Digital Model of a Hypertrophic Heart g

Executive Summary

A physical modeling allows surgeons to plan for the surgery and better treatment of the Hypertrophic cardiomyopathy. This project represents a physical model of Hypertrophic heart patient's anatomy using a scanIP software. CT scan images are analyzed in order to design 3-dimensional model of hypertrophic heart for pre-operational study and anatomical understanding of the diseased heart.

Background

Hypertrophic cardiomyopathy is a congenital disease that results in the thickening of the myocardial tissue. This thickening restricts the free flowing of blood through the heart due to the excess tissue in the ventricular septum which compresses the chambers and prevents the total ejection of blood from the ventricle.

Figure 1. Normal heart vs hypertrophic heart At least 1 in 500 people present symptoms of HCM. With the complexity of the surgery, itself pre-operational study is important. This need inspires the development of our project. We are using the ScanIP software for the reconstruction of the heart, which is able to read and render CT scans, called DICOM files. It is also able to create a 3D model based on user input.

Digital Model of a Hypertrophic Heart

Bogati, B., Mahler, T., Musozya, M., Tessema T. BE 4355-001 Senior Design II

Mentor: Dr. Jun Liao, Biomedical Engineering Department

Conceptual Design Phase

Design process was initiated by stepwise building strategy. As per the design method septum specification was the first priority followed by components inclusion and smoothness..

Specifications of the Model 1-1 scale of 3D heart model Length of heart approx~15cm Thickened septum, approx ~14mm Use of Patient IRB approved CT Scan ScanIP software for the design work

Constraints To create anatomically

Accurate Model Image Quality Cost Weight ~ 1-2 lbs

3 design plan outcome

Basis of Design analysis

Imaging on single plane Imaging on Matches Squares and Cubes Imaging on all Panes

Anatomic Parameters Model Smoothness

Scale Accuracy

Noise Cancellation

Heart Model Prototype and Testing

Virtual heart components measurements

Image 2: Heart Model Prototype

This hypertrophic heart model belongs to a 59 years old female. The thickness of the model derived from the SCANIP measurement was compared to a normal heart patient of similar age. The wide difference presented in the following line chart shows the complexity of the project.. This complex highlights the importance of this project, convenience for the surgeon and assurance for the patients.

Detail Design Phase

Imaging and segmentation on all three planes and combined 3D preview of the model were used as final design concept . The technical process applied are as follows: Import DICOM file (CT Scan) in to the software Set parameters and navigate the file in 2D and 3D views. Thresholding: Axial, Sagittal , Coronary Plane (1110

slices) Features Applied (Noise Cancellation, Cavity Fill,

Recursive Gaussian ) Surface Mesh Generation and 3D Print

Pericardial thickness designed to mimic human pericardium. Valves barely present to mediate proper view of the septum for the user.

a) Initial Phase

b) Preliminary Work

Final Complete HCM Heart Model

c) Mid Phase

Conclusions

Scan IP smoothing and remodeling of the heart CT Scans yielded a model that was very close to the desired outcome. Scan IP data showed a thickening of the septum of approx 14mm. Manual measurement of the septum thickening and imaging of the 3D model could not be performed due to constraints imposed by COVID-19 3D virtual heart model outcome was smooth, with desired heart components included Exclusion of the valves was decided upon to add to the overall look and accuracy of the finished heart model, and had to be done to be able to include the inner components of the heart

Acknowledgement

We would like to thank Dr. Jun Liao, Dr. Khosrow Behbehani, Katherine Copeland and Anura Shrestha for their support throughout the project course and providing us invaluable guidance and feedback.

References

1. Porcine heart image courtesy of Mutinta Musozya, Eyerus Tessema, Barsha Bogati. Image taken at The University of Texas at Arlington ERB 185 laboratory

2. All images obtained via Scan IP software screen printing 3. Hypertrophic cardiomyopathy. Mayo Clinic. 2018 Apr 14 [accessed 2020 Apr 14].



2020 UTA College of Engineering Innovation Day

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