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Abstract:BACKGROUND: Limited data are available that evaluated the effects of olive leaf extract (oleuropein) supplementation on blood pressure, lipid profile and oxidative stress markers in hypertensive patients. The present study was conducted to determine the effects of olive leaf extract administration on blood pressure, lipid profile and oxidative stress markers among hypertensive patients.Materials and Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 60 hypertensive patients age 45-75 years old. Participants were randomly allocated into two groups to receive either 500mg/day olive leaf extract supplements(n=30) or placebo(n=30) for 12 weeks.Blood pressure and fasting blood samples were obtained at the onset of the study and after 12 weeks treatment to assess blood pressure changes , lipid profile and oxidative stress markers.RESULTS:After 12 weeks of intervention, comparet with placebo, oleuropein supplementation resulted in a significant reduction in systolic blood pressure (p=0.001) , total cholesterol (p=0.001) and malondialdehyde (MDA) (p=0.001) , HDL (p=0.023) levels. Supplementation with oleuropein did not affect diastolic blood pressure (p=0.093), TG (p=0.235), Total antioxidanant capacity (TAC) (p=0274).CONCLUSION: overall, our study demonstrated that oleuropein for 12 weeks among hypertensive patients had beneficial effects on systolic blood pressure, total cholesterol, HDL and MDA levels.KEYWORDS: Olive leaf extract. Blood pressure. Lipid profile. Oxidative stress. Olive leaf extract. Hypertension. ................
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