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Tapentadol is a centrally acting opioid analgesic believed to act through a dual mechanism as a mu-opioid receptor agonist and an inhibitor of norepinephrine reuptake. Tramadol, a widely utilized analgesic, works by a similar mechanism as a mu-opioid agonist (parent drug and M1 metabolite) and a weak inhibitor of serotonin and norepinephrine ... ................
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