Review and Assessment of Chlorine Mammalian Lethality Data ...

REVIEW AND ASSESSMENT OF CHLORINE MAMMALIAN LETHALITY DATA AND THE DEVELOPMENT OF A

HUMAN ESTIMATE R-1

Prepared by: Douglas R. Sommerville John J. Bray

Sharon A. Reutter-Christy Raymond E. Jablonski Erin E. Shelly

Revised June 2009

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CBRNIAC Contract #SPO-700-00-D-3180 Task No. 628, Delivery Order No. 483

Department Of Homeland Security Chemical Security Analysis Center

REVIEW AND ASSESSMENT OF CHLORINE MAMMALIAN LETHALITY DATA AND THE

DEVELOPMENT OF A HUMAN ESTIMATE R-1

Prepared by: Douglas R. Sommerville Sharon A. Reutter-Christy

Erin E. Shelly Research and Technology Directorate US Army Edgewood Chemical Biological Center

Aberdeen Proving Ground, MD John J. Bray

OptiMetrics, Inc. Abingdon, MD 21009 Raymond E. Jablonski Chemical Security Analysis Center U.S. Department Of Homeland Security Aberdeen Proving Ground, MD Revised June 1, 2009

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PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS.

1. REPORT DATE (DD-MM-YYYY)

Revised 27-05-2009

2. REPORT TYPE

Final

3. DATES COVERED (From - To)

31-10-2007 to 23-01-2008

4. TITLE AND SUBTITLE

Review and Assessment of Chlorine Mammalian Lethality Data and the Development of a Human Estimate ? R-1

5a. CONTRACT NUMBER

SP0700-00-D-3180

5b. GRANT NUMBER

N/A

5c. PROGRAM ELEMENT NUMBER

N/A

6. AUTHOR(S)

Douglas R. Sommerville John J. Bray Sharon A. Reutter-Christy Raymond E. Jablonski Erin E. Shelly

5d. PROJECT NUMBER

N/A

5e. TASK NUMBER

628

5f. WORK UNIT NUMBER

N/A

7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)

Battelle Eastern Science and Technology Center 1204 Technology Drive Aberdeen, MD 21001

9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES)

Chemical Security Analysis Center 5183 Blackhawk Road Aberdeen Proving Ground, MD 21010?5424

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CBRNIAC-SS3-628

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CSAC

11. SPONSORING/MONITORING AGENCY REPORT NUMBER

12. DISTRIBUTION AVAILABILITY STATEMENT

Approved for public release, distribution is unlimited.

13. SUPPLEMENTARY NOTES

R-1 This report, published 23/01/2008, was originally FOUO. Permission to down grade has been obtained for wider distribution. No other changes have been made within the content of this report.

14. ABSTRACT

New human estimates for chlorine inhalation lethality as a function of exposure duration (for a healthy subpopulation and the general population) were derived via a review and statistical analysis of existing mammalian lethality data. Median lethal dosage and quantal response data were found and analyzed for eight species (mouse, rat, guinea pig, rabbit, cat, dog, goat and sheep) and for durations (T) from 8 min to 235 min. Resulting human estimates were expressed via the toxic load model, L(CnT)50 = k, where n = 2.75 and k = 6.79 x 1010 (military) or 2.58 x 1010 (general), with C in mg/m3 and T in minutes. For 2-min exposures, LCT50 equals 13,500 and 9500 mg-min/m3, for military and general population, respectively. The base 10 probit slope (concentration) was estimated to equal 8.0 (military) and 6.0 (general). Previous human estimates were reviewed, and one study identified as corresponding to the lower confidence limit for the new estimate. The impact of the new estimate was evaluated through a series of transport and dispersion modeling runs using the general population estimate. The predicted downwind hazard distances were consistent with what has been witnessed historically.

15. SUBJECT TERMS

16. SECURITY CLASSIFICATION OF:

a. REPORT

b. ABSTRACT c. THIS PAGE

17. LIMITATION OF 18. NUMBER

ABSTRACT

OF PAGES

127

19a. NAME OF RESPONSIBLE PERSON

Adolfo Negron

19b. TELEPONE NUMBER (Include area code)

410-436-4023

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