The Role Of Cardiovascular Magnetic Resonance Imaging In ...
The Role Of Cardiovascular Magnetic Resonance Imaging In Heart Failure Mark A Peterzan1,2, Oliver J Rider2, Lisa J Anderson1*1St George’s Hospital, Blackshaw Rd, London SW17 0QT2University of Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Level 0, John Radcliffe Hospital, Oxford OX3 9DUJan January 2016*corresponding authorAbstract (150 words)Cardiovascular imaging is key for the assessment of patients with heart failure. Today, cardiovascular magnetic resonance plays established roles in the assessment of patients with suspected and confirmed heart failure syndromes, in particular identifying aetiology. Its role in informing prognosis and guiding decisions around therapy are evolving. Key strengths include its accuracy, reproducibility, unrestricted field of view, lack of radiation, multiple abilities to characterize myocardial tissue, thrombus and scar and as well as unparalleled assessment of left and right ventricular volumes, thrombus, scar and the right ventricle. T2* has an established role in the assessment and follow-up of iron overload cardiomyopathy and a role for T1 in specific therapies for cardiac amyloid and AFD is emerging.Keywords (3-10)Cardiovascular magnetic resonanceHeart failureLate gadolinium enhancementDelayed enhancementT2*T1 mappingMyocarditisCardiomyopathy Cardio-oncologyPrognosis IntroductionHeart failure (HF) can be defined haemodynamically as any abnormality of cardiac structure or function resulting in a failure to deliver oxygen at a rate adequate for tissue requirements, despite normal filling pressures – or only at the expense of increased filling pressures PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb25pa293c2tpPC9BdXRob3I+PFllYXI+MjAxNjwvWWVh
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ADDIN EN.CITE.DATA ( HYPERLINK \l "_ENREF_132" \o "Ponikowski, 2016 #23333" Ponikowski et al., 2016). Around half of HF patients have reduced left ventricle (LV) ejection fraction (EF) (EF <450%) at rest (‘HF-REF’) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HaW1lbGxpPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48
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ADDIN EN.CITE.DATA [2]. Diagnosis of suspected HF starts with history, examination, 12-lead electrocardiogram, chest X-ray and natriuretic peptide measurement. Transthoracic echocardiography is the first-line imaging modality PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZWJhemFhPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48
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ADDIN EN.CITE.DATA [3-5]. Cardiovascular magnetic resonance (CMR) imaging plays an important complementary role in evaluating the underlying aetiology (or aetiologies), identifying LV thrombus, informing prognosis and guiding decision-making, particularly where echocardiographic windows are inadequate or findings inconclusive. CMR is not part of the assessment process in acute HF owing to reduced monitoring capability, patient intolerance of lying flat and reduced image quality (arrhythmias and reduced ability to breath-hold). For the diagnosis of the ambulatory patient with suspected HF, CMR receives a class IC recommendation in the ESC HF Guidelines PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb25pa293c2tpPC9BdXRob3I+PFllYXI+MjAxNjwvWWVh
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ADDIN EN.CITE.DATA [1]. CMR is frequently used in the management of HF patients: the Euro CMR Registry reported the commonest indications for CMR to include risk stratification in suspected ischaemia, assessment of viability, and assessment of suspected myocarditis and cardiomyopathy ADDIN EN.CITE <EndNote><Cite><Author>Bruder</Author><Year>2013</Year><RecNum>22077</RecNum><DisplayText>[6]</DisplayText><record><rec-number>22077</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451829203">22077</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bruder, Oliver</author><author>Wagner, Anja</author><author>Lombardi, Massimo</author><author>Schwitter, Jürg</author><author>van Rossum, Albert</author><author>Pilz, Günter</author><author>Nothnagel, Detlev</author><author>Steen, Henning</author><author>Petersen, Steffen</author><author>Nagel, Eike</author></authors></contributors><titles><title>European Cardiovascular Magnetic Resonance (EuroCMR) registry–multi national results from 57 centers in 15 countries</title><secondary-title>Journal of Cardiovascular Magnetic Resonance</secondary-title></titles><periodical><full-title>Journal of Cardiovascular Magnetic Resonance</full-title></periodical><pages>10.1186</pages><volume>15</volume><number>9</number><dates><year>2013</year></dates><urls></urls></record></Cite></EndNote>[6]. The image signal in MR arises from hydrogen nuclei which are aligned to the field of the scanner and then ‘excited’ by radiofrequency wave pulses. Energy is released as the excited nuclei or spins relax back to equilibrium magnetisation. Decay of the longitudinal and transverse components of magnetisation are exponential processes named T1 and T2 relaxation respectively. Whereas T2 relaxation takes into account dephasing due to random proton-proton interaction, T2* is a faster process, as it also takes into account dephasing accelerated by local inhomogeneities in the global magnetic field. Datasets in HF patients typically start with T1-weighted black-blood spin-echo sequences for anatomy, gradient-echo (bright-blood steady-state free precession) cine sequences in three long-axis and three short-axis planes to acquire chamber volumes, and contrast-enhanced inversion-recovery gradient-echo sequences with appropriate nulling of normal myocardium to look for late gadolinium enhancement (LGE). Further tissue characterisation sequences are acquired selectively to answer specific questions.The advantages of CMR over other non-invasive imaging modalities are accuracy, reproducibility PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZWxsZW5nZXI8L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFy
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ADDIN EN.CITE.DATA [14] and the right ventricle (RV) ADDIN EN.CITE <EndNote><Cite><Author>Kawut</Author><Year>2012</Year><RecNum>22341</RecNum><DisplayText>[15]</DisplayText><record><rec-number>22341</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451913757">22341</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kawut, Steven M.</author><author>Barr, R. Graham</author><author>Lima, Jo?o A.C.</author><author>Praestgaard, Amy</author><author>Johnson, W. Craig</author><author>Chahal, Harjit</author><author>Ogunyankin, Kofo O.</author><author>Bristow, Michael R.</author><author>Kizer, Jorge R.</author><author>Tandri, Harikrishna</author><author>Bluemke, David A.</author></authors></contributors><titles><title>Right Ventricular Structure Is Associated With the Risk of Heart Failure and Cardiovascular Death: The Multi-Ethnic Study of Atherosclerosis (MESA)-Right Ventricle Study</title><secondary-title>Circulation</secondary-title></titles><periodical><full-title>Circulation</full-title></periodical><pages>1681-1688</pages><volume>126</volume><number>14</number><dates><year>2012</year><pub-dates><date>October 2, 2012</date></pub-dates></dates><urls><related-urls><url>;[15]. CMR tissue characterisation techniques may include inversion recovery images acquired either early (for thrombus imaging) or late (for scar imaging) after contrast administration, diffuse fibrosis assessment with T1 mapping and extracellular volume (ECV) measurement PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JbGVzPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48UmVj
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ADDIN EN.CITE.DATA [16-18], iron concentration using T2* and non-contrast ‘native’ T1 measurement, oedema evaluation using T2-weighted images, fatty infiltration with fat saturation sequences or T1-weighting, perfusion imaging with first pass T1-weighted images, and metabolism assessment using MR spectroscopy (MRS) ADDIN EN.CITE <EndNote><Cite><Author>Hudsmith</Author><Year>2009</Year><RecNum>3319</RecNum><DisplayText>[19]</DisplayText><record><rec-number>3319</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1446890826">3319</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hudsmith, Lucy E.</author><author>Neubauer, Stefan</author></authors></contributors><titles><title>Magnetic Resonance Spectroscopy in Myocardial Disease</title><secondary-title>JACC: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>JACC: Cardiovascular Imaging</full-title></periodical><pages>87-96</pages><volume>2</volume><number>1</number><dates><year>2009</year></dates><isbn>1936-878X</isbn><urls><related-urls><url>;[19]. Its limitations are its availability, cost, the exclusion of patients with non-MR-compatible devices ADDIN EN.CITE <EndNote><Cite><Author>Naehle</Author><Year>2009</Year><RecNum>21971</RecNum><DisplayText>[20]</DisplayText><record><rec-number>21971</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450007765">21971</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Naehle, Claas P.</author><author>Strach, Katharina</author><author>Thomas, Daniel</author><author>Meyer, Carsten</author><author>Linhart, Markus</author><author>Bitaraf, Sascha</author><author>Litt, Harold</author><author>Schwab, J?rg Otto</author><author>Schild, Hans</author><author>Sommer, Torsten</author></authors></contributors><titles><title>Magnetic Resonance Imaging at 1.5-T in Patients With Implantable Cardioverter-Defibrillators</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>549-555</pages><volume>54</volume><number>6</number><dates><year>2009</year></dates><isbn>0735-1097</isbn><urls><related-urls><url>;[20], cerebrovascular clips or metallic objects in the eye, and the inability to scan patients who are too breathless to lie flat, or who have claustrophobia. In HF patients, electrocardiographic gating may be challenging in atrial fibrillation, high ectopic burden or broad QRS width. Furthermore, linear gadolinium chelates are contraindicated in individuals with estimated creatinine clearances <30ml/min, and renal dysfunction is relatively common in HF. Newer macrocyclic chelates have a better safety profile but should still be used with caution in advanced renal dysfunction ADDIN EN.CITE <EndNote><Cite><Author>Knuuti</Author><Year>2014</Year><RecNum>21993</RecNum><DisplayText>[21]</DisplayText><record><rec-number>21993</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450009816">21993</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Knuuti, Juhani</author><author>Bengel, Frank</author><author>Bax, Jeroen J.</author><author>Kaufmann, Philipp A.</author><author>Le Guludec, Dominique</author><author>Perrone Filardi, Pasquale</author><author>Marcassa, Claudio</author><author>Ajmone Marsan, Nina</author><author>Achenbach, Stephan</author><author>Kitsiou, Anastasia</author><author>Flotats, Albert</author><author>Eeckhout, Eric</author><author>Minn, Heikki</author><author>Hesse, Birger</author></authors></contributors><titles><title>Risks and benefits of cardiac imaging: an analysis of risks related to imaging for coronary artery disease</title><secondary-title>European Heart Journal</secondary-title></titles><periodical><full-title>Eur Heart J</full-title><abbr-1>European heart journal</abbr-1></periodical><pages>633-638</pages><volume>35</volume><number>10</number><dates><year>2014</year></dates><work-type>10.1093/eurheartj/eht512</work-type><urls><related-urls><url>;[21]. Ischaemic Cardiomyopathy (ICM)In patients presenting de novo with acute HF and no clinical or electrocardiographic suggestion of ischaemic aetiology, LGE-CMR is sensitive and specific for the presence of underlying significant coronary artery disease (CAD) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNvbG88L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [22, 23]. Identifying ICM as the aetiology of HF implies a worse prognosis than non-ischaemic cardiomyopathy ADDIN EN.CITE <EndNote><Cite><Author>Adams Jr</Author><Year>1996</Year><RecNum>22002</RecNum><DisplayText>[24]</DisplayText><record><rec-number>22002</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450034279">22002</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Adams Jr, Kirkwood F.</author><author>Dunlap, Stephanie H.</author><author>Sueta, Carla A.</author><author>Clarke, Susan W.</author><author>Patterson, James Herbert</author><author>Blauwet, Mary Beth</author><author>Jensen, Lynda R.</author><author>Tomasko, Lisa</author><author>Koch, Gary</author></authors></contributors><titles><title>Relation Between Gender, Etiology and Survival in Patients With Symptomatic Heart Failure</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>1781-1788</pages><volume>28</volume><number>7</number><dates><year>1996</year><pub-dates><date>12//</date></pub-dates></dates><isbn>0735-1097</isbn><urls><related-urls><url>(96)00380-4</electronic-resource-num></record></Cite></EndNote>[24]. Patients with single-vessel disease (<75% luminal stenosis) not involving the proximal left anterior descending (LAD) or left main arteries and with no history of myocardial infarction or prior revascularization have a prognosis similar to patients with non-ischaemic HF ADDIN EN.CITE <EndNote><Cite><Author>Felker</Author><Year>2002</Year><RecNum>22028</RecNum><DisplayText>[25]</DisplayText><record><rec-number>22028</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450547371">22028</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Felker, G. Michael</author><author>Shaw, Linda K.</author><author>O’Connor, Christopher M.</author></authors></contributors><titles><title>A standardized definition of ischemic cardiomyopathy for use in clinical research</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>210-218</pages><volume>39</volume><number>2</number><dates><year>2002</year><pub-dates><date>1/16/</date></pub-dates></dates><isbn>0735-1097</isbn><urls><related-urls><url>(01)01738-7</electronic-resource-num></record></Cite></EndNote>[25]. However, the absence of angina and significant stenoses on coronary angiography does not exclude CAD as the cause of HF, as infarction may follow coronary spasm, embolism, or be followed by coronary recanalization ADDIN EN.CITE <EndNote><Cite><Author>Karamitsos</Author><Year>2009</Year><RecNum>3318</RecNum><DisplayText>[26]</DisplayText><record><rec-number>3318</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1446890515">3318</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Karamitsos, T. D.</author><author>Francis, J. M.</author><author>Myerson, S.</author><author>Selvanayagam, J. B.</author><author>Neubauer, S.</author></authors></contributors><auth-address>Karamitsos,Theodoros D. University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.</auth-address><titles><title>The role of cardiovascular magnetic resonance imaging in heart failure</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>1407-24</pages><volume>54</volume><number>15</number><dates><year>2009</year></dates><accession-num>19796734</accession-num><work-type>Research Support, Non-U.S. Gov't
Review</work-type><urls><related-urls><url> Technologies</remote-database-provider></record></Cite></EndNote>[26]. A proportionround 15% of patients with unobstructed coronaries are found to have LGE in distributions typical of prior infarction and would be misclassified as dilated cardiomyopathy (DCM) were LGE-CMR imaging not performed PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NY0Nyb2hvbjwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+
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ADDIN EN.CITE.DATA [27, 28]. Patterns typical of prior infarction show subendocardial or transmural enhancement respecting one or more coronary territories, reflecting the “wavefront phenomenon” of ischaemic injury (Figure 2) ADDIN EN.CITE <EndNote><Cite><Author>Reimer</Author><Year>1977</Year><RecNum>22007</RecNum><DisplayText>[29]</DisplayText><record><rec-number>22007</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450042521">22007</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Reimer, K A</author><author>Lowe, J E</author><author>Rasmussen, M M</author><author>Jennings, R B</author></authors></contributors><titles><title>The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs</title><secondary-title>Circulation</secondary-title></titles><periodical><full-title>Circulation</full-title></periodical><pages>786-94</pages><volume>56</volume><number>5</number><dates><year>1977</year><pub-dates><date>November 1, 1977</date></pub-dates></dates><urls><related-urls><url>;[29]. For the detection of suspected stable CAD in patients with intermediate (15-85%) pre-test probability of disease and preserved and reduced LVEF, vasodilator stress CMR for first-pass perfusion and dobutamine stress CMR for inducible wall motion abnormalities (WMA) CMR is are well-established, feasible and safe (Figure 3) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYW5kYWx1cjwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+
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ADDIN EN.CITE.DATA [34, 35]. 3-dimensional stress perfusion techniques acquire datasets covering the whole heart rather than three short-axis slices, allowing quantitation of ischaemic burden with good agreement with stress perfusion scintigraphy (SPECT) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2dpeWE8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [38]. The incremental utility of quantitating ischaemic burden, however this is defined, over merely demonstrating the presence of ischaemia is under investigation.In hearts with resting LVEF ≤40% and established left-main, left-main-equivalent or significant proximal LAD and multivessel disease (with fractional flow-reserve <0.80), coronary revascularization is indicated for the relief of angina and for ‘prognosis’ (class IA recommendation) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XaW5kZWNrZXI8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy
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ADDIN EN.CITE.DATA [39]. CMR strategies for estimating the likelihood of improvement include assessing the response to low-dose dobutamine, extent of LGE transmurality, response to low-dose dobutamine, and myocardial thickness ADDIN EN.CITE <EndNote><Cite><Author>Knuesel</Author><Year>2003</Year><RecNum>22021</RecNum><DisplayText>[40]</DisplayText><record><rec-number>22021</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450291079">22021</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Knuesel, Patrick R.</author><author>Nanz, Daniel</author><author>Wyss, Christophe</author><author>Buechi, Martin</author><author>Kaufmann, Philip A.</author><author>von Schulthess, Gustav K.</author><author>Lüscher, Thomas F.</author><author>Schwitter, Juerg</author></authors></contributors><titles><title>Characterization of Dysfunctional Myocardium by Positron Emission Tomography and Magnetic Resonance: Relation to Functional Outcome After Revascularization</title><secondary-title>Circulation</secondary-title></titles><periodical><full-title>Circulation</full-title></periodical><pages>1095-1100</pages><volume>108</volume><number>9</number><dates><year>2003</year><pub-dates><date>September 2, 2003</date></pub-dates></dates><urls><related-urls><url>;[40]. CMR myocardial feature tracking reduces inter-observer variability compared with visual analysis of the response to low-dose dobutamine ADDIN EN.CITE <EndNote><Cite><Author>Schuster</Author><Year>2015</Year><RecNum>23284</RecNum><DisplayText>[41]</DisplayText><record><rec-number>23284</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463658753">23284</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schuster, Andreas</author><author>Paul, Matthias</author><author>Bettencourt, Nuno</author><author>Hussain, Shazia T.</author><author>Morton, Geraint</author><author>Kutty, Shelby</author><author>Bigalke, Boris</author><author>Chiribiri, Amedeo</author><author>Perera, Divaka</author><author>Nagel, Eike</author><author>Beerbaum, Philipp</author></authors></contributors><titles><title>Myocardial Feature Tracking Reduces Observer-Dependence in Low-Dose Dobutamine Stress Cardiovascular Magnetic Resonance</title><secondary-title>PLoS ONE</secondary-title></titles><periodical><full-title>PLoS One</full-title><abbr-1>PloS one</abbr-1></periodical><pages>e0122858</pages><volume>10</volume><number>4</number><dates><year>2015</year></dates><publisher>Public Library of Science</publisher><urls><related-urls><url>;[41]. Contractile reserve correlates inversely with infarct transmurality, but cannot be straightforwardly predicted in segments with infarction of intermediate transmural extent ADDIN EN.CITE <EndNote><Cite><Author>Kaandorp</Author><Year>2004</Year><RecNum>22017</RecNum><DisplayText>[42]</DisplayText><record><rec-number>22017</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450283733">22017</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kaandorp, Theodorus A. M.</author><author>Bax, Jeroen J.</author><author>Schuijf, Joanne D.</author><author>Viergever, Eric P.</author><author>van Der Wall, Ernst E.</author><author>de Roos, Albert</author><author>Lamb, Hildo J.</author></authors></contributors><titles><title>Head-to-Head comparison between Contrast-Enhanced magnetic resonance imaging and dobutamine magnetic resonance imaging in men with ischemic cardiomyopathy</title><secondary-title>The American Journal of Cardiology</secondary-title></titles><periodical><full-title>Am J Cardiol</full-title><abbr-1>The American journal of cardiology</abbr-1></periodical><pages>1461-1464</pages><volume>93</volume><number>12</number><dates><year>2004</year><pub-dates><date>6/15/</date></pub-dates></dates><isbn>0002-9149</isbn><urls><related-urls><url>;[42]. Greater transmurality of infarction as assessed by LGE-CMR has been shown to correlate inversely with the likelihood of segmental and global functional recovery post revascularization PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaW08L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxSZWNO
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ADDIN EN.CITE.DATA [43-45]. LGE transmurality is often used as a surrogate for viability, the attraction being that no stress or metabolic imaging step is required, and in a meta-analysis of prospective trials was shown to carry the highest sensitivity and negative predictive value for recovery ADDIN EN.CITE <EndNote><Cite><Author>Romero</Author><Year>2012</Year><RecNum>22334</RecNum><DisplayText>[46]</DisplayText><record><rec-number>22334</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451902011">22334</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Romero, Jorge</author><author>Xue, Xiaonan</author><author>Gonzalez, Waddy</author><author>Garcia, Mario J.</author></authors></contributors><titles><title>CMR Imaging Assessing Viability in Patients With Chronic Ventricular Dysfunction Due to Coronary Artery Disease: A Meta-Analysis of Prospective Trials</title><secondary-title>JACC: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>JACC: Cardiovascular Imaging</full-title></periodical><pages>494-508</pages><volume>5</volume><number>5</number><keywords><keyword>cardiac magnetic resonance</keyword><keyword>left ventricular dysfunction</keyword><keyword>myocardial viability</keyword><keyword>revascularization</keyword></keywords><dates><year>2012</year><pub-dates><date>5//</date></pub-dates></dates><isbn>1936-878X</isbn><urls><related-urls><url>;[46]. The potential of native T1 mapping as a fourth strategy to detect chronic infarction is under investigation. Multiple earlier reports and a meta-analysis showed that the presence of viability in ICM patients, as assessed by thallium nuclear perfusion SPECT, fluorodeoxyglucose metabolic imaging (FDG PET) or dobutamine echocardiography, predicted improved survival after revascularization PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbGxtYW48L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [55, 56]. A meta-analysis of studies of stress CMR in populations with known or suspected CAD which excluded patients with cardiomyopathy or recent infarction confirmed the excellent prognostic values of both positive and negative stress CMR scans with no difference between vasodilator and dobutamine stress ADDIN EN.CITE <EndNote><Cite><Author>Lipinski</Author><Year>2013</Year><RecNum>23160</RecNum><DisplayText>(Lipinski et al., 2013)</DisplayText><record><rec-number>23160</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463410399">23160</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lipinski, Michael J.</author><author>McVey, Courtney M.</author><author>Berger, Jeffrey S.</author><author>Kramer, Christopher M.</author><author>Salerno, Michael</author></authors></contributors><titles><title>Prognostic Value of Stress Cardiac Magnetic Resonance Imaging in Patients With Known or Suspected Coronary Artery DiseaseA Systematic Review and Meta-Analysis</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>826-838</pages><volume>62</volume><number>9</number><dates><year>2013</year></dates><isbn>0735-1097</isbn><urls><related-urls><url>;( HYPERLINK \l "_ENREF_100" \o "Lipinski, 2013 #23160" Lipinski et al., 2013). However, in one study that recruited patients with LVEF <55% and regional WMA at rest, dobutamine-induced increases in wall motion score index provided additive predictive power for MACE beyond resting LVEF when resting LVEF was >40%, but not <40% ADDIN EN.CITE <EndNote><Cite><Author>Dall'Armellina</Author><Year>2008</Year><RecNum>23252</RecNum><DisplayText>[57]</DisplayText><record><rec-number>23252</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463577768">23252</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dall'Armellina, Erica</author><author>Morgan, Timothy M.</author><author>Mandapaka, Sangeeta</author><author>Ntim, William</author><author>Carr, J. Jeffrey</author><author>Hamilton, Craig A.</author><author>Hoyle, John</author><author>Clark, Hollins</author><author>Clark, Paige</author><author>Link, Kerry M.</author><author>Case, Doug</author><author>Hundley, W. Gregory</author></authors></contributors><titles><title>Prediction of Cardiac Events in Patients With Reduced Left Ventricular Ejection Fraction With Dobutamine Cardiovascular Magnetic Resonance Assessment of Wall Motion Score Index</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>279-286</pages><volume>52</volume><number>4</number><dates><year>2008</year></dates><isbn>0735-1097</isbn><urls><related-urls><url>;[57]. In studies of patients with ICM and reduced EF, greater extents of scar volume as a proportion of total myocardial volume independently predicted MACE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Zb2tvdGE8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS
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ZT4A
ADDIN EN.CITE.DATA [58, 59] and larger peri-infarct ‘intermediate zone’ areas independently predicted mortality PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ld29uPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj
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ADDIN EN.CITE.DATA [60, 61] and inducibility of monomorphic ventricular tachycardia ADDIN EN.CITE <EndNote><Cite><Author>Schmidt</Author><Year>2007</Year><RecNum>22003</RecNum><DisplayText>[62]</DisplayText><record><rec-number>22003</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450039970">22003</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schmidt, André</author><author>Azevedo, Clerio F.</author><author>Cheng, Alan</author><author>Gupta, Sandeep N.</author><author>Bluemke, David A.</author><author>Foo, Thomas K.</author><author>Gerstenblith, Gary</author><author>Weiss, Robert G.</author><author>Marbán, Eduardo</author><author>Tomaselli, Gordon F.</author><author>Lima, Jo?o A.C.</author><author>Wu, Katherine C.</author></authors></contributors><titles><title>Infarct Tissue Heterogeneity by Magnetic Resonance Imaging Identifies Enhanced Cardiac Arrhythmia Susceptibility in Patients With Left Ventricular Dysfunction</title><secondary-title>Circulation</secondary-title></titles><periodical><full-title>Circulation</full-title></periodical><pages>2006-2014</pages><volume>115</volume><number>15</number><dates><year>2007</year><pub-dates><date>April 17, 2007</date></pub-dates></dates><urls><related-urls><url>;[62]. In the setting of recent acute myocardial infarction, CMR correlates of higher risk include LVEF, infarct and peri-infarct zone sizes, the presence of microvascular obstruction (MVO) (Figure 4), reduced RVEF ADDIN EN.CITE <EndNote><Cite><Author>Lockie</Author><Year>2009</Year><RecNum>21994</RecNum><DisplayText>[63]</DisplayText><record><rec-number>21994</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450009952">21994</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lockie, Tim</author><author>Nagel, Eike</author><author>Redwood, Simon</author><author>Plein, Sven</author></authors></contributors><titles><title>Use of Cardiovascular Magnetic Resonance Imaging in Acute Coronary Syndromes</title><secondary-title>Circulation</secondary-title></titles><periodical><full-title>Circulation</full-title></periodical><pages>1671-1681</pages><volume>119</volume><number>12</number><dates><year>2009</year><pub-dates><date>March 31, 2009</date></pub-dates></dates><urls><related-urls><url>;[63], and lower degrees of myocardial salvage, assessed as the difference between the area at risk on T2 weighting and the final infarct size ADDIN EN.CITE <EndNote><Cite><Author>Eitel</Author><Year>2010</Year><RecNum>23324</RecNum><DisplayText>[64]</DisplayText><record><rec-number>23324</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463739139">23324</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Eitel, Ingo</author><author>Desch, Steffen</author><author>Fuernau, Georg</author><author>Hildebrand, Lysann</author><author>Gutberlet, Matthias</author><author>Schuler, Gerhard</author><author>Thiele, Holger</author></authors></contributors><titles><title>Prognostic Significance and Determinants of Myocardial Salvage Assessed by Cardiovascular Magnetic Resonance in Acute Reperfused Myocardial Infarction</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>2470-2479</pages><volume>55</volume><number>22</number><dates><year>2010</year></dates><isbn>0735-1097</isbn><urls><related-urls><url>;[64]. CMR-detected MVO, defined as a lack of gadolinium retention (dark region) in the core of a segment surrounded by tissue showing gadolinium enhancement, iwas an independent predictor for of MACE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XdTwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJlY051
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ADDIN EN.CITE.DATA [65, 66] and the strongest predictor of changes in LV volumes and EF at four month follow-up adverse LV remodelling ADDIN EN.CITE <EndNote><Cite><Author>Nijveldt</Author><Year>2008</Year><RecNum>22006</RecNum><DisplayText>[67]</DisplayText><record><rec-number>22006</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450040897">22006</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nijveldt, Robin</author><author>Beek, Aernout M.</author><author>Hirsch, Alexander</author><author>Stoel, Martin G.</author><author>Hofman, Mark B. M.</author><author>Umans, Victor A. W. M.</author><author>Algra, Paul R.</author><author>Twisk, Jos W. R.</author><author>van Rossum, Albert C.</author></authors></contributors><titles><title>Functional Recovery After Acute Myocardial Infarction: Comparison Between Angiography, Electrocardiography, and Cardiovascular Magnetic Resonance Measures of Microvascular Injury</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>181-189</pages><volume>52</volume><number>3</number><keywords><keyword>magnetic resonance imaging</keyword><keyword>electrocardiography</keyword><keyword>angiography</keyword><keyword>myocardial infarction</keyword><keyword>microvascular injury</keyword></keywords><dates><year>2008</year><pub-dates><date>7/15/</date></pub-dates></dates><isbn>0735-1097</isbn><urls><related-urls><url>;[67]. Greater extents of late MVO (assessed 15 minutes after gadolinium administration), rather than early MVO (one minute after), independently predict MACE after primary PCI for STEMI ADDIN EN.CITE <EndNote><Cite><Author>de Waha</Author><Year>2010</Year><RecNum>23320</RecNum><DisplayText>[68]</DisplayText><record><rec-number>23320</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463684609">23320</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>de Waha, Suzanne</author><author>Desch, Steffen</author><author>Eitel, Ingo</author><author>Fuernau, Georg</author><author>Zachrau, Johannes</author><author>Leuschner, Anja</author><author>Gutberlet, Matthias</author><author>Schuler, Gerhard</author><author>Thiele, Holger</author></authors></contributors><titles><title>Impact of early vs. late microvascular obstruction assessed by magnetic resonance imaging on long-term outcome after ST-elevation myocardial infarction: a comparison with traditional prognostic markers</title><secondary-title>European Heart Journal</secondary-title></titles><periodical><full-title>Eur Heart J</full-title><abbr-1>European heart journal</abbr-1></periodical><pages>2660-2668</pages><volume>31</volume><number>21</number><dates><year>2010</year></dates><work-type>10.1093/eurheartj/ehq247</work-type><urls><related-urls><url>;[68]. Hypointense infarct cores on T2 weighting, a marker of intramyocardial haemorrhage (IMH), are associated with larger infarcts, greater extents of late MVO, and predict MACE and adverse LV remodelling independent of the presence of MVO ADDIN EN.CITE <EndNote><Cite><Author>Eitel</Author><Year>2011</Year><RecNum>23321</RecNum><DisplayText>[69]</DisplayText><record><rec-number>23321</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463738914">23321</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Eitel, Ingo</author><author>Kubusch, Konrad</author><author>Strohm, Oliver</author><author>Desch, Steffen</author><author>Mikami, Yoko</author><author>de Waha, Suzanne</author><author>Gutberlet, Matthias</author><author>Schuler, Gerhard</author><author>Friedrich, Matthias G.</author><author>Thiele, Holger</author></authors></contributors><titles><title>Prognostic Value and Determinants of a Hypointense Infarct Core in T2-Weighted Cardiac Magnetic Resonance in Acute Reperfused ST-Elevation Myocardial Infarction</title><secondary-title>Circulation: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>Circulation: Cardiovascular Imaging</full-title></periodical><dates><year>2011</year><pub-dates><date>April 25, 2011</date></pub-dates></dates><urls><related-urls><url>;[69]. IMH, alternativelyalso detected by a hypointense infarct core with T2* <20ms, also independently predicts MACE and adverse LV remodelling ADDIN EN.CITE <EndNote><Cite><Author>Carrick</Author><Year>2016</Year><RecNum>23318</RecNum><DisplayText>[70]</DisplayText><record><rec-number>23318</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463675657">23318</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Carrick, David</author><author>Haig, Caroline</author><author>Ahmed, Nadeem</author><author>McEntegart, Margaret</author><author>Petrie, Mark C.</author><author>Eteiba, Hany</author><author>Hood, Stuart</author><author>Watkins, Stuart</author><author>Lindsay, M. Mitchell</author><author>Davie, Andrew</author><author>Mahrous, Ahmed</author><author>Mordi, Ify</author><author>Rauhalammi, Samuli</author><author>Sattar, Naveed</author><author>Welsh, Paul</author><author>Radjenovic, Aleksandra</author><author>Ford, Ian</author><author>Oldroyd, Keith G.</author><author>Berry, Colin</author></authors></contributors><titles><title>Myocardial Hemorrhage After Acute Reperfused ST-Segment–Elevation Myocardial Infarction: Relation to Microvascular Obstruction and Prognostic Significance</title><secondary-title>Circulation: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>Circulation: Cardiovascular Imaging</full-title></periodical><pages>e004148</pages><volume>9</volume><number>1</number><dates><year>2016</year><pub-dates><date>January 1, 2016</date></pub-dates></dates><urls><related-urls><url>;[70]. An emerging technique in this setting, although not standardized between centres or vendors, is T1 mapping of infarcted ADDIN EN.CITE <EndNote><Cite><Author>!!! INVALID CITATION !!! [74]</Author><RecNum>0</RecNum><DisplayText>(!!! INVALID CITATION !!! [74])</DisplayText><record><dates><year>!!! INVALID CITATION !!! [74]</year></dates></record></Cite></EndNote>( HYPERLINK \l "_ENREF_1" \o ", !!! INVALID CITATION !!! [74]" !!! INVALID CITATION !!! [74]) and non-infarcted remote myocardium ADDIN EN.CITE <EndNote><Cite><Author>Chan</Author><Year>2012</Year><RecNum>23310</RecNum><DisplayText>(Chan et al., 2012)</DisplayText><record><rec-number>23310</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463675018">23310</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Chan, William</author><author>Duffy, Stephen J.</author><author>White, David A.</author><author>Gao, Xiao-Ming</author><author>Du, Xiao-Jun</author><author>Ellims, Andris H.</author><author>Dart, Anthony M.</author><author>Taylor, Andrew J.</author></authors></contributors><titles><title>Acute Left Ventricular Remodeling Following Myocardial Infarction: Coupling of Regional Healing With Remote Extracellular Matrix Expansion</title><secondary-title>JACC: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>JACC: Cardiovascular Imaging</full-title></periodical><pages>884-893</pages><volume>5</volume><number>9</number><keywords><keyword>diffuse fibrosis</keyword><keyword>left ventricular remodeling</keyword><keyword>T1 mapping</keyword></keywords><dates><year>2012</year><pub-dates><date>9//</date></pub-dates></dates><isbn>1936-878X</isbn><urls><related-urls><url>;( HYPERLINK \l "_ENREF_35" \o "Chan, 2012 #23310" Chan et al., 2012), which has been applied with and/or without contrast. One group recently observed that lower infarct core native T1 predicted adverse remodelling and MACE at six months post STEMI ADDIN EN.CITE <EndNote><Cite><Author>Carrick</Author><Year>2015</Year><RecNum>23316</RecNum><DisplayText>(Carrick et al., 2015a)</DisplayText><record><rec-number>23316</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463675454">23316</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Carrick, David</author><author>Haig, Caroline</author><author>Rauhalammi, Sam</author><author>Ahmed, Nadeem</author><author>Mordi, Ify</author><author>McEntegart, Margaret</author><author>Petrie, Mark C.</author><author>Eteiba, Hany</author><author>Hood, Stuart</author><author>Watkins, Stuart</author><author>Lindsay, Mitchell</author><author>Mahrous, Ahmed</author><author>Ford, Ian</author><author>Tzemos, Niko</author><author>Sattar, Naveed</author><author>Welsh, Paul</author><author>Radjenovic, Aleksandra</author><author>Oldroyd, Keith G.</author><author>Berry, Colin</author></authors></contributors><titles><title>Prognostic significance of infarct core pathology revealed by quantitative non-contrast in comparison with contrast cardiac magnetic resonance imaging in reperfused ST-elevation myocardial infarction survivors</title><secondary-title>European Heart Journal</secondary-title></titles><periodical><full-title>Eur Heart J</full-title><abbr-1>European heart journal</abbr-1></periodical><dates><year>2015</year></dates><work-type>10.1093/eurheartj/ehv372</work-type><urls><related-urls><url>;( HYPERLINK \l "_ENREF_32" \o "Carrick, 2015 #23316" Carrick et al., 2015a). The same associations, although not powered for clinical endpoints, were observed for remote zone native T1 in the upper tertile ADDIN EN.CITE <EndNote><Cite><Author>Carrick</Author><Year>2015</Year><RecNum>23311</RecNum><DisplayText>(Carrick et al., 2015b)</DisplayText><record><rec-number>23311</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463675082">23311</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Carrick, David</author><author>Haig, Caroline</author><author>Rauhalammi, Sam</author><author>Ahmed, Nadeem</author><author>Mordi, Ify</author><author>McEntegart, Margaret</author><author>Petrie, Mark C.</author><author>Eteiba, Hany</author><author>Lindsay, Mitchell</author><author>Watkins, Stuart</author><author>Hood, Stuart</author><author>Davie, Andrew</author><author>Mahrous, Ahmed</author><author>Sattar, Naveed</author><author>Welsh, Paul</author><author>Tzemos, Niko</author><author>Radjenovic, Aleksandra</author><author>Ford, Ian</author><author>Oldroyd, Keith G.</author><author>Berry, Colin</author></authors></contributors><titles><title>Pathophysiology of LV Remodeling in?Survivors of STEMI: Inflammation, Remote Myocardium, and Prognosis</title><secondary-title>JACC: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>JACC: Cardiovascular Imaging</full-title></periodical><pages>779-789</pages><volume>8</volume><number>7</number><keywords><keyword>cardiac magnetic resonance</keyword><keyword>inflammation</keyword><keyword>myocardial infarction</keyword><keyword>remodeling</keyword><keyword>reperfusion</keyword></keywords><dates><year>2015</year><pub-dates><date>7//</date></pub-dates></dates><isbn>1936-878X</isbn><urls><related-urls><url>;( HYPERLINK \l "_ENREF_33" \o "Carrick, 2015 #23311" Carrick et al., 2015b). Dilated Cardiomyopathy (DCM)DCM is a clinical diagnosis requiring dilation and systolic dysfunction of the left or both ventricles that is unexplained by abnormal loading conditions or CAD ADDIN EN.CITE <EndNote><Cite><Author>Elliott</Author><Year>2008</Year><RecNum>22071</RecNum><DisplayText>[71]</DisplayText><record><rec-number>22071</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451820096">22071</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Elliott, Perry</author><author>Andersson, Bert</author><author>Arbustini, Eloisa</author><author>Bilinska, Zofia</author><author>Cecchi, Franco</author><author>Charron, Philippe</author><author>Dubourg, Olivier</author><author>Kühl, Uwe</author><author>Maisch, Bernhard</author><author>McKenna, William J.</author><author>Monserrat, Lorenzo</author><author>Pankuweit, Sabine</author><author>Rapezzi, Claudio</author><author>Seferovic, Petar</author><author>Tavazzi, Luigi</author><author>Keren, Andre</author></authors></contributors><titles><title>Classification of the cardiomyopathies: a position statement from the european society of cardiology working group on myocardial and pericardial diseases</title><secondary-title>European Heart Journal</secondary-title></titles><periodical><full-title>Eur Heart J</full-title><abbr-1>European heart journal</abbr-1></periodical><pages>270-276</pages><volume>29</volume><number>2</number><dates><year>2008</year></dates><work-type>10.1093/eurheartj/ehm342</work-type><urls><related-urls><url>;[71]. CMR studies have shown that increased native T1 on T1 mapping, LA volumes and RV dysfunction, but not greater degrees of trabeculation, are independent predictors of survival and HF outcomes in DCM PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QdW50bWFubjwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+
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Pn==
ADDIN EN.CITE.DATA [72-75]. If present in DCM, LGE is typically found in a mid-wall distribution (Figure 5) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NY0Nyb2hvbjwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+
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ADDIN EN.CITE.DATA [27] of DCM patients in two adult case series. In contrast, in a paediatric series of patients presenting with non-ischaemic HF with and without inflammation on biopsy (median age seven months, mean LVEF 23%), focal LGE was found in four of the sixteen with chronic myocarditis and only one of the fifteen with idiopathic DCM , but may be less common in children ADDIN EN.CITE <EndNote><Cite><Author>Latus</Author><Year>2015</Year><RecNum>23163</RecNum><DisplayText>[77]</DisplayText><record><rec-number>23163</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463410609">23163</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Latus, Heiner</author><author>Gummel, Kerstin</author><author>Klingel, Karin</author><author>Moysich, Axel</author><author>Khalil, Markus</author><author>Mazhari, Nona</author><author>Bauer, Juergen</author><author>Kandolf, Reinhard</author><author>Schranz, Dietmar</author><author>Apitz, Christian</author></authors></contributors><titles><title>Focal myocardial fibrosis assessed by late gadolinium enhancement cardiovascular magnetic resonance in children and adolescents with dilated cardiomyopathy</title><secondary-title>Journal of Cardiovascular Magnetic Resonance</secondary-title></titles><periodical><full-title>Journal of Cardiovascular Magnetic Resonance</full-title></periodical><pages>34</pages><volume>17</volume><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[77]. In adults, Tthe presence of LGE in non-ischaemic DCM independently predicts an increased risk of MACE, including hospitalization for decompensated HF, sudden and non-sudden cardiac death, ventricular arrhythmia PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bc3NvbXVsbDwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+
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ADDIN EN.CITE.DATA [78, 79] and all-cause mortality PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdWxhdGk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [80]. Mid-wall LGE distribution confers a higher risk of inducible ventricular tachycardia PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXphcmlhbjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+
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ADDIN EN.CITE.DATA [81]. Larger extents of mid-wall LGE independently predict lower likelihoods of LV reverse-remodelling in recent-onset DCM PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LdWJhbmVrPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48
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ADDIN EN.CITE.DATA [82]. Cardiac energy metabolism is deranged in HF and MRS is the most powerful method for its non-invasive assessment in vivo ADDIN EN.CITE <EndNote><Cite><Author>Neubauer</Author><Year>2007</Year><RecNum>21896</RecNum><DisplayText>[83]</DisplayText><record><rec-number>21896</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1449312011">21896</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Neubauer, Stefan</author></authors></contributors><titles><title>The Failing Heart — An Engine Out of Fuel</title><secondary-title>New England Journal of Medicine</secondary-title></titles><periodical><full-title>New England Journal of Medicine</full-title></periodical><pages>1140-1151</pages><volume>356</volume><number>11</number><dates><year>2007</year><pub-dates><date>2007/03/15</date></pub-dates></dates><publisher>Massachusetts Medical Society</publisher><isbn>0028-4793</isbn><urls><related-urls><url>;[83]. Its clinical use has been limited owing to its low temporal and spatial resolution, but this is arguably less important in diffuse myocardial processes such as DCM. In DCM, myocardial phosphocreatine:ATP ratios are reduced and lower ratios independently predict mortality ADDIN EN.CITE <EndNote><Cite><Author>Neubauer</Author><Year>1997</Year><RecNum>22038</RecNum><DisplayText>[84]</DisplayText><record><rec-number>22038</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450638731">22038</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Neubauer, S.</author><author>Horn, Michael</author><author>Cramer, Monika</author><author>Harre, Kerstin</author><author>Newell, John B.</author><author>Peters, Werner</author><author>Pabst, Thomas</author><author>Ertl, Georg</author><author>Hahn, Dietbert</author><author>Ingwall, Joanne S.</author><author>Kochsiek, Kurt</author></authors></contributors><titles><title>Myocardial Phosphocreatine-to-ATP Ratio Is a Predictor of Mortality in Patients With Dilated Cardiomyopathy</title><secondary-title>Circulation</secondary-title></titles><periodical><full-title>Circulation</full-title></periodical><pages>2190-2196</pages><volume>96</volume><number>7</number><dates><year>1997</year><pub-dates><date>October 7, 1997</date></pub-dates></dates><urls><related-urls><url> </url><url> </url></related-urls></urls><electronic-resource-num>10.1161/01.cir.96.7.2190</electronic-resource-num></record></Cite></EndNote>[84]. Forward CK creatine kinase shuttle flux is reduced in non-ischaemic cardiomyopathy and this also independently predicts of mortality PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XZWlzczwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [88, 89]. Recently proposed diagnostic criteria include transient and reversible regional wall motion abnormalitiesWMA of the LV or RV frequently preceded by a stressful trigger, circumferential involvement of ventricular segments beyond a single coronary territory, the absence of culprit coronary events and viral myocarditis, new and reversible electrocardiographic changes, significant natriuretic peptide rises, and troponin rises that are modest for the degree of dysfunction ADDIN EN.CITE <EndNote><Cite><Author>Lyon</Author><Year>2015</Year><RecNum>22045</RecNum><DisplayText>[90]</DisplayText><record><rec-number>22045</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451325726">22045</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lyon, Alexander R.</author><author>Bossone, Eduardo</author><author>Schneider, Birke</author><author>Sechtem, Udo</author><author>Citro, Rodolfo</author><author>Underwood, S. Richard</author><author>Sheppard, Mary N.</author><author>Figtree, Gemma A.</author><author>Parodi, Guido</author><author>Akashi, Yoshihiro J.</author><author>Ruschitzka, Frank</author><author>Filippatos, Gerasimos</author><author>Mebazaa, Alexandre</author><author>Omerovic, Elmir</author></authors></contributors><titles><title>Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology</title><secondary-title>European Journal of Heart Failure</secondary-title></titles><periodical><full-title>Eur J Heart Fail</full-title><abbr-1>European journal of heart failure</abbr-1></periodical><pages>n/a-n/a</pages><keywords><keyword>Takotsubo syndrome</keyword><keyword>stress</keyword><keyword>heart failure</keyword><keyword>risk stratification</keyword></keywords><dates><year>2015</year></dates><publisher>John Wiley & Sons, Ltd</publisher><isbn>1879-0844</isbn><urls><related-urls><url>;[90]. CMR detects ‘typical’ apical ballooning and ‘atypical’ variants e.g. biventricular, midventricular, basal, and focal ballooning PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FaXRlbDwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [91-93]. Oedema is detected on T2-weighted CMR in both takotsubo and myocarditis. However, LGE is usually absent acutely in takotsubo PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYXJhbWl0c29zPC9BdXRob3I+PFllYXI+MjAwODwvWWVh
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ADDIN EN.CITE.DATA [94, 95], unlike in myocardial infarction (subendocardial) and acute myocarditis (non-ischaemic distribution). Where available, CMR is recommended within seven days of presentation in suspected takotsubo syndrome to aid diagnosis and detect LV thrombus, and to confirm myocardial recovery on follow-up ADDIN EN.CITE <EndNote><Cite><Author>Assomull</Author><Year>2007</Year><RecNum>22055</RecNum><DisplayText>[96]</DisplayText><record><rec-number>22055</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451327893">22055</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Assomull, Ravi G.</author><author>Lyne, Jonathan C.</author><author>Keenan, Niall</author><author>Gulati, Ankur</author><author>Bunce, Nicholas H.</author><author>Davies, Simon W.</author><author>Pennell, Dudley J.</author><author>Prasad, Sanjay K.</author></authors></contributors><titles><title>The role of cardiovascular magnetic resonance in patients presenting with chest pain, raised troponin, and unobstructed coronary arteries</title><secondary-title>European Heart Journal</secondary-title></titles><periodical><full-title>Eur Heart J</full-title><abbr-1>European heart journal</abbr-1></periodical><pages>1242-1249</pages><volume>28</volume><number>10</number><dates><year>2007</year></dates><work-type>10.1093/eurheartj/ehm113</work-type><urls><related-urls><url>;[96]. MyocarditisMyocarditis is an inflammation of myocardial tissue of infectious, immune or toxic aetiology that presents as an ACS, new-onset or worsening HF, or life-threatening arrhythmia in the absence of CAD or known causes of HF. It may resolve spontaneously, recur, or become chronic, and may predate the development of DCM. Strictly speaking, myocarditis is diagnosed when endomyocardial biopsy (EMB) findings meet certain histological, immunohistochemical and immunological criteria PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYWZvcmlvPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48
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ADDIN EN.CITE.DATA [97, 98]. In life-threatening presentations urgent EMB has a level 1B indication, as only EMB can distinguish aetiologies, e.g. viral from non-viral, lymphocytic from giant-cell. However as EMB may be limited by sampling error or complicated by tamponade, it is not recommended for all patients ADDIN EN.CITE <EndNote><Cite><Author>Cooper</Author><Year>2007</Year><RecNum>22067</RecNum><DisplayText>[99]</DisplayText><record><rec-number>22067</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451812896">22067</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cooper, Leslie T.</author><author>Baughman, Kenneth L.</author><author>Feldman, Arthur M.</author><author>Frustaci, Andrea</author><author>Jessup, Mariell</author><author>Kuhl, Uwe</author><author>Levine, Glenn N.</author><author>Narula, Jagat</author><author>Starling, Randall C.</author><author>Towbin, Jeffrey</author><author>Virmani, Renu</author></authors></contributors><titles><title>The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease: A Scientific Statement From the American Heart Association, the American College of Cardiology, and the European Society of Cardiology Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>1914-1931</pages><volume>50</volume><number>19</number><keywords><keyword>AHA Scientific Statements</keyword><keyword>biopsy</keyword><keyword>transplantation</keyword><keyword>heart failure</keyword><keyword>cardiomyopathy</keyword><keyword>myocarditis</keyword></keywords><dates><year>2007</year><pub-dates><date>11/6/</date></pub-dates></dates><isbn>0735-1097</isbn><urls><related-urls><url>;[99]. CMR is the primary non-invasive imaging modality for the assessment of suspected myocarditis in clinically stable patients – it supports the diagnosis by identifying abnormalities of cardiac structure, function and tissue characteristics, excludes ischaemic patterns of injury and acts as a gatekeeper to EMB PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GcmllZHJpY2g8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy
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ADDIN EN.CITE.DATA [100, 101]. The accuracy of CMR diagnosis of myocarditis is variably reported, and depends on the combination of techniques used, the time point in the inflammatory process at which images are taken, the severity of the inflammation in the group studied and whether EMB is the comparison standard. Combining tissue characterization techniques improves diagnostic performance ADDIN EN.CITE <EndNote><Cite><Author>Abdel-Aty</Author><Year>2005</Year><RecNum>22061</RecNum><DisplayText>[102]</DisplayText><record><rec-number>22061</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451810030">22061</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Abdel-Aty, Hassan</author><author>Boyé, Philipp</author><author>Zagrosek, Anja</author><author>Wassmuth, Ralf</author><author>Kumar, Andreas</author><author>Messroghli, Daniel</author><author>Bock, Petra</author><author>Dietz, Rainer</author><author>Friedrich, Matthias G.</author><author>Schulz-Menger, Jeanette</author></authors></contributors><titles><title>Diagnostic Performance of Cardiovascular Magnetic Resonance in Patients With Suspected Acute Myocarditis: Comparison of Different Approaches</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>1815-1822</pages><volume>45</volume><number>11</number><dates><year>2005</year><pub-dates><date>6/7/</date></pub-dates></dates><isbn>0735-1097</isbn><urls><related-urls><url>;[102]. The recommended clinical diagnostic algorithm for suspected myocarditis ADDIN EN.CITE <EndNote><Cite><Author>Caforio</Author><Year>2013</Year><RecNum>22069</RecNum><DisplayText>[98]</DisplayText><record><rec-number>22069</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451813213">22069</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Caforio, Alida L. P.</author><author>Pankuweit, Sabine</author><author>Arbustini, Eloisa</author><author>Basso, Cristina</author><author>Gimeno-Blanes, Juan</author><author>Felix, Stephan B.</author><author>Fu, Michael</author><author>Heli?, Tiina</author><author>Heymans, Stephane</author><author>Jahns, Roland</author><author>Klingel, Karin</author><author>Linhart, Ales</author><author>Maisch, Bernhard</author><author>McKenna, William</author><author>Mogensen, Jens</author><author>Pinto, Yigal M.</author><author>Ristic, Arsen</author><author>Schultheiss, Heinz-Peter</author><author>Seggewiss, Hubert</author><author>Tavazzi, Luigi</author><author>Thiene, Gaetano</author><author>Yilmaz, Ali</author><author>Charron, Philippe</author><author>Elliott, Perry M.</author></authors></contributors><titles><title>Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases</title><secondary-title>European Heart Journal</secondary-title></titles><periodical><full-title>Eur Heart J</full-title><abbr-1>European heart journal</abbr-1></periodical><pages>2636-2648</pages><volume>34</volume><number>33</number><dates><year>2013</year></dates><work-type>10.1093/eurheartj/eht210</work-type><urls><related-urls><url>;[98] includes the CMR criteria proposed in the 2009 JACC White Paper for CMR assessment of myocarditis ADDIN EN.CITE <EndNote><Cite><Author>Friedrich</Author><Year>2009</Year><RecNum>21975</RecNum><DisplayText>[103]</DisplayText><record><rec-number>21975</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450007950">21975</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Friedrich, Matthias G.</author><author>Sechtem, Udo</author><author>Schulz-Menger, Jeanette</author><author>Holmvang, Godtfred</author><author>Alakija, Pauline</author><author>Cooper, Leslie T.</author><author>White, James A.</author><author>Abdel-Aty, Hassan</author><author>Gutberlet, Matthias</author><author>Prasad, Sanjay</author><author>Aletras, Anthony</author><author>Laissy, Jean-Pierre</author><author>Paterson, Ian</author><author>Filipchuk, Neil G.</author><author>Kumar, Andreas</author><author>Pauschinger, Matthias</author><author>Liu, Peter</author></authors></contributors><titles><title>Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>1475-1487</pages><volume>53</volume><number>17</number><dates><year>2009</year></dates><isbn>0735-1097</isbn><urls><related-urls><url>;[103]. 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ADDIN EN.CITE.DATA [104, 105]. The sensitivity of the 2009 CMR-criteria is greatest for patients with infarct-like rather than HF presentations ADDIN EN.CITE <EndNote><Cite><Author>Francone</Author><Year>2014</Year><RecNum>22074</RecNum><DisplayText>[106]</DisplayText><record><rec-number>22074</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451826858">22074</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Francone, Marco</author><author>Chimenti, Cristina</author><author>Galea, Nicola</author><author>Scopelliti, Fernanda</author><author>Verardo, Romina</author><author>Galea, Roberto</author><author>Carbone, Iacopo</author><author>Catalano, Carlo</author><author>Fedele, Francesco</author><author>Frustaci, Andrea</author></authors></contributors><titles><title>CMR Sensitivity Varies With Clinical Presentation and Extent of Cell Necrosis in Biopsy-Proven Acute Myocarditis</title><secondary-title>JACC: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>JACC: Cardiovascular Imaging</full-title></periodical><pages>254-263</pages><volume>7</volume><number>3</number><keywords><keyword>acute myocarditis</keyword><keyword>apoptosis</keyword><keyword>cardiac magnetic resonance</keyword><keyword>necrosis</keyword><keyword>viruses</keyword></keywords><dates><year>2014</year><pub-dates><date>3//</date></pub-dates></dates><isbn>1936-878X</isbn><urls><related-urls><url>;[106]. Where conventional techniques do not detect abnormalities or where gadolinium is contra-indicated, native (non-contrast) T1-mapping (Figure 8) can detect oedema in non-ischaemic distributions and so improve diagnostic confidence when imaging is performed at a median of three days from presentation PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GZXJyZWlyYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+
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ADDIN EN.CITE.DATA [107, 108]. Native T1 values raised >5 SD above the mean of the normal range could independently identifiedy acute myocarditis and were more raised in acute compared with convalescent stages of the process ADDIN EN.CITE <EndNote><Cite><Author>Hinojar</Author><Year>2015</Year><RecNum>23301</RecNum><DisplayText>[109]</DisplayText><record><rec-number>23301</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463667961">23301</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hinojar, Rocio</author><author>Foote, Lucy</author><author>Arroyo Ucar, Eduardo</author><author>Jackson, Thomas</author><author>Jabbour, Andrew</author><author>Yu, Chung-Yao</author><author>McCrohon, Jane</author><author>Higgins, David M.</author><author>Carr-White, Gerry</author><author>Mayr, Manuel</author><author>Nagel, Eike</author><author>Puntmann, Valentina O.</author></authors></contributors><titles><title>Native T1 in Discrimination of Acute and Convalescent Stages in Patients With Clinical?Diagnosis of MyocarditisA Proposed Diagnostic Algorithm Using CMR</title><secondary-title>JACC: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>JACC: Cardiovascular Imaging</full-title></periodical><pages>37-46</pages><volume>8</volume><number>1</number><dates><year>2015</year></dates><isbn>1936-878X</isbn><urls><related-urls><url>;[109]. Conversely, In one in another study of patients with recent-onset HF and clinically suspected myocarditis, T2 mapping revealed higher median global myocardial T2 values in those with biopsy-proven active myocarditis compared with those without, while there were no significant differences in native or post-contrast global myocardial T1 or in conventional criteria PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb2huZW48L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [110]. The addition of ECV quantification to conventional criteria was shown to improve diagnostic accuracy ADDIN EN.CITE <EndNote><Cite><Author>!!! INVALID CITATION !!! [118]</Author><RecNum>0</RecNum><DisplayText>(!!! INVALID CITATION !!! [118])</DisplayText><record><dates><year>!!! INVALID CITATION !!! [118]</year></dates></record></Cite></EndNote>( HYPERLINK \l "_ENREF_2" \o ", !!! INVALID CITATION !!! [118]" !!! INVALID CITATION !!! [118]). The prognostic value of CMR findings in myocarditis requires further investigation. The presence of LGE on CMR within five days of presentation was an independent predictor of all-cause and cardiac mortality in biopsy-proven viral myocarditis ADDIN EN.CITE <EndNote><Cite><Author>Grün</Author><Year>2012</Year><RecNum>22065</RecNum><DisplayText>[111]</DisplayText><record><rec-number>22065</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451810754">22065</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Grün, Stefan</author><author>Schumm, Julia</author><author>Greulich, Simon</author><author>Wagner, Anja</author><author>Schneider, Steffen</author><author>Bruder, Oliver</author><author>Kispert, Eva-Maria</author><author>Hill, Stephan</author><author>Ong, Peter</author><author>Klingel, Karin</author><author>Kandolf, Reinhardt</author><author>Sechtem, Udo</author><author>Mahrholdt, Heiko</author></authors></contributors><titles><title>Long-Term Follow-Up of Biopsy-Proven Viral Myocarditis: Predictors of Mortality and Incomplete Recovery</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>1604-1615</pages><volume>59</volume><number>18</number><keywords><keyword>cardiovascular magnetic resonance</keyword><keyword>mortality</keyword><keyword>myocarditis</keyword><keyword>prognosis</keyword></keywords><dates><year>2012</year><pub-dates><date>5/1/</date></pub-dates></dates><isbn>0735-1097</isbn><urls><related-urls><url>;[111], and in a LGE positive cohort, initial LVEF, but not LGE extent, predicted outcome PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5ndWluZXRpPC9BdXRob3I+PFllYXI+MjAxNTwvWWVh
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ADDIN EN.CITE.DATA [112]. Iron Overload CardiomyopathyIn patients with HF and suspected cardiac iron overload, and especially in transfusion-dependent beta-thalassaemia major, CMR with T2* at 1.5T field strength should be performed at the earliest opportunity to expedite definitive diagnosis and treatment and advice from a centre of expertise sought ADDIN EN.CITE <EndNote><Cite><Author>Pennell</Author><Year>2013</Year><RecNum>22029</RecNum><DisplayText>[113]</DisplayText><record><rec-number>22029</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450603915">22029</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pennell, Dudley J.</author><author>Udelson, James E.</author><author>Arai, Andrew E.</author><author>Bozkurt, Biykem</author><author>Cohen, Alan R.</author><author>Galanello, Renzo</author><author>Hoffman, Timothy M.</author><author>Kiernan, Michael S.</author><author>Lerakis, Stamatios</author><author>Piga, Antonio</author><author>Porter, John B.</author><author>Walker, John Malcolm</author><author>Wood, John</author></authors></contributors><titles><title>Cardiovascular Function and Treatment in β-Thalassemia Major: A Consensus Statement From the American Heart Association</title><secondary-title>Circulation</secondary-title></titles><periodical><full-title>Circulation</full-title></periodical><pages>281-308</pages><volume>128</volume><number>3</number><dates><year>2013</year><pub-dates><date>July 16, 2013</date></pub-dates></dates><urls><related-urls><url>;[113]. T2* is a magnetic relaxation property of any tissue and is inversely related to intracellular iron stores. Myocardial T2* <20ms is a reproducible, specific marker of significant cardiac iron content, which does not correlate with liver iron concentration and serum ferritin (Figure 6) ADDIN EN.CITE <EndNote><Cite><Author>Anderson</Author><Year>2001</Year><RecNum>21992</RecNum><DisplayText>[114]</DisplayText><record><rec-number>21992</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450009802">21992</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Anderson, L. J.</author><author>Holden, S.</author><author>Davis, B.</author><author>Prescott, E.</author><author>Charrier, C. C.</author><author>Bunce, N. H.</author><author>Firmin, D. N.</author><author>Wonke, B.</author><author>Porter, J.</author><author>Walker, J. M.</author><author>Pennell, D. J.</author></authors></contributors><titles><title>Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload</title><secondary-title>European Heart Journal</secondary-title></titles><periodical><full-title>Eur Heart J</full-title><abbr-1>European heart journal</abbr-1></periodical><pages>2171-2179</pages><volume>22</volume><number>23</number><dates><year>2001</year></dates><work-type>10.1053/euhj.2001.2822</work-type><urls><related-urls><url>;[114]. Myocardial T2* and iron concentration in the septum are excellent predictors of mean total cardiac iron concentration in explanted hearts PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXJwZW50ZXI8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFy
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ADDIN EN.CITE.DATA [115]. T2* declines before LVEF, and is the best predictor of future HF and ventricular arrhythmias, with T2* <10ms indicating high risk and 10-20ms indicating intermediate risk ADDIN EN.CITE <EndNote><Cite><Author>Kirk</Author><Year>2009</Year><RecNum>22030</RecNum><DisplayText>[116]</DisplayText><record><rec-number>22030</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450607168">22030</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kirk, P.</author><author>Roughton, M.</author><author>Porter, J.B.</author><author>Walker, J.M.</author><author>Tanner, M.A.</author><author>Patel, J.</author><author>Wu, D.</author><author>Taylor, J.</author><author>Westwood, M.A.</author><author>Anderson, L.J.</author><author>Pennell, D.J.</author></authors></contributors><titles><title>Cardiac T2* Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Major</title><secondary-title>Circulation</secondary-title></titles><periodical><full-title>Circulation</full-title></periodical><pages>1961-1968</pages><volume>120</volume><number>20</number><dates><year>2009</year><pub-dates><date>November 17, 2009</date></pub-dates></dates><urls><related-urls><url>;[116]. If iron chelation therapy is started early, declines in LVEF are preventable and reversible: T2* imaging has had a major impact on survival in thalassaemic patients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb2RlbGw8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [117]. T1 also shortens in iron overload and in the presence of mild increases in iron concentration, native T1 mapping may be a more sensitive and reproducible technique than T2*, albeit not yet validated against outcome and with variation in absolute T1 values between centres ADDIN EN.CITE <EndNote><Cite><Author>!!! INVALID CITATION !!! [126-128]</Author><RecNum>0</RecNum><DisplayText>(!!! INVALID CITATION !!! [126-128])</DisplayText><record><dates><year>!!! INVALID CITATION !!! [126-128]</year></dates></record></Cite></EndNote>( HYPERLINK \l "_ENREF_3" \o ", !!! INVALID CITATION !!! [126-128]" !!! INVALID CITATION !!! [126-128])Cardiac AmyloidosisAmyloidosis results from extracellular deposition of abnormal insoluble fibrils derived from a misfolded, normally soluble protein ADDIN EN.CITE <EndNote><Cite><Author>Selvanayagam</Author><Year>2007</Year><RecNum>22031</RecNum><DisplayText>[118]</DisplayText><record><rec-number>22031</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450616543">22031</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Selvanayagam, Joseph B.</author><author>Hawkins, Philip N.</author><author>Paul, Biju</author><author>Myerson, Saul G.</author><author>Neubauer, Stefan</author></authors></contributors><titles><title>Evaluation and Management of the Cardiac Amyloidosis</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>2101-2110</pages><volume>50</volume><number>22</number><dates><year>2007</year><pub-dates><date>11/27/</date></pub-dates></dates><isbn>0735-1097</isbn><urls><related-urls><url>;[118]. The three commonest types of amyloidosis affecting the heart include systemic AL amyloidosis, where the fibrils derive from monoclonal immunoglobulin light chains in the setting of B-cell dyscrasias, hereditary systemic (variant) TTR amyloidosis, where the fibrils derive from variant transthyretin, and senile systemic (wild-type) ATTR amyloidosis. The V122I variant is the commonest mutation and is found in 3-4% of black Americans, carriers of which have an increased risk of HF compared with non-carriers over long-term follow-up ADDIN EN.CITE <EndNote><Cite><Author>Quarta</Author><Year>2015</Year><RecNum>22035</RecNum><DisplayText>[119]</DisplayText><record><rec-number>22035</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450617858">22035</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Quarta, C. Cristina</author><author>Buxbaum, Joel N.</author><author>Shah, Amil M.</author><author>Falk, Rodney H.</author><author>Claggett, Brian</author><author>Kitzman, Dalane W.</author><author>Mosley, Thomas H.</author><author>Butler, Kenneth R.</author><author>Boerwinkle, Eric</author><author>Solomon, Scott D.</author></authors></contributors><titles><title>The Amyloidogenic V122I Transthyretin Variant in Elderly Black Americans</title><secondary-title>New England Journal of Medicine</secondary-title></titles><periodical><full-title>New England Journal of Medicine</full-title></periodical><pages>21-29</pages><volume>372</volume><number>1</number><dates><year>2015</year><pub-dates><date>2015/01/01</date></pub-dates></dates><publisher>Massachusetts Medical Society</publisher><isbn>0028-4793</isbn><urls><related-urls><url>;[119]. ATTR amyloidosis is an underdiagnosed cause of HF. Biopsy remains the gold standard for diagnosis ADDIN EN.CITE <EndNote><Cite><Author>Gertz</Author><Year>2015</Year><RecNum>22036</RecNum><DisplayText>[120]</DisplayText><record><rec-number>22036</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450617965">22036</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Gertz, Morie A.</author><author>Benson, Merrill D.</author><author>Dyck, Peter J.</author><author>Grogan, Martha</author><author>Coelho, Terresa</author><author>Cruz, Marcia</author><author>Berk, John L.</author><author>Plante-Bordeneuve, Violaine</author><author>Schmidt, Hartmut H. J.</author><author>Merlini, Giampaolo</author></authors></contributors><titles><title>Diagnosis, Prognosis, and Therapy of?Transthyretin Amyloidosis</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>2451-2466</pages><volume>66</volume><number>21</number><keywords><keyword>familial amyloid cardiomyopathy</keyword><keyword>familial amyloid polyneuropathy</keyword><keyword>genetics</keyword><keyword>liver?transplantation</keyword></keywords><dates><year>2015</year><pub-dates><date>12/1/</date></pub-dates></dates><isbn>0735-1097</isbn><urls><related-urls><url>;[120].Given the short median survival in cardiac AL amyloidosis (~5 months), CMR is indicated in patients with HF and suspected cardiac amyloidosis to expedite diagnosis and treatment with chemotherapy. 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ADDIN EN.CITE.DATA [121-124]. Compared with AL, ATTR involvement is characterized by greater LV mass and LGE extent, greater likelihood of transmural and RV LGE, and longer survival ADDIN EN.CITE <EndNote><Cite><Author>Dungu</Author><Year>2014</Year><RecNum>21974</RecNum><DisplayText>[125]</DisplayText><record><rec-number>21974</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450007932">21974</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dungu, Jason N.</author><author>Valencia, Oswaldo</author><author>Pinney, Jennifer H.</author><author>Gibbs, Simon D. J.</author><author>Rowczenio, Dorota</author><author>Gilbertson, Janet A.</author><author>Lachmann, Helen J.</author><author>Wechalekar, Ashutosh</author><author>Gillmore, Julian D.</author><author>Whelan, Carol J.</author><author>Hawkins, Philip N.</author><author>Anderson, Lisa J.</author></authors></contributors><titles><title>CMR-Based Differentiation of AL and ATTR Cardiac Amyloidosis</title><secondary-title>JACC: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>JACC: Cardiovascular Imaging</full-title></periodical><pages>133-142</pages><volume>7</volume><number>2</number><dates><year>2014</year></dates><isbn>1936-878X</isbn><urls><related-urls><url>;[125]. Elevated T1 on native T1 mapping (Figure 8) has high accuracy for cardiac involvement in AL amyloidosis ADDIN EN.CITE <EndNote><Cite><Author>Karamitsos</Author><Year>2013</Year><RecNum>22091</RecNum><DisplayText>[126]</DisplayText><record><rec-number>22091</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451843262">22091</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Karamitsos, Theodoros D.</author><author>Piechnik, Stefan K.</author><author>Banypersad, Sanjay M.</author><author>Fontana, Marianna</author><author>Ntusi, Ntobeko B.</author><author>Ferreira, Vanessa M.</author><author>Whelan, Carol J.</author><author>Myerson, Saul G.</author><author>Robson, Matthew D.</author><author>Hawkins, Philip N.</author><author>Neubauer, Stefan</author><author>Moon, James C.</author></authors></contributors><titles><title>Noncontrast T1 Mapping for the Diagnosis of Cardiac Amyloidosis</title><secondary-title>JACC: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>JACC: Cardiovascular Imaging</full-title></periodical><pages>488-497</pages><volume>6</volume><number>4</number><keywords><keyword>amyloid</keyword><keyword>cardiovascular magnetic resonance</keyword><keyword>T1 time</keyword></keywords><dates><year>2013</year><pub-dates><date>4//</date></pub-dates></dates><isbn>1936-878X</isbn><urls><related-urls><url>;[126] and together with raised ECV predicts mortality ADDIN EN.CITE <EndNote><Cite><Author>Banypersad</Author><Year>2015</Year><RecNum>22092</RecNum><DisplayText>[127]</DisplayText><record><rec-number>22092</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451844081">22092</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Banypersad, Sanjay M.</author><author>Fontana, Marianna</author><author>Maestrini, Viviana</author><author>Sado, Daniel M.</author><author>Captur, Gabriella</author><author>Petrie, Aviva</author><author>Piechnik, Stefan K.</author><author>Whelan, Carol J.</author><author>Herrey, Anna S.</author><author>Gillmore, Julian D.</author><author>Lachmann, Helen J.</author><author>Wechalekar, Ashutosh D.</author><author>Hawkins, Philip N.</author><author>Moon, James C.</author></authors></contributors><titles><title>T1 mapping and survival in systemic light-chain amyloidosis</title><secondary-title>European Heart Journal</secondary-title></titles><periodical><full-title>Eur Heart J</full-title><abbr-1>European heart journal</abbr-1></periodical><pages>244-251</pages><volume>36</volume><number>4</number><dates><year>2015</year></dates><work-type>10.1093/eurheartj/ehu444</work-type><urls><related-urls><url>;[127]. Raised native T1 also has high accuracy in ATTR cardiac amyloid as compared with HCM, ATTR mutation carriers and normal controls and may represent an early disease marker ADDIN EN.CITE <EndNote><Cite><Author>Fontana</Author><Year>2014</Year><RecNum>21973</RecNum><DisplayText>[128]</DisplayText><record><rec-number>21973</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1450007908">21973</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fontana, Marianna</author><author>Banypersad, Sanjay M.</author><author>Treibel, Thomas A.</author><author>Maestrini, Viviana</author><author>Sado, Daniel M.</author><author>White, Steven K.</author><author>Pica, Silvia</author><author>Castelletti, Silvia</author><author>Piechnik, Stefan K.</author><author>Robson, Matthew D.</author><author>Gilbertson, Janet A.</author><author>Rowczenio, Dorota</author><author>Hutt, David F.</author><author>Lachmann, Helen J.</author><author>Wechalekar, Ashutosh D.</author><author>Whelan, Carol J.</author><author>Gillmore, Julian D.</author><author>Hawkins, Philip N.</author><author>Moon, James C.</author></authors></contributors><titles><title>Native T1 Mapping in Transthyretin Amyloidosis</title><secondary-title>JACC: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>JACC: Cardiovascular Imaging</full-title></periodical><pages>157-165</pages><volume>7</volume><number>2</number><dates><year>2014</year></dates><isbn>1936-878X</isbn><urls><related-urls><url>;[128]. 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ADDIN EN.CITE.DATA [129, 130]. In the presence of renal replacement therapy, cardiac involvement drives mortality. Early enzyme replacement therapy can cause regression of LVH ADDIN EN.CITE <EndNote><Cite><Author>Weidemann</Author><Year>2009</Year><RecNum>22317</RecNum><DisplayText>[131]</DisplayText><record><rec-number>22317</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451894839">22317</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Weidemann, Frank</author><author>Niemann, Markus</author><author>Breunig, Frank</author><author>Herrmann, Sebastian</author><author>Beer, Meinrad</author><author>St?rk, Stefan</author><author>Voelker, Wolfram</author><author>Ertl, Georg</author><author>Wanner, Christoph</author><author>Strotmann, J?rg</author></authors></contributors><titles><title>Long-Term Effects of Enzyme Replacement Therapy on Fabry Cardiomyopathy: Evidence for a Better Outcome With Early Treatment</title><secondary-title>Circulation</secondary-title></titles><periodical><full-title>Circulation</full-title></periodical><pages>524-529</pages><volume>119</volume><number>4</number><dates><year>2009</year><pub-dates><date>February 3, 2009</date></pub-dates></dates><urls><related-urls><url>;[131]. In AFD, LGE may be detected particularly affecting the basal inferolateral wall in the absence of CAD (Figure 98) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb29uPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVj
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ADDIN EN.CITE.DATA [134, 135], differentiating this condition from LGE caused by fibrosis, HCM, oedema and amyloid, where T1 is increased. CMR can identify AFD in unexplained LVH and offers the potential for early detection: in one study, native T1 was lowered in AFD genotype positive, LVH negative individuals, although correlation with lipid burden on biopsy was not performed ADDIN EN.CITE <EndNote><Cite><Author>Pica</Author><Year>2014</Year><RecNum>22060</RecNum><DisplayText>[136]</DisplayText><record><rec-number>22060</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451809925">22060</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pica, Silvia</author><author>Sado, Daniel M</author><author>Maestrini, Viviana</author><author>Fontana, Marianna</author><author>White, Steven K</author><author>Treibel, Thomas</author><author>Captur, Gabriella</author><author>Anderson, Sarah</author><author>Piechnik, Stefan K</author><author>Robson, Matthew D</author></authors></contributors><titles><title>Reproducibility of native myocardial T1 mapping in the assessment of Fabry disease and its role in early detection of cardiac involvement by cardiovascular magnetic resonance</title><secondary-title>Journal of Cardiovascular Magnetic Resonance</secondary-title></titles><periodical><full-title>Journal of Cardiovascular Magnetic Resonance</full-title></periodical><pages>99</pages><volume>16</volume><number>1</number><dates><year>2014</year></dates><isbn>1532-429X</isbn><urls></urls></record></Cite></EndNote>[136]. Current guidelines advocate the CMR measures of LV wall thickness, mass index and LGE to guide enzyme replacement therapy in AFD ADDIN EN.CITE <EndNote><Cite><Author>West</Author><Year>2012</Year><RecNum>22346</RecNum><DisplayText>[137]</DisplayText><record><rec-number>22346</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1452453453">22346</key></foreign-keys><ref-type name="Electronic Article">43</ref-type><contributors><authors><author>West, ML</author><author>Robin, C</author><author>Clarke, JT</author><author>Iwanochko, M</author><author>Moore, DF</author><author>Sirrs, S</author></authors></contributors><titles><title>Canadian Fabry disease treatment guidelines</title></titles><dates><year>2012</year></dates><pub-location>;[137]. HF with Preserved EF (HF-PEF)The diagnosis of HF-PEF requires resting LVEF ≥50%, a non-dilated LV (LVEDV index <97ml/m2), and sufficient biomarker, imaging and/or invasive evidence of diastolic dysfunction PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXVsdXM8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [138]. Although outcomes are similar in HF-PEF and HF-REF ADDIN EN.CITE <EndNote><Cite><Author>Bhatia</Author><Year>2006</Year><RecNum>22337</RecNum><DisplayText>[139]</DisplayText><record><rec-number>22337</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451906819">22337</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bhatia, R. Sacha</author><author>Tu, Jack V.</author><author>Lee, Douglas S.</author><author>Austin, Peter C.</author><author>Fang, Jiming</author><author>Haouzi, Annick</author><author>Gong, Yanyan</author><author>Liu, Peter P.</author></authors></contributors><titles><title>Outcome of Heart Failure with Preserved Ejection Fraction in a Population-Based Study</title><secondary-title>New England Journal of Medicine</secondary-title></titles><periodical><full-title>New England Journal of Medicine</full-title></periodical><pages>260-269</pages><volume>355</volume><number>3</number><dates><year>2006</year></dates><accession-num>16855266</accession-num><urls><related-urls><url>;[139], no drug therapies have been shown to improve survival in HF-PEF to date PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYXJnPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj
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ADDIN EN.CITE.DATA [140, 141].While 2D-echocardiography has superior temporal resolution for assessment of LV filling, CMR may contribute superior assessment of LVEF, LV mass and LA volumes, in addition to correlates of pulmonary hypertension e.g. pulmonary artery:aorta ratio PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYXJha3VzPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48
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ADDIN EN.CITE.DATA [142] and RV function ADDIN EN.CITE <EndNote><Cite><Author>Goliasch</Author><Year>2015</Year><RecNum>22129</RecNum><DisplayText>[143]</DisplayText><record><rec-number>22129</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451893744">22129</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Goliasch, G.</author><author>Zotter-Tufaro, C.</author><author>Aschauer, S.</author><author>Duca, F.</author><author>Koell, B.</author><author>Kammerlander, A. A.</author><author>Ristl, R.</author><author>Lang, I. M.</author><author>Maurer, G.</author><author>Mascherbauer, J.</author><author>Bonderman, D.</author></authors></contributors><auth-address>Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Section for Medical Statistics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.</auth-address><titles><title>Outcome in Heart Failure with Preserved Ejection Fraction: The Role of Myocardial Structure and Right Ventricular Performance</title><secondary-title>PLoS One</secondary-title><alt-title>PloS one</alt-title></titles><periodical><full-title>PLoS One</full-title><abbr-1>PloS one</abbr-1></periodical><alt-periodical><full-title>PLoS One</full-title><abbr-1>PloS one</abbr-1></alt-periodical><pages>e0134479</pages><volume>10</volume><number>7</number><edition>2015/08/01</edition><dates><year>2015</year></dates><isbn>1932-6203 (Electronic)
1932-6203 (Linking)</isbn><accession-num>26225557</accession-num><urls></urls><custom2>PMC4520449</custom2><electronic-resource-num>10.1371/journal.pone.0134479</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[143]. The utility of correlations between diastolic dysfunction and diffuse myocardial fibrosis ADDIN EN.CITE <EndNote><Cite><Author>Su</Author><Year>2014</Year><RecNum>22338</RecNum><DisplayText>[144]</DisplayText><record><rec-number>22338</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451907087">22338</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Su, Mao-Yuan M.</author><author>Lin, Lian-Yu</author><author>Tseng, Yao-Hui E.</author><author>Chang, Chin-Chen</author><author>Wu, Cho-Kai</author><author>Lin, Jiunn-Lee</author><author>Tseng, Wen-Yih I.</author></authors></contributors><titles><title>CMR-Verified Diffuse Myocardial Fibrosis?Is?Associated With Diastolic Dysfunction?in?HFpEF</title><secondary-title>JACC: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>JACC: Cardiovascular Imaging</full-title></periodical><pages>991-997</pages><volume>7</volume><number>10</number><keywords><keyword>cardiac magnetic resonance</keyword><keyword>extracellular volume fraction</keyword><keyword>heart failure with preserved ejection fraction</keyword></keywords><dates><year>2014</year><pub-dates><date>10//</date></pub-dates></dates><isbn>1936-878X</isbn><urls><related-urls><url>;[144] and between post-contrast T1 and outcome ADDIN EN.CITE <EndNote><Cite><Author>Mascherbauer</Author><Year>2013</Year><RecNum>22339</RecNum><DisplayText>[145]</DisplayText><record><rec-number>22339</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451907226">22339</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mascherbauer, Julia</author><author>Marzluf, Beatrice A.</author><author>Tufaro, Caroline</author><author>Pfaffenberger, Stefan</author><author>Graf, Alexandra</author><author>Wexberg, Paul</author><author>Panzenb?ck, Adelheid</author><author>Jakowitsch, Johannes</author><author>Bangert, Christine</author><author>Laimer, Daniela</author><author>Schreiber, Catharina</author><author>Karakus, Gültekin</author><author>Hülsmann, Martin</author><author>Pacher, Richard</author><author>Lang, Irene M.</author><author>Maurer, Gerald</author><author>Bonderman, Diana</author></authors></contributors><titles><title>Cardiac Magnetic Resonance Postcontrast T1 Time Is Associated With Outcome in Patients With Heart Failure and Preserved Ejection Fraction</title><secondary-title>Circulation: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>Circulation: Cardiovascular Imaging</full-title></periodical><pages>1056-1065</pages><volume>6</volume><number>6</number><dates><year>2013</year><pub-dates><date>November 1, 2013</date></pub-dates></dates><urls><related-urls><url>;[145] is under investigation and CMR indices of diastolic function are not yet routinely measured PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hw7Z0dGU8L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [151, 152]. Most children with childhood cancer will become long-term survivors and be more likely to develop HF than their siblings ADDIN EN.CITE <EndNote><Cite><Author>Oeffinger</Author><Year>2006</Year><RecNum>22327</RecNum><DisplayText>[153]</DisplayText><record><rec-number>22327</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1451900598">22327</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Oeffinger, Kevin C.</author><author>Mertens, Ann C.</author><author>Sklar, Charles A.</author><author>Kawashima, Toana</author><author>Hudson, Melissa M.</author><author>Meadows, Anna T.</author><author>Friedman, Debra L.</author><author>Marina, Neyssa</author><author>Hobbie, Wendy</author><author>Kadan-Lottick, Nina S.</author><author>Schwartz, Cindy L.</author><author>Leisenring, Wendy</author><author>Robison, Leslie L.</author></authors></contributors><titles><title>Chronic Health Conditions in Adult Survivors of Childhood Cancer</title><secondary-title>New England Journal of Medicine</secondary-title></titles><periodical><full-title>New England Journal of Medicine</full-title></periodical><pages>1572-1582</pages><volume>355</volume><number>15</number><dates><year>2006</year></dates><accession-num>17035650</accession-num><urls><related-urls><url>;[153]. Early detection and prompt treatment of anthracycline-related cardiotoxicity can prevent LV dysfunction and promote LV recovery PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXJkaW5hbGU8L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFy
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ADDIN EN.CITE.DATA [159], LV mass index <55 g/m2, a measure negatively correlated with anthracycline dose and predictor of MACE in patients with reduced LVEF post anthracycline therapy ADDIN EN.CITE <EndNote><Cite><Author>Neilan</Author><Year>2012</Year><RecNum>23273</RecNum><DisplayText>(Neilan et al., 2012)</DisplayText><record><rec-number>23273</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463653115">23273</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Neilan, Tomas G.</author><author>Coelho-Filho, Otavio R.</author><author>Pena-Herrera, Diego</author><author>Shah, Ravi V.</author><author>Jerosch-Herold, Michael</author><author>Francis, Sanjeev A.</author><author>Moslehi, Javid</author><author>Kwong, Raymond Y.</author></authors></contributors><titles><title>Left Ventricular Mass in Patients With a Cardiomyopathy After Treatment With Anthracyclines</title><secondary-title>The American Journal of Cardiology</secondary-title></titles><periodical><full-title>Am J Cardiol</full-title><abbr-1>The American journal of cardiology</abbr-1></periodical><pages>1679-1686</pages><volume>110</volume><number>11</number><dates><year>2012</year><pub-dates><date>12/1/</date></pub-dates></dates><isbn>0002-9149</isbn><urls><related-urls><url>;( HYPERLINK \l "_ENREF_120" \o "Neilan, 2012 #23273" Neilan et al., 2012), impaired RV function ADDIN EN.CITE <EndNote><Cite><Author>Yl?nen</Author><Year>2013</Year><RecNum>23272</RecNum><DisplayText>(Yl?nen et al., 2013)</DisplayText><record><rec-number>23272</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463652203">23272</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yl?nen, Kaisa</author><author>Poutanen, Tuija</author><author>Savikurki-Heikkil?, P?ivi</author><author>Rinta-Kiikka, Irina</author><author>Eerola, Anneli</author><author>Vettenranta, Kim</author></authors></contributors><titles><title>Cardiac Magnetic Resonance Imaging in the Evaluation of the Late Effects of Anthracyclines Among Long-Term Survivors of Childhood Cancer</title><secondary-title>Journal of the American College of Cardiology</secondary-title></titles><periodical><full-title>Journal of the American College of Cardiology</full-title></periodical><pages>1539-1547</pages><volume>61</volume><number>14</number><dates><year>2013</year></dates><isbn>0735-1097</isbn><urls><related-urls><url>;( HYPERLINK \l "_ENREF_179" \o "Yl?nen, 2013 #23272" Yl?nen et al., 2013), and and is useful in the assessment of the efficacy of treatments aimed at preventing HF in patients undergoing chemotherapy ADDIN EN.CITE <EndNote><Cite><Author>!!! INVALID CITATION !!! [173, 174]</Author><RecNum>0</RecNum><DisplayText>(!!! INVALID CITATION !!! [173, 174])</DisplayText><record><dates><year>!!! INVALID CITATION !!! [173, 174]</year></dates></record></Cite></EndNote>( HYPERLINK \l "_ENREF_4" \o ", !!! INVALID CITATION !!! [173, 174]" !!! INVALID CITATION !!! [173, 174]). Expert consensus guidelines recommend CMR in particular when ventricular function nears thresholds for chemotherapy discontinuation or when there is significant regurgitant valve disease PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QbGFuYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [160]. LGE is an insensitive marker with poor prognostic utility in cancer survivors ADDIN EN.CITE <EndNote><Cite><Author>Thavendiranathan</Author><Year>2013</Year><RecNum>23307</RecNum><DisplayText>[161]</DisplayText><record><rec-number>23307</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463672207">23307</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Thavendiranathan, Paaladinesh</author><author>Wintersperger, Bernd J.</author><author>Flamm, Scott D.</author><author>Marwick, Thomas H.</author></authors></contributors><titles><title>Cardiac MRI in the Assessment of Cardiac Injury and Toxicity From Cancer Chemotherapy: A Systematic Review</title><secondary-title>Circulation: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>Circulation: Cardiovascular Imaging</full-title></periodical><pages>1080-1091</pages><volume>6</volume><number>6</number><dates><year>2013</year><pub-dates><date>November 1, 2013</date></pub-dates></dates><urls><related-urls><url>;[161]. The utility of ECV, LA volume, oedema, and deformation imaging to detect cardiotoxicity before declines in LVEF is under investigation (PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OZWlsYW48L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [162-166]. In a series of childhood cancer survivors who previously received ≥200 mg/m2 anthracycline and had normal indices of global systolic function by standard CMR parameters, CMR tagging techniques detected significant falls in global and segmental LV peak longitudinal and circumferential strain and detected more widespread regional falls in strain than did speckle-tracking by echocardiography ADDIN EN.CITE <EndNote><Cite><Author>Toro-Salazar</Author><Year>2013</Year><RecNum>23268</RecNum><DisplayText>[167]</DisplayText><record><rec-number>23268</rec-number><foreign-keys><key app="EN" db-id="2vea0x5z7p0srce5rv85z00aedf5zap0afzt" timestamp="1463647908">23268</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Toro-Salazar, Olga H.</author><author>Gillan, Eileen</author><author>O’Loughlin, Michael T.</author><author>Burke, Georgine S.</author><author>Ferranti, Joanna</author><author>Stainsby, Jeffrey</author><author>Liang, Bruce</author><author>Mazur, Wojciech</author><author>Raman, Subha V.</author><author>Hor, Kan N.</author></authors></contributors><titles><title>Occult Cardiotoxicity in Childhood Cancer Survivors Exposed to Anthracycline Therapy</title><secondary-title>Circulation: Cardiovascular Imaging</secondary-title></titles><periodical><full-title>Circulation: Cardiovascular Imaging</full-title></periodical><pages>873-880</pages><volume>6</volume><number>6</number><dates><year>2013</year><pub-dates><date>November 1, 2013</date></pub-dates></dates><urls><related-urls><url>;[167]. Whether strain by CMR predicts later HF has yet to be demonstrated, but declines in global longitudinal strain by echocardiography have already been shown to predict later declines in LVEF ADDIN EN.CITE <EndNote><Cite><Author>!!! INVALID CITATION !!! [183, 184]</Author><RecNum>0</RecNum><DisplayText>(!!! INVALID CITATION !!! [183, 184])</DisplayText><record><dates><year>!!! INVALID CITATION !!! [183, 184]</year></dates></record></Cite></EndNote>( HYPERLINK \l "_ENREF_5" \o ", !!! INVALID CITATION !!! [183, 184]" !!! INVALID CITATION !!! [183, 184]).Other cardiomyopathiesHF is an uncommon first presentation for HCM, arrhythmogenic RV cardiomyopathy, and cardiac sarcoidosis, and the role of CMR in the assessment of these conditions has been reviewed extensively elsewhere PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYXJhbWl0c29zPC9BdXRob3I+PFllYXI+MjAwOTwvWWVh
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ADDIN EN.CITE.DATA [26, 168-171].PerspectiveCMR has established and evolving roles in the assessment of patients with HF particularly the confirmation of underlying aetiology. The extent of involvement detected on CMR carries prognostic information in ICM, DCM, iron overload, cardiac amyloid and AFD. The identification of diffuse interstitial fibrosis in many of the cardiomyopathies is increasing knowledge about the mechanisms of the disease processes involved. The role of T2* in assessment of response to therapy in iron overload is established and a potentialsimilar role for T1 in specific therapies for cardiac amyloid and AFD is emerging. The use of T1, T2 and T2* mapping sequences is increasing for myocardial tissue assessment in the cardiomyopathies.FIGURE LEGENDSFigure 1. LV thrombi identified on early gadolinium-enhanced images: (left) multiple thrombi in short-axis mid ventricle view; (right) apical thrombus with transmural apical enhancement in three-chamber view.Figure 2. Extensive anterior and anteroseptal subendocardial LGE distribution typical of anteroseptal ischaemic injury.Figure 3. Inferior and inferoseptal subendocardial inducible perfusion deficit on vasodilator-stress first-pass gadolinium contrast images.Figure 4. Microvascular obstruction is identified at the core of a recent anteroseptal infarct. There is surrounding subendocardial anteroseptal, inferoseptal and anterior LGE.Figure 5. Extensive mExtensive midwall septal LGE distribution seen on short-axis imaging in aa patient with DCM.Figure 6. T2* imaging of two thalassaemic patients showing iron loading of the heart sparing the liver (left), in the other patient, iron loading of the liver sparing the heart (right). LV; left ventricle. RV; right ventricle.Figure 7. LGE in cardiac amyloidosis: (left) widespread transmural distribution in ATTR, (right) global subendocardial distribution in AL with transmurality at the base of the LV. Figure 8. Top row: Normal appearances on LGE (left), T2 STIR imaging (middle), and native T1 mapping (right). Middle row: cardiac amyloidosis on LGE imaging (left, middle) demonstrates abnormal blood-pool appearance with ‘zebra-stripe’ enhancement of and difficulty nulling the myocardium; there is heterogeneous diffuse increase in myocardial T1 on native T1 mapping (right). Bottom row: acute myocarditis demonstrates subepicardial lateral wall enhancement on LGE imaging (left), diffusely increased signal relative to skeletal muscle on T2 STIR imaging (middle), and increased lateral wall T1 on native T1 mapping (right). Figure 89. Basal inferolateral LGE distribution seen in a patient with Anderson Fabry’s Disease.References ADDIN EN.REFLIST 1.Ponikowski, P., et al., 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. 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