Single Patient IND - Harvard University
Capecitabine
FDA Approved
Risks Associated with Capecitabine
Frequent (Between a 10-50% chance that this will happen)
• Low number of white blood cells which may increase the risk of infection. It may become life-threatening. Symptoms of infection may include fever, pain, redness, and/or difficulty breathing.
• Low number of red blood cells that can causes tiredness and shortness of breath. May require a blood transfusion.
• Loss of appetite and weight loss
• Diarrhea, which is frequent, loose watery stools, which can cause dehydration and may require hospitalization and treatment with intravenous fluids. Severe and prolonged diarrhea can be life-threatening.
• Numbness and tingling in arms, hands, legs or feet.
• Build up of fluid in the body or extremities causing swelling.
• Feeling tired, tiredness, weakness.
• High body temperature, a fever.
• Sores in the mouth and esophagus, which may be painful and cause difficulty swallowing.
• Feeling sick to the stomach
• Low number of platelets, which may cause bleeding and bruising. Bleeding may be serious or life threatening and may required a blood transfusion.
• Vomiting
• Pain
• Blisters on the skin
• Redness, pain or peeling of palms and soles.
Occasional (Between a 1-10% chance that this will happen)
• Any change from the normal heartbeat (abnormal heartbeat) which may be serious or life-threatening.
• Difficulty passing stool
• Dry eye
• Muscle spasms, body aches
• Restlessness, irritability
• Swelling of the face, fingers and lower legs
• Difficulty with balancing
Rare (Less than a 1% chance that this will happen)
• Allergic reaction that may include a rash, hives, fever, difficulty breathing, and low blood pressure. Although usually reversible with treatment, it can be severe or life threatening.
• Loss of muscle coordination including awkward, unsteady walking
• Damage to the heart
• Bleeding internally which may require hospitalization and surgery
• Speech problems
• Vision loss or vision changes that may be reversible.
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DANA-FARBER / HARVARD CANCER CENTER
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