Epidemiology and Determinants of Survival for Primary Intestinal Non ...

medRxiv preprint doi: ; this version posted July 18, 2022. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license .

Epidemiology and Determinants of Survival for Primary Intestinal Non-Hodgkin's Lymphoma ? A Population Based Study Short title: Epidemiology of Primary intestinal non-Hodgkin's lymphoma

Short Author: Singh et al.

Vinit Singha, Dhairya Gorb, Varsha Guptac,g, Aasems Jacobd, Doantrang Dua, Hussam Eltoukhye, Trishal Meghalf aDepartment of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA 07740 bDepartment of Internal Medicine, Jersey Shore University Medical Center, Neptune, New Jersey, USA 07753 cDepartment of Hematology ? Oncology, Jersey Shore University Medical Center, Neptune, New Jersey, USA 07753 dDepartment of Hematology ? Oncology, Leonard Lawson Cancer Center, Pikeville Medical Center, 911 S Bypass Rd, Pikeville, Kentucky, USA 41501 eDepartment of Hematology ? Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA 08901 fDepartment of Hematology ? Oncology, Monmouth Medical Center, Long Branch, New Jersey, USA 07740

g Corresponding Author: Varsha Gupta, Department of Hematology ? Oncology, Jersey Shore University Medical Center, Neptune, New Jersey, USA 07753, Phone ? 732-7707394. Email: Varsha.gupta@

NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.

medRxiv preprint doi: ; this version posted July 18, 2022. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license .

Abstract: Introduction: Gastrointestinal tract is the most common site of extra nodal nonHodgkin's lymphoma (EN-NHL). Most of the published data have been on gastric NHL with limited studies on primary intestinal - Non-Hodgkin's Lymphoma (PI-NHL) considering rare incidence. We performed epidemiological and survival analysis for PINHL from the Surveillance, Epidemiology, and End Results (SEER) 18 database.

Methods: A total of 9143 PI-NHL cases of age 18 years were identified from the

SEER 18 database for the period 2000-2015. 8568 Patients were included for survival analysis. Cause specific Survival (CSS) and overall survival analysis (OS) were done for PINHL and PI-diffuse large B-cell lymphoma (PI-DLBCL) using gender, age of onset, treatment, histology, stage, and Year of diagnosis. Survival analysis was done by using cox-proportional hazard model and Kaplan Meier plot with log-rank test.

Results: The percentage of PI-NHL of all the intestinal cancers and extra nodal nonHodgkin's lymphoma were 1.35 %, and 10.52%, respectively. The age-adjusted incidence was 0.9145/100,000 population for the study population. PI-NHL was more

common among patients aged60 Years, male and non-Hispanics whites. Majority of

patients were diagnosed at stage 1 and 2 (74%), and DLBCL (44.8%) was the most common histology. In OS analysis, Significant increased risk of mortality was seen with

T-cell NHLs vs. DLBCL (HR ? 2.56), patients aged 60 vs ................
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