinzani M, Reiser-Erkan C, Tsukamoto H, Wilson J. StellaTUM: Current consensus and discussion on pancreatic stellate cell research. Gut. 2012 Feb;61(2):172-8.

* All authos have contribute equally

37. Erkan M*, Reiser-Erkan C*, Michalski CW, Kong B, Esposito I, Friess H, Kleeff J. The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance. Curr Mol Med. 2012 Mar 1;12(3):288-303.

* Equally contributing first author

38. Herrmann K.*, Erkan M.*, Dobritz M., Schuster T., Siveke J.T., Beer A.J., Wester H.J., Schmid R.M., Friess H., Schwaiger M., Kleeff J., Buck A.K. Comparison of 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography (FLT-PET) and FDG-PET/CT for the detection and characterization of pancreatic tumors. Eur J Nucl Med Mol Imaging. 2012 May;39(5):846-51.

* Equally contributing first author

39. Regel I, Kong B, Raulefs S, Erkan M, Michalski CW, Hartel M, Kleeff J. Energy metabolism and proliferation in pancreatic carcinogenesis. Langenbecks Arch Surg. 2012 Apr;397(4):507-12.

40. De Oliveira T, Abiatari I, Raulefs S, Sauliunaite D, Erkan M, Kong B, Friess H, Michalski CW, Kleeff J. Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype. Mol Cancer. 2012 Apr 3;11(1):19

41. Mihaljevic AL, Michalski CW, Erkan M, Reiser-Erkan C, Jaeger C, Schuster T, Schuhmacher C, Kleeff J and Friess H. Standard abdominal wound edge protection with surgical dressings vs coverage with a sterile circular polyethylene drape for prevention of surgical site infections (BaFO): study protocol for a randomized controlled trial. Trials. 2012 May 15;13:57.

42. Erkan M, Hausmann S, Michalski CW, Fingerle AA, Dobritz M, Kleeff J, Friess H. The role of stroma in pancreatic cancer: diagnostic and therapeutic implications. Nat Rev Gastroenterol Hepatol. 2012 Aug;9(8):454-67.

43. Erkan M, Hausmann S, Michalski CW, Schlitter AM, Fingerle AA, Dobritz M, Friess H, Kleeff J. How fibrosis influences imaging and surgical decisions in pancreatic cancer. Front Physiol. 2012;3:389.

44. Erkan M. Antifibrotic therapy in pancreatic diseases. Gut. 2012 Dec 22. [Epub ahead of print]

45. Erkan M. Pancreatic stellate cells and cancer. Pancreatology, 2013 Mar-Apr;13(2):106-9.

46. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, Vandenberg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. J Clin Invest. 2013 May 1;123(5):2231-43.

47. Erkan M. Understanding the stroma of pancreatic cancer: Coevolution of the microenvironment with the epithelial carcinogenesis. J Pathol. 2013 May 28

48. Stellwag T, Michalski CW, Kong B, Erkan M, Reiser-Erkan C, Jäger C, Meinl C, Friess H, Kleeff J. Comparative analysis of the revenues of pylorus-preserving pancreatic head resections and laparoscopic cholecystectomies as prototypic surgical procedures in the German health care system. Langenbecks Arch Surg, 2013 Aug;398(6):825-31

49. Kong Bo, Qia C, Erkan M, Kleeff J, Michalski CW. Overview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels. Front Physiol. 2013 Sep 12;4:246

50. Balic A, Dræby Sørensen M, Trabulo SM, Sainz B Jr, Cioffi M, Vieira CR, Miranda-Lorenzo I, Hidalgo M, Kleeff J, Erkan M, Heeschen C. Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. Mol Cancer Ther. 2014 Jul;13(7):1758-71.

51. Hausmann S, Kong B, Michalski C, Erkan M, Friess H. The role of inflammation in pancreatic cancer. Adv Exp Med Biol. 2014;816:129-51.

52. Yalcin S, Erkan M, Ünsoy G, Parsian M, Kleeff J, Gündüz U. Effect of gemcitabine and retinoic acid loaded PAMAM dendrimer-coated magnetic nanoparticles on pancreatic cancer and stellate cell lines. Biomedicine & Pharmacotherapy, Biomed Pharmacother. 2014 Jul;68(6):737-43.

53. Irene Miranda-Lorenzo, Jorge Dorado, Enza Lonardo, Sonia Alcala, Alicia G. Serrano, Jenifer Clausell-Tormos, Michele Cioffi, Diego Megias, Sladjana Zagorac Anamaria Balic, Manuel Hidalgo, Mert Erkan, Joerg Kleeff, Aldo Scarpa, Bruno Sainz, Jr., Christopher Heeschen . Intracellular autofluorescence – A novel and universally inherited biomarker for epithelial cancer stem cells. Nat Methods. 2014 Nov;11(11):1161-9.

54. Andre´ L. Mihaljevic, Rebekka Schirren, Mine Ozer, Stephanie Ottl, Sybille Grün, Christoph W. Michalski, Mert Erkan, Carsten Jäger, Carolin Reiser-Erkan, Victoria Kehl, Tibor Schuster, Jürgen Roder, Ulf Clauer, Carolin Orlitsch, Tomas F. Hoffmann, Reinhard Lange, Thomas Harzenetter, Phillip Steiner, Milena Michalski, Karl Henkel, Josef Stadler, Georg A. Pistorius, Anja Jahn, Robert Obermaier, Robert Unger, Roland Strunk, Frank Willeke, Holger Vogelsang, Bert Halve, Karl-Heinz Dietl, Hendrik Hilgenstock, Alexander Meyer, Hans-Jörg Krämling, Markus Wagner, Michael H. Schoenberg, Florian Zeller, Johannes Schmidt, Helmut Friess, and Jörg Kleeff. Multicenter Double-Blinded Randomized Controlled Trial of Standard Abdominal Wound Edge Protection With Surgical Dressings Versus Coverage With a Sterile Circular Polyethylene Drape for Prevention of Surgical Site Infections. Ann Surg. 2014 Nov;260(5):730-9.

55. Berchtold S, Grünwald B, Krüger A, Reithmeier A, Hähl T, Cheng T, Feuchtinger A, Born D, Erkan M, Kleeff J, Esposito I. Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma. Cancer Lett. 2015 Jan 28].

56. Kalliope N. Diakopoulos, Marina Lesina, Wörmann Sonja, Song Liang, Thomas Wartmann, Walter Halangk, Lorenz Schild, Hans Zischka, Michaela Aichler, Mert Erkan , Ihsan Ekin Demir, Christos S. Mantzoros, Heiko Witt, Roland M. Schmid, Jerzy Adamski, Hana Algül. Impaired pancreatic autophagy induces chronic atrophic pancreatitis in mice in a gender- and nutrition-dependent fashion. Gastroenterology. 2015 Mar;148(3):626-638.e17

57. JA McCarroll, G Sharbeen, J Liu, J Youkhana, D Goldstein, N, McCarthy, D Dischl, GO Ceyhan, M Erkan, A Johns, A Biankin, M, Kavallaris, PA Phillips βIII-Tubulin: A Novel Mediator of Chemoresistance and Metastases in Pancreatic Cancer. Oncotarget. 2015 Feb 10.

58. Kong B, Wu W, Cheng T, Schlitter AM, Qian C, Bruns P, Jian Z, Jäger C, Regel I, Raulefs S, Behler N, Irmler M, Beckers J, Friess H, Erkan M, Siveke JT, Tannapfel A, Hahn SA, Theis FJ, Esposito I, Kleeff J, Michalski CW. A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling. Gut. 2015 Jan 19.

59. Späth C, Nitsche U, Müller TC, Michalski CW, Erkan M, Kong B, Kleeff J. Strategies to improve the outcome in locally advanced pancreatic cancer. Minerva Chir. 2015 Feb 6.

60. Bo Kong, WeiWei Wu, Natalya Valkovska, Carsten Jaeger, Xin Hong, Ulrich Nitsche, Helmut Friess, Irene Esposito, Mert Erkan, Jorg Kleeff, and Christoph Michalski. A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels. Sci Rep. Sci Rep. 2015 Feb 6

61. Cioffi M, Trabulo SM, Hidalgo M, Costello E, Greenhalf W, Erkan M, Kleeff J, Sainz B Jr, Heeschen C. Inhibition of CD47 effectively targets pancreatic cancer stem cells via dual mechanism. Clin Cancer Res. 2015 Feb 23

62. Bruno Sainz Jr, Sonia Alcala, Elena Garcia, Yolanda Sanchez-Ripoll, Maria M Azevedo, Michele Cioffi, Marianthi Tatari, Irene Miranda-Lorenzo, Manuel Hidalgo, Gonzalo Gomez-Lopez, Marta Cañamero, Mert Erkan, Jörg Kleeff, Susana García-Silva, Patricia Sancho, Patrick C Hermann, Christopher Heeschen. Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment. Gut. 2015 Apr 3.

63. Jorg Kleeff, Christoph Michalski, Bo Kong, Mert Erkan, Susanne Roth, Jens Siveke, Helmut Friess and Irene Esposito. Surgery for cystic pancreatic lesions in the post-Sendai era: a single institution experience. HPB Surg. 2015;2015:847837. doi: 10.1155/2015/847837. Epub 2015 Mar 19.

64. Daniela Stangel, Mert Erkan, Malte Buchholz, Thomas Gress, Christoph Michalski, Susanne Raulefs, Helmut Friess, Jörg Kleeff. Kif20a inhibition reduces migration and invasion of pancreatic cancer cells. J Surg Res. J Surg Res. 2015 Mar 30. pii: S0022-4804(15)00329-7.

65. Jörg Kleeff, Mert Erkan, Carsten Jäger, Maximilian Menacher, Friedemann Gebhardt, Mark Hartel. Umbilical microflora, antiseptic skin preparation and SSI in abdominal surgery. Surgical Infections. 2015 Jun 26

66. Veit Phillip, Tina Zahel, Assiye Danninger, Mert Erkan, Martin Dobritz, Jorg M. Steiner, Jorg Kleeff, Roland M. Schmid, Hana Algül. Volumetric gain of the human pancreas after left partial pancreatic resection - A CT-scan based retrospective study. Pancreatology. 2015 Jun 24.

67. Christoph W Michalski, Bo Kong, Carsten Jäger, Silke Kloe, Barbara Beier, Rickmer Braren, Irene Esposito, Mert Erkan, Helmut Friess, Jorg Kleeff. Outcomes of resections for pancreatic adenocarcinoma with suspected venous involvement: a single center experience. BMC Surg. 2015 Aug 22;15(1):100.

68. Ulrich Nitsche, Patrick Wenzel, Jens T. Siveke, Rickmer Braren, Konstantin Holzapfel, Anna M. Schlitter, Christian Stöß, Bo Kong, Lynne Cresswell, Irene Esposito, Mert Erkan, Christoph W. Michalski, Helmut Friess, Jörg Kleeff.Resectability after first-line FOLFIRINOX in initially unresectable locally advanced pancreatic cancer: A single center experience. Ann Surg Oncol. 2015 Sep 8. [Epub ahead of print]

69. Ana Santos Cravo, Edward Carter, Mert Erkan, Emma Harvey, Makoto Furutani-Seiki & Randall Mrsny Hippo pathway elements Co-localize with Occludin: A possible sensor system in pancreatic epithelial cells. Tissue Barriers, Volume 3, Issue 3, 2015.

70. Pawel K. Mazur, Alexander Herner, Stephano S. Mello, Matthias Wirth, Simone Hausmann, Timo Kuschma, Francisco J. Sanchez-Rivera, Shane Lofgren, Stephan A. Hahn, Deepak Vangala, Marija Trajkovic-Arsic, Aayush Gupta, Irina Heid, Peter B. Noël, Rickmer Braren, Mert Erkan, Jörg Kleeff, Bence Sipos, Leanne C. Sayles, Mathias Heikenwälder, Elisabeth Heßmann, Volker Ellenrieder, Irene Esposito, Tyler Jacks, James E. Bradner, Purvesh Khatri, E. Alejandro Sweet-Cordero, Laura D. Attardi, Roland M. Schmid, Guenter Schneider, Julien Sage, Jens T. Siveke. Synergistic suppression of pancreatic cancer by combined inhibition of BET and HDAC chromatin regulators. Nat Med. Accepted 2015.

71. Kong Bo, Tao Cheng, Weiwei Wu, Ivonne Regel, Susanne Raulefs, Helmut Friess, Mert Erkan, Irene Esposito, Jörg Kleeff, Christoph W. Michalski. Hypoxia-induced ER stress characterizes a necrotic phenotype of pancreatic cancer Oncotargets. Accepted 2015

72. sUlrich Nitsche, Daniela Stangel, Zheng Pan, Anna Melissa, Schlitter, Irene Esposito, Ivonne Regel, Susanne Raulefs, Helmut Friess, Jörg Kleeff, Mert Erkan. Periostin and tumor-stroma interactions in non-small cell lung cancer. Oncology Leters. Accepted 2015.

Book Chapters

1. Friess H, Erkan M, Kleeff J, Haberkorn U, Buchler MW. The role of PET in diagnosis of pancreatic cancer and recurrence. The Pancreas: 2008. Eds. H.G. Beger, A.L. Warshaw, R.C.G. Russell, M. Buchler, D. Carr Locke, J.Neoptolemos, M.G. Sarr.

2. Friess H, Kleeff J, Erkan M, Buchler MW. Palliative pancreatico-duodenectoy. The Pancreas: 2008. Eds. H.G. Beger, A.L. Warshaw, R.C.G. Russell, M. Buchler, D. Carr Locke, J.Neoptolemos, M.G. Sarr.

3. Mert Erkan, Helmut Friess, Jörg Kleeff. Apoptosis. In: “Molecular Biology of Cancer”, , 2008. Ed. S. Ossinsky.

4. Erkan M, Esposito I, Friess H, Kleeff J. Tumor-Stromal Interaction: Invasion and Metastasis. Handbook of Pancreatic Cancer: 2009. Eds: J.P. Neoptolemos, R. Urrutia, J.L. Abbruzzese, M.W. Büchler.

5. F. Kolligs, M. Erkan, A. Graser, S. Haraida, T. Helmberger, B. Neu, M. op den Winkel, C. Trumm, C. Tympner, M. Rentsch. Hepatozelluläres Karzinom, Manual: Gastrointestinale Tumoren, Tumorzentrum München. 9. Auflage 2013

6. Mert Erkan, Tania Brocks, Helmut Friess. The Role of Non-cancerous Cells in Cancer: Pancreatic Ductal Adenocarcinoma as a Model to Understand the Impact of Tumor Microenvironment on Epithelial Carcinogenesis. Cancer Targeted Drug Delivery. 2013 Eds: You Han Bae, Randall J. Mrsny, Kinam Park.

7. Simone Hausmann, Bo Kong, Christoph Michalski, Mert Erkan and Helmut Friess. Role of Inflammation in Pancreatic Cancer. Advs Exp. Medicine, Biology, Vol. 816, Inflammation and Cancer. 2014, Eds: Bharat B. Aggarwal et al.

Congress Presentations

1. Erkan M, Kleeff J, Giese NA, Esposito I, Büchler M.W., Friess H. (Heidelberg, Germany)

Loss of BNIP3 is a late event in pancreatic carcinogenesis increasing chemosesistance.

25. Deutscher Pankreas-Club 2004. 18.-20. November 2004, Berlin

2. Ceyhan GO, Müller MW, Giese NA, Erkan M, Büchler MW, Friess H (Heidelberg, Germany)

Der neurotropische Wachsttumfactor Artemin induziert eine Streigerung der Krebszellinvasion im Pankreaskarzinom

25. Deutscher Pankreas-Club 2004. 18.-20. November 2004, Berlin

3. Ceyhan GO, Kerscher AG, Bergmann F, Müller M, Giese N, Erkan M, Giese T, Büchler MW, Friess H. Neural Sprouting and Neural Hypertrophy in Pancreatic Ductal Adenocarcinoma is Related to the High Expressions of GAP-43, NGF and Artemin

37th European Pancreatic Club (EPC) Meeting. 6.-8.Juli 2005, Graz, Österreich

4. Erkan M, Kleeff J, Esposito I,Giese T,Ketterer K, Büchler M, Giese N, Friess H (Heidelberg Germany). Loss of BNIP3 expression is a late event in pancreatic carcinogenesis

contributiong to chemoresistance and worse prognosis. (Best Poster Prize)

6th Congress of the EHPBA, 25.-28. Mai 2005, Heidelberg

5. Kerscher A, Ceyhan GO, Müller M, Bergmann F, Giese NA, Erkan M, Giese T, Büchler MW, Friess H (Universitätsklinikum Heidelberg)

Die Expression von GAP-43, NGF und Artemin korrelieren mit der gesteigerten Nervendichte und Nervenhyperophie im Pankreaskarzinom. Südwestdeutsche Gesellschaft für Gastroenterologie XVI Kongress 2.-4. Juni 2005, Heidelberg

6. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Buchler MW, Giese NA, Friess H. Periostin creates a tumor supportive microenvironment in the pancreas by sustaining fibrogenic steallate cell activity. EPC, 7.-10. Juni 2006, Tampere, Finnland

7. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Buchler MW, Giese NA, Friess H. Periostin creates a tumor supportive microenvironment in the pancreas by sustaining fibrogenic steallate cell activity. IHPBA, 3.-7. September 2006, Edinburg, Scotland

8. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Buchler MW, Giese NA, Friess H. Periostin creates a tumor supportive microenvironment in the pancreas by sustaining fibrogenic steallate cell activity. DPC, 23.-25. November 2006 Greifswald

9. Maier M, Michalski CW, Erkan M, Giese NA, Friess H. Neue anti-fibrotische Effekte des Endocannabinoid-Systems in chronischer Pankreatitis. DPC, 23.-25. November 2006 Greifswald

10. Altintas B, Ceyhan GO, Bergmann F, Erkan M, Büchler MW, Giese NA, Friess H.Der neurotropische Faktor Artemin beeinflusst das Nervenwachstum und das Ausmaß des neuralen Schadens in der chronischen Pankreatitis. DPC, 23.-25. November 2006 Greifswald, Deutschland

11. Erkan M, Kleeff J, Reiser C, Hinz U, Esposito I, Friess H, Büchler MW. Pre-operative acute pancreatitis in periampullary tumors: Implications for surgical management. EPC, Newcastle, 2007, England

12. Erkan M, Michalski CW, Bachmann J, AlKatib J, Esposito I, Friess H, Kleeff J, Buechler MW. Assessment of resectability after an initial diagnosis of unresectable pancreatic cancer: Impact of patient centralization. APA, Chicago, 1.-3. November 2007, USA

13. Erkan M, Michalski CW, Rieder S, Reiser-Erkan C, Abiatari I, Kolb A, Giese NA, Esposito I, Friess H, Kleeff J. Activated stroma is an independent prognostic marker in pancreatic ductal adenocarcinoma. DPC, 22.-24. November 2007 Dresden

14. Erkan M, Reiser-Erkan C, Michalski CW, Deucker D, Sauliunaite D, Streit S, Esposito E, Friess H, Kleeff J. Cancer-Stellate cell interactions inhibit angiogenesis and perpetuate the hypoxia-fibrosis cycle in pancreatic cancer. 39th Annual APA-Meeting, 6.-7. November 2008, Chicago, USA

15. Michalski CW, Herner A, Sauliunaite D, Erkan M, DeOliveira T, Abiatari I, Esposito I, Friess H, Kleeff J. AMPA-Receptor antagonism inhibits pancreatic cancer growth. 39th Annual APA-Meeting, 6.-7. November 2008, Chicago, USA

16. Erkan M, Reiser-Erkan C, Michalski CW, Deucker D, Sauliunaite D, Streit S, Esposito E, Friess H, Kleeff J. Cancer-Stellate cell interactions inhibit angiogenesis and perpetuate the hypoxia-fibrosis cycle in pancreatic cancer. DPC 19.-21. November 2008, Magdeburg

17. Erkan M, Weis N, Pan Z, Schwager C, Wirkner U, Giese NA, Debus J, Friess H, Abdollahi A, Kleeff J Organ-, Inflammation- and Cancer Specific Transcriptional Fingerprints of Pancreatic and Hepatic Stellate Cells. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany

18. Samkharadze T, Erkan M, Reiser-Erkan C, Demir, IE, Kong Bo, Giese NA, Esposito I, Friess H, Kleeff J. Deregulated Expression of Pigment Epithelium-Derived Factor Increases Neuropathy and Fibrosis in Pancreatic Cancer. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany

19. Reiser-Erkan C, Erkan M, Fingerle A, Holzapfel K, Friess H, Kleeff J. Detektion von Lebermetastasen bei Patienten mit malignen Pankreastumoren durch Diffusions-MRT. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany

20. Reiser-Erkan C, Tardio M, Erkan M, Samkharadze T, Giese NA, Esposito I, Friess H, Kleef J. Membranous Claudin-10 expression is a strong positive prognostic factor in pancreatic cancer. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany

21. Erkan M, Samkharadze T, Reiser-Erkan C, Streit S, DeOliveira T, Giese NA, Espoisto I, Friess H, Kleeff J. Opposite effects of two BH3-only pro-apoptotic BCL-2 members in pancreatic cancer. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany

22. Sauliunaite D, Herner A, Michalski CW, DeOliveira T, Erkan M, Abiatari I, Kong B, Espostio I, Friess H, Kleeff J. Glutamate increases pancreatic cancer cell invasion and migration via AMPA receptor activation and K-ras-MAPK signalling. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany

23. Erkan M, Weis N, Pan Z, Schwager C, Jiang X, Wirkner U, Giese NA, Ansorge W, Debus J, Huber PE, Friess H, Abdollahi A, Kleeff J. Organ-, Inflammation- and Cancer Specific Transcriptional Fingerprints of Pancreatic and Hepatic Stellate Cells, UEGW/WCOG GASTRO 2009, 21. – 25. November 2009, London, UK

24. Erkan M, Streit S, Samkharadze T, Reiser-Erkan C, DeOliveira T, Giese NA, Esposito I, Friess H, Kleeff J. Opposite effects of two BH3-only pro-apoptotic Bcl-2 members in pancreatic cancer, UEGW/WCOG GASTRO 2009, 21.- 25. November 2009, London, UK

25. Erkan M, Fingerle A, Reiser-Erkan C, Samkharadze T, Pan Z, Esposito I, Tekant Y, Gaa J Friess H, Kleeff J. Prognostic molecular imaging in pancreatic cancer through analysis of the stromal activity. 9th World Congress of the International Hepato-Pancreato-Biliary Association, IHPBA 2010, 18.-22. April 2010, Buenos Aires, Argentinien

26. Samkharadze T, Erkan M, Reiser-Erkan C, Demir IE, Bo K, Esposito I, Friess H, Kleeff J. Deregulated Expression of Pigment Epithelium-Derived Factor Increases Neuropathy and Fibrosis in Pancreatic Cancer. 9th World Congress of the International Hepato-Pancreato-Biliary Association, IHPBA 2010, 18.-22. April 2010, Buenos Aires, Argentinien

27. Reiser-Erkan C, Erkan M, Fingerle A, Holzapfel K, Gaa J, Friess H, Kleeff J. Detection of liver metastasis in patients with malignant pancreatic tumors by diffusion-weighted MR imaging. 9th World Congress of the International Hepato-Pancreato-Biliary Association, IHPBA 2010, 18.-22. April 2010, Buenos Aires, Argentinien

28. Erkan M, Samkharadze T, Reiser-Erkan C, Demir E, Michalski CW, Friess H, Kleeff J. Pigment Epithelium-Derived Factor Increases Neuropathy and Fibrosis in Pancreatic. 41st Annual Meeting of the American Pancreatic Association, APA 2010, 3.-6.November 2010, Chicago, USA.

29. Reiser-Erkan C, Wang W, Erkan M, Michalski CW, Friess H, Kleeff J. BHLHB2 Overexpression Is a Positive Prognostic Factor Indicating Gemcitabine Responsiveness in Pancreatic Cancer. 41st Annual Meeting of the American Pancreatic Association, APA 2010, 3.-6. November 2010, Chicago, USA.

30. Erkan M, Fingerle AA, Reiser-Erkan C, Gaa J, Friess H, Kleeff J. Prognostic Molecular Imaging in Pancreatic Cancer through Analysis of the Stromal Activity. 41st Annual Meeting of the American Pancreatic Association, APA 2010, 3.-6. November 2010, Chicago, USA.

31. Reiser-Erkan C, Tardio M, Erkan M, Wang W, Samkharadze T, Friess H, Kleeff J. Membranous Claudin-10 Expression Is a Novel Positive Prognostic Factor in Pancreatic Cancer. 41st Annual Meeting of the American Pancreatic Association, APA 2010, 3.-6. November 2010, Chicago, USA.

32. Erkan M, Kleeff J. Does EMT contribute to the population of PSC? First meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate Cells. 4. March 2011, Munich, Germany.

33. Erkan M, Friess H. Purity and contaminants of PSC isolated by different methods. First meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate Cells. 4. March 2011, Munich, Germany.

34. Erkan M, Streit S, Reiser-Erkan C, Samkharadze T, Özer M, Giese NA, Esposito I, Friess H, Kleeff J.Opposite effects of two BH3-only pro-apoptotic Bcl-2 members in pancreatic cancer. 9th congress of the EHPBA, 12-16 April 2011 Cape Town, South Africa.

35. Erkan M, Reiser-Erkan C, Michalski C, Gertler R, Hartel M, Friess H, Kleeff J. Creation of a reference center for pancreatic surgery by team relocation - Is surgical expertise transferable? 9th congress of the EHPBA, 12-16 April 2011 Cape Town, South Africa.

36. Reiser-Erkan C, Erkan M, Fingerle A, Gaa J, Michalski C, Friess H, Kleeff J. Prognostic molecular imaging in pancreatic cancer through analysis of the stromal activity. 9th congress of the EHPBA, 12-16 April 2011 Cape Town, South Africa.

37. Reiser-Erkan C, Erkan M, Samkharadze T, Demir E, Michalski C, Friess H, Kleeff J. Pigment Epithelium-Derived Factor Increases Neuropathy and Fibrosis in Pancreatic Cancer. 9th congress of the EHPBA, 12-16 April 2011 Cape Town, South Africa.

38. Michalski CW, Rieder S, Erkan M, Friess H, Kleeff J. TRIF-Dependent Type I IFN Induction Constrains Inflammatory Injury in Murine Acute Pancreatitis. 9th congress of the EHPBA, 12-16 April 2011 Cape Town, South Africa.

39. B. Kong, C. W. Michalski, W. Wu, C. Tosolini, N. Valkovska, M. Erkan, H. Friess and J. Kleeff. HNF1A-mediated MIA2 Expression Regulates Metabolism of Pancreatic Cancer and Affects Response to Chemotherapy. 42nd Annual Meeting of the American Pancreatic Association, APA, 2.-5. November 2011, Chicago, USA.

40. D Sauliunaite, M Erkan, A Herner, C Reiser-Erkan, T Miethke, CW Michalski, H Friess, J Kleeff. Proposal of a Step-Down Approach for the Antibiotic Therapy in Preoperatively Stented Patients with Distal Bile Duct Obstruction. 42nd Annual Meeting of the American Pancreatic Association, APA 2010, 2.-5. November 2011, Chicago, USA.

41. M Erkan, J Kleeff, H Friess, M Apte, M Bachem. Pancreatic Star Alliance: After the First Meeting, Future Challenges. 42nd Annual Meeting of the American Pancreatic Association, APA 2010, 2.-5. November 2011, Chicago, USA.

42. C. W. Michalski, S. Kloe, M. Erkan, H. Friess, J. Kleeff. Resection of Pancreatic Cancer invading the Portal Vein – a Case-Control Study. 42nd Annual Meeting of the American Pancreatic Association, APA 2010, 2.-5. November 2011, Chicago, USA

43. B. Kong, C. W. Michalski, S. Kloe, M. Erkan, H. Friess, J. Kleeff Resection of pancreatic cancer invading the portal vein – a case-control study. 32. Deutscher Pankreasclub, 17.-19. November 2011, Marburg, Germany

44. S. Hausmann, I. Regel, C. W. Michalski, M. Erkan, H. Friess, J. Kleeff. Analysis of the extracellular matrix protein periostin in early pancreatic carcinogenesis. Annual Meeting of the European Pancreatic Club, 26-29 June 2013, Zurich, Switzerland.

45. B. Kong, W. Wu, T Cheng, AM Schlitter, P Bruns, C Jager, I Regel, S Raulefs, N Behler, M Irmler, J Beckers, M Erkan, FJ Theis, I Esposito, J Kleeff, CW Michalski. Identification and Characterization of an Aldh1a3-Positive Subtype of Pancreatic Ductal Adenocarcinoma Mediated by Oncogenic Krasg12d/Erk-Mtor Axis. 44th Annual Meeting of the American Pancreatic Association, APA 30 October.-2. November 2013, Miami, USA.

46. B Kong, N Behler, P Bruns, AM Schlitter, N Valkovska, S Fritzsche, S Raulefs, I Regel, M Erkan, FJ Theis, I Esposito, J Kleeff, CW Michalski. Pancreatic Progenitor Expansion, Mesenchymal Cell Proliferation and Inflammation are Required During Early Carcinogenesis. 44th Annual Meeting of the American Pancreatic Association, APA 30 October.-2. November 2013, Miami, USA.

47. CW Michalski, C Jager, B Kong, H Friess, M Erkan, J Kleeff. A Plea for Biological Resectability Criteria in Surgery of Locally Advanced Pancreatic Cancer. 44th Annual Meeting of the American Pancreatic Association, APA 30 October.-2. November 2013, Miami, USA.

48. İbrahim Büdeyri, Sencer Göklemez, Zheng Pan, Simone Hausmann, Christoph W. Michalski , Nathalia A. Giese3, Helmut Friess, Jörg Kleeff, Mert Erkan. Yüksek periostin ekspresyonu pankreatik duktal adenokarsinomda bağımsız bir iyi prognostik belirteçtir. 12. Hepatopankreatobilier Cerrahi Kongresi. 1-4 Nisan 2015, Antalya, Türkiye. En iyi sunum ödülü.

49. Sencer Göklemez, İbrahim Budeyri, Simone Hausmann, Christoph W. Michalski, Nathalia A. Giese, Helmut Friess, Jörg Kleeff, Mert Erkan. Pankreas Duktal Adenokarsinomu’nda Proapoptotik BNIP3L’nin Hipoksi ve p53’e Bağlı İndüksiyonu Kötü Prognozla İlişkilidir. 12. Hepatopankreatobilier Cerrahi Kongresi. 1-4 Nisan 2015, Antalya, Türkiye.

50. İbrahim Büdeyri, Sencer Göklemez, Zheng Pan, Simone Hausmann, Christoph W. Michalski , Nathalia A. Giese3, Helmut Friess, Jörg Kleeff, Mert Erkan. High periostin expression is an independent positive prognostic factor in pancreatic ductal adenocarcinoma. 11th International Congress of the European-African Hepato-Pancreato-Biliary Association. Manchester Central. Tuesday 21st to Friday 24th April. Manchester, UK.

51. Sencer Göklemez, İbrahim Budeyri, Simone Hausmann, Christoph W. Michalski, Nathalia A. Giese, Helmut Friess, Jörg Kleeff, Mert Erkan. BNIP3L expression is induced by hypoxia and p53 and is associated with worsened prognosis in Pancreatic Ductal Adenocarcinoma. 11th International Congress of the European-African Hepato-Pancreato-Biliary Association. Manchester Central. Tuesday 21st to Friday 24th April. Manchester, UK.

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