Review and Assessment of Chlorine Mammalian Lethality Data ...
REVIEW AND ASSESSMENT OF CHLORINE MAMMALIAN LETHALITY DATA AND THE DEVELOPMENT OF A
HUMAN ESTIMATE R-1
Prepared by: Douglas R. Sommerville John J. Bray
Sharon A. Reutter-Christy Raymond E. Jablonski Erin E. Shelly
Revised June 2009
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The Chemical, Biological, Radiological & Nuclear Defense Information Analysis Center is a Department of Defense Information Analysis Center operated by Battelle Memorial Institute and sponsored by the Defense Technical Information Center, (DTIC-I), Fort Belvoir, VA 22060-6218.
CBRNIAC Contract #SPO-700-00-D-3180 Task No. 628, Delivery Order No. 483
Department Of Homeland Security Chemical Security Analysis Center
REVIEW AND ASSESSMENT OF CHLORINE MAMMALIAN LETHALITY DATA AND THE
DEVELOPMENT OF A HUMAN ESTIMATE R-1
Prepared by: Douglas R. Sommerville Sharon A. Reutter-Christy
Erin E. Shelly Research and Technology Directorate US Army Edgewood Chemical Biological Center
Aberdeen Proving Ground, MD John J. Bray
OptiMetrics, Inc. Abingdon, MD 21009 Raymond E. Jablonski Chemical Security Analysis Center U.S. Department Of Homeland Security Aberdeen Proving Ground, MD Revised June 1, 2009
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PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS.
1. REPORT DATE (DD-MM-YYYY)
Revised 27-05-2009
2. REPORT TYPE
Final
3. DATES COVERED (From - To)
31-10-2007 to 23-01-2008
4. TITLE AND SUBTITLE
Review and Assessment of Chlorine Mammalian Lethality Data and the Development of a Human Estimate ? R-1
5a. CONTRACT NUMBER
SP0700-00-D-3180
5b. GRANT NUMBER
N/A
5c. PROGRAM ELEMENT NUMBER
N/A
6. AUTHOR(S)
Douglas R. Sommerville John J. Bray Sharon A. Reutter-Christy Raymond E. Jablonski Erin E. Shelly
5d. PROJECT NUMBER
N/A
5e. TASK NUMBER
628
5f. WORK UNIT NUMBER
N/A
7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)
Battelle Eastern Science and Technology Center 1204 Technology Drive Aberdeen, MD 21001
9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES)
Chemical Security Analysis Center 5183 Blackhawk Road Aberdeen Proving Ground, MD 21010?5424
8. PERFORMING ORGANIZATION REPORT NUMBER
CBRNIAC-SS3-628
10. SPONSOR/MONITOR'S ACRONYM(S)
CSAC
11. SPONSORING/MONITORING AGENCY REPORT NUMBER
12. DISTRIBUTION AVAILABILITY STATEMENT
Approved for public release, distribution is unlimited.
13. SUPPLEMENTARY NOTES
R-1 This report, published 23/01/2008, was originally FOUO. Permission to down grade has been obtained for wider distribution. No other changes have been made within the content of this report.
14. ABSTRACT
New human estimates for chlorine inhalation lethality as a function of exposure duration (for a healthy subpopulation and the general population) were derived via a review and statistical analysis of existing mammalian lethality data. Median lethal dosage and quantal response data were found and analyzed for eight species (mouse, rat, guinea pig, rabbit, cat, dog, goat and sheep) and for durations (T) from 8 min to 235 min. Resulting human estimates were expressed via the toxic load model, L(CnT)50 = k, where n = 2.75 and k = 6.79 x 1010 (military) or 2.58 x 1010 (general), with C in mg/m3 and T in minutes. For 2-min exposures, LCT50 equals 13,500 and 9500 mg-min/m3, for military and general population, respectively. The base 10 probit slope (concentration) was estimated to equal 8.0 (military) and 6.0 (general). Previous human estimates were reviewed, and one study identified as corresponding to the lower confidence limit for the new estimate. The impact of the new estimate was evaluated through a series of transport and dispersion modeling runs using the general population estimate. The predicted downwind hazard distances were consistent with what has been witnessed historically.
15. SUBJECT TERMS
16. SECURITY CLASSIFICATION OF:
a. REPORT
b. ABSTRACT c. THIS PAGE
17. LIMITATION OF 18. NUMBER
ABSTRACT
OF PAGES
127
19a. NAME OF RESPONSIBLE PERSON
Adolfo Negron
19b. TELEPONE NUMBER (Include area code)
410-436-4023
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