ANDREW P - Duke University



Andrew Paul Landstrom, MD, PHD, FAAP, FAHA, FHRS

PERSONAL INFORMATION

Place of Birth: Denver, Colorado

Citizenship: United States

Mailing Address: Duke University Medical Center, Box 2652, Durham, NC 27710

Office Phone: (919) 684-3028

Office Fax: (919) 385-9329‬

Email Address: andrew.landstrom@duke.edu

ORCiD ID: 2-1878-9631

PRESENT ACADEMIC RANK AND POSITION

2019 – Pres Assistant Professor, Department of Cell Biology, Duke University School of Medicine

2018 – Pres Assistant Professor, Department of Pediatrics, Division of Cardiology, Duke University School of Medicine

OTHER CURRENT APPOINTMENTS/AFFILIATIONS

2019 – Pres Faculty Member, Duke University Program in Genetics and Genomics

2019 – Pres Faculty Member, Duke University Program in Cell and Molecular Biology

2019 – Pres Faculty Member, Duke Children’s Health and Discovery Initiative, Duke University School of Medicine

2018 – Pres Faculty Member, Duke MEDx, Duke University School of Medicine and Duke Pratt School of Engineering

2018 – Pres Faculty Member, Duke Cardiovascular Research Center, Duke University School of Medicine

PREVIOUS ACADEMIC APPOINTMENTS/AFFILIATIONS

2017 – 2018 Faculty Member, Translational Biology and Molecular Medicine, Baylor College of Medicine Graduate School, Houston, Texas

2017 – 2018 Assistant Professor, Department of Pediatrics, Section of Cardiology, Baylor College of Medicine, Houston, Texas

2014 – 2017 Instructor, Department of Pediatrics, Baylor College of Medicine, Houston, Texas

EDUCATION/TRAINING

2017 – 2018 Advanced Clinical Fellowship in Pediatric Electrophysiology, Department of Pediatrics, Section of Cardiology, Baylor College of Medicine, Houston, Texas

2014 – 2017 Post-Doctoral Research Fellowship, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas. Mentor: Xander H. T. Wehrens, M.D., Ph.D., Juanita P. Quigley Endowed Chair in Cardiology and Professor in the Departments of Molecular Physiology, Biophysics, and Medicine; Director of Cardiovascular Research Institute

2014 – 2017 Clinical Fellowship in Pediatric Cardiology, Department of Pediatrics, Section of Cardiology, Baylor College of Medicine, Houston, Texas

2013 – 2014 Residency in Pediatrics, Department of Pediatrics, Baylor College of Medicine, Houston, Texas

2012 – 2013 Internship in Pediatrics, Department of Pediatrics, Baylor College of Medicine, Houston, Texas

2004 – 2012 Graduate School, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota. Mentor: Michael J. Ackerman, M.D., Ph.D., Windland Smith Rice Cardiovascular Genomics Research Professor in the Departments of Medicine, Pediatrics, and Pharmacology

2004 – 2012 Medical School, Mayo Clinic College of Medicine, Rochester, Minnesota

2000 – 2004 Bachelor of Science in Biology with Honors, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Mentor: Vytas A. Bankaitis, Ph.D., Professor, Chair of the Department of Cell and Developmental Biology

MEDICAL LICENSURE

2018 – Pres State of North Carolina

2014 – 2018 State of Texas

BOARD CERTIFICATIONS

2018 – Pres American Board of Pediatrics – Pediatric Cardiology

2015 – Pres American Board of Pediatrics – Pediatrics

PROFESSIONAL AFFILIATIONS

2018 – Pres Southeastern Pediatric Cardiovascular Society

2018 – Pres North Carolina Pediatric Society

2018 – Pres American Society of Human Genetics

2017 – Pres American Pediatric Society/Society for Pediatric Research

2017 – Pres American Association for the Advancement of Science

2017 – Pres Pediatric and Congenital Electrophysiology Society

2017 – Pres Sudden Arrhythmia Death Syndrome Foundation

2016 – Pres Heart Rhythm Society

2013 – Pres American Heart Association

2012 – Pres American Academy of Pediatrics

INSTITUTIONAL POSITIONS

2020 – Pres Associate Director, Duke Pediatric Research Scholars Program for Physician-Scientist Development

2020 – Pres Duke Site PI, North Carolina Congenital Heart Disease STAR Network, Centers for Disease Control and Prevention

2020 – Pres Advanced Clinical Training Curriculum Development Committee, Duke University School of Medicine Medical School

2020 – Pres Research Advisory Committee, Department of Pediatrics, Duke University School of Medicine

2019 – Pres Clinical Competency Committee, Duke University Pediatric Cardiology Fellowship Program

2019 – Pres Track Leader, Candidate Selection/Mentoring/Program Implementation Track, Unified Program for Therapeutics in Children (UPTiC), Duke/University of North Carolina Joint Pediatrics Departments

2019 – Pres Track Leader, Discovery Research Track, Unified Program for Therapeutics in Children (UPTiC), Duke/University of North Carolina Joint Pediatrics Departments

2019 – Pres Research Mentor, Human Genetics and Genomics Study Program, Duke University School of Medicine Medical School

2019 – Pres Research Mentor, Cardiovascular Study Program, Duke University School of Medicine Medical School

2019 – Pres Physician Ambassador, Duke Children’s Hospital

2018 – Pres Leadership Committee, Project ADAM North Carolina Affiliate

2018 – Pres Curriculum Committee, Duke University School of Medicine Medical School

2018 – Pres Research Committee, Duke Pediatric and Congenital Heart Center, Duke Children’s Hospital

2018 – Pres Research Mentor, Duke Clinical & Translational Science Institute, BIGGER Program

2018 – Pres Duke Academy for Health Professions Education and Academic Development (AHEAD)

2018 – Pres Admissions Committee, Duke University Medical Scientist Training Program

2018 – Pres Admissions Committee, Duke University School of Medicine Medical School

2018 – Pres Program Evaluation Committee, Duke University Pediatric Cardiology Fellowship Program

2018 – Pres Super Mentor, Duke Pediatric Research Scholars Program for Physician-Scientist Development

EXTRAMURAL POSITIONS

2020 – Pres Founding Member, STRIPE (Standardizing Laboratory Practices in Pharmacogenomics) Collaborative Community

2020 – Pres Leadership Committee, Council on Genomic and Precision Medicine, American Heart Association

2020 – Pres Early Career and Mentoring Committee, Council on Lifelong Congenital Heart Disease and Heart Health in the Young, American Heart Association

2020 – Pres Rare Disease Project Group, Inter-Society Coordinating Committee for Practitioner Education in Genomics, NHGRI, NIH

2020 – Pres Inter-Society Coordinating Committee for Practitioner Education in Genomics, NHGRI, NIH. American Heart Association Representative

2019 Developing a Multidisciplinary Collaborative Translational Research Agenda for Returning the Results of Genome Sequencing in Biobank and Learning Health Systems Workshop. NHLBI, NIH

2019 – Pres Professional Practice & Social Implications Committee, American Society for Human Genetics

2019 – Pres Research Committee, Pediatric and Congenital Electrophysiology Society

2019 – Pres Emerging Leaders, Pediatric and Congenital Electrophysiology Society

2019 – Pres Chair, Cardiovascular Genetics Certification Working Group, American Heart Association

2018 – Pres Membership Committee, Council on Genomic and Precision Medicine, American Heart Association

2016 – Pres Early Career Committee, Council on Genomic and Precision Medicine, American Heart Association (Vice Chair from 2020 – Pres)

2015 – Pres Early Career Workgroup, Section on Cardiology and Cardiothoracic Surgery, American Academy of Pediatrics

2014 – 2015 Council on Science and Public Health, Texas Medical Association

2013 – 2015 Committee on Medical Education, Texas Pediatric Society

2013 – 2015 Committee on Child Abuse and Neglect, Texas Pediatric Society

2009 – 2012 Editorial Board, Mayo Alumni Magazine

2009 – 2012 Board of Directors, Minnesota Medical Association Political Action Committee

2007 – 2009 Board of Directors and Executive Committee, Mayo Clinic Alumni Association

2007 – 2008 Vice Chair, Committee on Legislation and Advocacy, American Medical Association-Medical Student Section

2007 – 2008 Chair, Committee on Legislation and Advocacy Subcommittee on Political Education, American Medical Association-Medical Student Section

2006 – 2007 Chair, Committee on Legislation and Advocacy Subcommittee on Medical Education, American Medical Association-Medical Student Section

2006 – 2007 Chair, Minnesota Medical Association-Medical Student Section

2005 – 2010 Delegate, Minnesota Medical Association Southeastern District

2005 – 2006 Delegate, Mayo Medical School Chapter, American Medical Association-Medical Student Section

2005 – 2006 Chair, Committee on Legislation and Advocacy Subcommittee on Student Debt, American Medical Association-Medical Student Section

2005 – 2009 Committee on Legislation, Zumbro Valley Medical Society

2005 – 2006 Committee on Communications, Minnesota Medical Association

2004 – 2010 Delegate, Minnesota Medical Association Medical Student Governing Council

COMMUNITY INVOLVEMENT

2020 – Pres Parks and Recreation Council, Orange County, North Carolina

2020 – Pres Board of Equalization and Review, Orange County, North Carolina

2019 – Pres Parks and Recreation Advisory Board, Town of Hillsborough, North Carolina

HONORS & AWARDS

2020 Fellow of the Heart Rhythm Society

2019 Fellow of the Society for Pediatric Research

2019 Fellow of the American Heart Association

2018 Young Investigator Award, American Heart Association Council on Cardiovascular Disease in the Young

2017 Dan G. McNamara Fellow of the Year Award, Section of Cardiology, Department of Pediatrics

2017 Best Poster Award, Baylor College of Medicine 6th Annual Cardiovascular Research Institute Symposium

2017 Travel Award, Heart Rhythm Society Scientific Sessions 2017

2016 Top Abstract Award, Baylor College of Medicine 5th Annual Cardiovascular Research Institute Symposium

2015 Travel Award, Council on Cardiovascular Disease in the Young American Heart Association Society Scientific Sessions 2015

2015 Manohar Sai Gowda Memorial Young Investigator Cardiovascular Research Award Finalist, Kansas City Heart Rhythm Society

2015 Outstanding Fellow in Pediatrics, Baylor College of Medicine

2014 Jan Goddard-Finegold Award in Developmental Pediatrics, Baylor College of Medicine

2014 Adam Cohen Professionalism Award, Baylor College of Medicine

2014 Distinguished Educator Award, Baylor College of Medicine Department of Pediatrics

2014 Reba Michel Hill Pediatric Research Award

2013 Gold Humanism in Medicine Honor Society Inductee

2008 Student Leadership Award, Minnesota Medical Association

2008 Distinguished Service Award, American Medical Association Medical Student Section

2007 Travel Award, Central Society of Clinical Research

2006 Special Recognition Award, Zumbro Valley Medical Society

2006 American Society of Hematology Research Trainee Award

2005 Bonner Foundation Medical Scientist Training Program Scholar Award

2004 Lewis-Gale Foundation Scholar Award

2004 Edward Kidder Graham Award for Leadership and Service, University of North Carolina at Chapel Hill

2004 J. N. Couch Award for Excellence in Research, University of North Carolina at Chapel Hill

2004 Travel Award, University of North Carolina at Chapel Hill Office of Undergraduate Research

2004 Circle K President of the Year Award, Kiwanis International

2003 Award for Excellence in Undergraduate Research, Pfizer Global Research & Development

IMPACT OF PUBLICATIONS Scopus

Total citations 1846

h-index 19

PEER-REVIEWED PUBLICATIONS

47) Moore JP, Gallotti RG, Shannon KM, Bos JM, Sadeghi E, Strasburger J, Wakai RT, Horigome H, Clur SA, Hill AC, Shah MJ, Behere S, Sarquella-Brugada G, Czosek R, Etheride SP, Fischbach P, Kannakeril P, Motonaga K, Landstrom AP, Williams M, Patel A, Degradi F, Schwartz PJ, Tan RB, Stephenson E, Krishna MR, Miyake CY, Lee ME, Sanatani S, Balaji S, Young ML, Sidiqui S, Shivkumar K, Ackerman MJ. Genotype Predicts Outcomes in Fetuses and Neonates with Severe Congenital Long QT Syndrome. JACC Clin Electrophysiol. 2020 In Press.

46) Landstrom AP, Shah SH. Rare Things Being Common:  Implications for Common Variants in Rare Diseases Like Long QT Syndrome. Circulation. 2020 In Press.

45) Tadros HJ, Life CS, Garcia G, Pirozzi E, Jones EG, Datta S, Parvatiyar MS, Chase PB, Allen HD, Kim JJ, Pinto JR, Landstrom AP. Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hotspots that are associated with worse clinical outcomes. J Mol Cell Cardiol. 2020 Apr 9;142:118-125. PMID: 32278834

44) Levine AT, Born HA, Landstrom AP, Larson S, Lee WL, Dao AT, Wehrens XH, Lai YC, Anderson AE. Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus. Sci Rep. 2020 Mar 4;10(1):4043. PMID: 32132552

43) Ezekian JE, Clippinger SR, Garcia JM, Yanq Q, Denfield S, Jeewa A, Dreyer WJ, Zou W, Fan Y, Allen HD, Kim JJ, Greenberg MJ, Landstrom AP. The variant R94C in TNNT2-encoded troponin T predisposes to pediatric restrictive cardiomyopathy and sudden death through impaired thin filament relaxation resulting in myocardial diastolic dysfunction. J Am Heart Assoc. 2020 Mar 3;9(5):e015111. PMID: 32098556

42) Roberts JD, Asaki SY, Mazzanti A, Bos JM, Tuleta I, Muir AR, Crotti L, Krahn AD, Kutyifa V, Shoemaker MB, Johnsrude CL, Aiba T, Marcondes L, Baban A, Udupa S, Dechert B, Fischbach P, Knight LM, Vittinghoff E, Kukavica D, Stallmeyer B, Giudicessi JR, Spazzolini C, Shimamoto K, Tadros R, Cadrin-Tourigny J, Duff HJ, Simpson CS, Roston TM, Wijeyeratne YD, El Hajjaji I, Yousif MD, Gula LJ, Leong-Sit P, Chavali N, Landstrom AP, Marcus GM, Dittmann S, Wilde AAM, Behr ER, Tfelt-Hansen J, Scheinman MM, Perez MV, Kaski JP, Gow RM, Drago F, Aziz PF, Abrams DJ, Gollob MH, Skinner JR, Shimizu W, Kaufman ES, Roden DM, Zareba W, Schwartz PJ, Schulze-Bahr E, Etheridge SP, Priori SG, Ackerman MJ. An International Multi-Center Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition. Circulation. 2020 Feb 11;141(6):429-439. PMID: 31941373

41) Howard TS, Valdes SO, Hope KD, Morris SA, Landstrom AP, Schneider AE, Miyake CY, Denfield SW, Pignatelli RH, Wang Y, Kim JJ. Association of Wolff-Parkinson-White with left ventricular noncompaction cardiomyopathy in children. J Card Fail. 2019 Dec;25(12):1004-1008. PMID: 31626950

40) Jones EG, Mazaheri N, Maroofian R, Zamani M, Seifi T, Sedaghat A, Shariati G, Jamshidi Y, Allen HD, Wehrens XHT, Galehdari H, Landstrom AP. Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy. Sci Rep. 2019 June 21;9(1):9038. PMID: 31227780.

39) Headrick AT, Rosenfeld JA, Yang Y, Tunuguntla H, Allen HD, Penny DJ, Kim JJ, Landstrom AP. Incidentally identified genetic variants in arrhythmogenic right ventricular cardiomyopathy-associated genes among children undergoing exome sequencing reflect healthy population variation. Mol Genet Genom Med. 2019 Jun; 7(6):e593. PMID: 30985088.

38) Jones EG, Landstrom AP. Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation. J Vis Exp. 2019 Jan 16;(143), e58907. PMID: 30735170.

37) Connell PS, Jeewa A, Kearney DL, Denfield SW, Allen HD, Tunuguntla H, Landstrom AP. A 14-year-old in heart failure with multiple cardiomyopathy variants illustrates a role for signal-to-noise analysis in gene test re-interpretation. Clin Case Rep. 2018 Dec 14;7(1):211-217. PMID: 30656044.

36) Dailey-Schwartz AL, Tadros HJ, Azamian MS, Lalani S, Morris SA, Allen HD, Kim JJ, Landstrom AP. Copy number variants of undetermined significance are not associated with worse clinical outcomes in hypoplastic left heart syndrome. J Peds. 2018 Nov;202:206-211. PMID: 30172441.

35) Valdes SO, Landstrom AP, Schneider AE, Miyake CY, de la Uz CM, Kim JJ. Intravenous sotalol for the management of post-operative junctional ectopic tachycardia. HeartRhythm Case Rep. 2018 May 30;4(8):375-77. PMID: 30116712

34) Valdes SO, Miyake CY, Niu MC, de la Uz CM, Asaki SY, Landstrom AP, Schneider AE, Rusin CG, Patel R, Lam WW, Kim JJ. Early experience with intravenous sotalol in children with and without congenital heart disease. Heart Rhythm.  2018 Dec;15(12):1862-1869. PMID: 30003959.

33) Landstrom AP, Fernandez E, Rosenfeld JA, Yang Y, Dailey-Schwartz AL, Miyake CY, Allen HD, Penny DJ, Kim JJ. Amino acid-level signal-to-noise analysis of incidentally identified variants in genes associated with long QT syndrome during pediatric whole exome sequencing reflects background genetic noise. Heart Rhythm. 2018 July;15(7):1042-50. PMID: 29501670. (Corresponding Author)

32) Hildebrandt MAT, Reyes M, Wu X, Pu X, Thompson KA, Ma J, Landstrom AP, Morrison AC, Ater J. Hypertension susceptibility loci are predictors of anthracycline-related cardiotoxicity in long-term childhood cancer survivors. Sci Rep. 2017 Aug 29;7(1):9698. PMID: 28851949.

31) Landstrom AP, Dobrev D, Wehrens XHT. Calcium signaling and cardiac arrhythmias. Circ Res. 2017 June 9;120(12):1969-93. PMID: 28596175.

30) Veltri T, Landim-Vieira M, Parvatiyar MS, Gonzelez-Martinez D, Jones KD, Michell CA, Dweck D, Landstrom AP, Chase PB, Pinto JR. Hypertrophic cardiomyopathy cardiac troponin C mutations differentially affect slow skeletal and cardiac muscle regulation. Front Physiol. 2017 Apr 20;8:221. PMID: 28473771.

29) Landstrom AP, Dailey-Schwartz AL, Rosenfeld JA, Yang Y, McLean MJ, Miyake CY, Valdes SO, Allen HD, Penny DJ, Kim JJ. Interpreting incidentally identified variants in genes associated with catecholaminergic polymorphic ventricular tachycardia in a large cohort of clinical whole exome genetic test referrals. Circ Arrhythm Electrophysiol. 2017 Apr;10(4):e004742. PMID: 28404607 (Co-Corresponding Author, selected for Circ Arrhythm Electrophysiol “Year in Review in Cardiac Electrophysiology”)

28) Quick AP, Landstrom AP, Wang Q, Beavers DL, Reynolds JO, Barreto-Torres G, Tran V, Showell J, Philippen LE, Morris SA, Skapura D, Bos JM, Pedersen SE, Pautler RG, Ackerman MJ, Wehrens XHT. Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction. JACC Basic Transl Sci. 2017 Feb;2(1):56-67. PMID: 28393127

27) Landstrom AP, Boczek NJ, Ye D, Miyake CY, De la Uz CM, Allen HD, Ackerman MJ, Kim JJ. Novel long QT syndrome-associated missense mutation, L762F, in CACNA1C-encoded L-type calcium channel imparts a slower inactivation tau and increased sustained and window current. Int J Cardiol. 2016 Oct 1;220:290-8. PMID: 27390944

26) Quick AP, Landstrom AP, Wehrens XHT. Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling. Heart Rhythm. 2016 Mar;13(3):753-4. PMID: 26598319

25) Landstrom AP, Sun JJ, Ray RS, Wehrens XHT. It’s not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias. Heart Rhythm. 2015 Nov;12(11):2294-5. PMID: 26164374

24) Wang W, Landstrom AP, Wang Q, Munro ML, Beavers D, Ackerman MJ, Soeller C, Wehrens, XHT. Reduced junctional sodium/calcium exchanger activity contributes to sarcoplasmic reticulum calcium leak in junctophilin 2-deficient mice. 2014. Am J Physiol Heart Circ Physiol. 2014 Nov 1;307(9):H1317-26. PMID: 25193470

23) Beavers DL, Landstrom AP, Chiang DY, Wehrens XHT. Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases. Cardiovasc Res. 2014 Jul 15;103(2): 198-205. PMID: 24935431

22) Landstrom AP, Beavers DL, Wehrens XHT. The Junctophilin Family of Proteins: From Bench to Bedside. Trends Mol Med. 2014 Jun;20(6):353-362. PMID: 24636942

21) Kapplinger JD, Landstrom AP, Bos JM, Salisbury BA, Callis TE, Ackerman MJ. Distinguishing Hypertrophic Cardiomyopathy-Associated Mutations from Background Genetic Noise. J Cardiovasc Transl Res. 2014 Apr;7(3):347-61. PMID: 24510615. (Co-equal first author)

20) Beavers DL, Wang W, Ather S, Voigt N, Garbino A, Dixit SS, Landstrom AP, Li N, Wang Q, Olivotto I, Dobrev D, Ackerman MJ, Wehrens XHT. Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization. J Am Coll Cardiol. 2013 Nov 19;62(21):2010-19. PMID: 23973696

19) Reynolds J, Chiang DY, Wang W, Beavers DL, Dixit S, Skapura DG, Landstrom AP, Song LS, Ackerman MD, Wehrens XHT. Junctophilin-2 is necessary for T-tubule formation during mouse heart development. 2013. Cardiovasc Res. 2013 Oct 1;100(1):44-53. PMID: 23715556. (A “Most Cited Article Award” recipient)

18) Parvatiyar MS, Landstrom AP, Figueiredo-Freitas C, Potter JD, Ackerman MJ, Pinto JR. A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation. J Biol Chem. 2012 Sep 14;287(38):31845-55. PMID: 22815480. (Co-equal first author)

17) Landstrom AP, Ackerman MJ. Beyond the Cardiac Myofilament: Hypertrophic Cardiomyopathy-Associated Mutations in Genes that Encode Calcium-Handling Proteins. Curr Mol Med. 2012 Jun;12(5):507-18. PMID: 22515980

16) Landstrom AP, Ackerman MJ. The Achilles' Heel of Cardiovascular Genetic Testing: Distinguishing Pathogenic Mutations from Background Genetic Noise. Clin Pharmacol Ther. 2011 Oct;90(4):496-99. PMID: 21934721

15) Kapplinger JD, Landstrom AP, Salisbury BA, Callis TH, Pollevick GD, Tester DJ, Cox MGPJ, Bhuiyan Z, Bikker H, Wiesfeld ACP, Hauer RNW, van Tintelen JP, Jongbloed JDH, Calkins H, Wilde AAM, Ackerman MJ. Distinguishing Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia-Associated Mutations from Background Genetic Noise. J Am Coll Cardiol. 2011 Jun 7;57(23): 2317-27. PMID: 21636032. (Co-equal first author)

14) Waddell LB, Lemckert FA, Zheng XF, Tran J, Evesson FJ, Hawkes JM, Lek A, Street NE, Lin P, Clarke NF, Landstrom AP, Ackerman MJ, Weisleder N, Ma J, North KN, Cooper ST. Dysferlin, Annexin A1, and Mitsugumin 53 Are Upregulated in Muscular Dystrophy and Localize to Longitudinal Tubules of the T-System with Stretch. J Neuropathol Exp Neurol. 2011 Apr;70(4):302-13. PMID: 21412170

13) van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC, Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XHT. Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors Following Acute Junctophilin Knockdown in Mice. Circulation. 2011 Mar 8; 123(9):979-88. PMID: 21339484

12) Landstrom AP, Kellen CA, Dixit SS, van Oort RJ, Garbino A, Weisleder N, Ma J, Wehrens XHT, Ackerman MJ. Junctophilin-2 expression silencing causes cardiomyocyte hypertrophy and abnormal intracellular calcium handling. Circ Heart Fail. 2011 Mar;4(2):214-23. PMID: 21216834

11) Landstrom AP, Adekola BA, Bos JM, Ommen SR, Ackerman MJ. PLN-encoded Phospholamban Mutation in a Large Cohort of Hypertrophic Cardiomyopathy Cases: Summary of the Literature and Implications for Genetic Testing. Am Heart J. 2011 Jan;161(1):165-71. PMID: 21167350

10) Landstrom AP, Ackerman MJ. Mutation Type is Not Clinically Useful in Predicting Prognosis in Hypertrophic Cardiomyopathy. Circulation. 2010 Dec 7;122(23):2441-50. PMID: 21135372

9) Landstrom AP, Ackerman MJ. GWAS or Gee Whiz, PSAS or Pshaw: Elucidating the Biologic and Clinical Significance of Genetic Variation in Cardiovascular Disease. Heart Rhythm. 2009 Dec;6(12):1751-3. PMID: 19959124

8) Garbino A, van Oort RJ, Dixit SS, Landstrom AP, Ackerman MJ, Wehrens XHT. Molecular Evolution of the Junctophilin Gene Family. Physiol Genomics. 2009 May 13;37(3):175-86. PMID: 19318539

7) Landstrom AP, Parvatiyar MS, Pinto JR, Marquardt ML, Bos JM, Tester DJ, Ommen SR, Potter JD, Ackerman MJ. Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C. J Mol Cell Cardiol. 2008 Aug;45(2):281-8. PMID: 18572189

6) Ackerman MJ, Landstrom AP. Detection of Subclinical Fabry Disease in Patients Presenting with Hypertrophic Cardiomyopathy. J Am Coll Cardiol. 2007 Dec 18;50(25):2404-5. PMID: 18154966

5) Pandit B, Sarkozy A, Pennacchio LA, Carta C, Oishi K, Martinelli S, Pogna EA, Schackwitz W, Ustaszewska A, Martin J, Bristow J, Landstrom A, Bos JM, Ommen SR, Lepri F, Esposito G, Siguero JPL, Tenconi R, Selicorni A, Rossi C, Mazzanti L, Marino B, Digilio MC, Zampino G, Ackerman MJ, Dallapiccola B, Tartaglia M, Gelb BD. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nat Genet. 2007 Aug, 39(8):1007-12. PMID: 17603483

4) Landstrom AP, Weisleder N, Batalden KB, Bos JM, Tester DJ, Ommen SR, Wehrens XHT, Claycomb WC, Ko JK, Hwang M, Pan Z, Ma J, Ackerman MJ. Mutations in JPH2-Encoded Junctophilin-2 associated with hypertrophic cardiomyopathy in humans. J Mol Cell Cardiol. 2007 Jun;42(6):1026-35. PMID: 17509612

3) Landstrom AP, Ketterling RP, Dewald GW, Knudson RA, Tefferi A. Philadelphia chromosome mosaicism at diagnosis in chronic myeloid leukemia: Clinical correlates and effect on imatinib mesylate treatment outcome. Leuk Lymphoma. 2007 Nov;48(11):2137-40. PMID: 17926177

2) Landstrom AP, Ketterling RP, Knudson RA, Tefferi A. Utility of peripheral blood dual color, double fusion fluorescent in situ hybridization for BCR/ABL fusion to assess cytogenetic remission status in chronic myeloid leukemia. Leuk Lymphoma. 2006 Oct;47(10):2055-61. PMID: 17071476

1) Landstrom AP, Tefferi A. Fluorescent in situ hybridization in the diagnosis, prognosis, and treatment monitoring of chronic myeloid leukemia. Leuk Lymphoma. 2006 Mar;47(3):397-402. PMID: 1639676

BOOK CHAPTERS

1) Landstrom AP, Tester DJ, Ackerman MJ. Chapter: Role of Genetic Testing in Athletes in Sports Cardiology Essentials: Evaluation, Management and Case Studies. Springer Publishing. New York, New York, 2011.

ABSTRACTS

36) Ezekian JE, Draelos R, Zhuang F, Zhang Z, Manivannan PK, Eisner W, Henao R, Landstrom AP. Predicting pathogenicity of long QT syndrome-associated variants of uncertain significance using a functionally-validated machine-learning platform. Heart Rhythm Society Scientific Sessions 2020.

35) Ogbonna C, Moya-Mendez M, Prange L, McLean M, Ezekian JE, Mikati MA, Landstrom AP. Understanding the cardiac phenotype of patients with alternating hemiplegia of childhood. Abstract. Pediatric Academic Societies Meeting 2020.

34) Manivannan PK, Gong D, Chi X, Allen HD, Kim JJ, Landstrom AP. Sudden cardiac death-associated RYR2 variants localize to structural regions of ion gating and conductance compared to population and incidentally-identified variants. Abstract. American Heart Association Scientific Sessions 2019.

33) Ezekian JE, Clippinger SR, Garcia JM, Denfield S, Jeewa A, Dreyer WJ, Fan Y, Allen HD, Kim JJ, Greenberg MJ, Landstrom AP. The mutation R94C in TNNT2-encoded troponin T predisposes to restrictive cardiomyopathy and pediatric sudden death through impaired thin filament relaxation resulting in myocardial diastolic dysfunction. Abstract. American Heart Association Scientific Sessions 2019.

32) Cain N, Saul JPP, Gongwer R, Bulic A, Czosek RJ, DeWitt ES, Hill A, Janson C, Kaltman J, Kim JJ, Landstrom AP, LaPage MJ, Niu M, Silver ES, Singh AK, Thacker D, Trachtenberg F, Whitehiill R, Newburger JW. Is Norwood shunt type predictive of ventricular arrhythmias? Abstract. American Heart Association Scientific Sessions 2019.

31) Souder BM, Connel PS, Lovin JJ, Rosenfeld JA, Tunuguntla H, Allen HD, Denfield SW, Kim JJ, Landstrom AP. Incidentally identified variants in TTN-encoded titin found in children undergoing whole exome sequencing and association with cardiomyopathy. American Academy of Pediatrics National Conference & Exhibition 2019.

30) Landstrom AP, Tadros HJ, Sun B, Suh JH, Alsina K, Cao S, Reynolds JO, van der Sangen N, Li F, Kim JJ, Wehrens XHT. Loss of junctophilin 2 expression in cardiac nodal tissue results in junctional ectopic tachycardia. Abstract. American Heart Association Scientific Sessions 2018.

29) Tadros HJ, Life CS, Garcia G, Gong D, Parvatiyar MS, Allen HD, Kim JJ, Yan N, Pinto JR, Landstrom AP. Deletions and Loss of Function Mutations in PRDM16 are Associated with Pediatric Cardiomyopathy. Abstract. American Heart Association Scientific Sessions 2018.

28) Connell PS, Souder BM, Lovin JJ, Rosenfeld JA, Tunuguntla H, Allen HD, Denfield SW, Kim JJ, Landstrom AP. Incidentally Identified Variants in TTN-Encoded Cardiac Titin in Patients without Suspicion for Cardiomyopathy. Abstract. American Heart Association Scientific Sessions 2018.

27) Birjiniuk A, Rosenfeld JA, Yang Y, Tunuguntla H, Allen HD, Penny DJ, Kim JJ, Scott D, Landstrom AP. Deletions and Loss of Function Mutations in PRDM16 are Associated with Pediatric Cardiomyopathy. Abstract. American Heart Association Scientific Sessions 2018.

26) Landstrom AP, Gong D, Dailey-Schwartz AL, Allen HD, Kim JJ, Yan N. High-resolution spatial modeling of population-based and disease-associated ryanodine receptor type 2 genetic variants demonstrate pathologic variant clustering in pore-forming domains. Abstract. Heart Rhythm Society Scientific Sessions 2018.

25) Headrick A, Rosenfeld JA, Yang Y, Tunuguntla H, Allen HD, Penny DJ, Kim JJ, Landstrom AP. Incidentally Identified Variants in Genes Associated with Arrhythmogenic Right Ventricular Cardiomyopathy Do Not Represent Pathologic Biomarkers. Abstract. Heart Rhythm Society Scientific Sessions 2018.

24) Howard TS, Valdes SO, Hope KD, Landstrom AP, Schneider AE, Miyake CY, de la Uz CM, Kim JJ. Wolff Parkinson White Syndrome associated with left ventricular non-compaction: Population description, electrophysiological characteristics and ablation. Abstract. Heart Rhythm Society Scientific Sessions 2018.

23) Tunuguntla H, Landstrom AP, Kearney DL, Gates C, Choudhry S, Cabrera AG, Price JF, Adachi I, Dreyer WJ, Denfield SW. Arrhythmogenic Cardiomyopathy: Children don’t always follow the rules! Abstract. International Society of Heart and Lung Transplantation Scientific Sessions 2018.

22) Jones EG, Rosenfeld JA, Yang Y, Tunuguntla H, Allen HD, Penny DJ, Kim JJ, Landstrom AP. Diagnostic significance of incidentally identified variants in genes associated with hypertrophic cardiomyopathy among whole exome genetic test referrals. Abstract. American Heart Association Scientific Sessions 2017.

21) Dailey-Schwartz AL, Sababi M, Lalani S, Morris SA, Allen HD, Penny DJ, Kim JJ, Landstrom AP. Characterization and prognostic significance of chromosomal microarray findings of undetermined significance in hypoplastic left heart syndrome. Abstract. American Heart Association Scientific Sessions 2017.

20) Fernandez E, Dailey Schwartz A, Rosenfeld JA, Yaping Y, Miyake CY, Allen HD, Penny DJ, Kim JJ, Landstrom AP. Incidentally identified variants in genes associated with long QT syndrome among whole exome genetic test referrals. Abstract. Heart Rhythm Society Scientific Sessions 2017.

19) George R, Dailey Schwartz A, Landstrom A, Lara D, Azamian M, Lalani S, D’Alessandro L, Belmont J, Lewis A, Prakash S, Morris SA. Female sex is associated with increased mortality among infants with left-sided congenital heart disease. Abstract. American Academy of Pediatrics Scientific Sessions 2016.

18) Wang G, Ji R, Zou W, Penny D, Fan Y, Landstrom A, Fan R, Li L, Niewiadonski V. Identification of novel TBX5 variations in a cohort of 194 patients with suspected Holt-Oram syndrome. Abstract. American College of Medical Genetics Scientific Sessions 2016.

17) Landstrom AP, Dailey-Schwartz AL, Rosenfeld JA, Yang Y, Allen HD, Penny DJ, Miyake CY, Valdes SO, Kim JJ. Incidentally identified variants in genes associated with catecholaminergic polymorphic ventricular tachycardia in a large cohort of referrals for clinical whole exome genetic testing. Abstract. Heart Rhythm Society Scientific Sessions 2016.

16) Tunuguntla H, Denfield SW, Landstrom AP, Fan Y, Kearney DL, Cabrera AG, Price JF, Dreyer WJ, Jeewa A. The Perfect Storm: Two Forms of Cardiomyopathy Found in a Single Heart. Abstract. International Society of Heart and Lung Transplantation Scientific Sessions 2016.

15) Landstrom AP, Boczek NJ, Ye D, Allen HD, Ackerman MJ, Kim JJ. A novel mutation identified in a large multi-generational family with long QT syndrome reveals distinct, disease-specific mutation hot spots within the CACNA1C-encoded L-type calcium channel. Abstract. American Heart Association Scientific Sessions 2015.

14) Valdivia CR, Landstrom AP, Capes ME, Zhang J, Alvarado FJ, Powers PP, Ackerman MA, Valdivia HH. Common Polymorphism RYR2-Q2958R Increases Spontaneous Calcium Release Under Stress and May be Associated with Increased Risk of Sudden Cardiac Death. Abstract. American Heart Association Scientific Sessions 2015.

13) Ather S, Dixit S, Wang Q, McCauley M, Beavers D, Garbino A, Landstrom A, Olivotto I, Ackerman M, Wehrens XHT. The Junctophilin 2 Missense Mutation, E169K, Promotes Atrial Fibrillation in Mice. Abstract. American Heart Association Scientific Sessions 2011.

12) Wang W, Dixit S, Wang Q, van Oort R, Garbino A, Landstrom A, Ackerman MJ, Wehrens XHT. Dysfunction of Junctional NCX Following JPH2 Knockdown Alters Spatial Properties of Ca2+ Sparks and Contributes to Arrhythmogenesis in Mice. Abstract. American Heart Association Scientific Sessions 2011.

11) Parvatiyar MS, Landstrom AP, Pinto JR, Freitas C, Ackerman MJ, Potter JD. A Novel Mutation in TNNC1-Encoded Cardiac Troponin C Predisposes to Hypertrophic Cardiomyopathy and Recurrent Episodes of Aborted Sudden Cardiac Death. Abstract. Biophysical Society Scientific Sessions 2011.

10) Kapplinger JD, Landstrom AP, Bos JM, Salisbury BM, Callis TE, Ackerman MJ. Spectrum and Prevalence of Genetic Variation in Hypertrophic Cardiomyopathy-Susceptibility Genes Among Ostensibly Healthy Individuals. Abstract. American Heart Association Scientific Sessions 2010.

9) Pabbati CP, Landstrom AP, Bos JM, Girolami F, Olivotto I, Ackerman MJ. QT-interval modulating single nucleotide polymorphisms do not modify repolarization phenotype in hypertrophic cardiomyopathy. Abstract. Heart Rhythm Society Scientific Sessions 2010.

8) Landstrom AP, Garbino A, Wehrens XHT, Weisleder N, Ma J, Ackerman MJ. Cardiac Junctophilin-2 Expression Silencing Results in Cellular Hypertrophy and Isoproterenol-Sensitive Derangements in Calcium-Handling. Abstract. American Heart Association Scientific Sessions 2009

7) Tabatabaei N, Landstrom AP, Theis J, Miller DV, Ackerman MJ. Electron Microscopy of Myectomy Tissue Reveals Genotype-Specific Mitochondrial Phenotypes in Patients with Hypertrophic Cardiomyopathy. Abstract. Heart Rhythm Society Scientific Sessions 2009.

6) Landstrom AP, Benkusky N, Valdivia HH, Ackerman MJ. The Most Common Polymorphism, Q2958R, in the RYR2-Encoded Ryanodine Receptor 2 Increases Luminal Calcium Sensitivity of the Calcium Release Channel Resulting in Increased Channel Opening Probability. Abstract. Heart Rhythm Society Scientific Sessions 2009.

5) Antiel RM, Landstrom AP, Bos JM, Schaff HV, Dearani JA, Ackerman MJ. Transcriptome Profiling of Genetic Subtypes of Hypertrophic Cardiomyopathy Reveals Genotype-Specific Pro-Arrhythmic Cellular Responses. Abstract. Heart Rhythm Society Scientific Sessions 2009.

4) Landstrom AP, Weisleder N, Bos JM, Ma J, Tjondrokoesoemo A, Ommen SR, Olivotto I, Cecchi F, Girolami F, Ospedaliera A, Ackerman MJ. Identification and Characterization of a Novel Mutation in JPH2-Encoded Junctophilin-2 in an Italian Hypertrophic Cardiomyopathy Cohort. American Heart Association Scientific Sessions 2007.

3) Landstrom AP, Parvatiyar MS, Pinto JR, Marquardt ML, Bos JM, Ommen SR, Potter JD, Ackerman MJ. Molecular and Functional Characterization of Novel Hypertrophic Cardiomyopathy Susceptibility Mutations in TNNC1-Encoded Troponin C. Abstract. American Heart Association Scientific Sessions 2007.

2) Will ML, Landstrom AP, Bos JM, Gersh BJ, Ommen SR, Ackerman MJ. Prevalence and spectrum of thin filament mutations in 1025 patients with hypertrophic cardiomyopathy. Abstract. American Heart Association Scientific Sessions 2007.

1) Landstrom AP, Ketterling RP, Dewald GW, Knudson RA, Tefferi A. Philadelphia Chromosome Mosaicism Due to Additional Cytogenetic Abnormalities in Chronic Myeloid Leukemia Might Adversely Affect Prognosis and Response to Imatinib. Abstract. Central Society for Clinical Investigation Annual Meeting 2007.

PRESENTATIONS

Invited Lectures/Grand Rounds/Visiting Professorships

2020 “Using patient-derived stem cells to model disease and identify children at risk for sudden death”. Duke Pediatric Heart Center Grand Grounds, Duke University School of Medicine. Durham, North Carolina (Jun 3)

2020 “Sudden cardiac arrest in children and young adults: A family affair”. 2020 Parent Heart Watch Annual Meeting. Tampa, Florida. (Jan 18)

2020 “Patient-Based Cohorts and Models for Discovery: Pediatric Cardiovascular Genetics and Unexplained Death”. Duke University Interdisciplinary Colloquium on Identification of Noncoding Pathogenic Variants for Rare Disease. Durham, North Carolina. (Jan 15)

2019 “The impact of expansive genetic sequencing in children: Incidental variants in cardiovascular disease-associated genes”. Returning the Results of Genome Sequencing in Biobank and Learning Health Systems Workshop. NHLBI, National Institutes of Health. Bethesda, Maryland. (Dec 16)

2019 “The Next Frontier of Pediatric Cardiology: Molecular Genetic Diagnoses of Children at Risk for Sudden Cardiac Death”. Grand Rounds. Moses Cone Hospital, Cone Health. Greensboro, North Carolina. (Apr 17)

2019 “A Needle in the Haystack: Identifying Children at Risk for Sudden Cardiac Death”. Rare Disease Day. Cary, North Carolina. (Mar 16)

2017 “The Malignant Substrate Underlying Sudden Cardiac Arrest: Growing complexity that challenges advancement of clinical practice and basic science”. Children’s Medical Center. Division of Cardiology, Department of Pediatrics. University of Texas Southwestern. Dallas, Texas. (Jun 14)

2009 “The Impact of the Human Genome on Medicine and Science”. Twin Cities Carolina Alumni Club. Eden Prairie, Minnesota.

RESEARCH FUNDING

Current Research Funding

8) CSDA Landstrom (PI) 09/01/2020-8/31/2023 1.2 Cal

Doris Duke Charitable Foundation $495,000

Title: Targeting Wnt-signaling to prevent sudden death in pediatric arrhythmic cardiomyopathy

Goal: To develop iPSCs from a genotype-negative sudden death as a model for understanding the role of Wnt-signaling in pediatric-onset arrhythmic cardiomyopathy.

7) Bass Connections Dinin (PI), Landstrom (co-I) 07/01/2020 – 06/30/2021 0.0 Cal

Duke University $23,484

Title: Crowdsourced Health: Online Patient Communities Enabling Health Innovation

Goal: To determine strategies for utilizing social media to optimize access to healthcare and engagement in families with long QT syndrome

6) ASI Research Award Landstrom (PI) 03/01/2020 – 02/27/2021 0.0 Cal

American Sudden Infant Death Syndrome Institute $70,000

Title: Cord blood-based biomarker discovery for sudden infant death syndrome risk

Goal: To identify biomarkers present in cord blood plasma from SIDS victims compared to healthy infants

5) CHDI-TDH EDWB Landstrom (PI) 12/01/2019 – 11/30/2020 0.0 Cal

Duke University School of Medicine $100,000

Title: Defining heritability risk in families following a sudden infant death using cord blood

Goal: To utilize allele-specific gene expression to identify non-coding genetic variants among SIDS victims in a pilot feasibility study

4) 5NU50-DD000054 Li (PI), Landstrom (co-I) 09/30/2019 – 09/29/2024 1.2 Cal

CDC $115,000

Title: North Carolina Congenital Heart Defects Surveillance Network

Goal: To target gaps in case ascertainment and the timely delivery of high-quality care and address disparities by race/ethnicity and socio-economic status related to individuals with congenital heart disease

3) TDH CV Grant Landstrom (PI) 09/01/2019-08/31/2020 0.0 Cal

Duke University School of Medicine $100,000

Title: Determining the role of WNT/β-catenin signaling in genetically elusive arrhythmogenic cardiomyopathic disease

Goal: To determine the role of abnormal WNT/β-catenin signaling in the development of arrhythmogenic cardiomyopathy utilizing cardiac myocytes from patient-derived induced pluripotent stem cell.

2) AAP/CCF Research Grant Landstrom (PI) 08/01/2019-01/31/2021 0.12 Cal

American Academy of Pediatrics $50,000

Title: Determining the role of PRDM16 in rapidly progressive pediatric cardiomyopathy

Goal: To determine the role of TGF-beta signaling on divergent forms of cardiomyopathy using a knock-in mouse model of PRDM16 loss and induced pluripotent stem cells.

1) K08-HL136839 Landstrom (PI) 04/04/2017 – 03/31/2022 9.0 Cal

NIH $712,325

Title: The role of junctophilin type 2 in cardiac node automaticity

Goal: To determine the role of JPH2 in calcium dysregulation, molecular, and electrical remodeling of the cardiac pacemaker tissue using a conditional knockdown mouse

Pending Research Funding (under review)

5) R01 Landstrom (PI) 05/01/2021 – 04/31/2026 4.8 Cal

NIH NHLBI $2,240,415

Title: Determining the basis of innate cellular resistance to anthracycline toxicity in Hodgkin lymphoma survivors utilizing patient iPSC-derived cardiac myocytes

Goal: To determine the transcriptional and calcium-mediated drivers of innate resistance to cardiotoxicity following anthracycline exposure in Hodgkin lymphoma adolescent and young adult survivors.

4) PRMRP-DA Landstrom (PI) 11/01/2020 – 10/31/2022 0.54 Cal

DOD $322,000

Title: Establishing whole genome sequencing paired with allele-specific expression analysis in identifying the genetic cause of congenital heart disease 

Goal: To leverage allele-specific expression analysis combined with whole genome sequencing to discover novel genetic causes of CHD and build a genetics-based diagnostic platform.

3) R21 Landstrom (PI) 09/01/2020 – 08/31/2022 0.89 Cal

NIH NICHD $442,750

Title: Establishing cord blood-derived induced pluripotent stem cell models of sudden infant death syndrome

Goal: To establish cord blood-derived iPSCs from SIDS victims as a novel model for exploring mechanisms of infant sudden death

2) R21 Hildebrandt (PI), Landstrom (sub-PI) 09/01/2020 – 08/31/2022 0.6 Cal

NIH NHLBI $182,067

Title: Profiling patient iPSC-cardiomyocytes to link mechanisms of anthracycline-induced cardiotoxicity to clinical endpoints

Goal: To determine the mechanism of anthracycline-induced cardiotoxicity utilizing iPSCs-derived from adolescent and young adult survivors of sarcomoa

1) R01 Boudina (PI), Landstrom (sub-PI) 11/01/2020 – 10/31/2024 1.2 Cal

NIH NHLBI $736,215

Title: The role of PRDM16 in Cardiac Development and Cardiomyopathy

Goal: To determine the mechanism of cardiomyopathy development in genetic models of PRDM16 associated with altered metabolism and TGFb-signaling

Previous Research Funding

14) CMNH-DF Research Award Landstrom (PI) 07/01/2019 – 06/30/2020 0.12 Cal

Derfner Foundation (Duke Internal) $30,000

Title: The role of PRDM16 loss-of-function mutations in the development of neonatal cardiomyopathy

Goal: To determine the transcriptional impact of disease associated PRDM16 mutations on development of early onset cardiomyopathy using induced pluripotent stem cells

13) Andrew King Research Award Landstrom (PI) 05/01/2019 – 04/30/2020 0.0 Cal

Colin’s Kids Foundation $10,000

Title: Pediatric pluripotent stem cells as a model for post-operative arrhythmia in children after heart surgery

Goal: To utilize patient-derived induced pluripotent stem cell-derived cardiac myocytes to model differential drug response to anthracyclines to determine mechanisms of resistance and susceptibility

12) MEDx Pilot Grant Landstrom (PI) 11/01/2018 – 10/31/2019 0.0 Cal

Duke School of Medicine/Duke Pratt School of Engineering $50,000

Title: Machine learning prediction of pathologic long QT-associated mutations

Goal: To create a machine learning platform for long QT-associated mutation pathogenicity prediction

11) 5NU50-DD004933 Li (PI), Landstrom (co-I) 08/01/2018 – 09/31/2019 2.0 Cal

CDC $38,333

Title: North Carolina Congenital Heart Defects Surveillance Network

Goal: To target gaps in case ascertainment and the timely delivery of high-quality care and address disparities by race/ethnicity and socio-economic status related to individuals with congenital heart disease

10) IIRACCA Hildebrandt (PI), Landstrom (co-I) 08/01/2018 – 08/01/2018 0.84 Cal

CPRIT $300,261

Title: Molecular mechanisms of anthracycline response in cardiomyocytes and link to genetic susceptibility to cardiotoxicity in long-term childhood cancer survivors

Goal: To determine the genetic and molecular factors that predispose to late onset cardiac toxicity following pediatric exposure to anthracyclines. This grant was transferred to another investigator following award as eligibility requires residency in Texas and I was transitioning to North Carolina

9) Scholar Award Landstrom (PI) 01/01/2018 – 6/30/2018 0.12 Cal

Mike Hogg Fund $25,000

Title: In vivo evaluation of novel anti-arrhythmic compounds to terminate potentially fatal tachyarrhythmia

Goal: To test a novel small molecule for efficacy and toxicity as a therapy in a mouse model of nodal arrhythmia

8) Research Award Penny (PI) 07/01/2017 – 6/30/2018 0.0 Cal

BCM and Phoebe Muzzy-McCrae Foundation $100,000

Title: The genetic and cellular underpinnings of sudden cardiac death in children

Goal: To determine genomic markers of arrhythmic and cardiomyopathic sudden death predisposition using induced pluripotent stem cell-derived cardiac myocytes to determine biophysical and cellular changes associated with malignant mutations

7) Pilot Grant Landstrom (PI) 01/01/2017 – 12/31/2017 1.6 Cal

BCM, Dept of Pediatrics $50,000

Title: Junctophilin type 2 knockdown and cardiac nodal dysfunction

Goal: To determine the role of JPH2 knock-down and the development of sinus tachycardia and junctional ectopic tachycardia.

6) Paul C. Gillette Landstrom (PI) 06/01/2016 – 05/31/2017 0.8 Cal

PACES $10,000

Title: The role of junctophilin-2 in the development of youthful sinus and atrioventricular nodal disease

Goal: To determine the physiologic role of JPH2 in the nodal tissue of youthful mice with JPH2 knock-down

5) L40-HL129273 Landstrom (PI) 07/01/2015 – 06/30/2017 0.0 Cal

NIH LRP

Title: The role of RyR2-Asn4643del in CPVT with emotionally-triggered sudden death

Goal: To determine the mechanism of RyR2-mediated sudden death in a family with emotional sudden death

4) AHA08-15609G Landstrom (PI) 07/01/2008 – 06/30/2010 0.0 Cal

AHA Predoctoral Fellowship $53,688

Title: Molecular and functional characterization of hypertrophic cardiomyopathy-associated mutations in JPH2

Goal: To determine the spectrum and prevalence of JPH2 mutations in patients with HCM and to determine the calcium-signaling changes that drive hypertrophy

3) Howard B. Burchell Landstrom (PI) 08/01/2006 – 11/30/2006 0.0 Cal

AHA Research Fellowship $4,500

Title: Junctophilin-2 and the molecular pathogenesis of hypertrophic cardiomyopathy in an Italian cohort

2) T32-GM72474 Ames (PI) 07/01/2007 – 06/30/2008 0.0 Cal

NIH, Mayo Graduate School MPET Recipient

1) Scholar Award Landstrom (PI) 09/01/2005 – 6/30/2007 0.0 Cal

Corella and Bertram F. Bonner Foundation

PEER REVIEW PARTICIPATION

Editorial Positions

2019 – Pres Associate Editor, Am Heart J

2019 – Pres Associate Editor, Front Pediatr

2019 – Pres Associate Editor, Front Genet

2017 – Pres Assistant Editor, Circ Genom Precis Med (formerly Circ Cardiovasc Genet)

Ad Hoc Reviewer (Selected)

Am Heart J

Circulation

Circ Genom Precis Med

Clin Genet

FEBS Letters

Front Pediatr

Front Genet

J Am Heart Assoc

J Cardiovasc Transl Res

JCI Insight

Nat Commun

PLoS ONE

Sci Rep

Study Sections/Grant Review Participation

2019 Wellcome Trust Senior Research Fellowship, Wellcome Trust

2019 Transformational Project Award Clinical-Population Sciences, American Heart Association

2018 Student Scholarships in Cardiovascular Disease and Stroke, American Heart Association

2018 Uncovering New Patterns in Cardiovascular Disease and Stroke Grants, AHA Institute for Precision Cardiovascular Medicine, American Heart Association

2018 Uncovering New Patterns in Cardiovascular Disease and Stroke Fellowships, AHA Institute for Precision Cardiovascular Medicine, American Heart Association

Meeting/Scientific Sessions Peer Review Participation

2020 Session Proposal Reviewer, Social Issues Track, 2020 Annual Meeting of the American Society of Human Genetics

2019 Genomic and Precision Medicine YIA Application Reviewer, 2019 American Heart Association Scientific Sessions

2018 Abstract Reviewer, 2018 Annual Meeting of the American Society of Human Genetics

2018 Genomic and Precision Medicine YIA Application Reviewer, 2018 American Heart Association Scientific Sessions

TEACHING AND MENTORSHIP

National/International Educational Workshops Led

2019 Clinical Genomics Bootcamp. Moderator/Panelist. Council on Genomic and Precision Medicine, American Heart Association Scientific Sessions 2019, Philadelphia, PA

2019 Clinical Genomics Bootcamp. Panelist. European Society of Cardiology Congress 2019, Paris, France

2018 Clinical Genomics Bootcamp. Panelist. Council on Genomic and Precision Medicine, American Heart Association Scientific Sessions 2018, Chicago, IL

2017 Clinical Genomics Bootcamp. Panelist. Council on Genomic and Precision Medicine, American Heart Association Scientific Sessions 2017, Orlando, FL

2016 Clinical Genomics Bootcamp. Panelist. Council on Functional Genomics and Translational Biology, American Heart Association Scientific Sessions 2016, New Orleans, LA

2016 Next Generation Sequencing Bootcamp. Panelist. Council on Functional Genomics and Translational Biology, American Heart Association Scientific Sessions 2016, New Orleans, LA

Graduate School Didactic Courses Given and Educational Activities

2018 “The Genetic and Molecular Etiologies of Cardiomyopathies”. Cardiovascular Physiology Course, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX

2010 “Adrenergic Pharmacology”. Clinical Pharmacology Course, Mayo Medical School, Rochester, MN

2010 “Introduction to Pharmacology of the Autonomic Nervous System”. Clinical Pharmacology Course, Mayo Medical School, Rochester, MN

2010 “Individual Variation in Pharmacology”. Clinical Pharmacology Course, Mayo Medical School, Rochester, MN

2010 “Fundamentals of Receptor Biology and Signal Transduction”. Clinical Pharmacology Course, Mayo Medical School, Rochester, MN

2010 “Receptor-Ligand Interactions and Receptor Biology”. Molecular Pharmacology Course, Mayo Graduate School, Rochester, MN

2009 “Fundamentals of Receptor Biology and Signal Transduction”. Clinical Pharmacology Course, Mayo Medical School, Rochester, MN

2009 – 2010 Teaching Assistant, Molecular Pharmacology, Mayo Graduate School

2009 – 2010 Teaching Assistant, Clinical Pharmacology, Mayo Medical School

2008 Instructor, Anatomy and Physiology I, Rochester Community and Technical College

2008 Teaching Assistant, Cell and Molecular Biology, Mayo Graduate School

2008 Teaching Assistant, Cell Biology and Introduction to Pathology, Mayo Medical

School

Other Educational/Career Development Presentations

2019 “Navigating the academic job market for physician-scientists”. Duke Office of Physician-Scientist Development, Duke University School of Medicine, Durham, NC

2019 “Growing the Pie: Maintaining Balance During Training”. Duke Neonatology Grand Rounds, Duke University School of Medicine, Durham, NC

2019 “Growing the Pie: Maintaining Balance During Training”. Duke Pediatric Research Scholars Seminar Series, Duke University School of Medicine, Durham, NC

2018 “Experiences in Applying for K-Award and Junior Pilot Funding”. Pediatrician-Scientist Training and Development Program Parallel Educational Program. Department of Pediatrics, Baylor College of Medicine, Houston, TX

Clinical Education Mentorship

2020 – Pres Preceptor, Longitudinal Integrated Clerkship program, Duke Medical School for Mary Moya-Mendez

Research Mentorship Activities

2020 – Pres Chair, Scholarly Oversight Committee, Pediatric Residency and Duke Pediatric Research Scholars, Duke School of Medicine for Amy Berkman, MD

2019 – Pres Doctoral Dissertation Committee, Department of Computational Biology and Bioinformatics, Duke Graduate School for Scarlett Zou

2019 – Pres Chair, Scholarly Oversight Committee, Pediatric Cardiology Fellowship and Duke CTSA, Duke School of Medicine for Jordan Ezekian, MD, MPH

Research Mentees

2020 – Pres Robin Perelli. Duke Graduate Student, Cell and Molecular Biology

2019 – Pres Jennifer Cohen. Assistant Professor, Duke Department of Pediatrics, Division of Medical Genetics

2019 – Pres Michael Rosamilia. Duke Medical Student (CTSA Duke Clinical Research Training Program Scholar)

2019 – Pres Mary Moya-Mendez. Duke Medical Student

2019 – 2020 Ragavilasini Suresh, MBBS. Post-Doctoral Research Fellow

2019 – Pres Amy Berkman, MD. Duke Pediatrics Resident, Duke Pediatric Research Scholars Program (NIH R38 Duke SCI-StARR Award recipient)

2019 – 2020 Wisdom Talley. High School Student. North Carolina School of Science and Math Research Mentoring Program

2019 Chiagoziem Ogbonna. Post-Baccalaureate Student, Duke BIGGER Program

2019 – Pres Merick Yamada, MD. Duke Pediatric Cardiology Fellow

2019 – Pres Alice Chan, MD. Duke Pediatric Cardiology Fellow

2019 Megan Corey. High School Student.

2019 Elisa Pirozzi. Summer Medical Student Research Program (ms #45)

2019 – Pres Jordan Ezekian, MD, MPH. Post-Doctoral Research Fellow (CTSA TL1 Mentored Award recipient, Colin’s Kids Research Award, ms #43)

2019 – Pres Qixin Yang, MD. Post-Doctoral Research Fellow (ms #43)

2019 Sarah Romans. Duke Undergraduate, Education Independent Study

2019 – Pres Leonie Kurzlechner. Duke Undergraduate, Biology Independent Research Study

2018 – 2019 Kathleen Embury. Duke Undergraduate, Biomedical Engineering Independent Research Study

2018 – Pres Ellen Mines. Duke Undergraduate, Biology Independent Research Study (Duke University Deans’ Summer Undergraduate Research Fellowship recipient)

2018 – Pres Angela Renne. Duke Undergraduate, Biology Independent Research Study

2018 – Pres Alexandra Markunas. Duke Undergraduate, Biology Independent Research Study (Duke University Deans’ Summer Undergraduate Research Fellowship recipient)

2018 – 2019 Perathu Kannu Rakesh Manivannan, MBBS. Post-Doctoral Research Fellow. Current Position: West Virginia Internal Medicine Residency

2018 – Pres Bo Sun, PhD. Post-Doctoral Research Fellow

2018 – Pres Johnathan Tadros, MD. Post-Doctoral Research Fellow (ms #36, #45)

2018 – 2019 Julia Lovin, MD. BCM Pediatrics Resident

2017 – Pres Brianna Souder, MD. BCM Pediatrics Resident

2017 – Pres Patrick Connell, MD, PhD. BCM Pediatrics Resident (ms #37)

2017 – 2019 Alona Birjiniuk, MD, PhD. BCM Pediatrics Resident. Current Position: Lurie Children’s Pediatric Cardiology Fellowship

2017 – 2018 Sulaiman Jamal, BA. Post-Baccalaureate Student

2017 – 2018 Andrew Headrick, MD. BCM Pediatrics Resident (ms #39)

2016 – Pres Edward Jones, MD. BCM Pediatrics Resident (ms #38, #40, #45)

2016 – 2018 Ernesto Fernandez, MD. BCM Pediatrics Resident (ms #33)

2015 – 2018 Andrew Dailey-Schwartz, MD. BCM Pediatrics Resident. Current Position: Emory Pediatric Cardiology Fellowship (ms #29, 33, 36)

Mentored Awards/Fellowships

2020 – 2021 CTSA Duke Clinical Research Training Program Scholar. Duke Clinical Translational Science Institute. Michael Rosamilia.

2020 Colin’s Kids Foundation Research Award. Jordan Ezekian.

2020 Duke University Deans’ Summer Undergraduate Research Fellowship. Ellen Mines.

2020 Duke University Deans’ Summer Undergraduate Research Fellowship. Alexandra Markunas.

2020 – 2022 NIH R38. Duke University Scientist-Clinician Investigator/Stimulating Access to Research in Residency (Duke SCI-StARR) program. Amy Berkman.

2019 – 2021 CTSA TL1 Post-Doctoral/Physician Award. Duke Clinical Translational Science Institute. Jordan Ezekian.

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