Static.cambridge.org



Healthy and Unhealthy Dietary Patterns and Chronic Disease: An Umbrella Review of Meta-Analyses of Prospective Cohort StudiesSupplementary material including Supplementary Tables 1-5, Supplementary References, and PRISMA checklistsSupplementary Table 1. Search strategy to find published meta-analyses of dietary patterns and chronic diseases (September/5/2019)PubMed (710) (((("Food Habits") OR ("Food Habit") OR ("dietary Habits") OR ("dietary Habit") OR ("dietary pattern") OR ("dietary patterns") OR ("Western pattern") OR ("Prudent pattern") OR ("conservative pattern") OR ("traditional pattern") OR ("eating pattern") OR ("eating patterns") OR ("food intake pattern") OR ("food intake patterns") OR ("healthy pattern") OR ("unhealthy pattern") OR ("healthy dietary pattern") OR ("unhealthy dietary pattern") OR ("western dietary pattern") OR ("Prudent dietary pattern") OR ("traditional dietary pattern") OR ("conservative dietary pattern") OR (vegetarian) OR (“plant-based”)))) AND ((("systematic review") OR ("meta-analysis")))Scopus (773)TITLE-ABS("Food Habits") OR TITLE-ABS ("Food Habit") OR TITLE-ABS("dietary Habits") OR TITLE-ABS("dietary Habit") OR TITLE-ABS("dietary pattern") OR TITLE-ABS("dietary patterns") OR TITLE-ABS("Western pattern") OR TITLE-ABS("Prudent pattern") OR TITLE-ABS("conservative pattern") OR TITLE-ABS("traditional pattern") OR TITLE-ABS("eating pattern") OR TITLE-ABS("eating patterns") OR TITLE-ABS("food intake pattern") OR TITLE-ABS("food intake patterns") OR TITLE-ABS("healthy pattern") OR TITLE-ABS("unhealthy pattern") OR TITLE-ABS("healthy dietary pattern") OR TITLE-ABS("unhealthy dietary pattern") OR TITLE-ABS("western dietary pattern") OR TITLE-ABS("Prudent dietary pattern") OR TITLE-ABS("traditional dietary pattern") OR TITLE-ABS("conservative dietary pattern")OR TITLE-ABS(vegetarian)OR TITLE-ABS(“plant-based”)ANDTITLE-ABS("systematic review") OR TITLE-ABS("meta-analysis")Supplementary Table 2. List of excluded studies.Reason for exclusionIn patients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2NoZW1zPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48

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ADDIN EN.CITE.DATA (4; 5; 6; 7; 8; 9; 10; 11; 12)Meta-analyses with only one prospective cohort study PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NdTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJlY051

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ADDIN EN.CITE.DATA (21; 22; 23; 24; 25; 26; 27; 28; 29)Duplicates (meta-analyses that assessed the same outcome) PC92b2x1bWU+PGVkaXRpb24+MjAxNy8wNC8yMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+

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ADDIN EN.CITE.DATA (30; 31; 32; 33; 34; 35; 36; 37; 38; 39; 40; 41; 42; 43; 44; 45; 46; 47; 48; 49; 50; 51; 52; 53; 54)Supplementary Table 3. Detailed evaluation of the methodological quality with AMSTAR1.Author (ref), yearOutcomeQ12Q2Q3Q4Q5Q6Q7Q8Q9Q10Q11AllAlhazmi 29, 2014Type 2 diabetesYesYesYesYesNoYesYesNoYesYesYes9Esposito 30, 2014 Type 2 diabetesYesYesYesCANoYesYesNoYesYesYes8Fabiani 31, 2019FractureYesYesYesCAYesYesYesNoYesYesYes8Fabiani 32, 2019Metabolic syndromeYesYesYesCAYesYesYesNoYesYesYes8Garcia-Larsen 33, 2018Colorectal cancerYesNoYesYesNoYesYesNoYesYesYes8Godos 34, 2016Colorectal adenomaYesYesYesCANoYesYesNoYesYesYes8Grosso 35, 2017Pancreatic, gastric, and prostate cancersYesYesYesNoNoYesNoYesYesYesYes8Hou 36, 2015Coronary heart diseaseYesYesYesCANoYesYesNoYesYesYes8Li 37, 2015All-cause and cardiovascular mortalityYesYesNoNoNoYesNoNoYesYesYes6Lv 38, 2014AsthmaYesYesYesCANoYesYesNoYesYesYes8Molendijk 39, 2018DepressionYesNoYesCANoYesYesNoYesYesYes7Rashidi Pour Fard 40, 2019FrailtyYesYesYesCANoYesYesNoYesYesYes8Rodríguez-Monforte 41, 2015StrokeYesYesNoNoNoYesYesNoYesYesYes7Sun 42, 2016Lung cancerYesYesYesCANoYesYesYesYesYesYes9Xiao 43, 2019Breast cancerYesYesYesCAYesYesYesYesYesYesYes10Zheng 44, 2016Chronic obstructive pulmonary diseaseYesYesYesNoNoYesYesNoYesYesYes81 Reference numbers are related to the main text.2 Q1: Was an ?a priori‘ design provided?, Q2: Was there duplicate study selection and data extraction?, Q3: Was a comprehensive literature search performed?, Q4: Was the status of publication (i.e. grey literature) used as an inclusion criterion?, Q5: Was a list of studies (included and excluded) provided?, Q6: Were the characteristics of the included studies provided?, Q7: Was the scientific quality of the included studies assessed and documented?, Q8: Was the scientific quality of the included studies used appropriately in formulation conclusions?, Q9: Were the methods used to combine the findings of studies appropriate?, Q10: Was the likelihood of publication bias assessed?, Q11: Was the conflict of interest included?Abbreviations: CA, can’t answer; Q, Question; ref, reference number in the main text.Supplementary Table 4: Scoring for the different components of NutriGrade for each outcome1.Author (ref), yearExposureOutcomeRisk of bias2Precision3Heterogeneity4 Directness5Publication bias6Funding bias7Effect size8Dose-response9 SumNutriGrade Alhazmi 29, 2014Unhealthy patternType 2 diabetes1.510.8111107.3ModerateEsposito 30, 2014 Healthy pattern Type 2 diabetes210.8110.5006.3ModerateFabiani 31, 2019Healthy patternFracture1.510.410.51106.4ModerateFabiani 31, 2019Unhealthy patternFracture1.510.410.51106.4ModerateFabiani 32, 2019Healthy patternMetabolic syndrome1.510.6101005.1LowFabiani 32, 2019Unhealthy patternMetabolic syndrome1.510.6101106.1ModerateGarcia-Larsen 33, 2018Healthy patternColorectal cancer210.6111006.6ModerateGarcia-Larsen 33, 2018Unhealthy patternColorectal cancer200.6111005.6LowGodos 34, 2016Healthy patternColorectal adenoma1.500.5101004LowGodos 34, 2016Unhealthy patternColorectal adenoma1.500.5101105LowGodos 34, 2016Healthy patternPancreatic cancer1.500.2101003.7Very lowGodos 34, 2016Unhealthy patternPancreatic cancer1.500.4101003.9Very lowGrosso 35, 2017Healthy patternPancreatic cancer1.500.3101003.8Very lowGrosso 35, 2017Unhealthy patternPancreatic cancer1.500.3101003.8Very lowGrosso 35, 2017Healthy patternProstate cancer100.5101003.5Very lowGrosso 35, 2017Unhealthy patternProstate cancer100.3101003.3Very lowHou 36, 2015Healthy patternCoronary heart disease1.510.610.51005.6LowHou 36, 2015Unhealthy patternCoronary heart disease1.510.510.51005.5LowLi 37, 2015Healthy patternAll-cause mortality1.510.4101105.9LowLi 37, 2015Unhealthy patternAll-cause mortality1.510.410.51005.4LowLi 37, 2015Healthy patternCardiovascular mortality1.510.610.51005.6LowLi 37, 2015Unhealthy patternCardiovascular mortality1.500.410.51004.4LowLv 38, 2014Healthy patternAsthma100.5001002.2Very lowLv 38, 2014Unhealthy patternAsthma100.2001002.2Very lowMolendijk 39, 2018Healthy patternDepression100.510.51004LowMolendijk 39, 2018Unhealthy patternDepression100.410.51003.9Very lowRashidi Pour Fard 40, 2019Healthy patternFrailty1.500.4101003.9Very lowRodríguez-Monforte 41, 2015Healthy patternStroke1.500.510.51004.5LowRodríguez-Monforte 41, 2015Unhealthy patternStroke1.500.810.51004.8LowSun 42, 2016Healthy patternlung cancer100.4001103.4Very lowXiao 43, 2019Healthy patternBreast cancer1.510.8111006.3ModerateXiao 43, 2019Unhealthy patternBreast cancer1.500.5111005LowZheng 44, 2016Healthy patternChronic obstructive pulmonary disease1.500.5001104LowZheng 44, 2016Western patternChronic obstructive pulmonary disease1.500.2001002.7Very low1 Reference numbers are related to the main text.2 Modifications of original NutriGrade-scoring system: Study quality Newcastle Ottawa Scale: ≥8 (2 points); ≥7-<8 (1.5 points), ≥6-<7(1 point).3 Modifications of original NutriGrade-scoring system: >5000 cases and the 95%CI excludes the null value (1 point), <5000 cases or >5000 cases but 95%CI includes the null value (0 point).4 0 to 1 point on the basis of I2.5 No important differences in the population or hard clinical outcomes (1 point), important differences in the population (0 point).6 <5 studies or sever evidence of bias or publication bias not assessed (0 point), no evidence of bias for 5-9 studies or moderate evidence of bias for ≥10 studies (0.5 point), no evidence of bias for ≥10 studies (1 point).7 Funded by academic institutions or research institutions (1 point), funded by private institutions, foundations, or nongovernmental organizations (0.5 point), Industry funding or conflict of interest (0 point).8 No effect (RR: 0.80–1.20) when comparing the highest vs. lowest category (0 point), moderate effect size (RR: <0.80–0.50 and >1.20–2, and corresponding test is statistically significant) when comparing the highest vs. lowest category (0.5 point), large effect size (RR: <0.50 and >2.00, and corresponding test is statistically significant) when comparing the highest vs. lowest category (1 point).9 No dose-response analysis or dose-response analysis with corresponding statistical test nonsignificant (0 point), significant linear or nonlinear dose-response relationship (1 point).Supplementary References: ADDIN EN.REFLIST 1. 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Nutrition reviews 75, 883-908.Section/topic #Checklist item Reported on page # TITLE Title 1Identify the report as a systematic review, meta-analysis, or both. 1ABSTRACT Structured summary 2Provide a structured summary including, as applicable: background; objectives; data sources; study eligibility criteria, participants, and interventions; study appraisal and synthesis methods; results; limitations; conclusions and implications of key findings; systematic review registration number. 2,3INTRODUCTION Rationale 3Describe the rationale for the review in the context of what is already known. 4-5Objectives 4Provide an explicit statement of questions being addressed with reference to participants, interventions, comparisons, outcomes, and study design (PICOS). 5METHODS Protocol and registration 5Indicate if a review protocol exists, if and where it can be accessed (e.g., Web address), and, if available, provide registration information including registration number. None.Eligibility criteria 6Specify study characteristics (e.g., PICOS, length of follow-up) and report characteristics (e.g., years considered, language, publication status) used as criteria for eligibility, giving rationale. 6Information sources 7Describe all information sources (e.g., databases with dates of coverage, contact with study authors to identify additional studies) in the search and date last searched. 5-6Search 8Present full electronic search strategy for at least one database, including any limits used, such that it could be repeated. Supplementary Table 1Study selection 9State the process for selecting studies (i.e., screening, eligibility, included in systematic review, and, if applicable, included in the meta-analysis). 9, and Figure 1Data collection process 10Describe method of data extraction from reports (e.g., piloted forms, independently, in duplicate) and any processes for obtaining and confirming data from investigators. 6-7Data items 11List and define all variables for which data were sought (e.g., PICOS, funding sources) and any assumptions and simplifications made. 6-7Risk of bias in individual studies 12Describe methods used for assessing risk of bias of individual studies (including specification of whether this was done at the study or outcome level), and how this information is to be used in any data synthesis. 7-8Summary measures 13State the principal summary measures (e.g., risk ratio, difference in means). 8Synthesis of results 14Describe the methods of handling data and combining results of studies, if done, including measures of consistency (e.g., I2) for each meta-analysis. 8-9Page 1 of 2 Section/topic #Checklist item Reported on page # Risk of bias across studies 15Specify any assessment of risk of bias that may affect the cumulative evidence (e.g., publication bias, selective reporting within studies). 8-9Additional analyses 16Describe methods of additional analyses (e.g., sensitivity or subgroup analyses, meta-regression), if done, indicating which were pre-specified. Not applicableRESULTS Study selection 17Give numbers of studies screened, assessed for eligibility, and included in the review, with reasons for exclusions at each stage, ideally with a flow diagram. 9, Figure 1Study characteristics 18For each study, present characteristics for which data were extracted (e.g., study size, PICOS, follow-up period) and provide the citations. Table 2Risk of bias within studies 19Present data on risk of bias of each study and, if available, any outcome level assessment (see item 12). Tables 2-5Results of individual studies 20For all outcomes considered (benefits or harms), present, for each study: (a) simple summary data for each intervention group (b) effect estimates and confidence intervals, ideally with a forest plot. Tables 2-5Synthesis of results 21Present results of each meta-analysis done, including confidence intervals and measures of consistency. Tables 2-5Risk of bias across studies 22Present results of any assessment of risk of bias across studies (see Item 15). Tables 2-5Additional analysis 23Give results of additional analyses, if done (e.g., sensitivity or subgroup analyses, meta-regression [see Item 16]). Tables 2-5DISCUSSION Summary of evidence 24Summarize the main findings including the strength of evidence for each main outcome; consider their relevance to key groups (e.g., healthcare providers, users, and policy makers). 13-17Limitations 25Discuss limitations at study and outcome level (e.g., risk of bias), and at review-level (e.g., incomplete retrieval of identified research, reporting bias). 18-19Conclusions 26Provide a general interpretation of the results in the context of other evidence, and implications for future research. 20-21FUNDING Funding 27Describe sources of funding for the systematic review and other support (e.g., supply of data); role of funders for the systematic review. 21 ................
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